-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal, A., et al. Global cancer statistics. CA Cancer J. Clin. 61, 69-90 (2011)
-
(2011)
CA Cancer J. Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
-
2
-
-
33646568784
-
Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
-
DOI 10.1200/JCO.2005.05.2308
-
Kamangar, F., Dores, G. M. & Anderson, W. F. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J. Clin. Oncol. 24, 2137-2150 (2006) (Pubitemid 46655601)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.14
, pp. 2137-2150
-
-
Kamangar, F.1
Dores, G.M.2
Anderson, W.F.3
-
3
-
-
4043144935
-
Epidemiology of upper gastrointestinal malignancies
-
DOI 10.1053/j.seminoncol.2004.04.021, PII S0093775404002428
-
Crew, K. D. & Neugut, A. I. Epidemiology of upper gastrointestinal malignancies. Semin. Oncol. 31, 450-464 (2004) (Pubitemid 39070265)
-
(2004)
Seminars in Oncology
, vol.31
, Issue.4
, pp. 450-464
-
-
Crew, K.D.1
Neugut, A.I.2
-
4
-
-
84864367529
-
-
7th edn (eds Sobin, L. H., et al.) Wiley-Blackwell, Hoboken, New Jersey
-
Oesophagus including oesophagogastric junction in TNM classification of malignant tumours, 7th edn (eds Sobin, L. H., et al.) 66-72 (Wiley-Blackwell, Hoboken, New Jersey, 2009)
-
(2009)
Oesophagus Including Oesophagogastric Junction in TNM Classification of Malignant Tumours
, pp. 66-72
-
-
-
6
-
-
68049087844
-
Toward molecularly selected chemotherapy for advanced gastric cancer: State of the art and future perspectives
-
Scartozzi, M., et al. Toward molecularly selected chemotherapy for advanced gastric cancer: State of the art and future perspectives. Cancer Treat. Rev. 35, 451-462 (2009)
-
(2009)
Cancer Treat. Rev
, vol.35
, pp. 451-462
-
-
Scartozzi, M.1
-
7
-
-
77955174673
-
Advanced gastric cancer-slow but steady progress
-
Power, D. G., Kelsen, D. P. & Shah, M. A. Advanced gastric cancer-slow but steady progress. Cancer Treat. Rev. 36, 384-392 (2010)
-
(2010)
Cancer Treat. Rev
, vol.36
, pp. 384-392
-
-
Power, D.G.1
Kelsen, D.P.2
Shah, M.A.3
-
8
-
-
77951203998
-
Esophagogastric cancer: Targeted agents
-
Ku, G. Y. & Ilson, D. H. Esophagogastric cancer: targeted agents. Cancer Treat. Rev. 36, 235-248 (2010)
-
(2010)
Cancer Treat. Rev
, vol.36
, pp. 235-248
-
-
Ku, G.Y.1
Ilson, D.H.2
-
9
-
-
79952039238
-
Oesophagogastric junction adenocarcinoma: Which therapeutic approach?
-
Mariette, C., Piessen, G., Briez, N., Gronnier, C. & Triboulet, J. P. Oesophagogastric junction adenocarcinoma: which therapeutic approach? Lancet Oncol. 12, 296-305 (2011)
-
(2011)
Lancet Oncol
, vol.12
, pp. 296-305
-
-
Mariette, C.1
Piessen, G.2
Briez, N.3
Gronnier, C.4
Triboulet, J.P.5
-
10
-
-
0034773992
-
The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
-
PII S0959804901002301
-
Yarden, Y. The EGFR family and its ligands in human cancer: signaling mechanisms and therapeutic opportunities. Eur. J. Cancer 37 (Suppl. 4), S3-S8 (2000) (Pubitemid 32938123)
-
(2001)
European Journal of Cancer
, vol.37
, Issue.SUPPL. 4
-
-
Yarden, Y.1
-
11
-
-
0003079827
-
The erbB family of receptors and their ligands: Multiple targets for therapy
-
Salomon, D. & Gullick, W. The erbB family of receptors and their ligands: multiple targets for therapy. Signal 2, 4-11 (2001)
-
(2001)
Signal
, vol.2
, pp. 4-11
-
-
Salomon, D.1
Gullick, W.2
-
12
-
-
0031936410
-
Specificity within the EGF family/ErbB receptor family signaling network
-
DOI 10.1002/(SICI)1521-1878(199801)20:1<41::AID-BIES7>3.0.CO;2-V
-
Riese, D. J. 2nd & Stern, D. F. Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 20, 41-48 (1998) (Pubitemid 28111330)
-
(1998)
BioEssays
, vol.20
, Issue.1
, pp. 41-48
-
-
Riese II, D.J.1
Stern, D.F.2
-
13
-
-
55849126233
-
Signal integration: A framework for understanding the efficacy of therapeutics targeting the human EGFR family
-
Shepard, H. M., Brdlik, C. M. & Schreiber, H. Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family. J. Clin. Invest. 118, 3574-3581 (2008)
-
(2008)
J. Clin. Invest
, vol.118
, pp. 3574-3581
-
-
Shepard, H.M.1
Brdlik, C.M.2
Schreiber, H.3
-
14
-
-
0347386407
-
Signal Events: Cell Signal Transduction and Its Inhibition in Cancer
-
Rowinsky, E. K. Signal events: cell signal transduction and its inhibition in cancer. Oncologist 8 (Suppl. 3), 5-17 (2003) (Pubitemid 37523378)
-
(2003)
Oncologist
, vol.8
, Issue.SUPPL. 3
, pp. 5-17
-
-
Rowinsky, E.K.1
-
15
-
-
58149232649
-
Unraveling the biologic and clinical complexities of HER2
-
Park, J. W., Neve, R. M., Szollosi, J. & Benz, C. C. Unraveling the biologic and clinical complexities of HER2. Clin. Breast Cancer 8, 392-401 (2008)
-
(2008)
Clin. Breast Cancer
, vol.8
, pp. 392-401
-
-
Park, J.W.1
Neve, R.M.2
Szollosi, J.3
Benz, C.C.4
-
16
-
-
50849123421
-
HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target
-
Gravalos, C. & Jimeno, A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann. Oncol. 19, 1523-1529 (2008)
-
(2008)
Ann. Oncol
, vol.19
, pp. 1523-1529
-
-
Gravalos, C.1
Jimeno, A.2
-
17
-
-
3042767348
-
Epidermal growth factor receptor expression correlates with poor survival in gastric adenocarcinoma from Mexican patients: A multivariate analysis using a standardized immunohistochemical detection system
-
DOI 10.1038/modpathol.3800085
-
Gamboa-Dominguez, A., et al. Epidermal growth factor receptor expression correlates with poor survival in gastric adenocarcinoma from Mexican patients: a multivariate analysis using a standardized immunohistochemical detection system. Mod. Pathol. 17, 579-587 (2004) (Pubitemid 38868426)
-
(2004)
Modern Pathology
, vol.17
, Issue.5
, pp. 579-587
-
-
Gamboa-Dominguez, A.1
Dominguez-Fonseca, C.2
Quintanilla-Martinez, L.3
Reyes-Gutierrez, E.4
Green, D.5
Angeles-Angeles, A.6
Busch, R.7
Hermannstadter, C.8
Nahrig, J.9
Becker, K.-F.10
Becker, I.11
Hofler, H.12
Fend, F.13
Luber, B.14
-
18
-
-
38049177080
-
Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients
-
Lieto, E., et al. Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients. Ann. Surg. Oncol. 15, 69-79 (2008)
-
(2008)
Ann. Surg. Oncol
, vol.15
, pp. 69-79
-
-
Lieto, E.1
-
19
-
-
39449115649
-
Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer
-
DOI 10.1038/sj.bjc.6604211, PII 6604211
-
