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Volumn 14, Issue 2-3, 2014, Pages 151-162

Predictive factors to targeted treatment in gastrointestinal carcinomas

Author keywords

EGFR; Gastrointestinal cancer; HER2; targeted therapy; VEGF

Indexed keywords

AFLIBERCEPT; B RAF KINASE; BEVACIZUMAB; BIOLOGICAL MARKER; BRIVANIB ALANINATE; CEDIRANIB; CETUXIMAB; DIHYDROFOLATE REDUCTASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ETHYLENE TETRAHYDROFOLATE REDUCTASE; FLUOROURACIL; IRINOTECAN; K RAS PROTEIN; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE KINASE; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; RAMUCIRUMAB; REGORAFENIB; SUNITINIB; THYMIDYLATE SYNTHASE; TRASTUZUMAB; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VATALANIB; ANTINEOPLASTIC AGENT; BRAF PROTEIN, HUMAN; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN; RAS PROTEIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84904317949     PISSN: 15740153     EISSN: 18758592     Source Type: Journal    
DOI: 10.3233/CBM-130327     Document Type: Article
Times cited : (3)

References (96)
  • 1
    • 84863726328 scopus 로고    scopus 로고
    • Identification of predictive circulating biomarkers of bevacizumab-containing regimen efficacy in pre-treated metastatic colorectal cancer patients
    • A. Abajo, V. Boni, I. Lopez, M. Gonzalez-Huarriz, N. Bitarte, J. Rodriguez et al, Identification of predictive circulating biomarkers of bevacizumab-containing regimen efficacy in pre-treated metastatic colorectal cancer patients, British Journal of Cancer 107 (2012), 287-290.
    • (2012) British Journal of Cancer , vol.107 , pp. 287-290
    • Abajo, A.1    Boni, V.2    Lopez, I.3    Gonzalez-Huarriz, M.4    Bitarte, N.5    Rodriguez, J.6
  • 2
    • 0022647432 scopus 로고
    • The product of the human c-erbB-2 gene: A 185-kilo-dalton glycoprotein with tyrosine kinase activity
    • T. Akiyama, C. Sudo, H. Ogawara, K. Toyoshima, T. Yamamoto, The product of the human c-erbB-2 gene: A 185-kilo-Dalton glycoprotein with tyrosine kinase activity, Science 232 (1986), 644-646.
    • (1986) Science , vol.232 , pp. 644-646
    • Akiyama, T.1    Sudo, C.2    Ogawara, H.3    Toyoshima, K.4    Yamamoto, T.5
  • 5
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Y.J. Bang, E. Van Cutsem, A. Feyereislova, H.C. Chung, L. Shen, A. Sawaki et al, Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial, Lancet 376 (2010), 687-697.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3    Chung, H.C.4    Shen, L.5    Sawaki, A.6
  • 6
    • 64649096900 scopus 로고    scopus 로고
    • Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803
    • M.M. Bertagnolli, D. Niedzwiecki, C.C. Compton, H.P. Hahn, M. Hall, B. Damas et al, Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803, Journal of Clinical Oncology 27(11) (2009), 1814-1821.
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.11 , pp. 1814-1821
    • Bertagnolli, M.M.1    Niedzwiecki, D.2    Compton, C.C.3    Hahn, H.P.4    Hall, M.5    Damas, B.6
  • 7
    • 77956398850 scopus 로고    scopus 로고
    • Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-2005
    • V. Boige, J. Mendiboure, J.P. Pignon, M.A. Loriot, M. Castaing, M. Barrois et al, Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-2005, Journal of Clinical Oncology 28(15) (2010), 2556-2564.
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.15 , pp. 2556-2564
    • Boige, V.1    Mendiboure, J.2    Pignon, J.P.3    Loriot, M.A.4    Castaing, M.5    Barrois, M.6
  • 8
    • 0032534069 scopus 로고    scopus 로고
    • A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
    • C.R. Boland, S.N. Thibodeau, S.R. Hamilton, D. Sidransky, J.R. Eshleman, R.W. Burt et al, A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer, Cancer Research 58(22) (1998), 5248-5257.
    • (1998) Cancer Research , vol.58 , Issue.22 , pp. 5248-5257
    • Boland, C.R.1    Thibodeau, S.N.2    Hamilton, S.R.3    Sidransky, D.4    Eshleman, J.R.5    Burt, R.W.6
  • 9
    • 84873526361 scopus 로고    scopus 로고
    • Prognostic impact of FHIT, APC, and HER2 status in resected gastric cancer: A clinical-biological risk stratification model
    • [Abstract 4076]
    • E. Bria, S. Barbi, G. De Manzoni, et al, Prognostic impact of FHIT, APC, and HER2 status in resected gastric cancer: a clinical-biological risk stratification model, Journal of Clinical Oncology 30s (2012), [Abstract 4076].
    • (2012) Journal of Clinical Oncology , vol.30 S
    • Bria, E.1    Barbi, S.2    De Manzoni, G.3
  • 10
    • 84856452707 scopus 로고    scopus 로고
    • Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients: Implications for cancer therapy
    • P. Cejas, M. López-Gómez, C. Aguayo, R. Madero, J. Moreno-Rubio, J. de Castro Carpeño et al, Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients: implications for cancer therapy, Current Cancer Drug Targets 12(2) (2012), 124-131.
