Dehydration affects cerebral blood flow but not its metabolic rate for oxygen during maximal exercise in trained humans

Journal of Physiology

Volumn 592, Issue 14, 2014, Pages 3143-3160

  Trangmar, Steven J ^a   Chiesa, Scott T ^a   Stock, Christopher G ^a   Kalsi, Kameljit K ^a   Secher, Niels H ^a,b   González Alonso, José ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NORADRENALIN; OXYGEN;

ADULT; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; CEREBRAL METABOLIC RATE OF OXYGEN; CEREBRAL VASCULAR CONDUCTANCE; COMMON CAROTID ARTERY; CONDUCTANCE; CONTROLLED STUDY; DEHYDRATION; EXERCISE; EXHAUSTION; HEAT STRESS; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; INTERNAL CAROTID ARTERY; JUGULAR VEIN; MALE; MIDDLE CEREBRAL ARTERY; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; OXYGEN EXTRACTION FRACTION; PRIORITY JOURNAL; SYMPATHETIC TONE; BRAIN; BRAIN CIRCULATION; CAROTID ARTERY; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULARIZATION; YOUNG ADULT;

ADULT; BRAIN; CAROTID ARTERIES; CEREBROVASCULAR CIRCULATION; DEHYDRATION; EXERCISE; HUMANS; MALE; MIDDLE CEREBRAL ARTERY; OXYGEN; OXYGEN CONSUMPTION; YOUNG ADULT;

EID: 84904346940     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.272104     Document Type: Article

References (80)