Matsubara, J., et al. Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer. Br. J. Cancer 98, 832-839 (2008) (Pubitemid 351272605)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.4
, pp. 832-839
-
-
Matsubara, J.1
Nishina, T.2
Yamada, Y.3
Moriwaki, T.4
Shimoda, T.5
Kajiwara, T.6
Nakajima, T.E.7
Kato, K.8
Hamaguchi, T.9
Shimada, Y.10
Okayama, Y.11
Oka, T.12
Shirao, K.13
-
20
-
-
0023019645
-
Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas
-
Sakai, K., et al. Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas. J. Natl Cancer Inst. 77, 1047-1052 (1986) (Pubitemid 17184126)
-
(1986)
Journal of the National Cancer Institute
, vol.77
, Issue.5
, pp. 1047-1052
-
-
Sakai, K.1
Mori, S.2
Kawamoto, T.3
-
21
-
-
0025974889
-
Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short-term prognosis in gastric cancer
-
Yonemura, Y., et al. Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short-term prognosis in gastric cancer. Cancer Res. 51, 1034-1038 (1991)
-
(1991)
Cancer Res
, vol.51
, pp. 1034-1038
-
-
Yonemura, Y.1
-
22
-
-
0028292017
-
Significance of erbB-2 gene product as a target molecule for cancer therapy
-
DOI 10.1111/j.1365-3083.1994.tb03401.x
-
Ishida, T., et al. Significance of erbB-2 gene product as a target molecule for cancer therapy. Scand. J. Immunol. 39, 459-466 (1994) (Pubitemid 24227769)
-
(1994)
Scandinavian Journal of Immunology
, vol.39
, Issue.5
, pp. 459-466
-
-
Ishida, T.1
Tsujisaki, M.2
Hanzawa, Y.3
Hirakawa, T.4
Hinoda, Y.5
Imai, K.6
Yachi, A.7
-
23
-
-
0028907863
-
Clinical significance of epidermal growth factor (EGF), EGF receptor and c-erbB-2 in human gastric cancer
-
Tokunaga, A., et al. Clinical significance of epidermal growth factor (EGF), EGF receptor and c-erbB-2 in human gastric cancer. Cancer 75, 1418-1425 (1995)
-
(1995)
Cancer
, vol.75
, pp. 1418-1425
-
-
Tokunaga, A.1
-
24
-
-
20044372721
-
Amplification of HER-2 in gastric carcinoma: Association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
-
DOI 10.1093/annonc/mdi064
-
Tanner, M., et al. Amplification of HER-2 in gastric carcinoma: association with Topoisomerase II alpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann. Oncol. 16, 273-278 (2005) (Pubitemid 40309309)
-
(2005)
Annals of Oncology
, vol.16
, Issue.2
, pp. 273-278
-
-
Tanner, M.1
Hollmen, M.2
Junttila, T.T.3
Kapanen, A.I.4
Tommola, S.5
Soini, Y.6
Helin, H.7
Salo, J.8
Joensuu, H.9
Sihvo, E.10
Elenius, K.11
Isola, J.12
-
25
-
-
78649724338
-
Human epidermal growth factor receptor 2 (HER2) in gastric cancer: A new therapeutic target
-
De Vita, F., et al. Human epidermal growth factor receptor 2 (HER2) in gastric cancer: a new therapeutic target. Cancer Treat. Rev. 36 (Suppl. 3), S11-S15 (2010)
-
(2010)
Cancer Treat. Rev
, vol.36
, Issue.SUPPL. 3
-
-
De Vita, F.1
-
26
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
-
Bang, Y. J., et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376, 687-697 (2010)
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.J.1
-
27
-
-
33847663871
-
Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)
-
DOI 10.1093/annonc/mdl459
-
Pinto, C., et al. Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). Ann. Oncol. 18, 510-517 (2007) (Pubitemid 46359631)
-
(2007)
Annals of Oncology
, vol.18
, Issue.3
, pp. 510-517
-
-
Pinto, C.1
Di Fabio, F.2
Siena, S.3
Cascinu, S.4
Rojas Llimpe, F.L.5
Ceccarelli, C.6
Mutri, V.7
Giannetta, L.8
Giaquinta, S.9
Funaioli, C.10
Berardi, R.11
Longobardi, C.12
Piana, E.13
Martoni, A.A.14
-
28
-
-
58749089260
-
Phase II study and biomarker analysis of cetuximab in combination with modified FOLFOX6 in advanced gastric cancer
-
Han, S. W., et al. Phase II study and biomarker analysis of cetuximab in combination with modified FOLFOX6 in advanced gastric cancer. Br. J. Cancer 100, 298-304 (2009)
-
(2009)
Br. J. Cancer
, vol.100
, pp. 298-304
-
-
Han, S.W.1
-
29
-
-
76349109904
-
Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: A phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
-
Lordick, F., et al. Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: a phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Br. J. Cancer 102, 500-505 (2010)
-
(2010)
Br. J. Cancer
, vol.102
, pp. 500-505
-
-
Lordick, F.1
-
30
-
-
79957539777
-
A prospective phase II study of cetuximab in combination with XELOX (capecitabine and oxaliplatin) in patients with metastatic and/or recurrent advanced gastric cancer
-
Kim, C., et al. A prospective phase II study of cetuximab in combination with XELOX (capecitabine and oxaliplatin) in patients with metastatic and/or recurrent advanced gastric cancer. Invest. New Drugs 29, 366-373 (2011)
-
(2011)
Invest. New Drugs
, vol.29
, pp. 366-373
-
-
Kim, C.1
-
31
-
-
70349937924
-
Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study)
-
Pinto, C., et al. Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study). Br. J. Cancer 101, 1261-1268 (2009)
-
(2009)
Br. J. Cancer
, vol.101
, pp. 1261-1268
-
-
Pinto, C.1
-
32
-
-
79951532484
-
CALGB 80403/ECOG 1206: A randomized phase II study of three standard chemotherapy regimens (ECF IC FOLFOX) plus cetuximab in metastatic esophageal and GE junction cancer [abstract]
-
Enzinger, P. C., et al. CALGB 80403/ECOG 1206: a randomized phase II study of three standard chemotherapy regimens (ECF, IC, FOLFOX) plus cetuximab in metastatic esophageal and GE junction cancer [abstract]. J. Clin. Oncol. 28 (Suppl. 15), a4006 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.SUPPL. 15
-
-
Enzinger, P.C.1
-
33
-
-
79957864676
-
Cetuximab with irinotecan, folinic acid and 5-fluorouracil as first-line treatment in advanced gastroesophageal cancer: A prospective multi-center biomarker-oriented phase II study
-
doi:10.1093/annonc/mdq591
-
Moehler, M., et al. Cetuximab with irinotecan, folinic acid and 5-fluorouracil as first-line treatment in advanced gastroesophageal cancer: a prospective multi-center biomarker-oriented phase II study. Ann. Oncol. doi:10.1093/annonc/mdq591
-
Ann. Oncol
-
-
Moehler, M.1
-
34
-
-
72349094937
-
Phase II study of cetuximab plus weekly cisplatin and 24-h infusion of high-dose 5-fluorouracil and leucovorin for the first-line treatment of advanced gastric cancer [abstract]
-
Yeh, K., et al. Phase II study of cetuximab plus weekly cisplatin and 24-h infusion of high-dose 5-fluorouracil and leucovorin for the first-line treatment of advanced gastric cancer [abstract]. J. Clin. Oncol. 27 (Suppl. 15), a4567 (2009)
