-
1
-
-
0032985541
-
Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database
-
Sener SF, Fremgen A, Menck HR, et al. Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database. J Am Coll Surg. 1999;189(1):1-7.
-
(1999)
J Am Coll Surg
, vol.189
, Issue.1
, pp. 1-7
-
-
Sener, S.F.1
Fremgen, A.2
Menck, H.R.3
-
2
-
-
0027370407
-
Prognostic indicators for survival after resection of pancreatic adenocarcinoma
-
Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg. 1993;165(1):68-72.
-
(1993)
Am J Surg
, vol.165
, Issue.1
, pp. 68-72
-
-
Geer, R.J.1
Brennan, M.F.2
-
3
-
-
84876966246
-
-
seer.cancer.gov, Bethesda, MD, USA: National Cancer Institute. Available from, Accessed July 9
-
seer.cancer.gov [homepage on the Internet]. Bethesda, MD, USA: National Cancer Institute. Available from: http://seer.cancer.gov/statfacts/html/pancreas.html. Accessed July 9, 2013.
-
(2013)
Homepage On the Internet
-
-
-
4
-
-
79953299183
-
Drugs that target dynamic microtubules: A new molecular perspective
-
Stanton RA, Gernert KM, Nettles JH, Aneja R. Drugs that target dynamic microtubules: a new molecular perspective. Med Res Rev. 2011;31(3):443-481.
-
(2011)
Med Res Rev
, vol.31
, Issue.3
, pp. 443-481
-
-
Stanton, R.A.1
Gernert, K.M.2
Nettles, J.H.3
Aneja, R.4
-
5
-
-
45549107234
-
Novel cytotoxic agents: Epothilones
-
Goodin S. Novel cytotoxic agents: epothilones. Am J Health Sys Pharm. 2008;65(10):s10-s15.
-
(2008)
Am J Health Sys Pharm
, vol.65
, Issue.10
-
-
Goodin, S.1
-
6
-
-
0031872051
-
Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
-
Jordan A, Hadfield JA, Lawrence NJ, McGown AT. Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998;18(4):259-296.
-
(1998)
Med Res Rev
, vol.18
, Issue.4
, pp. 259-296
-
-
Jordan, A.1
Hadfield, J.A.2
Lawrence, N.J.3
McGown, A.T.4
-
7
-
-
84904317850
-
Antimicrotubule agents
-
In: DeVita VT, Lawrence TS, Rosenberg SA, editors, 9th ed. Philadelphia, PA, USA: Lippincott, Williams and Wilkins
-
Abu-Khalaf MM, Harris LN. Antimicrotubule agents. In: DeVita VT, Lawrence TS, Rosenberg SA, editors. DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology. 9th ed. Philadelphia, PA, USA: Lippincott, Williams and Wilkins; 2011.
-
(2011)
DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology
-
-
Abu-Khalaf, M.M.1
Harris, L.N.2
-
8
-
-
58149347705
-
Microtubule active agents: Beyond the taxane frontier
-
Morris PG, Fornier MN. Microtubule active agents: beyond the taxane frontier. Clin Cancer Res. 2008;14(22):7167-7172.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.22
, pp. 7167-7172
-
-
Morris, P.G.1
Fornier, M.N.2
-
9
-
-
38449120471
-
Novel tubulin-targeting agents: Anticancer activity and pharmacologic profile of epothilones and related analogues
-
Fumoleau P, Coudert B, Isambert N, Ferrant E. Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. Ann Oncol. 2007;18 Suppl 5:v9-v15.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 5
-
-
Fumoleau, P.1
Coudert, B.2
Isambert, N.3
Ferrant, E.4
-
10
-
-
12944277104
-
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cells
-
Giannakakou P, Gussio R, Nogales E, et al. A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cells. Proc Natl Acad Sci U S A. 2000;97(6):2904-2909.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, Issue.6
, pp. 2904-2909
-
-
Giannakakou, P.1
Gussio, R.2
Nogales, E.3
-
11
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
Bollag DM, McQueeney PA, Zhu J, et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 1995;55(11):2325-2333.
-
(1995)
Cancer Res
, vol.55
, Issue.11
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueeney, P.A.2
Zhu, J.3
-
12
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
Lee FY, Borzilleri R, Fairchild CR, et al. BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res. 2001;7(5):1429-1437.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.5
, pp. 1429-1437
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
-
13
-
-
0031027531
-
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel
-
Kowalski RJ, Giannakakou P, Hamel E. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel. J Biol Chem. 1997;272(4):2534-2541.