1. Aaslid R, Markwalder TM & Nornes H (1982). Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57, 769-774.
2. 2 and sympathetic stimulation in the cerebral and femoral circulations in humans. J Physiol 566, 613-624.
3. 2 and extra-cranial blood flow. J Appl Physiol 115, 653-659.
4. Bland JM & Altman DG (1995). Calculating correlation coefficients with repeated observations: Part 1 - correlation within subjects. BMJ 310, 446.
5. Brothers RM, Wingo JE, Hubing KA & Crandall CG (2009a). The effects of reduced end-tidal carbon dioxide tension on cerebral blood flow during heat stress. J Physiol 587, 3921-3927.
6. Brothers RM, Zhang R, Wingo JE, Hubing KA & Crandall CG (2009b). Effects of heat stress on dynamic cerebral autoregulation during large fluctuations in arterial blood pressure. J Appl Physiol 107, 1722-1729.
7. Cheuvront SN, Kenefick RW, Montain SJ & Sawka MN (2010). Mechanisms of aerobic performance impairment with heat stress and dehydration. J Appl Physiol 109, 1989-1995.
8. Crandall CG & González-Alonso J (2010). Cardiovascular function in the heat-stressed human. Acta Physiol (Oxf) 199, 407-423.
9. Crandall CG, Wilson TE, Marving J, Vogelsang TW, Kjaer A, Hesse B & Secher NH (2008). Effects of passive heating on central blood volume and ventricular dimensions in humans. J Physiol 586, 293-301.
10. 2 content. J Appl Physiol 65, 473-477.
11. Fan JL, Cotter JD, Lucas RA, Thomas K, Wilson L & Ainslie PN (2008). Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: effects of mild hypohydration. J Appl Physiol 105, 433-445.
12. Fisher JP, Hartwich D, Seifert T, Olesen ND, McNulty CL, Nielsen HB, van Lieshout JJ & Secher NH (2013). Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals. J Physiol 591, 1859-1870.
13. Gibbs EL, Lennox WG, Nims LF & Gibbs FA (1942). Arterial and cerebral venous blood: arterial-venous difference in man. J Biol Chem 144, 325-332.
14. Gjedde A, Johannsen P, Cold GE & Ostergaard L (2005). Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition. J Cereb Blood Flow Metab 25, 1183-1196.
15. González-Alonso J (1998). Separate and combined influences of dehydration and hyperthermia on cardiovascular responses to exercise. Int J Sports Med 19, Suppl. 2, S111-S114.
16. González-Alonso J (2012). ATP as a mediator of erythrocyte-dependent regulation of skeletal muscle blood flow and oxygen delivery in humans. J Physiol 590, 5001-5013.
17. González-Alonso J & Calbet JA (2003). Reductions in systemic and skeletal muscle blood flow and oxygen delivery limit maximal aerobic capacity in humans. Circulation 107, 824-830.
18. González-Alonso J, Calbet JA & Nielsen B (1998). Muscle blood flow is reduced with dehydration during prolonged exercise in humans. J Physiol 513, 895-905.
19. González-Alonso J, Crandall CG & Johnson JM (2008). The cardiovascular challenge of exercising in the heat. J Physiol 586, 45-53.
20. González-Alonso J, Dalsgaard MK, Osada T, Volianitis S, Dawson EA, Yoshiga CC & Secher NH (2004). Brain and central haemodynamics and oxygenation during maximal exercise in humans. J Physiol 557, 331-342.
21. González-Alonso J, Mora-Rodriguez R, Below PR & Coyle EF (1995). Dehydration reduces cardiac output and increases systemic and cutaneous vascular resistance during exercise. J Appl Physiol 79, 1487-1496.
22. González-Alonso J, Mora-Rodriguez R, Below PR & Coyle EF (1997). Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise. J Appl Physiol 82, 1229-1236.
23. Gorman MW, Marble DR, Ogimoto K & Feigl EO (2003). Measurement of adenine nucleotides in plasma. Luminescence 18, 173-181.
24. Hellström G, Fischer-Colbrie W, Wahlgren NG & Jogestrand T (1996). Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise. J Appl Physiol 81, 413-418.
25. Ide K, Horn A & Secher NH (1999). Cerebral metabolic response to submaximal exercise. J Appl Physiol 87, 1604-1608.
26. Ide K & Secher NH (2000). Cerebral blood flow and metabolism during exercise. Prog Neurobiol 61, 397-414.
27. Johnson JM & Kellogg DL Jr (2010). Local thermal control of the human cutaneous circulation. J Appl Physiol 109, 1229-1238.
28. Jørgensen LG (1995). Transcranial Doppler ultrasound for cerebral perfusion. Acta Physiol Scand Suppl 625, 1-44.
