Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals

Journal of Physiology

Volumn 591, Issue 7, 2013, Pages 1859-1870

  Fisher, James P ^a   Hartwich, Doreen ^a   Seifert, Thomas ^b   Olesen, Niels D ^b   Mcnulty, Clare L ^a   Nielsen, Henning B ^b   van Lieshout, Johannes J ^c,d,e   Secher, Niels H ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b Rigshospitalet   (Denmark)

^c Department of Internal Medicine ^*  (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID;

ADULT; AGED; AGING; ARTICLE; BLOOD CARBON DIOXIDE TENSION; BLOOD SAMPLING; BRACHIAL ARTERY; BRAIN LEVEL; BRAIN METABOLISM; BRAIN OXYGEN TENSION; BRAIN PERFUSION; CEREBRAL METABOLIC RATE OF OXYGEN; CEREBRAL VASCULAR CONDUCTANCE INDEX; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; EXERCISE; EXERCISE INTENSITY; EXHAUSTION; GLUCOSE BRAIN LEVEL; GLUCOSE TRANSPORT; HEART OUTPUT; HEMODYNAMIC PARAMETERS; HUMAN; HUMAN EXPERIMENT; INTERNAL JUGULAR VEIN; LACTIC ACID BRAIN LEVEL; MEAN ARTERIAL PRESSURE; MEAN MIDDLE CEREBRAL ARTERY BLOOD VELOCITY; MIDDLE CEREBRAL ARTERY; NEUROIMAGING; OXYGEN CONCENTRATION; PRIORITY JOURNAL; REST; TISSUE OXYGENATION;

ADULT; AGED; AGING; BLOOD PRESSURE; BRAIN; CARDIAC OUTPUT; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; EXERCISE; GLUCOSE; HUMANS; LACTIC ACID; MIDDLE AGED; OXYGEN; PERFUSION; YOUNG ADULT;

EID: 84875667385     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.244905     Document Type: Article

References (69)

