Cerebral oxygenation is reduced during hyperthermic exercise in humans

Acta Physiologica

Volumn 199, Issue 1, 2010, Pages 63-70

  Rasmussen, P ^a   Nybo, L ^a   Volianitis, S ^b   Moller K ^a   Secher, N H ^a   Gjedde, A ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Central fatigue; Cerebral blood flow; Hyperthermia; Oxygen tension

Indexed keywords

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN MITOCHONDRION; BRAIN OXYGEN CONSUMPTION; BRAIN OXYGEN TENSION; CLOTHING; CONTROLLED STUDY; CORE TEMPERATURE; EXERCISE INTENSITY; EXERCISE PHYSIOLOGY; EXERCISE TOLERANCE; HEAT STRESS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; VENOUS OXYGEN TENSION;

ADULT; BODY TEMPERATURE; BRAIN; CEREBROVASCULAR CIRCULATION; ENERGY METABOLISM; EXERCISE; HOT TEMPERATURE; HUMANS; MALE; MITOCHONDRIA; OXYGEN; OXYGEN CONSUMPTION; STRESS, PHYSIOLOGICAL; YOUNG ADULT;

EID: 77950801034     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2010.02084.x     Document Type: Article

References (42)

1. Amann, M. Dempsey, J.A. 2008. Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance. J Physiol 586, 161 173.
2. Amann, M., Eldridge, M.W., Lovering, A.T., Stickland, M.K., Pegelow, D.F. Dempsey, J.A. 2006. Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 575, 937 952.
3. Cabanac, M. White, M.D. 1995. Core temperature thresholds for hyperpnea during passive hyperthermia in humans. Eur J Appl Physiol 71, 71 76.
4. Davis, S.L., Fadel, P.J., Cui, J., Thomas, G.D. Crandall, C.G. 2006. Skin blood flow influences near-infrared spectroscopy-derived measurements of tissue oxygenation during heat stress. J Appl Physiol 100, 221 224.
5. Dempsey, J.A. Wagner, P.D. 1999. Exercise-induced arterial hypoxemia. J Appl Physiol 87, 1997 2006.
6. Drust, B., Rasmussen, P., Mohr, M., Nielsen, B. Nybo, L. 2005. Elevations in core and muscle temperature impairs repeated sprint performance. Acta Physiol Scand 183, 181 190.
7. Gjedde, A., Johannsen, P., Cold, G.E. Østergaard, L. 2005. Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition. J Cereb Blood Flow Metab 25, 1183 1196.
8. Göbel, U., Klein, B., Schrock, H. Kuschinsky, W. 1989. Lack of capillary recruitment in the brains of awake rats during hypercapnia. J Cereb Blood Flow Metab 9, 491 499.
9. Haldane, J.S. 1905. The influence of high air temperatures. J Hyg 55, 497 513.
10. Høedt-Rasmussen, K., Sveinsdottir, E. Lassen, N.A. 1966. Regional cerebral blood flow in man determined by intra-arterial injection of radioactive inert gas. Circ Res 18, 237 247.
11. Ide, K. Secher, N.H. 2000. Cerebral blood flow and metabolism during exercise. Prog Neurobiol 61, 397 414.
12. Ide, K., Horn, A. Secher, N. 1999. Cerebral metabolic response to submaximal exercise. J Appl Physiol 87, 1604 1608.
13. Jørgensen, L., Perko, M. Secher, N.H. 1992. Regional cerebral artery mean flow velocity and blood flow during dynamic exercise in humans. J Appl Physiol 73, 1825 1830.
14. Kastrup, A., Kruger, G., Neumann-Haefelin, T., Glover, G.H. Moseley, M.E. 2002. Changes of cerebral blood flow, oxygenation, and oxidative metabolism during graded motor activation. Neuroimage 15, 74 82.
15. Kelman, G.R. 1966. Digital computer subroutine for the conversion of oxygen tension into saturation. J Appl Physiol 21, 1375 1376.
16. Kety, S.S. 1957. Determinants of tissue oxygen tension. Fed Proc 16, 666 671.
17. Kety, S.S. Schmidt, C.F. 1948. The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27, 476 483.
18. Kraaier, V., Van Huffelen, A.C., Wieneke, G.H., Van der Worp, H.B. Bär, P.R. 1992. Quantitative EEG changes due to cerebral vasoconstriction. Indomethacin versus hyperventilation-induced reduction in cerebral blood flow in normal subjects. Electroencephalogr Clin Neurophysiol 82, 208 212.
19. 2 pressures. Pflugers Arch 359, 81 95.
20. Linkis, P., Jørgensen, L., Olesen, H.L., Madsen, P.L., Lassen, N.A. Secher, N.H. 1995. Dynamic exercise enhances regional cerebral artery mean flow velocity. J Appl Physiol 78, 12 16.
