The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: A new therapeutic approach

International Journal of Oncology

Volumn 45, Issue 3, 2014, Pages 1109-1122

  Agostinelli, Enzo ^a   Condello, Maria ^b   Tempera, Giampiero ^a   Macone, Alberto ^a   Bozzuto, Giuseppina ^b   Ohkubo, Shinji ^a   Calcabrini, Annarica ^b   Arancia, Giuseppe ^b   Molinari, Agnese ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Amine oxidase; Cytotoxicity; Lysosomotropic compounds; Melanocytes; Melanoma; Spermine

Indexed keywords

ACROLEIN; AMINE OXIDASE (FLAVIN CONTAINING); BOVINE SERUM AMINE OXIDASE; CHLOROQUINE; DOXORUBICIN; SPERMINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL DEATH; CELL DIFFERENTIATION; CELL MEMBRANE; CELL ORGANELLE; CELL SURFACE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG BINDING; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; MELANOCYTE; MELANOMA CELL; MULTIDRUG RESISTANCE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; CELL CULTURE; CELL CYCLE; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; MELANOMA; OXIDATION REDUCTION REACTION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL CYCLE; CELLS, CULTURED; CHLOROQUINE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MELANOCYTES; MELANOMA; OXIDATION-REDUCTION; SPERMINE;

EID: 84904406951     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2502     Document Type: Article

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