1. Ainslie PN, Cotter JD, George KP, Lucas S, Murrell C, Shave R, Thomas KN, Williams MJ & Atkinson G (2008). Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. J Physiol 586, 4005-4010.
2. Ajmani RS, Metter EJ, Jaykumar R, Ingram DK, Spangler EL, Abugo OO & Rifkind JM (2000). Hemodynamic changes during aging associated with cerebral blood flow and impaired cognitive function. Neurobiol Aging 21, 257-269.
3. Beason-Held LL, Moghekar A, Zonderman AB, Kraut MA & Resnick SM (2007). Longitudinal changes in cerebral blood flow in the older hypertensive brain. Stroke 38, 1766-1773.
4. Bogert LW & van Lieshout JJ (2005). Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp Physiol 90, 437-446.
5. Borg GA (1982). Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14, 377-381.
6. 2/carbohydrate uptake ratio in humans. J Physiol 540, 681-689.
7. Dalsgaard MK, Nybo L, Cai Y & Secher NH (2003). Cerebral metabolism is influenced by muscle ischaemia during exercise in humans. Exp Physiol 88, 297-302.
8. Dalsgaard MK, Volianitis S, Yoshiga CC, Dawson EA & Secher NH (2004). Cerebral metabolism during upper and lower body exercise. J Appl Physiol 97, 1733-1739.
9. de Leon MJ, George AE, Ferris SH, Christman DR, Fowler JS, Gentes CI, Brodie J, Reisberg B & Wolf AP (1984). Positron emission tomography and computed tomography assessments of the aging human brain. J Comput Assist Tomogr 8, 88-94.
10. Dinenno FA & Joyner MJ (2006). α-Adrenergic control of skeletal muscle circulation at rest and during exercise in aging humans. Microcirculation 13, 329-341.
11. Doherty TJ (2003). Invited review: Aging and sarcopenia. J Appl Physiol 95, 1717-1727.
12. Donders AR, van der Heijden GJ, Stijnen T & Moons KG (2006). Review: a gentle introduction to imputation of missing values. J Clin Epidemiol 59, 1087-1091.
13. Duara R, Margolin RA, Robertson-Tchabo EA, London ED, Schwartz M, Renfrew JW, Koziarz BJ, Sundaram M, Grady C, Moore AM, et al (1983). Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. Brain 106, 761-775.
14. Fisher JP, Ogoh S, Young CN, Raven PB & Fadel PJ (2008). Regulation of middle cerebral artery blood velocity during dynamic exercise in humans: influence of aging. J Appl Physiol 105, 266-273.
15. Fleg JL, O'Connor F, Gerstenblith G, Becker LC, Clulow J, Schulman SP & Lakatta EG (1995). Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol 78, 890-900.
16. Fox PT, Raichle ME, Mintun MA & Dence C (1988). Nonoxidative glucose consumption during focal physiologic neural activity. Science 241, 462-464.
17. Gjedde A, Johannsen P, Cold GE & Ostergaard L (2005). Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition. J Cereb Blood Flow Metab 25, 1183-1196.
18. Hagberg JM, Allen WK, Seals DR, Hurley BF, Ehsani AA & Holloszy JO (1985). A hemodynamic comparison of young and older endurance athletes during exercise. J Appl Physiol 58, 2041-2046.
19. Hagberg JM, Seals DR, Yerg JE, Gavin J, Gingerich R, Premachandra B & Holloszy JO (1988). Metabolic responses to exercise in young and older athletes and sedentary men. J Appl Physiol 65, 900-908.
20. Heckmann JG, Brown CM, Cheregi M, Hilz MJ & Neundorfer B (2003). Delayed cerebrovascular autoregulatory response to ergometer exercise in normotensive elderly humans. Cerebrovasc Dis 16, 423-429.
21. Hellstrom G, Fischer-Colbrie W, Wahlgren NG & Jogestrand T (1996). Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise. J Appl Physiol 81, 413-418.
22. Ide K, Horn A & Secher NH (1999). Cerebral metabolic response to submaximal exercise. J Appl Physiol 87, 1604-1608.
23. Ide K & Secher NH (2000). Cerebral blood flow and metabolism during exercise. Prog Neurobiol 61, 397-414.
24. Jellema WT, Wesseling KH, Groeneveld AB, Stoutenbeek CP, Thijs LG & van Lieshout JJ (1999). Continuous cardiac output in septic shock by simulating a model of the aortic input impedance: a comparison with bolus injection thermodilution. Anesthesiology 90, 1317-1328.
