Interleukin-1β increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-κB pathway

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 6, 2011, Pages 3767-3774

  Hu, Dan Ning ^a   Chen, Min ^a   Zhang, David Y ^b   Ye, Fei ^b   McCormick, Steven A ^a   Chan, Chi Chao ^c  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN S 100; STRESS ACTIVATED PROTEIN KINASE; ENZYME INHIBITOR; IL6 PROTEIN, HUMAN; MESSENGER RNA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MELANOCYTE; NORMAL HUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UVEA; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION;

CELLS, CULTURED; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MELANOCYTES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UVEA;

EID: 80051752870     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6908     Document Type: Article

References (52)

1. Hu DN, McCormick SA, Ritch R, Pelton-Henrion K. Studies of human uveal melanocytes in vitro: isolation, purification and cultivation of human uveal melanocytes. Invest Ophthalmol Vis Sci. 1993;33:2210-2219.
2. Hu DN, McCormick SA, Ritch R. Studies of human uveal melanocytes in vitro: growth regulation of cultured human uveal melanocytes. Invest Ophthalmol Vis Sci. 1993;34:2220-2227.
3. Hu DN, McCormick SA, Orlow SJ, Rosemblat S, Lin AY, Wo K. Melanogenesis in cultured human uveal melanocytes. Invest Ophthalmol Vis Sci. 1995;36:931-938.
4. Hu DN, McCormick SA, Orlow SJ, Rosemblat S, Lin AY. Regulation of melanogenesis by human uveal melanocytes in vitro. Exp Eye Res. 1997;64:397-404.
5. Hu DN. Regulation of growth and melanogenesis of uveal melanocytes (Keynote Lecture). Pigment Cell Res. 2000;13(suppl. 8): 81-86.
6. Wang Y, Hu DN, McCormick SA, Savage HE, O'Rourke J. Tissue plasminogen activator is released into cultured medium by cultured human uveal melanocytes. Pigment Cell Res. 2002;15:373-378.
7. Chu SC, Hu DN, Yang SF, et al. Uveal melanocytes produce matrix metalloproteinases-2 and-9 in vitro. Pigment Cell Res. 2004;17: 636-642.
8. Wakamatsu K, Hu DN, McCormick SA, Ito S. Characterization of melanin in human iridal and choroidal melanocytes from eyes with various colored irides. Pigment Cell Res. 2008;21:97-105.
9. Hu DN, McCormick SA. Biochemical pathways: different gene expression and cellular pathways determining tumor phenotype comparison of uveal melanocytes and uveal melanoma cells in vitro. Albert DM, Polans A, eds. Ocular Oncology. New York: Marcel Dekker; 2003:189-210.
10. Thomson AW, Lotze MT. The Cytokine Handbook. 4th ed. Amsterdam: AP Academic Press; 2003.
11. Park JY, Phillinger MH. Interleukin-6 in the pathogenesis of rheumatoid arthritis. Bull NYU Hosp Joint Dis. 2007;65:S4-S10.
12. Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferate disease. Cytokine Growth Factor Rev. 2002;13:357-368.
13. Badolato R, Oppenheim JJ. Role of cytokines, acute-phase proteins, and chemokines in the progression of rheumatoid arthritis. Semin Arthritis Rheum. 1996;26:526-538.
14. Sebba A. Tocilizumab: the first interleukin-6-receptor inhibitor. Am J Health Syst Pharm. 2008;65:1413-1418.
15. Planck SR, Dang TT, Graves D, Tara D, Ansel JC, Rosenbaum JT. Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1. Invest Ophthalmol Vis Sci. 1992;33:78-82.
16. Nagineni CN, Detrick B, Hooks JJ. Synergistic effects of gamma interferon on inflammatory mediators that induce interleukin-6 gene expression and secretion by human retinal pigment epithelial cells. Clin Diagn Lab Immunol. 1994;1:569-577.
17. Benson MT, Shepherd L, Rees RC, Rennie IG. Production of interleukin-6 by human retinal pigment epithelium in vitro and its regulation by other cytokines. Curr Eye Res. 1992;11(suppl):173-179.
18. Holtkamp GM, Van Rossem M, de Vos AF, Willekens B, Peek R, Kijlstra A. Polarized secretion of IL-6 and IL-8 by human retinal pigment epithelial cells. Clin Exp Immunol. 1998;112:34-43.
19. Leung KW, Barnstable CJ, Tombran-Tink J. Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. Mol Immunol. 2009;46:1374-1386.
20. Jaffe GJ, Roberts WL, Wong HL, Yurochko AD, Cianciolo GJ. Monocyte-induced cytokine expression in cultured human retinal pigment epithelial cells. Exp Eye Res. 1995;60:533-543.
21. Murray PI, Hoekzema R, van Haren MAC, de Hon FD, Kijlstra A. Aqueous humor interleukin-6 levels in uveitis. Invest Ophthalmol Vis Sci. 1990;31:917-920.
22. van Kooij B, Rothova A, Rijkers GT, de Groot-Mijnes JD. Distinct cytokine and chemokine profiles in the aqueous of patients with uveitis and cystoid macular edema. Am J Ophthalmol. 2006;142: 192-194.
23. Roh MI, Kim HS, Song JH, Lim JB, Kwon OW. Effect of intravitreal bevacizumab injection on aqueous humor cytokine levels in clinically significant macular edema. Ophthalmology. 2009;116: 80-86.