29. Jørgensen LG, Perko M, Hanel B, Schroeder TV & Secher NH (1992). Middle cerebral artery flow velocity and blood flow during exercise and muscle ischemia in humans. J Appl Physiol 72, 1123-1132.
30. Kalsi KK & González-Alonso J (2012). Temperature-dependent release of ATP from human erythrocytes: mechanism for the control of local tissue perfusion. Exp Physiol 97, 419-432.
31. Kety SS & Schmidt CF (1948). The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest 27, 484-492.
32. King BD, Sokoloff L & Wechsler RL (1952). The effects of l-epinephrine and l-norepinephrine upon cerebral circulation and metabolism in man. J Clin Invest 31, 273-279.
33. 2 and bicarbonate on pial vessels. Stroke 8, 226-229.
34. 2 action of cat pial arterioles. Stroke 8, 358-360.
35. Lee TJ, Su C & Bevan JA (1976). Neurogenic sympathetic vasoconstriction of the rabbit basilar artery. Circ Res 39, 120-126.
36. Linkis P, Jørgensen LG, Olesen HL, Madsen PL, Lassen NA & Secher NH (1995). Dynamic exercise enhances regional cerebral artery mean flow velocity. J Appl Physiol 78, 12-16.
37. 2 uptake during dynamic exercise. J Appl Physiol 74, 245-250.
38. Mitchell DA, Lambert G, Secher NH, Raven PB, van Lieshout J & Esler MD (2009). Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans. J Physiol 587, 2589-2597.
39. Miyazawa T, Horiuchi M, Ichikawa D, Subudhi AW, Sugawara J & Ogoh S (2012). Face cooling with mist water increases cerebral blood flow during exercise: effect of changes in facial skin blood flow. Front Physiol 3, 308.
40. Montain SJ & Coyle EF (1992a). Fluid ingestion during exercise increases skin blood flow independent of increases in blood volume. J Appl Physiol 73, 903-910.
41. Montain SJ & Coyle EF (1992b). Influence of graded dehydration on hyperthermia and cardiovascular drift during exercise. J Appl Physiol 73, 1340-1350.
42. Montain SJ, Sawka MN, Latzka WA & Valeri CR (1998). Thermal and cardiovascular strain from hypohydration: influence of exercise intensity. Int J Sports Med 19, 87-91.
43. Moraine JJ, Lamotte M, Berre J, Niset G, Leduc A & Naeije R (1993). Relationship of middle cerebral artery blood flow velocity to intensity during dynamic exercise in normal subjects. Eur J Appl Physiol Occup Physiol 67, 35-38.
44. Munck O & Lassen NA (1957). Bilateral cerebral blood flow and oxygen consumption in man by use of krypton 85. Circ Res 5, 163-168.
45. Nelson MD, Haykowsky MJ, Stickland MK, Altamirano-Diaz LA, Willie CK, Smith KJ, Petersen SR & Ainslie PN (2011). Reductions in cerebral blood flow during passive heat stress in humans: partitioning the mechanisms. J Physiol 589, 4053-4064.
46. 2) during hypothermia in rats. Anesth Analg 83, 1262-1267.
47. Nybo L, Møller K, Volianitis S, Nielsen B & Secher NH (2002). Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans. J Appl Physiol 93, 58-64.
48. Nybo L & Nielsen B (2001a). Hyperthermia and central fatigue during prolonged exercise in humans. J Appl Physiol 91, 1055-1060.
49. Nybo L & Nielsen B (2001b). Middle cerebral artery blood velocity is reduced with hyperthermia during prolonged exercise in humans. J Physiol 534, 279-286.
50. Nybo L & Rasmussen P (2007). Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise. Exerc Sport Sci Rev 35, 110-118.
51. Ogoh S & Ainslie PN (2009a). Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol 107, 1370-1380.
52. Ogoh S & Ainslie PN (2009b). Regulatory mechanisms of cerebral blood flow during exercise: new concepts. Exerc Sport Sci Rev 37, 123-129.
53. Ogoh S, Sato K, Okazaki K, Miyamoto T, Hirasawa A, Morimoto K & Shibasaki M (2013). Blood flow distribution during heat stress: cerebral and systemic blood flow. J Cereb Blood Flow Metab 33, 1915-1920.
54. Paulson OB, Strandgaard S & Edvinsson L (1990). Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2, 161-192.
55. Pearson J, Low DA, Stohr E, Kalsi K, Ali L, Barker H & González-Alonso J (2011). Hemodynamic responses to heat stress in the resting and exercising human leg: insight into the effect of temperature on skeletal muscle blood flow. Am J Physiol Regul Integr Comp Physiol 300, R663-R673.
56. 2 reactivity to end-tidal, arterial and internal jugular vein P CO 2. J Physiol 584, 347-357.