25. Jorgensen LG, Perko G & Secher NH (1992). Regional cerebral artery mean flow velocity and blood flow during dynamic exercise in humans. J Appl Physiol 73, 1825-1830.
26. Kety SS (1956). Human cerebral blood flow and oxygen consumption as related to aging. J Chronic Dis 3, 478-486.
27. Kirby BS, Crecelius AR, Voyles WF & Dinenno FA (2012). Impaired skeletal muscle blood flow control with advancing age in humans: attenuated ATP release and local vasodilation during erythrocyte deoxygenation. Circ Res 111, 220-230.
28. 18F]fluorodeoxyglucose method. J Cereb Blood Flow Metab 2, 163-171.
29. Larsen TS, Rasmussen P, Overgaard M, Secher NH & Nielsen HB (2008). Non-selective β-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans. J Physiol 586, 2807-2815.
30. Leenders KL, Perani D, Lammertsma AA, Heather JD, Buckingham P, Healy MJ, Gibbs JM, Wise RJ, Hatazawa J, Herold S, et al (1990). Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 113, 27-47.
31. Madsen PL, Hasselbalch SG, Hagemann LP, Olsen KS, Bulow J, Holm S, Wildschiodtz G, Paulson OB & Lassen NA (1995). Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety- Schmidt technique. J Cereb Blood Flow Metab 15, 485-491.
32. Markel TA, Daley JC, 3rd, Hogeman CS, Herr MD, Khan MH, Gray KS, Kunselman AR & Sinoway LI (2003). Aging and the exercise pressor reflex in humans. Circulation 107, 675-678.
33. Marsden KR, Haykowsky MJ, Smirl JD, Jones H, Nelson MD, Altamirano-Diaz LA, Gelinas JC, Tzeng YC, Smith KJ, Willie CK, Bailey DM & Ainslie PN (2012). Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise. Age (Dordr) 34, 725-735.
34. Martin AJ, Friston KJ, Colebatch JG & Frackowiak RS (1991). Decreases in regional cerebral blood flow with normal aging. J Cereb Blood Flow Metab 11, 684-689.
35. Mayhan WG, Arrick DM, Sharpe GM & Sun H (2008). Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress. Microcirculation 15, 225-236.
36. Mitchell DA, Lambert G, Secher NH, Raven PB, van Lieshout J & Esler MD (2009). Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans. J Physiol 587, 2589-2597.
37. Murrell CJ, Cotter JD, Thomas KN, Lucas SJ, Williams MJ & Ainslie PN (2012). Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training. Age (Dordr) ; DOI: 10.1007/s11357-012-9414-x.
38. 2 supplementation. Am J Physiol Heart Circ Physiol 277, H1045-H1052.
39. Nybo L & Rasmussen P (2007). Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise. Exerc Sport Sci Rev 35, 110-118.
40. Ogoh S, Dalsgaard MK, Yoshiga CC, Dawson EA, Keller DM, Raven PB & Secher NH (2005). Dynamic cerebral autoregulation during exhaustive exercise in humans. Am J Physiol Heart Circ Physiol 288, H1461-H1467.
41. Overgaard M, Rasmussen P, Bohm AM, Seifert T, Brassard P, Zaar M, Homann P, Evans KA, Nielsen HB & Secher NH (2012). Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain. FASEB J 26, 3012-3020.
42. Pantano P, Baron JC, Lebrun-Grandie P, Duquesnoy N, Bousser MG & Comar D (1984). Regional cerebral blood flow and oxygen consumption in human aging. Stroke 15, 635-641.
43. Phillips B, Williams J, Atherton P, Smith K, Hildebrandt W, Rankin D, Greenhaff P, Macdonald I & Rennie MJ (2012). Resistance exercise training improves age-related declines in leg vascular conductance and rejuvenates acute leg blood flow responses to feeding and exercise. J Appl Physiol 112, 347-353.
44. Poeppel TD, Terborg C, Hautzel H, Herzog H, Witte OW, Mueller HW & Krause BJ (2007). Cerebral haemodynamics during hypo- and hypercapnia: determination with simultaneous 15O-butanol-PET and transcranial Doppler sonography. Nuklearmedizin 46, 93-100.
45. Pott F, Van Lieshout JJ, Ide K, Madsen P & Secher NH (2003). Middle cerebral artery blood velocity during intense static exercise is dominated by a Valsalva maneuver. J Appl Physiol 94, 1335-1344.
46. Proctor DN & Parker BA (2006). Vasodilation and vascular control in contracting muscle of the aging human. Microcirculation 13, 315-327.
47. Quistorff B, Secher NH & Van Lieshout JJ (2008). Lactate fuels the human brain during exercise. FASEB J 22, 3443-3449.
