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Volumn 44, Issue 7, 2014, Pages 2096-2110

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)

Author keywords

Autoinflammation; Protein microarray; Signalome; TNF receptor 1; TRAPS

Indexed keywords

AUTOINFLAMMATION; PROTEIN MICROARRAY; SIGNALOME; TNF RECEPTOR 1; TRAPS;

EID: 84904396578     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344328     Document Type: Article
Times cited : (35)

References (40)
  • 1
    • 0033515520 scopus 로고    scopus 로고
    • Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
    • McDermott, M. F., Aksentijevich, I., Galon, J., McDermott, E. M., Ogunkolade, B. W., Centola, M., Mansfield, E. et al., Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 1999. 97: 133-144.
    • (1999) Cell , vol.97 , pp. 133-144
    • McDermott, M.F.1    Aksentijevich, I.2    Galon, J.3    McDermott, E.M.4    Ogunkolade, B.W.5    Centola, M.6    Mansfield, E.7
  • 3
    • 4043090739 scopus 로고    scopus 로고
    • Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types
    • Huggins, M. L., Radford, P. M., McIntosh, R. S., Bainbridge, S. E., Dickinson, P., Draper-Morgan, K. A., Tighe, P. J. et al., Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types. Arthritis Rheum. 2004. 50: 2651-2659.
    • (2004) Arthritis Rheum. , vol.50 , pp. 2651-2659
    • Huggins, M.L.1    Radford, P.M.2    McIntosh, R.S.3    Bainbridge, S.E.4    Dickinson, P.5    Draper-Morgan, K.A.6    Tighe, P.J.7
  • 4
    • 4444320270 scopus 로고    scopus 로고
    • Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling functions but show abnormal behaviour
    • Todd, I., Radford, P. M., Draper-Morgan, K. A., McIntosh, R., Bainbridge, S., Dickinson, P., Jamhawi, L. et al., Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling functions but show abnormal behaviour. Immunology 2004. 113: 65-79.
    • (2004) Immunology , vol.113 , pp. 65-79
    • Todd, I.1    Radford, P.M.2    Draper-Morgan, K.A.3    McIntosh, R.4    Bainbridge, S.5    Dickinson, P.6    Jamhawi, L.7
  • 5
    • 33746971927 scopus 로고    scopus 로고
    • Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function
    • Rebelo, S. L., Bainbridge, S. E., Amel-Kashipaz, M. R., Radford, P. M., Powell, R. J., Todd, I. and Tighe, P. J., Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function. Arthritis Rheum. 2006. 54: 2674-2687.
    • (2006) Arthritis Rheum. , vol.54 , pp. 2674-2687
    • Rebelo, S.L.1    Bainbridge, S.E.2    Amel-Kashipaz, M.R.3    Radford, P.M.4    Powell, R.J.5    Todd, I.6    Tighe, P.J.7
  • 6
    • 34547778343 scopus 로고    scopus 로고
    • Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor-associated periodic syndrome is altered antigenically and is retained within patients' leukocytes
    • Todd, I., Radford, P. M., Daffa, N., Bainbridge, S. E., Powell, R. J. and Tighe, P. J., Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor-associated periodic syndrome is altered antigenically and is retained within patients' leukocytes. Arthritis Rheum. 2007. 56: 2765-2773.
    • (2007) Arthritis Rheum. , vol.56 , pp. 2765-2773
    • Todd, I.1    Radford, P.M.2    Daffa, N.3    Bainbridge, S.E.4    Powell, R.J.5    Tighe, P.J.6
  • 7
    • 25444485148 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation
    • Yousaf, N., Gould, D. J., Aganna, E., Hammond, L., Mirakian, R. M., Turner, M. D., Hitman, G. A. et al., Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation. Arthritis Rheum. 2005. 52: 2906-2916.
    • (2005) Arthritis Rheum. , vol.52 , pp. 2906-2916
    • Yousaf, N.1    Gould, D.J.2    Aganna, E.3    Hammond, L.4    Mirakian, R.M.5    Turner, M.D.6    Hitman, G.A.7
  • 8
    • 58249124371 scopus 로고    scopus 로고
    • Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line
    • Rebelo, S. L., Amel-Kashipaz, M. R., Radford, P. M., Bainbridge, S. E., Fiets, R., Fang, J., McDermott, E. M. et al., Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line. Arthritis Rheum. 2009. 60: 269-280.
    • (2009) Arthritis Rheum. , vol.60 , pp. 269-280
    • Rebelo, S.L.1    Amel-Kashipaz, M.R.2    Radford, P.M.3    Bainbridge, S.E.4    Fiets, R.5    Fang, J.6    McDermott, E.M.7
  • 9
    • 84868446260 scopus 로고    scopus 로고
    • Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome
    • Dickie, L. J., Aziz, A. M., Savic, S., Lucherini, O. M., Cantarini, L., Geiler, J., Wong, C. H. et al., Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome. Ann. Rheum. Dis. 2012. 71: 2035-2043.
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 2035-2043
    • Dickie, L.J.1    Aziz, A.M.2    Savic, S.3    Lucherini, O.M.4    Cantarini, L.5    Geiler, J.6    Wong, C.H.7
  • 10
  • 11
    • 77953089570 scopus 로고    scopus 로고
    • Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome
    • Simon, A., Park, H., Maddipati, R., Lobito, A. A., Bulua, A. C., Jackson, A. J., Chae, J. J. et al., Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome. Proc. Natl. Acad. Sci. U.S.A. 2010. 107: 9801-9806.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 9801-9806
    • Simon, A.1    Park, H.2    Maddipati, R.3    Lobito, A.A.4    Bulua, A.C.5    Jackson, A.J.6    Chae, J.J.7
  • 12
    • 33747162175 scopus 로고    scopus 로고
    • Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)
    • Lobito, A. A., Kimberley, F. C., Muppidi, J. R., Komarow, H., Jackson, A. J., Hull, K. M., Kastner, D. L. et al. Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS). Blood 2006. 108: 1320-1327.
    • (2006) Blood , vol.108 , pp. 1320-1327
    • Lobito, A.A.1    Kimberley, F.C.2    Muppidi, J.R.3    Komarow, H.4    Jackson, A.J.5    Hull, K.M.6    Kastner, D.L.7
  • 13
    • 79952184583 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
    • Bulua, A. C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K. Y., Sack, M. N. et al., Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J. Exp. Med. 2011. 208: 519-533.
    • (2011) J. Exp. Med. , vol.208 , pp. 519-533
    • Bulua, A.C.1    Simon, A.2    Maddipati, R.3    Pelletier, M.4    Park, H.5    Kim, K.Y.6    Sack, M.N.7
  • 14
    • 47749089820 scopus 로고    scopus 로고
    • Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
    • Schutze, S., Tchikov, V. and Schneider-Brachert, W., Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat. Rev. Mol. Cell. Biol. 2008. 9: 655-662.
    • (2008) Nat. Rev. Mol. Cell. Biol. , vol.9 , pp. 655-662
    • Schutze, S.1    Tchikov, V.2    Schneider-Brachert, W.3
  • 16
    • 34147099560 scopus 로고    scopus 로고
    • TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells
    • Zhou, Z., Connell, M. C. and MacEwan, D. J., TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells. Cell Signal. 2007. 19: 1238-1248.
    • (2007) Cell Signal. , vol.19 , pp. 1238-1248
    • Zhou, Z.1    Connell, M.C.2    MacEwan, D.J.3
  • 17
    • 0031779350 scopus 로고    scopus 로고
    • Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor
    • Adam-Klages, S., Schwandner, R., Adam, D., Kreder, D., Bernardo, K. and Kronke, M., Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. J. Leukoc. Biol. 1998. 63: 678-682.
    • (1998) J. Leukoc. Biol. , vol.63 , pp. 678-682
    • Adam-Klages, S.1    Schwandner, R.2    Adam, D.3    Kreder, D.4    Bernardo, K.5    Kronke, M.6
  • 18
    • 49049106608 scopus 로고    scopus 로고
    • Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity
    • Pincheira, R., Castro, A. F., Ozes, O. N., Idumalla, P. S. and Donner, D. B., Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity. J. Immunol. 2008. 181: 1288-1298.
    • (2008) J. Immunol. , vol.181 , pp. 1288-1298
    • Pincheira, R.1    Castro, A.F.2    Ozes, O.N.3    Idumalla, P.S.4    Donner, D.B.5
  • 20
    • 0036121098 scopus 로고    scopus 로고
    • TNF receptor subtype signalling: differences and cellular consequences
    • MacEwan, D. J., TNF receptor subtype signalling: differences and cellular consequences. Cell Signal. 2002. 14: 477-492.
    • (2002) Cell Signal. , vol.14 , pp. 477-492
    • MacEwan, D.J.1
  • 21
    • 38149024911 scopus 로고    scopus 로고
    • Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome
    • Nedjai, B., Hitman, G. A., Yousaf, N., Chernajovsky, Y., Stjernberg-Salmela, S., Pettersson, T., Ranki, A. et al., Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum. 2008. 58: 273-283.
    • (2008) Arthritis Rheum. , vol.58 , pp. 273-283
    • Nedjai, B.1    Hitman, G.A.2    Yousaf, N.3    Chernajovsky, Y.4    Stjernberg-Salmela, S.5    Pettersson, T.6    Ranki, A.7
