Functional evidence for a pH sensor of erythrocyte K-Cl cotransport through inhibition by internal protons and diethylpyrocarbonate

Cellular Physiology and Biochemistry

Volumn 8, Issue 1-2, 1998, Pages 46-60

  Lauf, Peter K ^a   Adragna, Norma C ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Diethylpyrocarbonate; Histidine; K Cl cotransport; pH sensor; Protons; Regulation; Sheep red blood cells

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CALCIMYCIN; CARRIER PROTEIN; CHLORIDE CHANNEL; DIETHYL PYROCARBONATE; HISTIDINE; POTASSIUM CHANNEL; SUCROSE;

ANIMAL CELL; ARTICLE; CELL PH; CELL VOLUME; CONTROLLED STUDY; CULTURE MEDIUM; ION TRANSPORT; NONHUMAN; OSMOLALITY; PH; PRIORITY JOURNAL; SHEEP ERYTHROCYTE; WATER CONTENT;

ANIMALIA; OVIS ARIES; STROPHANTHUS GRATUS;

EID: 0031973372     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000016270     Document Type: Article

References (47)

1. Lauf PK, Bauer J, Adragna NC, Fujise H, Zade-Oppen AMM, Ryu KH, Delpire E: Erythrocyte K-Cl cotransport: Properties and regulation. Am J Physiol 1992;263:C917-C932.
2. Gillen CM, Brill S, Payne JA, Forbush B III: Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat and human. J Biol Chem 1996;271:16237-16244.
3. Payne JA, Stevenson TJ, Donaldson LF: Molecular characterization of a putative K-Cl cotransporter in rat brain. J Biol Chem 1996;271: 16245-16252.
4. Lauf PK, Adragna NC: A thermodynamic study of electroneutral K-Cl cotransport in pH- and volume-clamped low K sheep erythrocytes with normal and low internal magnesium. J Gen Physiol 1996;108: 341-350.
5. Brugnara C, Van Ha T, Tosteson DC: Role of chloride in potassium transport through a K-Cl cotransport system in human red blood cells. Am J Physiol 1989;256:C994-C1003.
6. Kaji DM: Effect of membrane potential on K-Cl transport in human erythrocytes. Am J Physiol 1993; 264:C376-C382.
7. Berg C, Kelley S, Dunham PB: K-Cl cotransport in LK sheep erythrocytes: Kinetics of stimulation and cell swelling. J Membr Biol 1990; 117:177-188.
8. Delpire E, Lauf PK: Kinetics of Cl-dependent K fluxes in hyposmotically swollen low K sheep erythrocytes. J Gen Physiol 1991;97:173-193.
9. Adragna NC, Lauf PK: Oxidative activation of K-Cl cotransport by diamide in erythrocytes from humans with red cell disorders, and from several other mammalian species. J Membr Biol 1997;155:207-217.
10. + ] ions. J Membr Biol 1983;73:247-256.
11. Lauf PK, Adragna NC: Temperature-induced functional deocclusion of thiols inhibitory for sheep erythrocyte K-Cl cotransport. Am J Physiol 1995;269:C1167-C1175.
12. Bize I, Dunhan PB: Staurosporine, a protein kinase inhibitor, activates K-Cl cotransport in LK sheep erythrocytes. Am J Physiol 1994;266: C759-C770.
13. Flatman PW, Adragna NC, Lauf PK: Role of protein kinases in regulating sheep erythrocyte K-Cl cotransport. Am J Physiol 1996;271: C255-C263.
14. + sheep red blood cells. J Physiol (Lond) 1991;441: 219-231.
15. Dunham PB, Klimczak J, Logue PJ: Swelling activation of K-Cl cotransport in LK sheep erythrocytes: A three-state process. J Gen Physiol 1993;101:733-766.
16. + sheep erythrocytes: modulation by A23187 and bivalent cations. Am J Physiol 1985;249:C271-C278.
17. - cotransport: sulfhydryls, divalent cations, and the mechanism of volume activation in a red cell. J Membr Biol 1985;82: 167-178.
18. Lauf PK, Erdmann A, Adragna NC: K-Cl cotransport, pH, and role of Mg in volume-clamped low-K sheep erythrocytes: Three equilibrium states. Am J Physiol 1994;266:C95-C103.
