Reductions in cerebral blood flow during passive heat stress in humans: Partitioning the mechanisms

Journal of Physiology

Volumn 589, Issue 16, 2011, Pages 4053-4064

  Nelson, Michael D ^a   Haykowsky, Mark J ^b   Stickland, Michael K ^b   Altamirano Diaz, Luis A ^c   Willie, Christopher K ^d   Smith, Kurt J ^d   Petersen, Stewart R ^a   Ainslie, Philip N ^d  

^a Faculty Physical Education and Recreation   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c STOLLERY CHILDREN S HOSPITAL   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTERIAL OXYGEN TENSION; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN PERFUSION; BRAIN VASCULAR RESISTANCE; BREATHING RATE; CONTROLLED STUDY; CORE TEMPERATURE; DOPPLER ECHOGRAPHY; END TIDAL CARBON DIOXIDE TENSION; HEAD TILTING; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEAT STRESS; HUMAN; HUMAN EXPERIMENT; HYPOCAPNIA; LUNG VENTILATION; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; PASSIVE HEAT STRESS; POSTERIOR CEREBRAL ARTERY; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN TEMPERATURE; SWEATING; TIDAL VOLUME; TWO DIMENSIONAL ECHOCARDIOGRAPHY; VENOUS RETURN;

ADULT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BODY TEMPERATURE; CEREBROVASCULAR CIRCULATION; HEART RATE; HEAT STRESS DISORDERS; HEAT-SHOCK RESPONSE; HUMANS; MALE; SEVERITY OF ILLNESS INDEX; STROKE VOLUME; YOUNG ADULT;

EID: 80051655493     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.212118     Document Type: Article

References (39)