  • 22
    • 24944465008 scopus 로고    scopus 로고
    • Mutation of the extracellular domain of tumour necrosis factor receptor 1 causes reduced NF-kappaB activation due to decreased surface expression
    • Siebert, S., Fielding, C. A., Williams, B. D. and Brennan, P., Mutation of the extracellular domain of tumour necrosis factor receptor 1 causes reduced NF-kappaB activation due to decreased surface expression. FEBS Lett. 2005. 579: 5193-5198.
    • (2005) FEBS Lett. , vol.579 , pp. 5193-5198
    • Siebert, S.1    Fielding, C.A.2    Williams, B.D.3    Brennan, P.4
  • 23
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata, H., Honda, S., Maeda, S., Chang, L., Hirata, H. and Karin, M., Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005. 120: 649-661.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 24
    • 33644878847 scopus 로고    scopus 로고
    • Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications
    • D'Osualdo, A., Ferlito, F., Prigione, I., Obici, L., Meini, A., Zulian, F., Pontillo, A. et al., Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications. Arthritis Rheum. 2006. 54: 998-1008.
    • (2006) Arthritis Rheum. , vol.54 , pp. 998-1008
    • D'Osualdo, A.1    Ferlito, F.2    Prigione, I.3    Obici, L.4    Meini, A.5    Zulian, F.6    Pontillo, A.7
  • 25
    • 59649101629 scopus 로고    scopus 로고
    • Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome
    • Nedjai, B., Hitman, G. A., Quillinan, N., Coughlan, R. J., Church, L., McDermott, M. F. and Turner, M. D., Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum. 2009. 60: 619-625.
    • (2009) Arthritis Rheum. , vol.60 , pp. 619-625
    • Nedjai, B.1    Hitman, G.A.2    Quillinan, N.3    Coughlan, R.J.4    Church, L.5    McDermott, M.F.6    Turner, M.D.7
  • 26
    • 84875963811 scopus 로고    scopus 로고
    • Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review
    • Ter Haar, N., Lachmann, H., Ozen, S., Woo, P., Uziel, Y., Modesto, C., Kone-Paut, I. et al., Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann. Rheum. Dis. 2013. 72: 678-685.
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 678-685
    • Ter Haar, N.1    Lachmann, H.2    Ozen, S.3    Woo, P.4    Uziel, Y.5    Modesto, C.6    Kone-Paut, I.7
  • 27
    • 29844442446 scopus 로고    scopus 로고
    • Systemic cytokine levels and the effects of etanercept in TNF receptor-associated periodic syndrome (TRAPS) involving a C33Y mutation in TNFRSF1A
    • Nowlan, M. L., Drewe, E., Bulsara, H., Esposito, N., Robins, R. A., Tighe, P. J., Powell, R. J. et al., Systemic cytokine levels and the effects of etanercept in TNF receptor-associated periodic syndrome (TRAPS) involving a C33Y mutation in TNFRSF1A. Rheumatol. (Oxford) 2006. 45: 31-37.
    • (2006) Rheumatol. (Oxford) , vol.45 , pp. 31-37
    • Nowlan, M.L.1    Drewe, E.2    Bulsara, H.3    Esposito, N.4    Robins, R.A.5    Tighe, P.J.6    Powell, R.J.7
  • 28
    • 79953689919 scopus 로고    scopus 로고
    • Role of interleukin-6 in a patient with tumor necrosis factor receptor-associated periodic syndrome: Assessment of outcomes following treatment with the anti-interleukin-6 receptor monoclonal antibody tocilizumab
    • Vaitla, P. M., Radford, P. M., Tighe, P. J., Powell, R. J., McDermott, E. M., Todd, I. and Drewe, E., Role of interleukin-6 in a patient with tumor necrosis factor receptor-associated periodic syndrome: Assessment of outcomes following treatment with the anti-interleukin-6 receptor monoclonal antibody tocilizumab. Arthritis Rheum. 2011. 63: 1151-1155.
    • (2011) Arthritis Rheum. , vol.63 , pp. 1151-1155
    • Vaitla, P.M.1    Radford, P.M.2    Tighe, P.J.3    Powell, R.J.4    McDermott, E.M.5    Todd, I.6    Drewe, E.7
  • 29
    • 84882274510 scopus 로고    scopus 로고
    • Inflammasome and cytokine blocking strategies in autoinflammatory disorders
    • Moll, M. and Kuemmerle-Deschner, J. B., Inflammasome and cytokine blocking strategies in autoinflammatory disorders. Clin. Immunol. 2013. 147: 242-275.
    • (2013) Clin. Immunol. , vol.147 , pp. 242-275
    • Moll, M.1    Kuemmerle-Deschner, J.B.2
  • 30
    • 84863061090 scopus 로고    scopus 로고
    • A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases
    • Murakami, M. and Hirano, T., A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases. Frontiers Immunol. 2011. 2: 22.
    • (2011) Frontiers Immunol. , vol.2 , pp. 22
    • Murakami, M.1    Hirano, T.2
  • 31
    • 55049118394 scopus 로고    scopus 로고
    • Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction
    • Ogura, H., Murakami, M., Okuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M. et al., Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 2008. 29: 628-636.
    • (2008) Immunity , vol.29 , pp. 628-636
    • Ogura, H.1    Murakami, M.2    Okuyama, Y.3    Tsuruoka, M.4    Kitabayashi, C.5    Kanamoto, M.6    Nishihara, M.7
  • 32
    • 77955012323 scopus 로고    scopus 로고
    • Imaging evidence for persistent subclinical fasciitis and arthritis in tumour necrosis factor receptor-associated periodic syndrome (TRAPS) between febrile attacks
    • Quillinan, N., Mohammad, A., Mannion, G., O'Keeffe, D., Bergin, D., Coughlan, R., McDermott, M. F. et al., Imaging evidence for persistent subclinical fasciitis and arthritis in tumour necrosis factor receptor-associated periodic syndrome (TRAPS) between febrile attacks. Ann. Rheum. Dis. 2010. 69: 1408-1409.
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1408-1409
    • Quillinan, N.1    Mohammad, A.2    Mannion, G.3    O'Keeffe, D.4    Bergin, D.5    Coughlan, R.6    McDermott, M.F.7
  • 33
    • 0036676098 scopus 로고    scopus 로고
    • Monocytic fasciitis: a newly recognized clinical feature of tumor necrosis factor receptor dysfunction
    • Hull, K. M., Wong, K., Wood, G. M., Chu, W. S. and Kastner, D. L., Monocytic fasciitis: a newly recognized clinical feature of tumor necrosis factor receptor dysfunction. Arthritis Rheum. 2002. 46: 2189-2194.
    • (2002) Arthritis Rheum. , vol.46 , pp. 2189-2194
    • Hull, K.M.1    Wong, K.2    Wood, G.M.3    Chu, W.S.4    Kastner, D.L.5
  • 34
    • 75549091673 scopus 로고    scopus 로고
    • The IL-1 family: regulators of immunity
    • Sims, J. E. and Smith, D. E., The IL-1 family: regulators of immunity. Nature Rev. Immunol. 2010. 10: 89-102.
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 89-102
    • Sims, J.E.1    Smith, D.E.2
  • 35
    • 80051752870 scopus 로고    scopus 로고
    • Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway
    • Hu, D. N., Chen, M., Zhang, D. Y., Ye, F., McCormick, S. A. and Chan, C. C., Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway. Invest. Ophthalmol. Vis. Sci. 2011. 52: 3767-3774.
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 3767-3774
    • Hu, D.N.1    Chen, M.2    Zhang, D.Y.3    Ye, F.4    McCormick, S.A.5    Chan, C.C.6
  • 36
    • 0035176070 scopus 로고    scopus 로고
    • Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor
    • You, M., Flick, L. M., Yu, D. and Feng, G. S., Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. J. Exp. Med. 2001. 193: 101-110.
    • (2001) J. Exp. Med. , vol.193 , pp. 101-110
    • You, M.1    Flick, L.M.2    Yu, D.3    Feng, G.S.4
  • 37
    • 84858159116 scopus 로고    scopus 로고
    • Heparin serves as a natural stimulant of the inflammasome and exacerbates the symptoms of tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
    • Ohmori, S., Hino, R., Nakamura, M. and Tokura, Y., Heparin serves as a natural stimulant of the inflammasome and exacerbates the symptoms of tumor necrosis factor receptor-associated periodic syndrome (TRAPS). J. Dermatol. Sci. 2012. 66: 82-84.
    • (2012) J. Dermatol. Sci. , vol.66 , pp. 82-84
    • Ohmori, S.1    Hino, R.2    Nakamura, M.3    Tokura, Y.4
  • 38
    • 78651481470 scopus 로고    scopus 로고
    • The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins
    • Cheon, H., Yang, J. and Stark, G. R., The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins. J. Interferon Cytokine Res. 2011. 31: 33-40.
    • (2011) J. Interferon Cytokine Res. , vol.31 , pp. 33-40
    • Cheon, H.1    Yang, J.2    Stark, G.R.3
  • 39
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang, J., Liao, X., Agarwal, M. K., Barnes, L., Auron, P. E. and Stark, G. R., Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Develop. 2007. 21: 1396-1408.
    • (2007) Genes Develop. , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6


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