    • (2012) Current Cancer Drug Targets , vol.12 , Issue.2 , pp. 124-131
    • Cejas, P.1    López-Gómez, M.2    Aguayo, C.3    Madero, R.4    Moreno-Rubio, J.5    De Castro-Carpeño, J.6
  • 11
    • 79959712087 scopus 로고    scopus 로고
    • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health
    • W.H. Chappell, L.S. Steelman, J.M. Long, R.C. Kempf, S.L. Abrams, R.A. Franklin et al, Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health, Oncotarget 2(3) (2011), 135-164.
    • (2011) Oncotarget , vol.2 , Issue.3 , pp. 135-164
    • Chappell, W.H.1    Steelman, L.S.2    Long, J.M.3    Kempf, R.C.4    Abrams, S.L.5    Franklin, R.A.6
  • 12
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • KY. Chung, J. Shia, NE. Kemeny, M. Shah, GK. Schwartz, A. Tse et al, Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry, Journal of Clinical Oncology 23(9) (2005), 1803-1810.
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.9 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3    Shah, M.4    Schwartz, G.K.5    Tse, A.6
  • 13
    • 77949678177 scopus 로고    scopus 로고
    • Drug discovery: Inhibitors that activate
    • K. Cichowski, PA. Jänne, Drug discovery: inhibitors that activate, Nature 464 (7287) (2010), 358-359.
    • (2010) Nature , vol.464 , Issue.7287 , pp. 358-359
    • Cichowski, K.1    Jänne, P.A.2
  • 14
    • 0031014938 scopus 로고    scopus 로고
    • The significance of allelic deletions and aneuploidy in colorectal carcinoma. Results of a 5-year follow-up study
    • K.H. Cohn, D.L. Ornstein, F. Wang, F.D. LaPaix, K. Phipps, C. Edelsberg et al, The significance of allelic deletions and aneuploidy in colorectal carcinoma. Results of a 5-year follow-up study, Cancer 79(2) (1997), 233-244.
    • (1997) Cancer , vol.79 , Issue.2 , pp. 233-244
    • Cohn, K.H.1    Ornstein, D.L.2    Wang, F.3    Lapaix, F.D.4    Phipps, K.5    Edelsberg, C.6
  • 15
    • 79960680277 scopus 로고    scopus 로고
    • Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases
    • B.C. Danner, J.S. Gerdes, K. Jung, B. Sander, C. Enders, T. Liersch et al, Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases, Cancer Genetics 204(3) (2011), 122-128.
    • (2011) Cancer Genetics , vol.204 , Issue.3 , pp. 122-128
    • Danner, B.C.1    Gerdes, J.S.2    Jung, K.3    Sander, B.4    Enders, C.5    Liersch, T.6
  • 17
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • W. De Roock, B. Claes, D. Bernasconi, J. De Schutter, B. Biesmans, G. Fountzilas et al, Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis, Lancet Oncology 11(8) (2010), 753-762.
    • (2010) Lancet Oncology , vol.11 , Issue.8 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5    Fountzilas, G.6
  • 18
    • 78049341541 scopus 로고    scopus 로고
    • Association of KRAS p. G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
    • W. De Roock, D.J. Jonker, F. Di Nicolantonio, A. Sartore-Bianchi, D. Tu, S. Siena et al, Association of KRAS p. G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab, The Journal of the American Medical Association 304(16) (2010), 1812-1820.
    • (2010) The Journal of the American Medical Association , vol.304 , Issue.16 , pp. 1812-1820
    • De Roock, W.1    Jonker, D.J.2    Di Nicolantonio, F.3    Sartore-Bianchi, A.4    Tu, D.5    Siena, S.6
  • 19
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resis tance to targeted EGFR blockade in colorectal cancers
    • L.A. Jr Diaz, R.T. Williams, J. Wu, I. Kinde, J.R. Hecht, J. Berlin et al, The molecular evolution of acquired resis tance to targeted EGFR blockade in colorectal cancers, Nature 486(7404) (2012), 537-540.
    • (2012) Nature , vol.486 , Issue.7404 , pp. 537-540
    • Diaz Jr., L.A.1    Williams, R.T.2    Wu, J.3    Kinde, I.4    Hecht, J.R.5    Berlin, J.6
  • 20
    • 79954508175 scopus 로고    scopus 로고
    • Molecular predictors of response to chemotherapy in colorectal cancer
    • R. Dienstmann, E. Vilar, J. Tabernero, Molecular predictors of response to chemotherapy in colorectal cancer, The Cancer Journal 17 (2011), 114-126.
    • (2011) The Cancer Journal , vol.17 , pp. 114-126
    • Dienstmann, R.1    Vilar, E.2    Tabernero, J.3
  • 22
    • 72449124114 scopus 로고    scopus 로고
    • Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors
    • A. Duffy, S. Kummar, Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors, Target Oncology 4(4) (2009), 267-273.
    • (2009) Target Oncology , vol.4 , Issue.4 , pp. 267-273
    • Duffy, A.1    Kummar, S.2
  • 23
    • 56849089479 scopus 로고    scopus 로고
    • Phase II trial of docetaxel, cisplatin, irinotecan, and bevacizumab in metastatic esophagogastric cancer
    • P. Enzinger, D. Ryan, E. Regan, et al, Phase II trial of docetaxel, cisplatin, irinotecan, and bevacizumab in metastatic esophagogastric cancer, Journal of Clinical Oncology 26 (2008) Suppl 15: S4552.
