Immunohistochemical localization of Pax6 in the developing tooth germ of mice

Journal of Molecular Histology

Volumn 45, Issue 4, 2014, Pages 373-379

  Lei, Haihua ^a   Liu, He ^a   Ding, Yun ^a   Ge, Lihong ^a  

^a PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

Author keywords

Immunohistochemistry; Mice; Odontogenesis; Pax6 expression

Indexed keywords

PARAFFIN; TRANSCRIPTION FACTOR PAX6; EYE PROTEIN; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

AMELOBLAST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EPITHELIUM; GENE EXPRESSION; GERM CELL; HAIR FOLLICLE; IMMUNOHISTOCHEMISTRY; INCISOR; MESENCHYME CELL; MOLAR TOOTH; MOUSE; NONHUMAN; ODONTOBLAST; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RUMINANT STOMACH; STELLATE CELL; SUBMANDIBULAR GLAND; TOOTH DEVELOPMENT; ANIMAL; C57BL MOUSE; EMBRYOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PREGNANCY; TOOTH FLORA;

MUS; RATTUS;

ANIMALS; EYE PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; ODONTOGENESIS; PAIRED BOX TRANSCRIPTION FACTORS; PREGNANCY; REPRESSOR PROTEINS; TOOTH GERM;

EID: 84904363714     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-014-9564-5     Document Type: Article

References (36)

1. Cobourne MT, Sharpe PT (2010) Making up the numbers: the molecular control of mammalian dental formula. Semin Cell Dev Biol 21:314-324
2. D'Souza RN, Klein OD (2007) Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. Cells Tissues Organs 186:60-69 (Pubitemid 47026717)
3. D'Souza RN, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I (1999) Cbfa1 is required for epithelial - mesenchymal interactions regulating tooth development in mice. Development 126:2911-2920 (Pubitemid 29355684)
4. Du J, Wang Q, Wang L, Wang X, Yang P (2012) The expression pattern of FHL2 during mouse molar development. J Mol Histol 43:289-295
5. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754 (Pubitemid 27516177)
6. Feng J, McDaniel JS, Chuang HH, Huang O, Rakian A, Xu X, Steffensen B, Donly KJ, MacDougall M, Chen S (2012) Binding of amelogenin to MMP-9 and their co-expression in developing mouse teeth. J Mol Histol 43:473-485
7. Fleming PS, Xavier GM, DiBiase AT, Cobourne MT (2010) Revisiting the supernumerary: the epidemiological and molecular basis of extra teeth. Br Dent J 208:25-30
8. Glaser T, Walton DS, Maas RL (1992) Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene. Nat Genet 2:232-239
9. Hill RE, Favor J, Hogan BL, Ton CC, Saunders GF, Hanson IM, Prosser J, Jordan T, Hastie ND, van Heyningen V (1991) Mouse small eye results from mutations in a paired-like homeoboxcontaining gene. Nature 354:522-525 (Pubitemid 21896831)
10. Hogan BL, Horsburgh G, Cohen J, Hetherington CM, Fisher G, Lyon MF (1986) Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. J Embryol Exp Morphol 97:95-110 (Pubitemid 16044934)
11. Hou C, Liu ZX, Tang KL, Wang MG, Sun J, Wang J, Li S (2012) Developmental changes and regional localization of Dspp, Mepe, Mimecan and Versican in post natal developing mouse teeth. J Mol Histol 43:9-16
12. Jernvall J, Thesleff I (2000) Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev 92:19-29 (Pubitemid 30125959)
13. Jonker L, Kist R, Aw A, Wappler I, Peters H (2004) Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Mech Dev 121:1313-1322 (Pubitemid 39349205)
14. Jordan T, Hanson I, Zaletayev D, Hodgson S, Prosser J, Seawright A, Hastie N, van Heyningen V (1992) The human PAX6 gene is mutated in two patients with aniridia. Nat Genet 1:328-332
15. Kaufman MH, Chang HH, Shaw JP (1995) Craniofacial abnormalities in homozygous Small eye (Sey/Sey) embryos and newborn mice. J Anat 186:607-617
16. Klein ML, Nieminen P, Lammi L, Niebuhr E, Kreiborg S (2005) Novel mutation of the initiation codon of PAX9 causes oligodontia. J Dent Res 84:43-47 (Pubitemid 43822060)
17. Komori T, Yagi H, Nomura S et al (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764 (Pubitemid 27516178)
18. Kriangkrai R, Chareonvit S, Yahagi K, Fujiwara M, Eto K, Iseki S (2006) Study of Pax6 mutant rat revealed the association between upper incisor formation and midface formation. Dev Dyn 235:2134-2143 (Pubitemid 44205049)
19. Lei HH, Liu H, Gao X, Wen JH, Ge LH (2008) Occurrence of supernumerary upper incisor teeth in Pax6-/- mouse fetuses. Zhonghua Kou Qiang Yi Xue Za Zhi 43:675-679
20. McDonald RE (2004) Dentistry for the child and adolescent. In: Avery DR (ed) 8th edn. Mosby, St. Louis, pp 665-666
21. Otto F, Thornell AP, Crompton T et al (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771 (Pubitemid 27516179)
22. Peters H, Neubüser A, Kratochwil K, Balling R (1998) Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev 12:2735-2747 (Pubitemid 28420653)
23. Quinn JC, West JD, Kaufman MH (1997) Genetic background effects on dental and other craniofacial abnormalities in homozygous small eye (Pax6Sey/Pax6Sey) mice. Anat Embryol (Berl) 196:311-321 (Pubitemid 27464172)
24. Sander M, Neubüser A, Kalamaras J, Ee HC, Martin GR, German MS (1997) Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11:1662-1673 (Pubitemid 27300592)
25. Simpson TI, Price DJ (2002) Pax6; a pleiotropic player in development. Bioessays 24:1041-1051
26. Stockton DW, Das P, Goldenberg M, D'Souza RN, Patel PI (2000) Mutation of PAX9 is associated with oligodontia. Nat Genet 24:18-19 (Pubitemid 30041414)
27. Suda N, Ogawa T, Kojima T, Saito C, Moriyama K (2011) Nonsyndromic oligodontia with a novel mutation of PAX9. J Dent Res 90:382-386
28. Tang RH, Wang Q, Du JX, Yang PS, Wang XY (2013) Expression and localization of Nell-1 during murine molar development. J Mol Histol 44:175-181
29. Thesleff I (2006) The genetic basis of tooth development and dental defects. Am J Med Genet A 140:2530-2535
30. Thesleff I, Mikkola M (2002) The role of growth factors in tooth development. Int Rev Cytol 217:93-135 (Pubitemid 34498931)
31. Thesleff I, Sharpe P (1997) Signalling networks regulating dental development. Mech Dev 67:111-123 (Pubitemid 27473911)
32. Underhill DA (2000) Genetic and biochemical diversity in the Pax gene family. Biochem Cell Biol 78:629-638
33. Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R, Gruss P (1991) Pax: a murine multigene family of paired box-containing genes. Genomics 11:424-434
34. Wang XP, Fan J (2011) Molecular genetics of supernumerary tooth formation. Genesis 49:261-277
35. Wen JH, Chen YY, Song SJ et al (2009) Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia 52:504-513
36. Zhang W, Vazquez B, Andreeva V, Spear D, Kong E, Hinds PW, Yelick PC (2012) Discrete phosphorylated retinoblastoma protein isoform expression in mouse tooth development. J Mol Histol 43:281-288