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.SUPPL. 15
-
-
Yeh, K.1
-
35
-
-
79957973335
-
A phase II study of cetuximab with cisplatin and capecitabine as first-line treatment in advanced gastric cancer [abstract]
-
Zhang, X., et al. A phase II study of cetuximab with cisplatin and capecitabine as first-line treatment in advanced gastric cancer [abstract]. Proceedings ASCO 2009 Gastrointestinal Cancers Symposium LBA39 (2009)
-
(2009)
Proceedings ASCO 2009 Gastrointestinal Cancers Symposium LBA39
-
-
Zhang, X.1
-
36
-
-
72349092875
-
Oxaliplatin, irinotecan, and cetuximab in advanced gastric cancer. First efficacy results of a multicenter phase II trial of the AGMT [abstract]
-
Woell, E., et al. Oxaliplatin, irinotecan, and cetuximab in advanced gastric cancer. First efficacy results of a multicenter phase II trial of the AGMT [abstract]. J. Clin. Oncol. 27 (Suppl. 15), a4538 (2009)
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.SUPPL. 15
-
-
Woell, E.1
-
37
-
-
67349242264
-
Cetuximab with irinotecan as salvage therapy in heavily pretreated patients with metastatic gastric cancer [abstract]
-
Stein, A., et al. Cetuximab with irinotecan as salvage therapy in heavily pretreated patients with metastatic gastric cancer [abstract]. Proceedings ASCO 2007 Gastrointestinal Cancers Symposium a47 (2007)
-
(2007)
Proceedings ASCO 2007 Gastrointestinal Cancers Symposium
, vol.47
-
-
Stein, A.1
-
38
-
-
79960099141
-
Cetuximab (C225) plus irinotecan/cisplatin (CPT/CDDP) for CPT/CDDP-refractory esophageal cancer [abstract]
-
Ku, G., et al. Cetuximab (C225) plus irinotecan/cisplatin (CPT/CDDP) for CPT/CDDP-refractory esophageal cancer [abstract]. Proceedings ASCO 2008 Gastrointestinal Cancers Symposium a54 (2008)
-
(2008)
Proceedings ASCO 2008 Gastrointestinal Cancers Symposium
, vol.54
-
-
Ku, G.1
-
39
-
-
79960094623
-
ATTAX2-docetaxel plus cetuximab as second-line treatment for docetaxel refractory oesophago-gastric cancer: Final results of a multi-center phase II trial by the AGITG [abstract]
-
Tebbutt, N., et al. ATTAX2-docetaxel plus cetuximab as second-line treatment for docetaxel refractory oesophago-gastric cancer: final results of a multi-center phase II trial by the AGITG [abstract]. Proceedings ASCO 2008 Gastrointestinal Cancers Symposium a87 (2008)
-
(2008)
Proceedings ASCO 2008 Gastrointestinal Cancers Symposium
, vol.87
-
-
Tebbutt, N.1
-
40
-
-
84861355311
-
Biweekly cetuximab and irinotecan as second-line therapy to patients with platinum-resistant gastroesophageal cancer [abstract]
-
Schønnemann, K., et al. Biweekly cetuximab and irinotecan as second-line therapy to patients with platinum-resistant gastroesophageal cancer [abstract]. Proceedings ASCO 2009 Gastrointestinal Cancers Symposium a73 (2009)
-
(2009)
Proceedings ASCO 2009 Gastrointestinal Cancers Symposium
, vol.73
-
-
Schønnemann, K.1
-
41
-
-
75549087436
-
Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients
-
Park, S. R., et al. Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients. Cancer Chemother. Pharmacol. 65, 579-587 (2010)
-
(2010)
Cancer Chemother. Pharmacol
, vol.65
, pp. 579-587
-
-
Park, S.R.1
-
43
-
-
72849135336
-
Palliative treatment of unresectable metastatic colorectal cancer
-
Fornaro, L., Masi, G., Loupakis, F., Vasile, E. & Falcone, A. Palliative treatment of unresectable metastatic colorectal cancer. Expert Opin. Pharmacother. 11, 63-77 (2010)
-
(2010)
Expert Opin. Pharmacother
, vol.11
, pp. 63-77
-
-
Fornaro, L.1
Masi, G.2
Loupakis, F.3
Vasile, E.4
Falcone, A.5
-
44
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan- refractory metastatic colorectal cancer
-
DOI 10.1056/NEJMoa033025
-
Cunningham, D., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 351, 337-345 (2004) (Pubitemid 38944402)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
Chau, I.11
Van Cutsem, E.12
-
45
-
-
78149274146
-
EGFR antibodies in colorectal cancer: Where do they belong?
-
Grothey, A. EGFR antibodies in colorectal cancer: where do they belong? J. Clin. Oncol. 28, 4668-4670 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 4668-4670
-
-
Grothey, A.1
-
46
-
-
77957552916
-
Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: Dose-finding study for the prospective multicenter, randomized, phase II/III REAL-3 trial
-
Okines, A. F., et al. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: dose-finding study for the prospective multicenter, randomized, phase II/III REAL-3 trial. J. Clin. Oncol. 28, 3945-3950 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 3945-3950
-
-
Okines, A.F.1
-
47
-
-
77958496605
-
Matuzumab plus epirubicin, cisplatin and capecitabine (ECX) compared with epirubicin, cisplatin and capecitabine alone as first-line treatment in patients with advanced oesophago-gastric cancer: A randomised, multicentre open-label phase II study
-
Rao, S., et al. Matuzumab plus epirubicin, cisplatin and capecitabine (ECX) compared with epirubicin, cisplatin and capecitabine alone as first-line treatment in patients with advanced oesophago-gastric cancer: a randomised, multicentre open-label phase II study. Ann. Oncol. 21, 2213-2219 (2010)
-
(2010)
Ann. Oncol
, vol.21
, pp. 2213-2219
-
-
Rao, S.1
-
48
-
-
79955425807
-
Randomized phase II study of nimotuzumab an anti-EGFR antibody plus irinotecan in patients with 5-fluorouracil-based regimen-refractory advanced or recurrent gastric cancer in Korea and Japan: Preliminary results [abstract]
-
Kim, Y. H., et al. Randomized phase II study of nimotuzumab, an anti-EGFR antibody, plus irinotecan in patients with 5-fluorouracil-based regimen-refractory advanced or recurrent gastric cancer in Korea and Japan: Preliminary results [abstract]. J. Clin. Oncol. 29 (Suppl. 4), a87 (2011)
-
(2011)
J. Clin. Oncol
, vol.29
, Issue.SUPPL. 4
-
-
Kim, Y.H.1
-
49
-
-
4143135982
-
Efficacy tolerability and pharmacokinetics of gefitinib (ZD1839) in pretreated patients with metastatic gastric cancer [abstract]
-
Doi, T., et al. Efficacy, tolerability and pharmacokinetics of gefitinib (ZD1839) in pretreated patients with metastatic gastric cancer [abstract]. J. Clin. Oncol. 22 (Suppl.), a1036 (2003)
-
(2003)
J. Clin. Oncol
, vol.22
, Issue.SUPPL.