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.SUPPL. 15
    • Enzinger, P.1    Ryan, D.2    Regan, E.3
  • 25
  • 27
    • 55649115722 scopus 로고    scopus 로고
    • Colorectal cancer screening tests: Pros and cons, and for whom?
    • G.M. Forbes, Colorectal cancer screening tests: pros and cons, and for whom? Expert Review of Gastroenterology and Hepatology 2 (2) (2008), 197-205.
    • (2008) Expert Review of Gastroenterology and Hepatology , vol.2 , Issue.2 , pp. 197-205
    • Forbes, G.M.1
  • 29
    • 3042767348 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression correlates with poor survival in gastric adenocarcinoma from Mexican patients: A multivariate analysis using a standardized immunohistochemical detection system
    • A. Gamboa-Dominguez, C. Dominguez-Fonseca, L. Quintanilla-Martinez, E. Reyes-Gutierrez, D. Green, A. Angeles-Angeles, et al., Epidermal growth factor receptor expression correlates with poor survival in gastric adenocarcinoma from Mexican patients: A multivariate analysis using a standardized immunohistochemical detection system, Modern Pathology 17 (2004), 579-587.
    • (2004) Modern Pathology , vol.17 , pp. 579-587
    • Gamboa-Dominguez, A.1    Dominguez-Fonseca, C.2    Quintanilla-Martinez, L.3    Reyes-Gutierrez, E.4    Green, D.5    Angeles-Angeles, A.6
  • 30
    • 5444227865 scopus 로고    scopus 로고
    • Guilty as charged: B-RAF is a human oncogene
    • M.J. Garnett, R. Marais, Guilty as charged: B-RAF is a human oncogene, Cancer Cell 6(4) (2004), 313-319.
    • (2004) Cancer Cell , vol.6 , Issue.4 , pp. 313-319
    • Garnett, M.J.1    Marais, R.2
  • 32
    • 8044236424 scopus 로고    scopus 로고
    • Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer
    • B. Glimelius, K. Ekström, K. Hoffman, W. Graf, P.O. Sjödén, U. Haglund, et al, Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer, Annals of Oncology 8 (1997), 163-168.
    • (1997) Annals of Oncology , vol.8 , pp. 163-168
    • Glimelius, B.1    Ekström, K.2    Hoffman, K.3    Graf, W.4    Sjödén, P.O.5    Haglund, U.6
  • 33
    • 82255173982 scopus 로고    scopus 로고
    • Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients
    • A. Gnoni, A. Russo, N. Silvestris, E. Maiello, A. Vacca, I. Marech, et al, Pharmacokinetic and metabolism determinants of fluoropyrimidines and oxaliplatin activity in treatment of colorectal patients, Current Drug Metabolism 12(10) (2011), 918-931.
    • (2011) Current Drug Metabolism , vol.12 , Issue.10 , pp. 918-931
    • Gnoni, A.1    Russo, A.2    Silvestris, N.3    Maiello, E.4    Vacca, A.5    Marech, I.6
  • 34
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • M.S. Gordon, K. Margolin, M. Talpaz, G.W. Jr Sledge, E. Holmgren, R. Benjamin et al, Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer, Journal of Clinical Oncology 19 (2001), 843-850.
    • (2001) Journal of Clinical Oncology , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3    Sledge Jr., G.W.4    Holmgren, E.5    Benjamin, R.6
  • 35
    • 50849123421 scopus 로고    scopus 로고
    • HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target
    • C. Gravalos, A. Jimeno, HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target, Annals of Oncology 19 (2008), 1523-1529.
    • (2008) Annals of Oncology , vol.19 , pp. 1523-1529
    • Gravalos, C.1    Jimeno, A.2
  • 36
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • A. Grothey, M.M. Sugrue, D.M. Purdie, W. Dong, D. Sargent, E. Hedrick et al, Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE), Journal of Clinical Oncology 26(33) (2008), 5326-5334.
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.33 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3    Dong, W.4    Sargent, D.5    Hedrick, E.6
  • 37
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • S.J. Heidorn, C. Milagre, S. Whittaker, A. Nourry, I. Niculescu-Duvas, N. Dhomen et al, Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF, Cell 140(2) (2010), 209-221.
    • (2010) Cell , vol.140 , Issue.2 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3    Nourry, A.4    Niculescu-Duvas, I.5    Dhomen, N.6
  • 38
    • 34547871259 scopus 로고    scopus 로고
    • Targeting HER proteins in cancer therapy and the role of the non-target HER3
    • A.C. Hsieh, M.M. Moasser, Targeting HER proteins in cancer therapy and the role of the non-target HER3, British Journal of Cancer 97 (2007), 453-457.
    • (2007) British Journal of Cancer , vol.97 , pp. 453-457
    • Hsieh, A.C.1    Moasser, M.M.2
  • 39
    • 80054057131 scopus 로고    scopus 로고
    • Southwest Oncology Group study S0413: A phase II trial of lapatinib (GW572016) as firstline therapy in patients with advanced or metastatic gastric cancer
    • S. Iqbal, B. Goldman, C.M. Fenoglio-Preiser, H.J. Lenz, W. Zhang, K.D. Danenberg et al, Southwest Oncology Group study S0413: a phase II trial of lapatinib (GW572016) as firstline therapy in patients with advanced or metastatic gastric cancer, Annals of Oncology 22 (2011), 2610-2615.