48. Rai AT, Hogg JP, Cline B & Hobbs G (2012). Cerebrovascular geometry in the anterior circulation: an analysis of diameter, length and the vessel taper. J Neurointerv Surg ; DOI: 10.1136/neurintsurg-2012-010314.
49. Rasmussen P, Dawson EA, Nybo L, van Lieshout JJ, Secher NH & Gjedde A (2007). Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. J Cereb Blood Flow Metab 27, 1082-1093.
50. Rasmussen P, Nielsen J, Overgaard M, Krogh-Madsen R, Gjedde A, Secher NH & Petersen NC (2010). Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans. J Physiol 588, 1985-1995.
51. mean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip. J Appl Physiol 101, 1406-1411.
52. Rasmussen P, Wyss MT & Lundby C (2011). Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans. FASEB J 25, 2865-2873.
53. Raz N (2000). Aging of the brain and its impact on cognitive performance: integration of structural and functional findings. In Handbook of Aging and Cognition, ed. Craik FIM & Salthouse TA, pp. 90. Lawrence Erlbaum Associates, Mahwah, NJ, USA
54. Rogers RL, Meyer JS & Mortel KF (1990). After reaching retirement age physical activity sustains cerebral perfusion and cognition. J Am Geriatr Soc 38, 123-128.
55. Sato K, Ogoh S, Hirasawa A, Oue A & Sadamoto T (2011). The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans. J Physiol 589, 2847-2856.
56. Scheel P, Ruge C, Petruch UR & Schoning M (2000). Color duplex measurement of cerebral blood flow volume in healthy adults. Stroke 31, 147-150.
57. Schrage WG, Eisenach JH & Joyner MJ (2007). Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans. J Physiol 579, 227-236.
58. Secher NH, Seifert T & Van Lieshout JJ (2008). Cerebral blood flow and metabolism during exercise: implications for fatigue. J Appl Physiol 104, 306-314.
59. Seifert T, Rasmussen P, Brassard P, Homann PH, Wissenberg M, Nordby P, Stallknecht B, Secher NH & Nielsen HB (2009a). Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males. Am J Physiol Regul Integr Comp Physiol 297, R867-R876.
60. Seifert T, Rasmussen P, Secher NH & Nielsen HB (2009b). Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockade. Acta Physiol (Oxf) 196, 295-302.
61. Seifert T & Secher NH (2011). Sympathetic influence on cerebral blood flow and metabolism during exercise in humans. Prog Neurobiol 95, 406-426.
62. Seifert TS, Brassard P, Jorgensen TB, Hamada AJ, Rasmussen P, Quistorff B, Secher NH & Nielsen HB (2009c). Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline. J Physiol 587, 285-293.
63. Serrador JM, Picot PA, Rutt BK, Shoemaker JK & Bondar RL (2000). MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31, 1672-1678.
64. 2 uptake. Respir Physiol Neurobiol ; DOI: 10.1016/j.resp.2012.08.012.
65. Sugawara J, Tanabe T, Miyachi M, Yamamoto K, Takahashi K, Iemitsu M, Otsuki T, Homma S, Maeda S, Ajisaka R & Matsuda M (2003). Non-invasive assessment of cardiac output during exercise in healthy young humans: comparison between Modelflow method and Doppler echocardiography method. Acta Physiol Scand 179, 361-366.
66. Tam E, Azabji Kenfack M, Cautero M, Lador F, Antonutto G, di Prampero PE, Ferretti G & Capelli C (2004). Correction of cardiac output obtained by Modelflow from finger pulse pressure profiles with a respiratory method in humans. Clin Sci (Lond) 106, 371-376.
67. van Hall G, Stromstad M, Rasmussen P, Jans O, Zaar M, Gam C, Quistorff B, Secher NH & Nielsen HB (2009). Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab 29, 1121-1129.
68. Volianitis S, Fabricius-Bjerre A, Overgaard A, Stromstad M, Bjarrum M, Carlson C, Petersen NT, Rasmussen P, Secher NH & Nielsen HB (2008). The cerebral metabolic ratio is not affected by oxygen availability during maximal exercise in humans. J Physiol 586, 107-112.
69. Yamaguchi T, Kanno I, Uemura K, Shishido F, Inugami A, Ogawa T, Murakami M & Suzuki K (1986). Reduction in regional cerebral metabolic rate of oxygen during human aging. Stroke 17, 1220-1228.