24. Funk M, Kriechbaum K, Prager F, et al. Intraocular concentrations of growth factors and cytokines in retinal vein occlusion and the effect of therapy with bevacizumab. Invest Ophthalmol Vis Sci. 2009;50:1025-1032.
25. Sato T, Kusaka S, Shimojo H, Fujikado T. Simultaneous analyses of vitreous levels of 27 cytokines in eyes with retinopathy of prematurity. Ophthalmology. 2009;116:2165.
26. Canataroglu H, Varinli I, Ozcan AA, Canataroglu A, Doran F, Varinli S. Interleukin (IL)-6, interleukin (IL)-8 levels and cellular composition of the vitreous humor in proliferative diabetic retinopathy, proliferative vitreoretinopathy, and traumatic proliferative vitreoretinopathy. Ocul Immunol Inflamm. 2005;13:375-381.
27. Foxman EF, Zhang M, Hurst SD, et al. Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1-versus Th2-mediated ocular inflammation. J Immunol. 2002;168: 2483-2492.
28. Ooi KGJ, Galatowicz G, Calder VL, Lightman SL. Cytokines and chemokines in uveitis-is there a correlation with clinical phenotype? Clin Med Res. 2006;4:294-309.
29. Sims JE, Smith DE. The IL-1 family: regulators of immunity. Nat Rev Immunol. 2010;10:89-102.
30. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood. 1996;87:2095-2147.
31. Ferrik MR, Thurau SR, Oppenheim MH, et al. Ocular inflammation stimulated by intravitreal interleukin-8 and interleukin-1. Invest Ophthalmol Vis Sci. 1991;32:1534-1539.
32. Hu DN, Savage H, Roberts JE. Uveal melanocytes, ocular pigment epithelium and Müller cells in culture: in vitro toxicology. Int J Toxicol. 2002;21:465-472.
33. Sugita S, Takase H, Taguchi C, et al. Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens. Invest Ophthalmol Vis Sci. 2006;47: 2547-2554.
34. Damico FM, Bezerra FT, Silva GC, Gasparin F, Yamamoto JH. New insights into Vogt-Koyanagi-Harada disease. Arq Bras Oftalmol. 2009;72:413-420.
35. Chan CC, Hikita N, Dastgheib K, Whitcup SM, Gery I, Nussenblatt RB. Experimental melanin-protein-induced uveitis in the Lewis rat: immunopathologic processes. Ophthalmology. 1994;101:1275-1280.
36. Smith JR, Rosenbaum JT, Williams KA. Experimental melanininduced uveitis: experimental model of human acute anterior uveitis. Ophthalmic Res. 2008;40:136-140.
37. Lu F, Yan D, Zhou X, Hu DN, Qu J. Expression of melanin-related genes in cultured adult human retinal pigment epithelium and uveal melanoma cells. Mol Vis. 2007;13:2066-2072.
38. Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol. 1998;16:249-284.
39. Yoshino O, Osuga Y, Hirota Y, et al. Possible pathophysiological toles of mitogen-activated protein kinases (MAPKs) in endometriosis. Am J Reprod Immunol. 2004;52:306-311.
40. Kandere-Grzybowska K, Kempuraj D, Cao J, Cetrulo CL, Theoharides TC. Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin. Br J Pharmacol. 2006;148:208-215.
41. Yoshino O, Osuga Y, Hirota Y, et al. Endometrial stromal cells undergoing decidualization down-regulate their properties to produce proinflammatory cytokines in response to interleukin-1 beta via reduced p38 mitogen-activated protein kinase phosphorylation. J Clin Endocrinol Metab. 2003;88:2236-2241.
42. Birkenkamp KU, Esselink MT, Kruijer W, Vellenga E. Differential effects of interleukin-3 and interleukin-1 on the proliferation and interleukin-6 protein secretion of acute myeloid leukemic cells: the involvement of ERK, p38 and STAT5. Eur Cytokine Netw. 1999;10:479-490.
43. You M, Flick LM, Yu D, Feng GS. Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. J Exp Med. 2001;193:101-110.
44. Maliner-Stratton MS, Klein RD, Udayakumar TS, Nagle RB, Bowden GT. Interleukin-1beta-induced promatrilysin expression is mediated by NFkappaB-regulated synthesis of interleukin-6 in the prostate carcinoma cell line, LNCaP. Neoplasia. 2001;3:509-520.
45. Nakao T, Kim S, Ohta K, et al. Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. Br J Pharmacol. 2002;136:975-984.
46. Xu H, Chen M, Forrester JV. Para-inflammation in the aging retina. Prog Retin Eye Res. 2009;28:348-368.
47. Hu F. Mah K. Choroidal melanocytes-a model for studying the aging process in nonreplicative differentiated cells. Mech Ageing Dev. 1979;11:227-235.
48. Patel M, Chan CC. Immunopathological aspects of age-related macular degeneration. Semin Immunopathol. 2008;30:97-110.
49. Dinarello CA. Interleukin-1beta and the autoinflammatory diseases. N Engl J Med. 2009;360:2467-2470.
50. Kumar A, Takada Y, Boriek AM, Aggarwal BB. Nuclear factor-K{green}B: its role in health and disease. J Mol Med. 2004;82:434-448.
51. Wu WC, Hu DN, Gao HX, et al. Subtoxic dosage of hydrogen peroxide stimulated production of interleukin-6 by retinal pigment epithelial cells. Mol Vis. 2010;16:1864-1873.
52. Roh MI, Kim HS, Song JH, Lim JB, Koh HJ, Kwon OW. Concentration of cytokines in the aqueous humor of patients with naive, recurrent and regressed CNV associated with AMD after bevacizumab treatment. Retina. 2009;29:523-529.