    • (2011) Annals of Oncology , vol.22 , pp. 2610-2615
    • Iqbal, S.1    Goldman, B.2    Fenoglio-Preiser, C.M.3    Lenz, H.J.4    Zhang, W.5    Danenberg, K.D.6
  • 40
    • 40649125816 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy number
    • A. Italiano, P. Follana, FX. Caroli, JL. Badetti, D. Benchimol, G. Garnier et al, Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy number, Annals of Surgical Oncology 15 (2008), 649-654.
    • (2008) Annals of Surgical Oncology , vol.15 , pp. 649-654
    • Italiano, A.1    Follana, P.2    Caroli, F.X.3    Badetti, J.L.4    Benchimol, D.5    Garnier, G.6
  • 41
    • 82155203054 scopus 로고    scopus 로고
    • Biomarkers predicting tumor response and evasion to anti-angiogenic therapy
    • A. Jahangiri, M.K. Aghi, Biomarkers predicting tumor response and evasion to anti-angiogenic therapy, Biochimica and Biophysica Acta 1825 (2012), 86-100.
    • (2012) Biochimica and Biophysica Acta , vol.1825 , pp. 86-100
    • Jahangiri, A.1    Aghi, M.K.2
  • 43
    • 33644825389 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-D and its receptor VEGFR-3: Two novel independent prognostic markers in gastric adenocarcinoma
    • S. Juttner, C. Wissmann, T. Jons, M. Vieth, J. Hertel, S. Gretsche et al, Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma, Journal of Clinical Oncology 24(2) (2006), 228-240.
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.2 , pp. 228-240
    • Juttner, S.1    Wissmann, C.2    Jons, T.3    Vieth, M.4    Hertel, J.5    Gretsche, S.6
  • 45
    • 33947546541 scopus 로고    scopus 로고
    • Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A Nationa Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study
    • G.P. Kim, L.H. Colangelo, H.S. Wieand, S. Paik, M.J. O'Connell, I.R. Kirsch et al, Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a Nationa Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study, Journal of Clinical Oncology 25(7) (2007), 767-772.
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.7 , pp. 767-772
    • Kim, G.P.1    Colangelo, L.H.2    Wieand, H.S.3    Paik, S.4    O'Connell, M.J.5    Kirsch, I.R.6
  • 46
    • 84904344550 scopus 로고    scopus 로고
    • P16 (INK4A) gene hypermethylation and kras mutation are independent predictors of FOLFIRI and cetuximab chemotherapy in patients with metastatic colorectal cancer (MCRC)
    • doi:10.1093/annonc/mds397
    • S.H. Kim, K.H. Park, S.J. Shin, K.Y. Lee, T.I. Kim, N.K. Kim et al, P16 (INK4A) gene hypermethylation and kras mutation are independent predictors of FOLFIRI and cetuximab chemotherapy in patients with metastatic colorectal cancer (MCRC), Annals of Oncology 23 (Supplement 9) (2012) doi:10.1093/annonc/mds397.
    • (2012) Annals of Oncology , vol.23 , Issue.SUPPL. 9
    • Kim, S.H.1    Park, K.H.2    Shin, S.J.3    Lee, K.Y.4    Kim, T.I.5    Kim, N.K.6
  • 48
    • 84904369560 scopus 로고    scopus 로고
    • Vascular endothelial growth factor polymorphisms and clinical outcome in colorectal cancer patients treated with irinotecan-based chemotherapy and bevacizumab in the first-line setting
    • Chicago, IL
    • A. Koutras, A. Antonacopoulou, F. Fostira, E.C. Briasoulis, I. Sgouros, A. Koumarianou et al, Vascular endothelial growth factor polymorphisms and clinical outcome in colorectal cancer patients treated with irinotecan-based chemotherapy and bevacizumab in the first-line setting, American Society of Clinical Oncology Annual Meeting, Chicago, IL (2010).
    • (2010) American Society of Clinical Oncology Annual Meeting
    • Koutras, A.1    Antonacopoulou, A.2    Fostira, F.3    Briasoulis, E.C.4    Sgouros, I.5    Koumarianou, A.6
  • 49
    • 67650674112 scopus 로고    scopus 로고
    • Ramucirumab, a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR-2 for the potential treatment of cancer
    • Y. Krupitskaya, H.A. Wakelee, Ramucirumab, a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR-2 for the potential treatment of cancer, Current Opinion in Investigational Drugs 10 (2009), 597-605.
    • (2009) Current Opinion in Investigational Drugs , vol.10 , pp. 597-605
    • Krupitskaya, Y.1    Wakelee, H.A.2
  • 50
    • 84863092492 scopus 로고    scopus 로고
    • VEGFpathway genetic variants as biomarkers of treatment outcome with bevacizumab: An analysis of data from the AViTA and AVOREN randomised trials
    • D. Lambrechts, B. Claes, P. Delmar, J. Reumers, M. Mazzone, B.T. Yesilyurt et al, VEGFpathway genetic variants as biomarkers of treatment outcome with bevacizumab: An analysis of data from the AViTA and AVOREN randomised trials, Lancet Oncology 13 (2012), 724-733.