-
-
Doi, T.1
-
50
-
-
33750618860
-
Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127
-
DOI 10.1200/JCO.2006.07.1316
-
Dragovich, T., et al. Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. J. Clin. Oncol. 24, 4922-4927 (2006) (Pubitemid 46630921)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.30
, pp. 4922-4927
-
-
Dragovich, T.1
McCoy, S.2
Fenoglio-Preiser, C.M.3
Wang, J.4
Benedetti, J.K.5
Baker, A.F.6
Hackett, C.B.7
Urba, S.G.8
Zaner, K.S.9
Blanke, C.D.10
Abbruzzese, J.L.11
-
51
-
-
67650395446
-
Early results of a trial of trastuzumab cisplatin and docetaxel (TCD) for the treatment of metastatic gastric cancer overexpressing HER-2 [abstract]
-
Nicholas, G., et al. Early results of a trial of trastuzumab, cisplatin, and docetaxel (TCD) for the treatment of metastatic gastric cancer overexpressing HER-2 [abstract]. Ann. Oncol. 17 (Suppl. 9), a1105P (2006)
-
(2006)
Ann. Oncol
, vol.17
, Issue.SUPPL. 9
-
-
Nicholas, G.1
-
52
-
-
42449156456
-
Phase II trial of trastuzumab and cisplatin in patients (pts) with advanced gastric cancer (AGC) with HER2/neu overexpression/amplification [abstract]
-
Cortés-Funes, H., et al. Phase II trial of trastuzumab and cisplatin in patients (pts) with advanced gastric cancer (AGC) with HER2/neu overexpression/amplification [abstract]. J. Clin. Oncol. 25 (Suppl. 18), a4613 (2007)
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.SUPPL. 18
-
-
Cortés-Funes, H.1
-
53
-
-
77649162889
-
Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo
-
Wainberg, Z. A., et al. Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin. Cancer Res. 16, 1509-1519 (2010)
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 1509-1519
-
-
Wainberg, Z.A.1
-
54
-
-
38649093257
-
S0413: A phase II SWOG study of GW572016 (lapatinib) as first line therapy in patients (pts) with advanced or metastatic gastric cancer [abstract]
-
Iqbal, S., Goldman, B., Lenz, H. J., Fenoglio-Preiser, C. M. & Blanke, C. D. S0413: a phase II SWOG study of GW572016 (lapatinib) as first line therapy in patients (pts) with advanced or metastatic gastric cancer [abstract]. J. Clin. Oncol. 25 (Suppl. 18), a4621 (2007)
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.SUPPL. 18
-
-
Iqbal, S.1
Goldman, B.2
Lenz, H.J.3
Fenoglio-Preiser, C.M.4
Blanke, C.D.5
-
55
-
-
77953453066
-
Lapatinib monotherapy in recurrent upper gastrointestinal malignancy: Phase II efficacy and biomarker analyses [abstract]
-
Hecht, J., et al. Lapatinib monotherapy in recurrent upper gastrointestinal malignancy: phase II efficacy and biomarker analyses [abstract]. Proceedings ASCO 2008 Gastrointestinal Cancers Symposium a43 (2008)
-
(2008)
Proceedings ASCO 2008 Gastrointestinal Cancers Symposium
, vol.43
-
-
Hecht, J.1
-
56
-
-
79952977646
-
Lapatinib + capecitabine in advanced gastric cancer: An open-label, phase II study of non-ErbB2-targeted disease
-
Lenz, H. J., et al. Lapatinib + capecitabine in advanced gastric cancer: an open-label, phase II study of non-ErbB2-targeted disease. Ann. Oncol. 21 (Suppl. 8), a817P (2010)
-
(2010)
Ann. Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Lenz, H.J.1
-
57
-
-
79960080459
-
Lapatinib in combination with ECF/X in EGFR1 or HER2-overexpressing first-line metastatic gastric cancer (GC): A phase II randomized placebo controlled trial (EORTC 40071) [abstract]
-
Roth, A., et al. Lapatinib in combination with ECF/X in EGFR1 or HER2-overexpressing first-line metastatic gastric cancer (GC): a phase II randomized placebo controlled trial (EORTC 40071) [abstract]. J. Clin. Oncol. 28 (Suppl. 15), a205 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.SUPPL. 15
-
-
Roth, A.1
-
58
-
-
79960081156
-
Interim safety analysis from TYTAN: A phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer [abstract]
-
Satoh, T., et al. Interim safety analysis from TYTAN: A phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer [abstract]. J. Clin. Oncol. 28 (15 Suppl.), a4057 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Satoh, T.1
-
60
-
-
70349939382
-
Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
-
Siena, S., Sartore-Bianchi, A., Di Nicolantonio, F., Balfour, J. & Bardelli, A. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J. Natl Cancer Inst. 101, 1308-1324 (2009)
-
(2009)
J. Natl Cancer Inst
, vol.101
, pp. 1308-1324
-
-
Siena, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Balfour, J.4
Bardelli, A.5
-
61
-
-
51649085865
-
Platinum-based chemotherapy plus cetuximab in head and neck cancer
-
Vermorken, J. B., et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N. Engl. J. Med. 359, 1116-1127 (2008)
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1116-1127
-
-
Vermorken, J.B.1
-
62
-
-
33144461661
-
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group Study
-
DOI 10.1200/JCO.2005.02.4646
-
Burtness, B., Goldwasser, M. A., Flood, W., Mattar, B. & Forastiere, A. A. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J. Clin. Oncol. 23, 8646-8654 (2005) (Pubitemid 46211507)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.34
, pp. 8646-8654
-
-
Burtness, B.1
Goldwasser, M.A.2
Flood, W.3
Mattar, B.4
Forastiere, A.A.5
-
63
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
-
Pirker, R., et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 373, 1525-1531 (2009)
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
-
64
-
-
77949886293
-
Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer
-
Khambata-Ford, S., et al. Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer. J. Clin. Oncol. 28, 918-927 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 918-927
-
-
Khambata-Ford, S.1
-
65
-
-
70450195266
-
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC
-
Normanno, N., et al. Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. Nat. Rev. Clin. Oncol. 6, 519-527 (2009)
-
(2009)
Nat. Rev. Clin. Oncol
, vol.6
, pp. 519-527
-
-
Normanno, N.1
-
66
-
-
77949435827
-
Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
-
Bardelli, A. & Siena, S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J. Clin. Oncol. 28, 1254-1261 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 1254-1261
-
-
Bardelli, A.1
Siena, S.2
-
67
-
-
0037194728
-