21. Madsen, P.L., Holm, S., Herning, M. Lassen, N.A. 1993. Average blood flow and oxygen uptake in the human brain during resting wakefulness: a critical appraisal of the Kety-Schmidt technique. J Cereb Blood Flow Metab 13, 646 655.
22. Millet, G.Y., Aubert, D., Favier, F.B., Busso, T. Benoit, H. 2009. Effect of acute hypoxia on central fatigue during repeated isometric leg contractions. Scand J Med Sci Sports 19, 695 702.
23. Morrison, S., Sleivert, G.G. Cheung, S.S. 2004. Passive hyperthermia reduces voluntary activation and isometric force production. Eur J Appl Physiol 91, 729 736.
24. Morrison, S.A., Sleivert, G.G., Neary, J.P. Cheung, S.S. 2009. Prefrontal cortex oxygenation is preserved and does not contribute to impaired neuromuscular activation during passive hyperthermia. Appl Physiol Nutr Metab 34, 66 74.
25. 2 supplementation. Am J Physiol Heart Circ Physiol 277, H1045 H1052.
26. Nybo, L. 2008. Hyperthermia and fatigue. J Appl Physiol 104, 871 878.
27. Nybo, L. Nielsen, B. 2001a. Hyperthermia and central fatigue during prolonged exercise in humans. J Appl Physiol 91, 1055 1060. (Pubitemid 32803896)
28. Nybo, L. Nielsen, B. 2001b. Middle cerebral artery blood velocity is reduced with hyperthermia during prolonged exercise in humans. J Physiol 534, 279 286.
29. Nybo, L. Nielsen, B. 2001c. Perceived exertion is associated with an altered brain activity during exercise with progressive hyperthermia. J Appl Physiol 91, 2017 2023.
30. Nybo, L. Secher, N.H. 2004. Cerebral perturbations provoked by prolonged exercise. Prog Neurobiol 72, 223 261.
31. Nybo, L., Moller, K., Volianitis, S., Nielsen, B. Secher, N.H. 2002a. Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans. J Appl Physiol 93, 58 64. (Pubitemid 34686193)
32. Nybo, L., Secher, N.H. Nielsen, B. 2002b. Inadequate heat release from the human brain during prolonged exercise with hyperthermia. J Physiol 545, 697 704. (Pubitemid 36004397)
33. Olesen, J. 1971. Contralateral focal increase of cerebral blood flow in man during arm work. Brain 94, 646 653.
34. Poca, M.A., Sahuquillo, J., Vilalta, A. Garnacho, A. 2007. Lack of utility of arteriojugular venous differences of lactate as a reliable indicator of increased brain anaerobic metabolism in traumatic brain injury. J Neurosurg 106, 530 537.
35. Rasmussen, P., Stie, H., Nybo, L. Nielsen, B. 2004. Heat induced fatigue and changes of the EEG is not related to reduced perfusion of the brain during prolonged exercise in humans. J Therm Biol 29, 731 737.
36. 2 reactivity during strenuous exercise in man. Eur J Appl Physiol 96, 299 304.
37. Rasmussen, P., Dawson, E.A., Nybo, L., van Lieshout, J.J., Secher, N.H. Gjedde, A. 2007. Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. J Cereb Blood Flow Metab 27, 1082 1093.
38. Rasmussen, P., Overgaard, A., Fabricius-Bjerre, A., Bjarrum, M., Carlsson, C., Petersen, N., Nielsen, H.B., Volianitis, S., Gjedde, A. Secher, N.H. 2010. The effects of normoxia, hypoxia, and hyperoxia on cerebral haemoglobin saturation using near infrared spectroscopy during maximal exercise. Int J Ind Ergon 40, 190 196.
39. Seifert, T., Rasmussen, P., Brassard, P., Homann, P.H., Wissenberg, M., Nordby, P., Stallknecht, B., Secher, N.H. Nielsen, H.B. 2009a. Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males. Am J Physiol Regul Integr Comp Physiol 297, R867 R876.
40. Seifert, T., Rasmussen, P., Secher, N.H. Nielsen, H.B. 2009b. Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockade. Acta Physiol (Oxf) 196, 295 302.
41. Springett, R., Newman, J., Cope, M. Delpy, D.T. 2000. Oxygen dependency and precision of cytochrome oxidase signal from full spectral NIRS of the piglet brain. Am J Physiol Heart Circ Physiol 279, H2202 H2209.
42. Subudhi, A.W., Lorenz, M.C., Fulco, C.S. Roach, R.C. 2008. Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance. Am J Physiol Heart Circ Physiol 294, H164 H171.