57. Querido JS & Sheel AW (2007). Regulation of cerebral blood flow during exercise. Sports Med 37, 765-782.
58. Ramanathan NL ( 1964). A new weighting system for mean surface temperature of the human body. J Appl Physiol 19, 531-533.
59. Rasmussen P, Dawson EA, Nybo L, van Lieshout JJ, Secher NH & Gjedde A (2007). Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. J Cereb Blood Flow Metab 27, 1082-1093.
60. Rasmussen P, Nybo L, Volianitis S, Møller K, Secher NH & Gjedde A (2010). Cerebral oxygenation is reduced during hyperthermic exercise in humans. Acta Physiol 199, 63-70.
61. Ross EZ, Cotter JD, Wilson L, Fan JL, Lucas SJ & Ainslie PN (2012). Cerebrovascular and corticomotor function during progressive passive hyperthermia in humans. J Appl Physiol 112, 748-758.
62. Sato K, Ogoh S, Hirasawa A, Oue A & Sadamoto T (2011). The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans. J Physiol 589, 2847-2856.
63. 2 in human internal and external carotid and vertebral arteries. J Physiol 15, 3277-3290.
64. Sawka MN, Knowlton RG & Critz JB (1979). Thermal and circulatory responses to repeated bouts of prolonged running. Med Sci Sports Exerc 11, 177-180.
65. Sawka MN, Young AJ, Francesconi RP, Muza SR & Pandolf KB (1985). Thermoregulatory and blood responses during exercise at graded hypohydration levels. J Appl Physiol 59, 1394-1401.
66. Scheinberg P, Blackburn LI, Rich M & Saslaw M (1954). Effects of vigorous physical exercise on cerebral circulation and metabolism. Am J Med 16, 549-554.
67. Schöning M, Walter J & Scheel P (1994). Estimation of cerebral blood flow through color duplex sonography of the carotid and vertebral arteries in healthy adults. Stroke 25, 17-22.
68. Secher NH, Seifert T & Van Lieshout JJ (2008). Cerebral blood flow and metabolism during exercise: implications for fatigue. J Appl Physiol 104, 306-314.
69. Seifert T, Rasmussen P, Secher NH & Nielsen HB (2009). Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockade. Acta Physiol (Oxf) 196, 295-302.
70. Seifert T & Secher NH (2011). Sympathetic influence on cerebral blood flow and metabolism during exercise in humans. Prog Neurobiol 95, 406-426.
71. Slinker BK & Glantz SA (2008). Multiple linear regression: Accounting for multiple simultaneous determinants of a continuous dependent variable. Circulation 117, 1732-1737.
72. Strandgaard S & Sigurdsson ST (2008). Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Counterpoint: Sympathetic nerve activity does not influence cerebral blood flow. J Appl Physiol 105, 1366-1367; discussion 1367-1368.
73. van Lieshout JJ & Secher NH (2008). Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Point: Sympathetic activity does influence cerebral blood flow. J Appl Physiol 105, 1364-1366.
74. Van Lieshout JJ, Wieling W, Karemaker JM & Secher NH (2003). Syncope, cerebral perfusion, and oxygenation. J Appl Physiol 94, 833-848.
75. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA & Ainslie PN (2012). Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol 590, 3261-3275.
76. Willie CK, Tzeng YC, Fisher JA & Ainslie PN (2014). Integrative regulation of human brain blood flow. J Physiol 592, 841-859.
77. Wilson MH, Edsell ME, Davagnanam I, Hirani SP, Martin DS, Levett DZ, Thornton JS, Golay X, Strycharczuk L, Newman SP, Montgomery HE, Grocott MP, Imray CH & Caudwell Xtreme Everest Research Group (2011). Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia-an ultrasound and MRI study. J Cereb Blood Flow Metab 31, 2019-2029.
78. Wilson TE, Cui J, Zhang R & Crandall CG (2006). Heat stress reduces cerebral blood velocity and markedly impairs orthostatic tolerance in humans. Am J Physiol Regul Integr Comp Physiol 291, R1443-R1448.
79. Wilson TE, Cui J, Zhang R, Witkowski S & Crandall CG (2002). Skin cooling maintains cerebral blood flow velocity and orthostatic tolerance during tilting in heated humans. J Appl Physiol 93, 85-91.
80. Zauner A, Doppenberg EM, Woodward JJ, Choi SC, Young HF & Bullock R (1997). Continuous monitoring of cerebral substrate delivery and clearance: initial experience in 24 patients with severe acute brain injuries. Neurosurgery 41, 1082-1091; discussion 1091-1093.