19. Ortiz-Carranza O, Adragna NC, Lauf PK: Modulation of K-Cl Cotransport in volume-clamped low K sheep erythrocytes by pH, magnesium, and ATP. Am J Physiol 1996; 271:C1049-C1058.
20. De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G: Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport. J Clin Invest 1997;99:220-227.
21. - transport: The volume-sensitive parameter is the rate constant for inactivation. J Gen Physiol 1990;95:1021-1040.
22. Starke LC, Jennings ML: K-Cl cotransport in rabbit red cells: further evidence for regulation by protein phosphatase type 1. Am J Physiol 1993;264:C118-C124.
23. Brugnara C, Van Ha T, Tosteson DC: Acid pH induces formation of dense cells in sickle erythrocytes. Blood 1989;74:487-495.
24. Beauge LA, Adragna NC: pH dependence of rubidium influx in human red blood cells. Biochim Biophys Acta 1974;352:441-447.
25. Garay R, Adragna N, Canessa M, Tosteson DC: Outward sodium and potassium cotransport in human red cells. J Membr Biol 1981;62:169-174.
26. Brugnara C, Tosteson DC: Inhibition of K transport by divalent cations in sickle erythrocytes. Blood 1987;70:1810-1815.
27. + transport in resealed human erythrocyte ghosts. Am J Physiol 1988;255:C346-C356.
28. Gunn RB, Dalmark M, Tosteson DC, Wieth JO: Characteristics of chloride transport in human red blood cells. J Gen Physiol 1973;61: 185-206.
29. i -clamped low Mg LK sheep erythrocytes. Biophys J 1997;72:A408.
30. + ] fluxes. J Membr Biol 1984;82:167-178.
31. Lauf PK: Thiol-dependent passive K:Cl transport in sheep red blood cells. X. A hydroxylamine-oxidation induced K flux blocked by diethylcarbonate. J Membr Biol 1990;118: 153-159.
32. Lauf PK: Foreign anions modulate volume set point of sheep erythrocyte K-Cl cotransport. Am J Physiol 1989;260:C503-C512.
33. Payne JA, Lytle C, McManus TJ: Foreign anion substitution for chloride in human red blood cells. Effect on ionic and osmotic equilibria. Am J Physiol 1990;259:C819-C827.
34. - -free solutions. J Membr Biol 1997;156:287-295.
35. + fluxes in human red blood cells. Biochim Biophys Acta 1986;886:373-382.
36. - cotransport by different mechanisms in squid axons. J Gen Physiol 1996;107:261-270.
37. Lauf PK: Modulation of K:Cl cotransport by diethylpyrocarbonate; in Butterfield A (ed): Biological and Synthetic Membranes. New York, Liss, 1989, pp 339-347.
38. + antiporter in Escherichia coli. Proc Natl Acad Sci USA 1993;90:1212-1216.
39. Miles EW: Modification of histidyl residues in proteins by diethylpyrocarbonate. Methods Enzymol 1977; 47:431-442.
40. + exchanger by histidine-specific reagents. J Biol Chem 1986; 261:1120-1125.
41. + exchanger. Am J Physiol 1995;269:C392-C402.
42. + antiport in Escherichia coli membrane vesicles. Eur J Biochem 1985;148:183-188.
43. Bucci E, Fronticelli C, Ragatz R: The proton-binding behavior of human hemoglobin and its subunits in their native state. J Biol Chem 1968; 243:241.
44. Borghese F, Garcia-Romeo F, Motais R: Ion movements and volume changes in erythrocytes of rainbow trout: effect of pH. J Physiol (Lond) 1987;382:145-157.
45. Kee SM, Graves DJ: Properties of the γ subunit of phosphorylase kinase. J Biol Chem 1987;262:9448-9543.
46. Killimann MW, Heilmeyer LMG Jr: Multiple activities of phosphorylase kinase. 1. Characterization of three practical activities by their response to calcium ion, magnesium ion, pH, and ammonium chloride and effect of activation by phosphorylation and proteolysis. Biochemistry 1982; 21:1727-1734.
47. Shenolikar S: Protein serine/threonine phosphatases-new avenues for cell regulation. Ann Rev Cell Biol 1994;10:55-86.