Structures of benzylsuccinate synthase elucidate roles of accessory subunits in glycyl radical enzyme activation and activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 28, 2014, Pages 10161-10166

  Funk, Michael A ^a   Judd, Evan T ^b   Marsh, E Neil G ^c   Elliott, Sean J ^b   Drennan, Catherine L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Boston University   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Bioremediation; Crystallography; Iron sulfur cluster; Microbial metabolism; Radical chemistry

Indexed keywords

BENZYLSUCCINATE SYNTHASE; ENZYME; GLYCYL RADICAL ENZYME; IRON SULFUR PROTEIN; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBUNIT; HYDROPHILICITY; HYDROPHOBICITY; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEQUENCE HOMOLOGY; THAUERA AROMATICA;

BIOREMEDIATION; CRYSTALLOGRAPHY; IRON-SULFUR CLUSTER; MICROBIAL METABOLISM; RADICAL CHEMISTRY;

BACTERIAL PROTEINS; CARBON-CARBON LYASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; FREE RADICALS; GLYCINE; IRON-SULFUR PROTEINS; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; THAUERA;

EID: 84904315879     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1405983111     Document Type: Article

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