1. 2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol 296, R1473-R1495.
2. Allan JR & Crossley RJ (1972). Effect of controlled elevation of body temperature on human tolerance to +G z acceleration. J Appl Physiol 33, 418-420.
3. Brothers RM, Ganio MS, Hubing KA, Hastings JL & Crandall CG (2011). End-tidal carbon dioxide tension reflects arterial carbon dioxide tension in the heat-stressed human with and without simulated hemorrhage. Am J Physiol Regul Integr Comp Physiol 300, R978-R983.
4. Brothers RM, Wingo JE, Hubing KA & Crandall CG (2009). The effects of reduced end-tidal carbon dioxide tension on cerebral blood flow during heat stress. J Physiol 587, 3921-3927.
5. Charkoudian N & Joyner MJ (2004). Physiologic considerations for exercise performance in women. Clin Chest Med 25, 247-255.
6. Charkoudian N, Joyner MJ, Johnson CP, Eisenach JH, Dietz NM & Wallin BG (2005). Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation. J Physiol 568, 315-321.
7. Crandall CG, Wilson TE, Marving J, Vogelsang TW, Kjaer A, Hesse B & Secher NH (2008). Effects of passive heating on central blood volume and ventricular dimensions in humans. J Physiol 586, 293-301.
8. Fan J-L, Cotter JD, Lucas RAI, Thomas K, Wilson L & Ainslie PN (2008). Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: effects of mild hypohydration. J Appl Physiol 105, 433-445.
9. Fu Q, Witkowski S, Okazaki K & Levine BD (2005). Effects of gender and hypovolemia on sympathetic neural responses to orthostatic stress. Am J Physiol Regul Integr Comp Physiol 289, R109-R116.
10. Giller C, Bowman G, Dyer H, Mootz L & Krippner W (1993). Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery 32, 737-741, discussion 741-742.
11. 2 in the hypocapnic-hypercapnic range in humans. J Appl Physiol 95, 129-137.
12. Ide K, Pott F, Lieshout JJV & Secher NH (1998). Middle cerebral artery blood velocity depends on cardiac output during exercise with a large muscle mass. Acta Physiol Scand 162, 13-20.
13. Johnson JM, Niederberger M, Rowell LB, Eisman MM & Brengelmann GL (1973). Competition between cutaneous vasodilator and vasoconstrictor reflexes in man. J Appl Physiol 35, 798-803.
14. Krediet CTP, de Bruin IGJM, Ganzeboom KS, Linzer M, van Lieshout JJ & Wieling W (2005). Leg crossing, muscle tensing, squatting, and the crash position are effective against vasovagal reactions solely through increases in cardiac output. J Appl Physiol 99, 1697-1703.
15. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA et al (2005). Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18, 1440-1463.
16. Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A et al (2002). Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J Physiol 538, 331-340.
17. Lind AR, Leithead CS & McNicol GW (1968). Cardiovascular changes during syncope induced by tilting men in the heat. J Appl Physiol 25, 268-276.
18. Low DA, Wingo JE, Keller DM, Davis SL, Cui J, Zhang R & Crandall CG (2009). Dynamic cerebral autoregulation during passive heat stress in humans. Am J Physiol Regul Integr Comp Physiol 296, R1598-R1605.
19. 2 during passive heat stress. J Appl Physiol 104, 976-981.
20. Lucas SJE, Burgess KR, Thomas KN, Donnelly J, Peebles KC, Lucas RAI et al (2011). Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m. J Physiol 589, 741-753.
21. Lucas SJE, Tzeng YC, Galvin SD, Thomas KN, Ogoh S & Ainslie PN (2010). Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55, 698-705.
22. Nelson MD, Altamirano-Diaz LA, Petersen SR, DeLorey DS, Stickland MK, Thompson RB & Haykowsky MJ (2011). Left ventricular systolic and diastolic function during tilt table positioning and passive heat stress in humans. Am J Physiol Heart Circ Physiol.
23. Nelson MD, Haykowsky MJ, Petersen SR, DeLorey DS, Cheng-Baron J & Thompson RB (2010a). Increased left ventricular twist, untwisting rates, and suction maintain global diastolic function during passive heat stress in humans. Am J Physiol Heart Circ Physiol 298, H930-H937.
24. Nelson MD, Haykowsky MJ, Petersen SR, DeLorey DS, Stickland MK, Cheng-Baron J & Thompson RB (2010b). Aerobic fitness does not influence the biventricular response to whole-body passive heat stress. J Appl Physiol 109, 1545-1551.
25. Ogoh S & Ainslie PN (2009). Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol 107, 1370-1380.
26. Ogoh S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, O-Yurvati A & Raven PB (2005). The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. J Physiol 569, 697-704.
27. Ramanathan NL (1964). A new weighting system for mean surface temperature of the human body. J Appl Physiol 19, 531-533.
28. Rowell LB, Brengelmann GL & Murray JA (1969). Cardiovascular responses to sustained high skin temperature in resting man. J Appl Physiol 27, 673-680.
29. Sato K, Ogoh S, Hirasawa A, Oue A & Sadamoto T (2011). The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans. J Physiol 589, 2847-2856.
30. Sato K & Sadamoto T (2010). Different blood flow responses to dynamic exercise between internal carotid and vertebral arteries in women. J Appl Physiol 109, 864-869.
31. Serrador JM, Picot PA, Rutt BK, Shoemaker JK & Bondar RL (2000). MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31, 1672-1678.
32. Shvartz E, Strydom NB & Kotze H (1975). Orthostatism and heat acclimation. J Appl Physiol 39, 590-595.
33. Valdueza J, Balzer J, Villringer A, Vogl T, Kutter R & Einhaupl K (1997). Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography. AJNR Am J Neuroradiol 18, 1929-1934.
34. Van Lieshout JJ, Wieling W, Karemaker JM & Secher NH (2003). Syncope, cerebral perfusion, and oxygenation. J Appl Physiol 94, 833-848.
35. Verheyden B, Liu J, van Dijk N, Westerhof BE, Reybrouck T, Aubert AE & Wieling W (2008). Steep fall in cardiac output is main determinant of hypotension during drug-free and nitroglycerine-induced orthostatic vasovagal syncope. Heart Rhythm 5, 1695-1701.
36. Willie CK, Colino FL, Bailey DM, Tzeng YC, Binsted G, Jones LW et al (2011). Utility of transcranial doppler ultrasound for the integrative assessment of cerebrovascular function. J Neurosci Methods 196, 221-237.
37. Willie CK, Cowan EC, Ainslie PN, Taylor CE, Smith KJ, Sin PYW & Tzeng YC (2011). Neurovascular coupling and distribution of cerebral blood flow during exercise. J Neurosci Methods 198, 270-273.
38. Wilson TE, Cui J, Zhang R & Crandall CG (2006). Heat stress reduces cerebral blood velocity and markedly impairs orthostatic tolerance in humans. Am J Physiol Regul Integr Comp Physiol 291, R1443-R1448.
39. Wilson TE, Cui J, Zhang R, Witkowski S & Crandall CG (2002). Skin cooling maintains cerebral blood flow velocity and orthostatic tolerance during tilting in heated humans. J Appl Physiol 93, 85-91.