RAF/RAS oncogenes and mismatch-repair status
-
DOI 10.1038/418934a
-
Rajagopalan, H., et al. Tumorigenesis: RAF/RAS oncogenes and mismatch repair status. Nature 418, 934 (2002) (Pubitemid 34976022)
-
(2002)
Nature
, vol.418
, Issue.6901
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.E.6
-
68
-
-
0029072186
-
Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases
-
Lee, K. H., et al. Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases. Cancer 75, 2794-2801 (1995)
-
(1995)
Cancer
, vol.75
, pp. 2794-2801
-
-
Lee, K.H.1
-
69
-
-
0025215205
-
Infrequent point mutations of ras oncogenes in gastric cancers
-
Nanus, D. M., Kelsen, D. P., Mentle, I. R., Altorki, N. & Albino, A. P. Infrequent point mutations of ras oncogenes in gastric cancers. Gastroenterology 98, 955-960 (1990) (Pubitemid 20095847)
-
(1990)
Gastroenterology
, vol.98
, Issue.4
, pp. 955-960
-
-
Nanus, D.M.1
Kelsen, D.P.2
Mentle, I.R.3
Altorki, N.4
Albino, A.P.5
-
70
-
-
0029041377
-
Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence Italy
-
Hongyo, T., et al. Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy. Cancer Res. 55, 2665-2672 (1995)
-
(1995)
Cancer Res
, vol.55
, pp. 2665-2672
-
-
Hongyo, T.1
-
71
-
-
0242574321
-
BRAF and KRAS mutations in stomach cancer
-
DOI 10.1038/sj.onc.1206749
-
Lee, S. H., et al. BRAF and KRAS mutations in stomach cancer. Oncogene 22, 6942-6945 (2003) (Pubitemid 37386695)
-
(2003)
Oncogene
, vol.22
, Issue.44
, pp. 6942-6945
-
-
Lee, S.H.1
Lee, J.W.2
Soung, Y.H.3
Kim, H.S.4
Park, W.S.5
Kim, S.Y.6
Lee, J.H.7
Park, J.Y.8
Cho, Y.G.9
Kim, C.J.10
Nam, S.W.11
Kim, S.H.12
Lee, J.Y.13
Yoo, N.J.14
-
72
-
-
0345256381
-
Mutations of BRAF and KRAS in Gastric Cancer and Their Association with Microsatellite Instability
-
DOI 10.1002/ijc.11553
-
Zhao, W., et al. Mutations of BRAF and KRAS in gastric cancer and their association with microsatellite instability. Int. J. Cancer 108, 167-169 (2004) (Pubitemid 37444461)
-
(2004)
International Journal of Cancer
, vol.108
, Issue.1
, pp. 167-169
-
-
Zhao, W.1
Chan, T.L.2
Chu, K.-M.3
Chan, A.S.4
Stratton, M.R.5
Yuen, S.T.6
Leung, S.Y.7
-
73
-
-
0346057796
-
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency
-
DOI 10.1038/sj.onc.1207061
-
Oliveira, C., et al. BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency. Oncogene 22, 9192-9196 (2007) (Pubitemid 38067995)
-
(2003)
Oncogene
, vol.22
, Issue.57
, pp. 9192-9196
-
-
Oliveira, C.1
Pinto, M.2
Duval, A.3
Brennetot, C.4
Domingo, E.5
Espin, E.6
Armengol, M.7
Yamamoto, H.8
Hamelin, R.9
Seruca, R.10
Schwartz Jr., S.11
-
74
-
-
78650236616
-
Concordant analysis of KRAS status in primary colon carcinoma and matched metastasis
-
Mariani, P., et al. Concordant analysis of KRAS status in primary colon carcinoma and matched metastasis. Anticancer Res. 30, 4229-4223 (2010)
-
(2010)
Anticancer Res
, vol.30
, pp. 4229-4223
-
-
Mariani, P.1
-
75
-
-
58749102224
-
High concordance of KRAS status between primary colorectal tumors and related metastatic sites: Implications for clinical practice
-
Santini, D., et al. High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice. Oncologist 13, 1270-1275 (2008)
-
(2008)
Oncologist
, vol.13
, pp. 1270-1275
-
-
Santini, D.1
-
76
-
-
77949617829
-
KRAS and BRAF mutational status as response biomarkers to cetuximab combination therapy in advanced gastric cancer patients [abstract]
-
Stella, G., et al. KRAS and BRAF mutational status as response biomarkers to cetuximab combination therapy in advanced gastric cancer patients [abstract]. J. Clin. Oncol. 27 (Suppl.), a15503 (2009)
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.SUPPL.
-
-
Stella, G.1
-
77
-
-
84865698216
-
Analysis of biomarker expression (ki67 EGFR HER2 ERK NFkB and mTOR) in patients with advanced gastric and gastroesophageal junction (GEJ) cancer treated with cetuximab plus cisplatin/docetaxel: DOCETUX study [abstract]
-
Pinto, C., et al. Analysis of biomarker expression (ki67, EGFR, HER2, ERK, NFkB, and mTOR) in patients with advanced gastric and gastroesophageal junction (GEJ) cancer treated with cetuximab plus cisplatin/docetaxel: DOCETUX study [abstract]. J. Clin. Oncol. 28 (15 Suppl.), a4133 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Pinto, C.1
-
78
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
DOI 10.1200/JCO.2006.10.5437
-
Khambata-Ford, S., et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J. Clin. Oncol. 25, 3230-3237 (2007) (Pubitemid 47325606)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.22
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
Basik, M.4
Harbison, C.T.5
Wu, S.6
Wong, T.W.7
Huang, X.8
Takimoto, C.H.9
Godwin, A.K.10
Tan, B.R.11
Krishnamurthi, S.S.12
Burris III, H.A.13
Poplin, E.A.14
Hidalgo, M.15
Baselga, J.16
Clark, E.A.17
Mauro, D.J.18
-
79
-
-
73349098041
-
Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab
-
Jacobs, B., et al. Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab. J. Clin. Oncol. 27, 5068-5074 (2009)
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 5068-5074
-
-
Jacobs, B.1
-
80
-
-
72449212283
-
Amphiregulin (AR) expression in the prediction of benefit from cetuximab plus irinotecan in KRAS wild-type metastatic colorectal cancer (mCRC) patients [abstract]
-
Loupakis, F., et al. Amphiregulin (AR) expression in the prediction of benefit from cetuximab plus irinotecan in KRAS wild-type metastatic colorectal cancer (mCRC) patients [abstract]. J. Clin. Oncol. 27 (15 Suppl.), a4021 (2009)
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Loupakis, F.1
-
81
-
-
79960101756
-
Circulating levels of EGFR ligands as surrogate markers of EGFR inhibition with cetuximab in metastatic colorectal cancer (mCRC) patients (pts) [abstract]
-
Cremolini, C., et al. Circulating levels of EGFR ligands as surrogate markers of EGFR inhibition with cetuximab in metastatic colorectal cancer (mCRC) patients (pts) [abstract]. Proceedings ASCO 2010 Molecular Markers a99 (2010)
-
(2010)
Proceedings ASCO 2010 Molecular Markers
, vol.99
-
-
Cremolini, C.1
-
82
-
-
77949630161
-
Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6
-
Han, S. W., et al. Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6. Cancer Sci. 101, 793-799 (2010)
