Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 7, 2014, Pages 1865-1873

  Finegersh, Andrey ^a   Homanics, Gregg E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; Chromatin immunoprecipitation; Epigenetics; Ethanol; Histones

Indexed keywords

ALCOHOL; HISTONE;

ACETYLATION; ANIMAL; BRAIN CORTEX; DRUG EFFECTS; GENETIC EPIGENESIS; HIPPOCAMPUS; MALE; METABOLISM; METHYLATION; MOUSE; PROMOTER REGION;

ACETYLATION; ANIMALS; CEREBRAL CORTEX; EPIGENESIS, GENETIC; ETHANOL; HIPPOCAMPUS; HISTONES; MALE; METHYLATION; MICE; PROMOTER REGIONS, GENETIC;

EID: 84904392922     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12465     Document Type: Article

References (38)

1. Bachtell RK, Ryabinin AE (2001) Interactive effects of nicotine and alcohol co-administration on expression of inducible transcription factors in mouse brain. Neuroscience 103:941-954.
2. Black J, Van Rechem C, Whetstine J (2012) Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell 48:491-507.
3. Botia B, Legastelois R, Alaux-Cantin S, Naassila M (2012) Expression of ethanol-induced behavioral sensitization is associated with alteration of chromatin remodeling in mice. PLoS One 7:e47527.
4. Chandler LJ, Newsom H, Sumners C, Crews F (1993) Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons. J Neurochem 60:1578-1581.
5. D'Addario C, Caputi F, Ekström T, Di Benedetto M, Maccarrone M, Romualdi P, Candeletti S (2013) Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex. J Mol Neurosci 49:312-319.
6. Devaud LL, Smith FD, Grayson DR, Morrow AL (1995) Chronic ethanol consumption differentially alters the expression of gamma-aminobutyric acidA receptor subunit mRNAs in rat cerebral cortex: competitive, quantitative reverse transcriptase-polymerase chain reaction analysis. Mol Pharmacol 48:861-868.
7. Guan J-S, Haggarty SJ, Giacometti E, Dannenberg J-H, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang X, Mazitschek R, Bradner JE, Depinho RA, Jaenisch R, Tsai L-H (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459:55-60.
8. Harper C, Matsumoto I (2005) Ethanol and brain damage. Curr Opin Pharmacol 5:73-78.
9. Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Sikela JM, Williams RW, Miles MF (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. J Neurosci 25:2255-2266.
10. Kouzarides T (2007) Chromatin modifications and their function. Cell 128:693-705.
11. Kurita M, Moreno JL, Holloway T, Kozlenkov A, Mocci G, García-Bea A, Hanks JB, Neve R, Nestler EJ, Russo SJ, González-Maeso J (2013) Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice. Mol Pharmacol 83:1166-1175.
12. Legastelois R, Botia B, Naassila M (2013) Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum. Alcohol Clin Exp Res 37:1143-1153.
13. Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res 24:1873-1882.
14. Maurice T, Duclot F, Meunier J, Naert G, Givalois L, Meffre J, Celerier A, Jacquet C, Copois V, Mechti N, Ozato K, Gongora C (2007) Altered memory capacities and response to stress in p300/CBP-Associated Factor (PCAF) histone acetylase knockout mice. Neuropsychopharmacology 33:1584-1602.
15. Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 81:802-813.
16. Meyer KB, Maia A-T, O'Reilly M, Teschendorff AE, Chin S-F, Caldas C, Ponder BAJ (2008) Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol 6:e108.
17. Moonat S, Sakharkar AJ, Zhang H, Tang L, Pandey SC (2013) Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism. Biol Psychiatry 73:763-773.
18. Moonat S, Starkman B, Sakharkar A, Pandey S (2010) Neuroscience of alcoholism: molecular and cellular mechanisms. Cell Mol Life Sci 67:73-88.
19. Nagy Z, Riss A, Fujiyama S, Krebs A, Orpinell M, Jansen P, Cohen A, Stunnenberg H, Kato S, Tora L (2010) The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Cell Mol Life Sci 67:611-628.
20. Nestoros J (1980) Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex. Science 209:708-710.
21. Orpinell M, Fournier M, Riss A, Nagy Z, Krebs AR, Frontini M, Tora L (2010) The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J 29:2381-2394.
22. Pandey SC, Ugale R, Zhang H, Tang L, Prakash A (2008) Brain chromatin remodeling: a novel mechanism of alcoholism. J Neurosci 28:3729-3737.
23. Pascual M, Do Couto BR, Alfonso-Loeches S, Aguilar MA, Rodriguez-Arias M, Guerri C (2012) Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning. Neuropharmacology 62:2309-2319.
24. Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL (2007) Alcohol regulates gene expression in neurons via activation of heat shock factor 1. J Neurosci 27:12957-12966.
25. Ponomarev I, Wang S, Zhang L, Harris RA, Mayfield RD (2012) Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J Neurosci 32:1884-1897.
26. Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18:247-291.
27. Robison AJ, Nestler EJ (2011) Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 12:623-637.
28. Sakharkar AJ, Zhang H, Tang L, Shi G, Pandey SC (2012) Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. Alcohol Clin Exp Res 36:61-71.
29. Schneider R, Bannister AJ, Myers FA, Thorne AW, Crane-Robinson C, Kouzarides T (2004) Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol 6:73-77.
30. Smith E, Shilatifard A (2010) The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell 40:689-701.
31. Treadwell J, Singh S (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. Neurochem Res 29:357-369.
32. Warnault V, Darcq E, Levine A, Barak S, Ron D (2013) Chromatin remodeling-a novel strategy to control excessive alcohol drinking. Transl Psychiatry 3:e231.
33. Wolen AR, Phillips CA, Langston MA, Putman AH, Vorster PJ, Bruce NA, York TP, Williams RW, Miles MF (2012) Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. PLoS One 7:e33575.
34. Wolstenholme JT, Warner JA, Capparuccini MI, Archer KJ, Shelton KL, Miles MF (2011) Genomic analysis of individual differences in ethanol drinking: evidence for non-genetic factors in C57BL/6 mice. PLoS One 6:e21100.
35. Yu M, Mazor T, Huang H, Huang H-T, Kathrein K, Woo A, Chouinard C, Labadorf A, Akie T, Moran T, Xie H, Zacharek S, Taniuchi I, Roeder R, Kim C, Zon L, Fraenkel E, Cantor A (2012) Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell 45:330-343.
36. Zhao XD, Han X, Chew JL, Liu J, Chiu KP, Choo A, Orlov YL, Sung W-K, Shahab A, Kuznetsov VA, Bourque G, Oh S, Ruan Y, Ng H-H, Wei C-L (2007) Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 1:286-298.
37. Zhou Z, Yuan Q, Mash DC, Goldman D (2011) Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcohol. Proc Natl Acad Sci USA 108:6626-6631.
38. Ziemann U, Lönnecker S, Paulus W (1995) Inhibition of human motor cortex by ethanol. A transcranial magnetic stimulation study. Brain 118:1437-1446.