Structural basis for a Kolbe-type decarboxylation catalyzed by a glycyl radical enzyme

Journal of the American Chemical Society

Volumn 133, Issue 37, 2011, Pages 14666-14674

  Martins, Berta M ^a   Blaser, Martin ^b,c   Feliks, Mikolaj ^d   Ullmann, G Matthias ^d   Buckel, Wolfgang ^b,c   Selmer, Thorsten ^b,e  

^a HUMBOLDT UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c MAX PLANCK INSTITUTE FOR TERRESTRIAL MICROBIOLOGY   (Germany)

^d UNIVERSITY OF BAYREUTH   (Germany)

^e AACHEN UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4-METHYLPHENOL; ACTIVE SITE; ACTIVE SITE POCKET; C-TERMINAL DOMAINS; CARBOXYL GROUPS; CLOSTRIDIUM DIFFICILE; CYSTEINE RESIDUES; DECARBOXYLASES; DIRECT INTERACTIONS; HETERODIMERS; HUMAN PATHOGENS; HYDROXYL GROUPS; IRON-SULFUR PROTEINS; N-TERMINAL DOMAINS; N-TERMINALS; P-CRESOL; RADICAL ENZYMES; STRUCTURAL BASIS; SUBSTRATE-BOUND; SUBSTRATE-FREE; TETRAMERS; TWO DOMAINS; VIRULENCE FACTORS;

AMINO ACIDS; CARBOXYLATION; CLOSTRIDIUM; ENZYMES; OLIGOMERS; SCAFFOLDS (BIOLOGY); SULFUR;

SUBSTRATES;

4 HYDROXYPHENYLACETATE DECARBOXYLASE; BACTERIAL ENZYME; CARBOXYL GROUP; CYSTEINE; GLUTAMIC ACID; HISTIDINE; HYDROXYL GROUP; IRON SULFUR PROTEIN; PARA CRESOL; TETRAMER; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; ASYMMETRIC CATALYSIS; BINDING KINETICS; CARBOXY TERMINAL SEQUENCE; CLOSTRIDIUM; CLOSTRIDIUM SCATOLOGENES; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; PROTEIN DOMAIN; PROTEIN INTERACTION; STRUCTURE ANALYSIS;

CARBOXY-LYASES; CLOSTRIDIUM; CRESOLS; CRYSTALLOGRAPHY, X-RAY; DECARBOXYLATION; IRON-SULFUR PROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; SUBSTRATE SPECIFICITY;

EID: 80052784900     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja203344x     Document Type: Article

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