-
(2010)
Cancer Sci
, vol.101
, pp. 793-799
-
-
Han, S.W.1
-
83
-
-
0040886242
-
Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1
-
Gebhardt, F., Zanker, K. S. & Brandt, B. Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1. J. Biol. Chem. 274, 13176-13180 (1999)
-
(1999)
J. Biol. Chem
, vol.274
, pp. 13176-13180
-
-
Gebhardt, F.1
Zanker, K.S.2
Brandt, B.3
-
84
-
-
41149140325
-
Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer
-
Graziano, F., et al. Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer. J. Clin. Oncol. 26, 1427-1434 (2008)
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 1427-1434
-
-
Graziano, F.1
-
85
-
-
77953276067
-
Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer
-
Pander, J., et al. Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer. Eur. J. Cancer 46, 1829-1834 (2010)
-
(2010)
Eur. J. Cancer
, vol.46
, pp. 1829-1834
-
-
Pander, J.1
-
86
-
-
59449091688
-
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab
-
Lurje, G., et al. Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. Clin. Cancer Res. 14, 7884-7895 (2008)
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 7884-7895
-
-
Lurje, G.1
-
87
-
-
33847323129
-
Epidermal growth factor receptor mutations in lung cancer
-
Sharma, S. V., Bell, D. W., Settleman, J. & Haber, D. A. Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 7, 169-181 (2007)
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 169-181
-
-
Sharma, S.V.1
Bell, D.W.2
Settleman, J.3
Haber, D.A.4
-
88
-
-
17144411518
-
Biomarkers for prediction of sensitivity to EGFR inhibitors in non-small cell lung cancer
-
Hirsch, F. R. & Witta, S. Biomarkers for prediction of sensitivity to EGFR inhibitors in non-small cell lung cancer. Curr. Opin. Oncol. 17, 118-122 (2007)
-
(2007)
Curr. Opin. Oncol
, vol.17
, pp. 118-122
-
-
Hirsch, F.R.1
Witta, S.2
-
89
-
-
33845240595
-
Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis
-
DOI 10.1038/sj.bjc.6603459, PII 6603459
-
Yokoyama, H., et al. Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis. Br. J. Cancer 95, 1504-1513 (2006) (Pubitemid 44863353)
-
(2006)
British Journal of Cancer
, vol.95
, Issue.11
, pp. 1504-1513
-
-
Yokoyama, H.1
Ikehara, Y.2
Kodera, Y.3
Ikehara, S.4
Yatabe, Y.5
Mochizuki, Y.6
Koike, M.7
Fujiwara, M.8
Nakao, A.9
Tatematsu, M.10
Nakanishi, H.11
-
90
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht, J. R., et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J. Clin. Oncol. 27, 672-668 (2009)
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 672-668
-
-
Hecht, J.R.1
-
91
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol, J., et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N. Engl. J. Med. 360, 563-572 (2009)
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
-
92
-
-
33644876397
-
Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer
-
Yano, T., et al. Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer. Oncol. Rep. 15, 65-71 (2006)
-
(2006)
Oncol. Rep
, vol.15
, pp. 65-71
-
-
Yano, T.1
-
93
-
-
77749273477
-
HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value-conclusions from 924 cases of two independent series
-
Grabsch, H., Sivakumar, S., Gray, S., Gabbert, H. E. & Müller, W. HER2 expression in gastric cancer: rare, heterogeneous and of no prognostic value-conclusions from 924 cases of two independent series. Cell. Oncol. 32, 57-65 (2010)
-
(2010)
Cell. Oncol
, vol.32
, pp. 57-65
-
-
Grabsch, H.1
Sivakumar, S.2
Gray, S.3
Gabbert, H.E.4
Müller, W.5
-
94
-
-
44249092320
-
Assessment of a HER2 scoring system for gastric cancer: Results from a validation study
-
DOI 10.1111/j.1365-2559.2008.03028.x
-
Hofmann, M., et al. Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology 52, 797-805 (2008) (Pubitemid 351724903)
-
(2008)
Histopathology
, vol.52
, Issue.7
, pp. 797-805
-
-
Hofmann, M.1
Stoss, O.2
Shi, D.3
Buttner, R.4
Van De Vijver, M.5
Kim, W.6
Ochiai, A.7
Ruschoff, J.8
Henkel, T.9
-
95
-
-
79251502276
-
HER2 over-expression and gene amplification in gastric cancer [abstract]
-
Park, Y. S., et al. HER2 over-expression and gene amplification in gastric cancer [abstract]. Ann. Oncol. 21 (Suppl. 8), a822P (2010)
-
(2010)
Ann. Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Park, Y.S.1
-
97
-
-
0034473776
-
The role of HER-2 expression in predicting response to therapy in breast cancer
-
Mass, R. The role of HER-2 expression in predicting response to therapy in breast cancer. Semin. Oncol. 27, 46-52 (2000) (Pubitemid 32172256)
-
(2000)
Seminars in Oncology
, vol.27
, Issue.6 SUPPL. 11
, pp. 46-52
-
-
Mass, R.1
-
98
-
-
0034327895
-
Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: A direct comparison of fluorescence in situ hybridization and immunohistochemistry
-
Pauletti, G., et al. Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry. J. Clin. Oncol. 18, 3651-3664 (2000)
-
(2000)
J. Clin. Oncol
, vol.18
, pp. 3651-3664
-
-
Pauletti, G.1
-
99
-
-
0035162262
-
Evaluating HER2 amplification and overexpression in breast cancer
-
DOI 10.1002/path.971
-
Bartlett, J. M. S., Going, J. J. & Mallon, E. A. Evaluating HER2 amplification and overexpression in breast cancer. J. Pathol. 195, 422-428 (2001) (Pubitemid 33069666)
-
(2001)
Journal of Pathology
, vol.195
, Issue.4
, pp. 422-428
-
-
Bartlett, J.M.S.1
Going, J.J.2
Mallon, E.A.3
Watters, A.D.4
Reeves, J.R.5
Stanton, P.6
Richmond, J.7
Donald, B.8
Ferrier, R.9
Cooke, T.G.10
-
100
-
-
0033973884
-
Determination of Her-2/neu status in breast carcinoma: Comparative analysis of immunohistochemistry and fluorescent in situ hybridization
-
Jimenez, R. E., Wallis, T., Tabasczka, P. & Visscher, D. W. Determination of Her-2/neu status in breast carcinoma: comparative analysis of immunohistochemistry and fluorescent in situ hybridization. Mod. Pathol. 13, 37-45 (2000) (Pubitemid 30077902)
-
(2000)
Modern Pathology
, vol.13
, Issue.1
, pp. 37-45
-
-
Jimenez, R.E.1
Wallis, T.2
Tabasczka, P.3
Visscher, D.W.4
-
101
-
-
0035863284
-
HER-2/neu analysis in archival tissue samples of human breast cancer: Comparison of immunohistochemistry and fluorescence in situ hybridization
-