    • (2012) Lancet Oncology , vol.13 , pp. 724-733
    • Lambrechts, D.1    Claes, B.2    Delmar, P.3    Reumers, J.4    Mazzone, M.5    Yesilyurt, B.T.6
  • 51
    • 84864464474 scopus 로고    scopus 로고
    • The potential for BRAF V600 inhibitors in advanced cutaneous melanoma: Rationale and latest evidence
    • C. Lemech, J. Infante, HT. Arkenau, The potential for BRAF V600 inhibitors in advanced cutaneous melanoma: rationale and latest evidence, Therapeutic Advances in Medical Oncology 4(2) (2012), 61-73.
    • (2012) Therapeutic Advances in Medical Oncology , vol.4 , Issue.2 , pp. 61-73
    • Lemech, C.1    Infante, J.2    Arkenau, H.T.3
  • 52
    • 38049177080 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients
    • E. Lieto, F. Ferraraccio, M. Orditura, P. Castellano, A.L. Mura, M. Pinto et al, Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients, Annals of Surgical Oncology 15(1) (2008), 69-79.
    • (2008) Annals of Surgical Oncology , vol.15 , Issue.1 , pp. 69-79
    • Lieto, E.1    Ferraraccio, F.2    Orditura, M.3    Castellano, P.4    Mura, A.L.5    Pinto, M.6
  • 53
    • 79954451405 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer
    • F. Loupakis, C. Cremolini, A. Fioravanti, P. Orlandi, L. Salvatore, G. Masi et al, Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer, British Journal of Cancer 104 (2011), 1262-1269.
    • (2011) British Journal of Cancer , vol.104 , pp. 1262-1269
    • Loupakis, F.1    Cremolini, C.2    Fioravanti, A.3    Orlandi, P.4    Salvatore, L.5    Masi, G.6
  • 54
    • 34249100236 scopus 로고    scopus 로고
    • Vascular endothelial growth factor levels in immunodepleted plasma of cancer patients as a possible pharmacodynamic marker for bevacizumab activity
    • F. Loupakis, A. Falcone, G. Masi, A. Fioravanti, R.S. Kerbel, M. Del Tacca et al, Vascular endothelial growth factor levels in immunodepleted plasma of cancer patients as a possible pharmacodynamic marker for bevacizumab activity, Journal of Clinical Oncology 25 (2007), 1816-1818.
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 1816-1818
    • Loupakis, F.1    Falcone, A.2    Masi, G.3    Fioravanti, A.4    Kerbel, R.S.5    Del Tacca, M.6
  • 55
    • 24344489058 scopus 로고    scopus 로고
    • Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a urine model
    • Y. Matsui, M. Inomata, M. Tojigamori, K. Sonoda, N. Shiraishi, S. Kitano, Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a urine model, International Journal of Oncology 27 (2005), 681-685.
    • (2005) International Journal of Oncology , vol.27 , pp. 681-685
    • Matsui, Y.1    Inomata, M.2    Tojigamori, M.3    Sonoda, K.4    Shiraishi, N.5    Kitano, S.6
  • 56
    • 79958803154 scopus 로고    scopus 로고
    • An open-label, multicentre biomarkeroriented AIO phase II trial of sunitinib for patients with chemo-refractory advanced gastric cancer
    • M. Moehler, A. Mueller, J.T. Hartmann, M.P. Ebert, S.E. Al-Batran, P. Reimer et al, An open-label, multicentre biomarkeroriented AIO phase II trial of sunitinib for patients with chemo-refractory advanced gastric cancer, European Journal of Cancer 47 (2011), 1511-1520.
    • (2011) European Journal of Cancer , vol.47 , pp. 1511-1520
    • Moehler, M.1    Mueller, A.2    Hartmann, J.T.3    Ebert, M.P.4    Al-Batran, S.E.5    Reimer, P.6
  • 58
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti-EGFR treatment in colorectal cancer: A cohort study
    • M. Moroni, S. Veronese, S. Benvenuti, G. Marrapese, A. Sartore-Bianchi, F. Di Nicolantonio et al, Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti-EGFR treatment in colorectal cancer: A cohort study, Lancet Oncology 6 (2005), 279-286.
    • (2005) Lancet Oncology , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3    Marrapese, G.4    Sartore-Bianchi, A.5    Di Nicolantonio, F.6
  • 59
    • 15244362062 scopus 로고    scopus 로고
    • P53 abnormalities and outcomes in colorectal cancer: A systematic review
    • A.J. Munro, S. Lain, D.P. Lane, P53 abnormalities and outcomes in colorectal cancer: A systematic review, British Journal of Cancer 92(3) (2005), 434-444.
    • (2005) British Journal of Cancer , vol.92 , Issue.3 , pp. 434-444
    • Munro, A.J.1    Lain, S.2    Lane, D.P.3
  • 63
    • 80053573446 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study
    • A. Ohtsu, M.A. Shah, E. Van Cutsem, S.Y. Rha, A. Sawaki, S.R. Park et al, Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study, Journal of Clinical Oncology 29(30) (2011), 3968-3976.
    • (2011) Journal of Clinical Oncology , vol.29 , Issue.30 , pp. 3968-3976
    • Ohtsu, A.1    Shah, M.A.2    Van Cutsem, E.3    Rha, S.Y.4    Sawaki, A.5    Park, S.R.6
  • 65
    • 80054760645 scopus 로고    scopus 로고
    • Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer
    • J.H. Park, S.W. Han, D.Y. Oh, S.A. Im, S.Y. Jeong, K.J. Park et al, Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer, Cancer Chemotherapy and Pharmacology 68(4) (2011), 1045-1055.
