Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells

Journal of Cellular and Molecular Medicine

Volumn 13, Issue 8 B, 2009, Pages 2293-2303

  Keating, Niamh ^a   Mroz, Magdalena S ^a   Scharl, Michael M ^b   Marsh, Christine ^a   Ferguson, Gail ^a   Hofmann, Alan F ^b   Keely, Stephen J ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Bile acid; Chloride secretion; Epithelium; Physiology of the colon

Indexed keywords

BILE ACID;

ANIMAL; ARTICLE; CELL LINE; COLON; CYTOLOGY; DOWN REGULATION; INTESTINE MUCOSA; PHYSIOLOGY; RAT; SECRETION;

ANIMALS; BILE ACIDS AND SALTS; CELL LINE; COLON; DOWN-REGULATION; INTESTINAL MUCOSA; RATS;

EID: 70449726007     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00838.x     Document Type: Article

References (39)

1. Montrose MM, Keely SJ, Barrett KE. Secretion and absorption: small intestine and colon. In : Yamada T, Alpers D, Kaplowitz N, Laine L, Owyang C, Powell D, editors. Textbook of gastroenterology, 4th ed. Philadelphia : Lippencott-Raven, 2003 pp. 308 339.
2. Barrett KE, Keely SJ. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Ann Rev Physiol. 2000 62 : 535 572.
3. Münch A, Ström M, Söderholm JD. Dihydroxy bile acids increase mucosal permeability and bacterial uptake in human colon biopsies. Scand J Gasteoenterol. 2007 42 : 1167 1174.
4. Muhlbauer M, Allard B, Bosserhoff AK, et al. Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-{kappa}B signal transduction and IL-8 gene expression in colonic epithelial cells. Am J Physiol. 2004 286 : G1000 8.
5. Cheng K, Raufman JP. Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors. Biochem Pharmacol. 2005 70 : 1035 1047.
6. Milovic V, Teller IC, Murphy GM, et al. Deoxycholic acid stimulates migration in colon cancer cells. Eur J Gastroenterol Hepatol. 2001, 13 : 945 949.
7. Barcelo A, Claustre J, Toumi F, et al. Effect of bile salts on colonic mucus secretion in isolated vascularly perfused rat colon. Dig Dis Sci. 2000 46 : 1223 1231.
8. Hofmann AF, Poley JR. Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride. Gastroenterology. 1972 62 : 918 934.
9. Potter GD. Bile acid diarrhea. Dig Dis Sci. 1998 16 : 118 124.
10. Dawson PA, Haywood J, Craddock AL, et al. Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J Biol Chem. 2003 278 : 33920 33927.
11. Kruis W, Kalek HD, Stellaard F, et al. Altered fecal bile acid pattern in patients with inflammatory bowel disease. Digestion. 1986 35 : 189 198.
12. Nyhlin H, Merrick MV, Eastwood MA. Bile acid malabsorption in Crohn's disease and indications for its assessment using SeHCAT. Gut. 1994 35 : 90 3.
13. Ung K-A, Gillberg R, Kilander A, et al. Role of bile acids and bile acid binding agents in patients with collagenous colitis. Gut. 2000 46 : 170 175.
14. Kalia N, Hardcastle J, Grasa L, et al. Intestinal secretory and absorptive function in Trichinella spiralis mouse model of post-infective gut dysfunction role of bile acids. Gut. 2008 57 : 41 9.
15. Fernandez-Banares F, Salas A, Esteve M, et al. Collagenous and lymphocytic colitis: evaluation of clinical and histological features, response to treatment, and long-term follow-up. Am J Gastroenterol. 2003 98 : 340 347.
16. Smith MJ, Cherian P, Raju GS, et al. Bile acid malabsorption in persistent diarrhoea. J R Coll Physicians Lond. 2000 34 : 448 451.
17. - secretion induced by bile salts. A study of the mechanism of action based on a cultured colonic epithelial cell line. J Clin Invest. 1989 84 : 945 953.
18. Keely SJ, Scharl MM, Bertelsen LS, et al. Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: structure-activity relationships. Am J Physiol. 2007 292 : G290 7.
19. 84). J Clin Invest. 1993 92 : 2173 2181.
20. Mauricio AC, Slawik M, Heitzmann D, et al. Deoxycholic acid (DOC) affects the transport properties of distal colon. Eur J Physiol. 2000 439 : 532 540.
21. Gelbmann CM, Schteingart CD, Thompson SM, et al. Mast cells and histamine contribute to bile acid-stimulated secretion in the mouse colon. J Clin Invest. 1995 95 : 2831 2839.
22. - transport. Am J Physiol. 2001 280 : C646 58.
23. Weihrauch D, Kanchanapoo J, Ao M, et al. Weanling, but not adult, rabbit colon absorbs bile acids: flux is linked to expression of putative bile acid transporters. Am J Physiol. 2006 290 : G439 50.
24. Mekjian HS, Phillips SF, Hofmann AF. Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Invest. 1971 50 : 1569 1577.
25. Cartwright CA, McRoberts JA, Mandel KG, et al. Synergistic action of cyclic adenosine monophosphate- and calcium-mediated chloride secretion in a colonic epithelial cell line. J Clin Invest. 1985 76 : 1837 1842.
26. Kok TM, Van Faassen A, Glinghammar B, et al. Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas. Dig Dis Sci. 1999 44 : 2218 2225.
27. Hamilton JP, Xie G, Raufman J-P, et al. Human cecal bile acids: concentration and spectrum. Am J Physiol. 2007 293 : G256 63.
28. Raufman J-P, Cheng K, Zimniak P. Activation of muscarinic receptor signaling by bile acids: physiological and medical implications. Dig Dis Sci. 2003 48 : 1431 1444.
29. 84 cells. Implications for carbachol-stimulated chloride secretion. J Biol Chem. 1998 273 : 27111 27117.
30. 84 colonic epithelial cells. Am J Physiol. 2003 284 : C339 48.
31. Raimondi F, Santoro P, Barone MV, et al. Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation. Am J Physiol. 2008 294 : G906 13.
32. Cheng K, Xie G, Raufman J-P. Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line. Biochem Pharmacol. 2007 73 : 1001 1012.
33. Teem MV, Phillips SF. Perfusion of the hamster jejunum with conjugated and unconjugated bile acids: inhibition of water absorption and effects on morphology. Gastroenterology 1972 62 : 261 267.
34. Chadwick VS, Gaginella TS, Carlson GL, et al. Effect of molecular structure on bile acid-induced alterations in absorptive function, permeability, and morphology in the perfused rabbit colon. J Lab Clin Med. 1979 94 : 661 674.
35. Dawson PA, Hubbert M, Haywood J, et al. The heteromeric organic solute transporter {alpha}-{beta}, Ost{alpha}-Ost{beta}, is an ileal basolateral bile acid transporter. J Biol Chem. 2005 280 : 6960 6968.
36. Gordon SJ, Kinsey MD, Magen JS, et al. Structure of bile acids associated with secretion in the rat cecum. Gastroenterology. 1979 77 : 38 44.
37. 84 cells: implications for cAMP-dependent chloride secretion. J Biol Chem. 2004 279 : 6271 6279.
38. + exchange. J Biol Chem. 1996 271 : 9919 9927.
39. Merchant NB, Rogers CM, Trivedi B, et al. Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 138 : 415 421.