Lebeau, A., et al. HER-2/neu analysis in archival tissue samples of human breast cancer: comparison of immunohistochemistry and fluorescence in situ hybridization. J. Clin. Oncol. 19, 354-363 (2001) (Pubitemid 32112846)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.2
, pp. 354-363
-
-
Lebeau, A.1
Deimling, D.2
Kaltz, C.3
Sendelhofert, A.4
Iff, A.5
Luthardt, B.6
Untch, M.7
Lohrs, U.8
-
102
-
-
77949884456
-
Targeted HER2 treatment in advanced gastric cancer
-
Jørgensen, J. T. Targeted HER2 treatment in advanced gastric cancer. Oncology 78, 26-33 (2010)
-
(2010)
Oncology
, vol.78
, pp. 26-33
-
-
Jørgensen, J.T.1
-
103
-
-
70450209516
-
Pathological features of advanced gastric cancer (GC): Relationship to human epidermal growth factor receptor 2 (HER2) positivity in the global screening programme of the ToGA trial [abstract]
-
Bang, Y., et al. Pathological features of advanced gastric cancer (GC): relationship to human epidermal growth factor receptor 2 (HER2) positivity in the global screening programme of the ToGA trial [abstract]. J. Clin. Oncol. 27 (Suppl. 15), a4556 (2009)
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.SUPPL. 15
-
-
Bang, Y.1
-
104
-
-
79251532001
-
Determining the HER2 status in gastric cancer: A method comparison study of two patient cohorts [abstract]
-
Powell, W. C., et al. Determining the HER2 status in gastric cancer: a method comparison study of two patient cohorts [abstract]. Proceedings 2010 ASCO Gastrointestinal Cancers Symposium a17 (2010)
-
(2010)
Proceedings 2010 ASCO Gastrointestinal Cancers Symposium
, vol.17
-
-
Powell, W.C.1
-
105
-
-
79952079704
-
HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH)
-
Boers, J. E., Meeuwissen, H. & Methorst, N. HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH). Histopathology 58, 383-394 (2011)
-
(2011)
Histopathology
, vol.58
, pp. 383-394
-
-
Boers, J.E.1
Meeuwissen, H.2
Methorst, N.3
-
106
-
-
84874117551
-
Human epidermal growth factor receptor 2 (HER2) in gastric cancer (GC): Results of the ToGA trial screening programme and recommendations for HER2 testing [abstract]
-
Chung, H., et al. Human epidermal growth factor receptor 2 (HER2) in gastric cancer (GC): results of the ToGA trial screening programme and recommendations for HER2 testing [abstract]. Eur. J. Cancer 364 (Suppl. 7), a6511 (2009)
-
(2009)
Eur. J. Cancer
, vol.364
, Issue.SUPPL. 7
-
-
Chung, H.1
-
107
-
-
77954217471
-
Trastuzumab in gastric cancer
-
Okines, A. F. C. & Cunningham, D. Trastuzumab in gastric cancer. Eur. J. Cancer 46, 1949-1959 (2010)
-
(2010)
Eur. J. Cancer
, vol.46
, pp. 1949-1959
-
-
Okines, A.F.C.1
Cunningham, D.2
-
108
-
-
77956895978
-
HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing
-
Rüschoff, J. R., et al. HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing. Virchows Arch. 457, 299-307 (2010)
-
(2010)
Virchows Arch
, vol.457
, pp. 299-307
-
-
Rüschoff, J.R.1
-
109
-
-
79551510050
-
The need to examine metastatic tissue at the time of progression of breast cancer: Is re-biopsy a necessity or a luxury?
-
Khasraw, M., Brogi, E. & Seidman, A. D. The need to examine metastatic tissue at the time of progression of breast cancer: is re-biopsy a necessity or a luxury? Curr. Oncol. Rep. 13, 17-25 (2011)
-
(2011)
Curr. Oncol. Rep
, vol.13
, pp. 17-25
-
-
Khasraw, M.1
Brogi, E.2
Seidman, A.D.3
-
110
-
-
79251477797
-
HER2 status in primary and paired distant metastatic sites of gastric carcinoma [abstract]
-
Negri, F. V., et al. HER2 status in primary and paired distant metastatic sites of gastric carcinoma [abstract]. Ann. Oncol. 21 (Suppl. 8), a823P (2010)
-
(2010)
Ann. Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Negri, F.V.1
-
111
-
-
80051550763
-
Identification of a subpopulation of metastatic breast cancer patients with very high HER2 expression levels and possible resistance to trastuzumab
-
doi:10.1093/annonc/mdq706
-
Bates, M., et al. Identification of a subpopulation of metastatic breast cancer patients with very high HER2 expression levels and possible resistance to trastuzumab. Ann. Oncol. doi:10.1093/annonc/mdq706
-
Ann. Oncol
-
-
Bates, M.1
-
112
-
-
76449104021
-
Molecular predictors of response to trastuzumab and lapatinib in breast cancer
-
Esteva, F. J., Yu, D., Hung, M. C. & Hortobagyi, G. N. Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat. Rev. Clin. Oncol. 7, 98-107 (2010)
-
(2010)
Nat. Rev. Clin. Oncol
, vol.7
, pp. 98-107
-
-
Esteva, F.J.1
Yu, D.2
Hung, M.C.3
Hortobagyi, G.N.4
-
114
-
-
67649814136
-
PI3K/PTEN signaling in angiogenesis and tumorigenesis
-
Jiang, B. H. & Liu, L. Z. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv. Cancer Res. 102, 19-65 (2009)
-
(2009)
Adv. Cancer Res
, vol.102
, pp. 19-65
-
-
Jiang, B.H.1
Liu, L.Z.2
-
115
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
DOI 10.1016/j.ccr.2004.06.022, PII S1535610804002107
-
Nagata, Y., et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell. 6, 117-127 (2004) (Pubitemid 39485684)
-
(2004)
Cancer Cell
, vol.6
, Issue.2
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.-H.2
Zhou, X.3
Tan, M.4
Esteva, F.J.5
Sahin, A.A.6
Klos, K.S.7
Li, P.8
Monia, B.P.9
Nguyen, N.T.10
Hortobagyi, G.N.11
Hung, M.-C.12
Yu, D.13
-
116
-
-
35148885729
-
A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer
-
DOI 10.1016/j.ccr.2007.08.030, PII S1535610807002620
-
Berns, K., et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. 12, 395-402 (2007) (Pubitemid 47539306)
-
(2007)
Cancer Cell
, vol.12
, Issue.4
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
Van De Vijver, M.J.13
Bernards, R.14
-
117
-
-
20144387695
-
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
-
DOI 10.1158/0008-5472-CAN-04-3913
-
Saal, L. H., et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res. 65, 2554-2559 (2005) (Pubitemid 40490050)
-
(2005)
Cancer Research
, vol.65
, Issue.7
, pp. 2554-2559
-
-
Saal, L.H.1
Holm, K.2
Maurer, M.3
Memeo, L.4
Su, T.5
Wang, X.6
Yu, J.S.7
Malmstrom, P.-O.8
Mansukhani, M.9
Enoksson, J.10
Hibshoosh, H.11
Borg, A.12
Parsons, R.13
-
118
-
-
56449111358
-
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NvP-BEZ235
-
Eichhorn, P. J., et al. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/ phosphatidylinositol 3-kinase inhibitor NvP-BEZ235. Cancer Res. 68, 9221-9230 (2008)