    • (2011) Cancer Chemotherapy and Pharmacology , vol.68 , Issue.4 , pp. 1045-1055
    • Park, J.H.1    Han, S.W.2    Oh, D.Y.3    Im, S.A.4    Jeong, S.Y.5    Park, K.J.6
  • 66
    • 78149239651 scopus 로고    scopus 로고
    • Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer
    • M. Peeters, TJ. Price, A. Cervantes, AF. Sobrero, M. Ducreux, Y. Hotko et al, Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer, Journal of Clinical Oncology 28 (2010), 4706-4713.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 4706-4713
    • Peeters, M.1    Price, T.J.2    Cervantes, A.3    Sobrero, A.F.4    Ducreux, M.5    Hotko, Y.6
  • 68
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatellite-instability status as a predictor of benefit from fluorouracil based adjuvant chemotherapy for colon cancer
    • C.M. Ribic, D.J. Sargent, M.J. Moore, S.N. Thibodeau, A.J. French, R.M. Goldberg et al, Tumor microsatellite-instability status as a predictor of benefit from fluorouracil based adjuvant chemotherapy for colon cancer, The New England Journal of Medicine 349(3) (2003), 247-257.
    • (2003) The New England Journal of Medicine , vol.349 , Issue.3 , pp. 247-257
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3    Thibodeau, S.N.4    French, A.J.5    Goldberg, R.M.6
  • 69
    • 78649744892 scopus 로고    scopus 로고
    • Prognostic vs predictive molecular biomarkers in colorectal cancer: Is KRAS and BRAF wild type status required for anti-EGFR therapy?
    • S. Rizzo, G. Bronte, D. Fanale, L. Corsini, N. Silvestris, D. Santini et al, Prognostic vs predictive molecular biomarkers in colorectal cancer: Is KRAS and BRAF wild type status required for anti-EGFR therapy? Cancer Treatment Reviews 36(Suppl 3) (2010), 56-61.
    • (2010) Cancer Treatment Reviews , vol.36 , Issue.SUPPL. 3 , pp. 56-61
    • Rizzo, S.1    Bronte, G.2    Fanale, D.3    Corsini, L.4    Silvestris, N.5    Santini, D.6
  • 70
    • 0347386407 scopus 로고    scopus 로고
    • Signal events: Cell signal transduction and its inhibition in cancer
    • E.K. Rowinsky, Signal events: Cell signal transduction and its inhibition in cancer, Oncologist 8 (Suppl. 3) (2003), 5-17.
    • (2003) Oncologist , vol.8 , Issue.SUPPL.. 3 , pp. 5-17
    • Rowinsky, E.K.1
  • 71
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumorderived cell lines in vitro and in vivo
    • D.W. Rusnak, K. Lackey, K. Affleck, E.R. Wood, K.J. Alligood, N. Rhodes et al, The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumorderived cell lines in vitro and in vivo, Molecular Cancer Therapeutics 1 (2001), 85-94.
    • (2001) Molecular Cancer Therapeutics , vol.1 , pp. 85-94
    • Rusnak, D.W.1    Lackey, K.2    Affleck, K.3    Wood, E.R.4    Alligood, K.J.5    Rhodes, N.6
  • 72
    • 77954259787 scopus 로고    scopus 로고
    • High concordance of BRAF status between primary colorectal tumours and related metastatic sites: Implications for clinical practice
    • D. Santini, C. Spoto, F. Loupakis, B. Vincenzi, N. Silvestris, C. Cremolini et al, High concordance of BRAF status between primary colorectal tumours and related metastatic sites: implications for clinical practice, Annals of Oncology 21(7) (2010), 1565.
    • (2010) Annals of Oncology , vol.21 , Issue.7 , pp. 1565
    • Santini, D.1    Spoto, C.2    Loupakis, F.3    Vincenzi, B.4    Silvestris, N.5    Cremolini, C.6
  • 73
    • 77954748953 scopus 로고    scopus 로고
    • Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
    • D.J. Sargent, S. Marsoni, G. Monges, S.N. Thibodeau, R. Labianca, S.R. Hamilton et al, Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer, Journal of Clinical Oncology 28(20) (2010), 3219-3226.
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.20 , pp. 3219-3226
    • Sargent, D.J.1    Marsoni, S.2    Monges, G.3    Thibodeau, S.N.4    Labianca, R.5    Hamilton, S.R.6
  • 74
    • 70350028742 scopus 로고    scopus 로고
    • Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer
    • A. Sartore-Bianchi, F. Di Nicolantonio, M. Nichelatti, F. Molinari, S. De Dosso, P. Saletti et al, Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer, PLoS One 4(10) (2009), e728743.
    • (2009) PLoS One , vol.4 , Issue.10
    • Sartore-Bianchi, A.1    Di Nicolantonio, F.2    Nichelatti, M.3    Molinari, F.4    De Dosso, S.5    Saletti, P.6
  • 75
    • 79960081156 scopus 로고    scopus 로고
    • Interim safety analysis from TYTAN: A phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer
    • (Abstract 4057)
    • T. Satoh, Y. Bang, J. Wang et al, Interim safety analysis from TYTAN: A phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer, Journal of Clinical Oncology 28 (2010), (Abstract 4057).