-
(1997)
J Biol Chem
, vol.272
, Issue.4
, pp. 2534-2541
-
-
Kowalski, R.J.1
Giannakakou, P.2
Hamel, E.3
-
14
-
-
84876424353
-
Randomized phase III study of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic adenocarcinoma of the pancreas (MPACT)
-
Von Hoff DD, Ervin TJ, Arena FP, et al. Randomized phase III study of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic adenocarcinoma of the pancreas (MPACT). J Clin Oncol. 2012;30(Suppl 34):LBA148.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL. 34
-
-
von Hoff, D.D.1
Ervin, T.J.2
Arena, F.P.3
-
15
-
-
84856720068
-
The use of GTX as a second-line and later chemotherapy for metastatic pancreatic cancer: A retrospective analysis
-
Dakik HK, Moskovic DJ, Carlson PJ, et al. The use of GTX as a second-line and later chemotherapy for metastatic pancreatic cancer: a retrospective analysis. Cancer Chemother Pharmacol. 2012;69(2):425-430.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, Issue.2
, pp. 425-430
-
-
Dakik, H.K.1
Moskovic, D.J.2
Carlson, P.J.3
-
16
-
-
84856741290
-
A multicenter analysis of GTX chemotherapy in patients with locally advanced and metastatic pancreatic adenocarcinoma
-
De Jesus-Acosta A, Oliver GR, Blackford A, et al. A multicenter analysis of GTX chemotherapy in patients with locally advanced and metastatic pancreatic adenocarcinoma. Cancer Chemother Pharmacol. 2012;69(2):415-424.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, Issue.2
, pp. 415-424
-
-
De Jesus-Acosta, A.1
Oliver, G.R.2
Blackford, A.3
-
17
-
-
58749113261
-
Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors
-
Rivera E, Lee J, Davies A. Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors. Oncologist. 2008;13(12):1207-1223.
-
(2008)
Oncologist
, vol.13
, Issue.12
, pp. 1207-1223
-
-
Rivera, E.1
Lee, J.2
Davies, A.3
-
18
-
-
84904297989
-
-
US Food and Drug Administration, Available from, Accessed July 31
-
US Food and Drug Administration. FDA approves Ixempra for advanced breast cancer patients. Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2007/ucm109015.htm. Accessed July 31, 2013.
-
(2013)
FDA Approves Ixempra For Advanced Breast Cancer Patients
-
-
-
19
-
-
58249142470
-
Phase I dose escalation study of weekly ixabepilone, an epothilone analog, in patients with advanced solid tumors who have failed standard therapy
-
Awada A, Piccart M, Jones SF, et al. Phase I dose escalation study of weekly ixabepilone, an epothilone analog, in patients with advanced solid tumors who have failed standard therapy. Cancer Chemother Pharmacol. 2009;63(3):417-425.
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, Issue.3
, pp. 417-425
-
-
Awada, A.1
Piccart, M.2
Jones, S.F.3
-
20
-
-
39749126801
-
Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone, an epothilone B analog, in Japanese patients with refractory solid tumors
-
Shimizu T, Yamamoto N, Yamada Y, et al. Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone, an epothilone B analog, in Japanese patients with refractory solid tumors. Cancer Chemother Pharmacol. 2008;61(5):751-758.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, Issue.5
, pp. 751-758
-
-
Shimizu, T.1
Yamamoto, N.2
Yamada, Y.3
-
21
-
-
84904343461
-
A phase I study of an oral formulation of ixabepilone in patients with advanced cancer
-
He AR, Kunz PL, Pishvaian MJ, et al. A phase I study of an oral formulation of ixabepilone in patients with advanced cancer. J Clin Oncol. 2010;28(Suppl 15):e13090.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL. 15
-
-
He, A.R.1
Kunz, P.L.2
Pishvaian, M.J.3
-
22
-
-
84875494655
-
Phase I trial of ixabepilone administered as three oral doses each separated by 6 hours every 3 weeks in patients with advanced solid tumors
-
Kunz PL, He AR, Colevas AD, et al. Phase I trial of ixabepilone administered as three oral doses each separated by 6 hours every 3 weeks in patients with advanced solid tumors. Invest New Drugs. 2012;30(6):2364-2370.