-
(2008)
Cancer Res
, vol.68
, pp. 9221-9230
-
-
Eichhorn, P.J.1
-
119
-
-
41949119777
-
Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy
-
Johnston, S., et al. Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy. J. Clin. Oncol. 26, 1066-1072 (2008)
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 1066-1072
-
-
Johnston, S.1
-
120
-
-
33847013396
-
Lapatinib antitumor activity is not dependent upon phosphatase and tensin homolog deleted on chromosome 10 in ErbB2-overexpressing breast cancers
-
Xia, W., et al. Lapatinib antitumor activity is not dependent upon phosphatase and tensin homolog deleted on chromosome 10 in ErbB2-overexpressing breast cancers. Cancer Res. 67, 1170-1175 (2007)
-
(2007)
Cancer Res
, vol.67
, pp. 1170-1175
-
-
Xia, W.1
-
121
-
-
14644392200
-
Epidermal growth factor receptor coexpression modulates susceptibility to Herceptin in HER2/neu overexpressing breast cancer cells via specific erbB-receptor interaction and activation
-
DOI 10.1016/j.yexcr.2004.12.008
-
Diermeier, S., et al. Epidermal growth factor receptor coexpression modulates susceptibility to Herceptin in HER2/neu overexpressing breast cancer cells via specific erbB-receptor interaction and activation. Exp. Cell Res. 304, 604-619 (2005) (Pubitemid 40321136)
-
(2005)
Experimental Cell Research
, vol.304
, Issue.2
, pp. 604-619
-
-
Diermeier, S.1
Horvath, G.2
Knuechel-Clarke, R.3
Hofstaedter, F.4
Szollosi, J.5
Brockhoff, G.6
-
122
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to transtuzumab (Herceptin)
-
Lu, Y., Zi, X., Zhao, Y., Mascarenhas, D. & Pollak, M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (herceptin). J. Natl Cancer Inst. 93, 1852-1857 (2001) (Pubitemid 34048651)
-
(2001)
Journal of the National Cancer Institute
, vol.93
, Issue.24
, pp. 1852-1857
-
-
Lu, Y.1
Zi, X.2
Zhao, Y.3
Mascarenhas, D.4
Pollak, M.5
-
123
-
-
33947246109
-
Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer
-
DOI 10.1158/1078-0432.CCR-06-1304
-
Harris, L. N., et al. Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin. Cancer Res. 13, 1198-1207 (2007) (Pubitemid 46424061)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.4
, pp. 1198-1207
-
-
Harris, L.N.1
You, F.2
Schnitt, S.J.3
Witkiewicz, A.4
Lu, X.5
Sgroi, D.6
Ryan, P.D.7
Come, S.E.8
Burstein, H.J.9
Lesnikoski, B.-A.10
Kamma, M.11
Friedman, P.N.12
Gelman, R.13
Iglehart, J.D.14
Winer, E.P.15
-
124
-
-
33644600485
-
Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
-
Adams, C. W., et al. Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab. Cancer Immunol. Immunother. 55, 717-727 (2006)
-
(2006)
Cancer Immunol. Immunother
, vol.55
, pp. 717-727
-
-
Adams, C.W.1
-
125
-
-
1942474587
-
The HER-2-Targeting Antibodies Trastuzumab and Pertuzumab Synergistically Inhibit the Survival of Breast Cancer Cells
-
DOI 10.1158/0008-5472.CAN-03-3856
-
Nahta, R., Hung, M. C. & Esteva, F. J. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 64, 2343-2346 (2004) (Pubitemid 38523885)
-
(2004)
Cancer Research
, vol.64
, Issue.7
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.-C.2
Esteva, F.J.3
-
126
-
-
73649149433
-
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
-
Scheuer, W., et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 69, 9330-9336 (2009)
-
(2009)
Cancer Res
, vol.69
, pp. 9330-9336
-
-
Scheuer, W.1
-
127
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
Baselga, J., et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J. Clin. Oncol. 28, 1138-1144 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 1138-1144
-
-
Baselga, J.1
-
128
-
-
77949901499
-
Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of Pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Gianni, L., et al. Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of Pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer. J. Clin. Oncol. 28, 1131-1137 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 1131-1137
-
-
Gianni, L.1
-
129
-
-
77950497981
-
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer
-
Burstein, H. J., et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. J. Clin. Oncol. 28, 1301-1307 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 1301-1307
-
-
Burstein, H.J.1
-
130
-
-
67349230135
-
Gene expression levels of HER2 and IL-8 and polymorphism in IL-8 associated with clinical outcome in advanced or metastatic gastric cancer treated with lapatinib in SWOG 0413 trial [abstract]
-
Chang, H., et al. Gene expression levels of HER2 and IL-8 and polymorphism in IL-8 associated with clinical outcome in advanced or metastatic gastric cancer treated with lapatinib in SWOG 0413 trial [abstract]. J. Clin. Oncol. 25 (Suppl. 18), a4647 (2007)
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.SUPPL. 18
-
-
Chang, H.1
-
131
-
-
79960102841
-
Everolimus in patients with previously treated metastatic gastric cancer: Final results of a multicenter phase II study [abstract]
-
Takiuchi, H., et al. Everolimus in patients with previously treated metastatic gastric cancer: Final results of a multicenter phase II study [abstract]. Proceedings 2010 ASCO Gastrointestinal Cancers Symposium a52 (2010)
-
(2010)
Proceedings 2010 ASCO Gastrointestinal Cancers Symposium
, vol.52
-
-
Takiuchi, H.1
-
132
-
-
79960078638
-
Phase II study of everolimus in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum [abstract]
-
Yoon, D., et al. Phase II study of everolimus in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum [abstract]. Proceedings 2011 ASCO Gastrointestinal Cancers Symposium a93 (2011)
-
(2011)
Proceedings 2011 ASCO Gastrointestinal Cancers Symposium
, vol.93
-
-
Yoon, D.1
-
134
-
-
77958495206
-
AVAGAST: A randomized double-blind placebo-controlled phase III study of first-line capecitabine and cisplatin plus bevacizumab or placebo in patients with advanced gastric cancer (AGC) [abstract]
-
Kang, Y., et al. AVAGAST: a randomized, double-blind, placebo-controlled, phase III study of first-line capecitabine and cisplatin plus bevacizumab or placebo in patients with advanced gastric cancer (AGC) [abstract]. J. Clin. Oncol. 28 (Suppl. 18), aLBA4007 (2010)
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.SUPPL. 18
-
-
Kang, Y.1
|