    • (2010) Journal of Clinical Oncology , vol.28
    • Satoh, T.1    Bang, Y.2    Wang, J.3
  • 76
    • 84856736532 scopus 로고    scopus 로고
    • Phase I study of cediranib in combination with cisplatin plus fluoropyrimidine (S-1 or capecitabine) in Japanese patients with previously untreated advanced gas tric cancer
    • T. Satoh, Y. Yamada, K. Muro, H. Hayashi, Y. Shimada, D. Takahari et al, Phase I study of cediranib in combination with cisplatin plus fluoropyrimidine (S-1 or capecitabine) in Japanese patients with previously untreated advanced gas tric cancer, Cancer Chemotherapy and Pharmacology 69(2) (2011), 439-446.
    • (2011) Cancer Chemotherapy and Pharmacology , vol.69 , Issue.2 , pp. 439-446
    • Satoh, T.1    Yamada, Y.2    Muro, K.3    Hayashi, H.4    Shimada, Y.5    Takahari, D.6
  • 77
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • N.V. Sergina, M. Rausch, D. Wang, J. Blair, B. Hann, K.M. Shokat et al, Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3, Nature 445 (2007), 437-441.
    • (2007) Nature , vol.445 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3    Blair, J.4    Hann, B.5    Shokat, K.M.6
  • 78
    • 68849110472 scopus 로고    scopus 로고
    • Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer
    • R. Seth, S. Crook, S. Ibrahem, W. Fadhil, D. Jackson, M. Ilyas, Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer, Gut 58(9) (2009), 1234-1241.
    • (2009) Gut , vol.58 , Issue.9 , pp. 1234-1241
    • Seth, R.1    Crook, S.2    Ibrahem, S.3    Fadhil, W.4    Jackson, D.5    Ilyas, M.6
  • 79
    • 33846629672 scopus 로고    scopus 로고
    • Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma
    • M.A. Shah, R.K. Ramanathan, D.H. Ilson, A. Levnor, D. D'Adamo, E. O'Reilly et al, Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma, Journal of Clinical Oncology 24(33) (2006), 5201-5206.
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.33 , pp. 5201-5206
    • Shah, M.A.1    Ramanathan, R.K.2    Ilson, D.H.3    Levnor, A.4    D'Adamo, D.5    O'Reilly, E.6
  • 80
    • 55849126233 scopus 로고    scopus 로고
    • Signal integration: A framework for understanding the efficacy of therapeutics targeting the human EGFR family
    • H.M. Shepard, C.M. Brdlik, H. Schreiber, Signal integration: A framework for understanding the efficacy of therapeutics targeting the human EGFR family, The Journal of Clinical Investigation 118 (2008), 3574-3581.
    • (2008) The Journal of Clinical Investigation , vol.118 , pp. 3574-3581
    • Shepard, H.M.1    Brdlik, C.M.2    Schreiber, H.3
  • 81
    • 84904355682 scopus 로고    scopus 로고
    • Possible role of vascular endothelial growth factor (VEGF) levels in immunodepleted plasma of metastatic colorectal cancer (mCRC) patients (pts) treated with a biweekly administration of capecitabine plus oxaliplatin (XELOX-2) plus bevacizumab: Preliminary results
    • Chicago, IL
    • N. Silvestris, A. Azzariti, L. Porcelli, A.E. Quatrale, A. Paradiso, G. Colucci, Possible role of vascular endothelial growth factor (VEGF) levels in immunodepleted plasma of metastatic colorectal cancer (mCRC) patients (pts) treated with a biweekly administration of capecitabine plus oxaliplatin (XELOX-2) plus bevacizumab: Preliminary results, American Society of Clinical Oncology Annual Meeting, Chicago, IL (2010).
    • (2010) American Society of Clinical Oncology Annual Meeting
    • Silvestris, N.1    Azzariti, A.2    Porcelli, L.3    Quatrale, A.E.4    Paradiso, A.5    Colucci, G.6
  • 82
    • 77949888718 scopus 로고    scopus 로고
    • The dark side of the Moon: The PI3K/PTEN/AKT pathway in colorectal carcinoma
    • N. Silvestris, S. Tommasi, D. Petriella, D. Santini, E. Fistola, A. Russo et al, The Dark Side of the Moon: The PI3K/PTEN/AKT pathway in colorectal carcinoma, Oncology 77(suppl 1) (2009), 69-74.
    • (2009) Oncology , vol.77 , Issue.SUPPL. 1 , pp. 69-74
    • Silvestris, N.1    Tommasi, S.2    Petriella, D.3    Santini, D.4    Fistola, E.5    Russo, A.6
  • 83
    • 67649092280 scopus 로고    scopus 로고
    • KRAS mutations and sensitivity to anti-EGFR monoclonal antibodies in metastatic colorectal carcinoma: An open issue
    • N. Silvestris, S. Tommasi, D. Santini, A. Russo, G. Simone, D. Petriella et al, KRAS mutations and sensitivity to anti-EGFR monoclonal antibodies in metastatic colorectal carcinoma: an open issue, Expert Opinion on Therapeutic Patents 9(5) (2009), 565-577.