-
(2012)
Invest New Drugs
, vol.30
, Issue.6
, pp. 2364-2370
-
-
Kunz, P.L.1
He, A.R.2
Colevas, A.D.3
-
23
-
-
33747689092
-
A Phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: A southwest oncology group study
-
Whitehead RP, McCoy S, Rivkin SE, et al. A Phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: a southwest oncology group study. Invest New Drugs. 2006;24(6):515-520.
-
(2006)
Invest New Drugs
, vol.24
, Issue.6
, pp. 515-520
-
-
Whitehead, R.P.1
McCoy, S.2
Rivkin, S.E.3
-
24
-
-
0030900150
-
Phase II trial of paclitaxel and granulocyte colony-stimulating factor in patients with pancreatic carcinoma: A Southwest Oncology Group study
-
Whitehead RP, Jacobson J, Brown TD, Taylor SA, Weiss GR, Macdonald JS. Phase II trial of paclitaxel and granulocyte colony-stimulating factor in patients with pancreatic carcinoma: a Southwest Oncology Group study. J Clin Oncol. 1997;15(6):2414-2419.
-
(1997)
J Clin Oncol
, vol.15
, Issue.6
, pp. 2414-2419
-
-
Whitehead, R.P.1
Jacobson, J.2
Brown, T.D.3
Taylor, S.A.4
Weiss, G.R.5
Macdonald, J.S.6
-
25
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA, Moore, MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15(6):2403-2413.
-
(1997)
J Clin Oncol
, vol.15
, Issue.6
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
-
26
-
-
40749128006
-
Safety of repeated administrations of ixabepilone given as a 3-hour infusion every other week in combination with irinotecan in patients with advanced malignancies
-
Faivre S, Delbaldo C, Boige V, et al. Safety of repeated administrations of ixabepilone given as a 3-hour infusion every other week in combination with irinotecan in patients with advanced malignancies. Eur J Cancer. 2008;44(5):674-682.
-
(2008)
Eur J Cancer
, vol.44
, Issue.5
, pp. 674-682
-
-
Faivre, S.1
Delbaldo, C.2
Boige, V.3
-
27
-
-
58149355287
-
A phase I and pharmacokinetic study of ixabepilone in combination with carboplatin in patients with advanced solid malignancies
-
Plummer R, Woll P, Fyfe D, et al. A phase I and pharmacokinetic study of ixabepilone in combination with carboplatin in patients with advanced solid malignancies. Clin Cancer Res. 2008;14(24):8288-8294.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.24
, pp. 8288-8294
-
-
Plummer, R.1
Woll, P.2
Fyfe, D.3
-
28
-
-
84904320980
-
Phase I trial of weekly and every 3 weeks ixabepilone and sunitinib in advanced solid tumors
-
Kittaneh M, Montero AJ, Kovacs K. Phase I trial of weekly and every 3 weeks ixabepilone and sunitinib in advanced solid tumors. J Clin Oncol. 2011;29(Suppl 15):3081.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 15
, pp. 3081
-
-
Kittaneh, M.1
Montero, A.J.2
Kovacs, K.3
-
29
-
-
84873095545
-
Phase I trial of dasatinib and ixabepilone in patients with solid tumors
-
Herbolsheimer P, Kapoor R, Smith KL, et al. Phase I trial of dasatinib and ixabepilone in patients with solid tumors. Invest New Drugs. 2013;31(1):92-98.
-
(2013)
Invest New Drugs
, vol.31
, Issue.1
, pp. 92-98
-
-
Herbolsheimer, P.1
Kapoor, R.2
Smith, K.L.3
-
30
-
-
84904360548
-
-
Princeton, NJ, USA: Bristol-Myers Squibb Company
-
Sprycel [package insert]. Princeton, NJ, USA: Bristol-Myers Squibb Company; 2013.
-
(2013)
Sprycel [package Insert]
-
-
-
31
-
-
84873449753
-
A phase 2 trial of ixabepilone plus cetuximab in first line-treatment of metastatic pancreatic cancer
-
Rocha Lima CM, Lin EH, Kim GP, et al. A phase 2 trial of ixabepilone plus cetuximab in first line-treatment of metastatic pancreatic cancer. Gastrointest Cancer Res. 2012;5(5):155-160.
-
(2012)
Gastrointest Cancer Res
, vol.5
, Issue.5
, pp. 155-160
-
-
Rocha, L.C.M.1
Lin, E.H.2
Kim, G.P.3
-
32
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364(19): 1817-1825
-
(2011)
N Engl J Med
, vol.364
, Issue.19
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
|