    • (2009) Expert Opinion on Therapeutic Patents , vol.9 , Issue.5 , pp. 565-577
    • Silvestris, N.1    Tommasi, S.2    Santini, D.3    Russo, A.4    Simone, G.5    Petriella, D.6
  • 84
    • 84867235528 scopus 로고    scopus 로고
    • Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy
    • W. Sun, Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy, Journal of Hematology & Oncology 5 (2012), 63.
    • (2012) Journal of Hematology & Oncology , vol.5 , pp. 63
    • Sun, W.1
  • 85
    • 77954574658 scopus 로고    scopus 로고
    • Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203
    • rd, Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203, Journal of Clinical Oncology 28 (2010), 2947-2951.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 2947-2951
    • Sun, W.1    Powell, M.2    O'Dwyer, P.J.3    Catalano, P.4    Ansari, R.H.5    Benson III, A.B.6
  • 86
    • 20044372721 scopus 로고    scopus 로고
    • Amplification of HER-2 in gastric carcinoma: Association with Topoisomerase IIa gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
    • M. Tanner, M. Hollmen, T.T. Junttila, A.I. Kapanen, S. Tommola, Y. Soini et al, Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIa gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab, Annals of Oncology 16 (2005), 273-278.
    • (2005) Annals of Oncology , vol.16 , pp. 273-278
    • Tanner, M.1    Hollmen, M.2    Junttila, T.T.3    Kapanen, A.I.4    Tommola, S.5    Soini, Y.6
  • 87
    • 84867117207 scopus 로고    scopus 로고
    • Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab
    • S. Tejpar, I. Celik, M. Schlichting, U. Sartorius, C. Bokemeyer, E. Van Cutsem, Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab, Journal of Clinical Oncology 30 (29) (2012), 3570-3577.
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.29 , pp. 3570-3577
    • Tejpar, S.1    Celik, I.2    Schlichting, M.3    Sartorius, U.4    Bokemeyer, C.5    Van Cutsem, E.6
  • 89
    • 63849316277 scopus 로고    scopus 로고
    • The crystal study: Assessment of the predictive value of KRAS status on clinical outcome in patients with mCRC receiving first-line treatment with cetuximab or cetuximab plus folfiri [Abstract]
    • E. Van Cutsem, I. Lang, G. D'haens, V. Moiseyenko, J. Zaluski, C. Kohne et al, The crystal study: assessment of the predictive value of KRAS status on clinical outcome in patients with mCRC receiving first-line treatment with cetuximab or cetuximab plus folfiri [Abstract], Annals of Oncology 19(Suppl 6) (2008), vi17-8.
    • (2008) Annals of Oncology , vol.19 , Issue.SUPPL. 6
    • Van Cutsem, E.1    Lang, I.2    D'Haens, G.3    Moiseyenko, V.4    Zaluski, J.5    Kohne, C.6
  • 90
    • 4544376914 scopus 로고    scopus 로고
    • Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
    • S.C. Wang, H.C. Lien, W. Xia, I.F. Chen, H.W. Lo, Z. Wang et al, Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2, Cancer Cell 6 (2004), 251-261.
    • (2004) Cancer Cell , vol.6 , pp. 251-261
    • Wang, S.C.1    Lien, H.C.2    Xia, W.3    Chen, I.F.4    Lo, H.W.5    Wang, Z.6
  • 92
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients
    • C.G. Willett, Y. Boucher, D.G. Duda, E. di Tomaso, L.L. Munn, R.T. Tong et al, Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients, Journal of Clinical Oncology 23 (2005), 8136-8139.
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 8136-8139
    • Willett, C.G.1    Boucher, Y.2    Duda, D.G.3    Di Tomaso, E.4    Munn, L.L.5    Tong, R.T.6
  • 93
    • 67649921334 scopus 로고    scopus 로고
    • Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: A multidisciplinary phase II study
    • C.G. Willett, D.G. Duda, E. di Tomaso, Y. Boucher, M. Ancukiewicz, D.V. Sahani et al, Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: A multidisciplinary phase II study, Journal of Clinical Oncology 27 (2009), 3020-3026.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 3020-3026
    • Willett, C.G.1    Duda, D.G.2    Di Tomaso, E.3    Boucher, Y.4    Ancukiewicz, M.5    Sahani, D.V.6
  • 95
    • 84864916835 scopus 로고    scopus 로고
    • EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: A meta-analysis
    • Z.Y. Yang, W.X. Shen, X.F. Hu, D.Y. Zheng, X.Y. Wu, Y.F. Huang et al, EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: A meta-analysis, Journal of Hematology & Oncology 5 (2012), 52.
    • (2012) Journal of Hematology & Oncology , vol.5 , pp. 52
    • Yang, Z.Y.1    Shen, W.X.2    Hu, X.F.3    Zheng, D.Y.4    Wu, X.Y.5    Huang, Y.F.6
  • 96
    • 0025974889 scopus 로고
    • Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short-term prognosis in gastric cancer
    • Y. Yonemura, I. Ninomiya, A. Yamaguchi, S. Fushida, H. Kimura, S. Ohoyama, et al, Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short-term prognosis in gastric cancer, Cancer Research 51 (1991), 1034-1038.
    • (1991) Cancer Research , vol.51 , pp. 1034-1038
    • Yonemura, Y.1    Ninomiya, I.2    Yamaguchi, A.3    Fushida, S.4    Kimura, H.5    Ohoyama, S.6


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