A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation

GLIA

Volumn 62, Issue 9, 2014, Pages 1407-1417

  Yasui, Masaya ^a,b   Yoshimura, Takashi ^a   Takeuchi, So ^a   Tokizane, Kyohei ^a   Tsuda, Makoto ^b,c   Inoue, Kazuhide ^b,c   Kiyama, Hiroshi ^a,b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Chronic fatigue syndrome; Chronic stress; Fibromyalgia; Microglia; Pain

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; MINOCYCLINE;

ANIMAL; CHRONIC FATIGUE SYNDROME; DISEASE MODEL; DRUG EFFECTS; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MALE; MENTAL STRESS; MICROGLIA; PAIN MEASUREMENT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; SPINAL CORD DORSAL HORN; SPRAGUE DAWLEY RAT; TOUCH;

ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; DISEASE MODELS, ANIMAL; FATIGUE SYNDROME, CHRONIC; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MINOCYCLINE; MUSCLE, SKELETAL; NEUROIMMUNOMODULATION; PAIN MEASUREMENT; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD DORSAL HORN; STRESS, PSYCHOLOGICAL; TOUCH;

EID: 84904298065     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22687     Document Type: Article

References (34)

1. Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UA, Marquez G, Blackwell TS, Ohira Y, Hirano T, Murakami M. 2012. Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell 148:447-457.
2. Clauw DJ. 2009. Fibromyalgia: An overview. Am J Med 122:S3-S13.
3. Clauw DJ. 2010. Perspectives on fatigue from the study of chronic fatigue syndrome and related conditions. PM R 2:414-430.
4. Clauw DJ, Chrousos GP. 1997. Chronic pain and fatigue syndromes: Overlapping clinical and neuroendocrine features and potential pathogenic mechanisms. Neuroimmunomodulation 4:134-153.
5. Couch Y, Anthony DC, Dolgov O, Revischin A, Festoff B, Santos AI, Steinbusch HW, Strekalova T. 2013. Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia. Brain Behav Immun 29:136-146.
6. Ellis A, Bennett DL. 2013. Neuroinflammation and the generation of neuropathic pain. Br J Anaesth 111:26-37.
7. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. 1994. The chronic fatigue syndrome: A comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 121:953-959.
8. Gerecke KM, Kolobova A, Allen S, Fawer JL. 2013. Exercise protects against chronic restraint stress-induced oxidative stress in the cortex and hippocampus. Brain Res 1509:66-78.
9. Hinwood M, Morandini J, Day TA, Walker FR. 2012. Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex. Cereb Cortex 22:1442-1454.
10. Hinwood M, Tynan RJ, Charnley JL, Beynon SB, Day TA, Walker FR. 2013. Chronic stress induced remodeling of the prefrontal cortex: Structural re-organization of microglia and the inhibitory effect of minocycline. Cereb Cortex 23:1784-1797.
11. Inoue K, Tsuda M. 2009. Microglia and neuropathic pain. Glia 57:1469-1479.
12. Ji RR, Berta T, Nedergaard M. 2013. Glia and pain: Is chronic pain a gliopathy? Pain 154:S10-S28.
13. Kiryu-Seo S, Sasaki M, Yokohama H, Nakagomi S, Hirayama T, Aoki S, Wada K, Kiyama H. 2000. Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers. Proc Natl Acad Sci USA 97:4345-4350.
14. Koizumi S, Ohsawa K, Inoue K, Kohsaka S. 2013. Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors. Glia 61:47-54.
15. Konishi H, Ogawa T, Kawahara S, Matsumoto S, Kiyama H. 2011. Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland. Biochem Biophys Res Commun 407:7-12.
16. Konishi H, Ogawa T, Nakagomi S, Inoue K, Tohyama M, Kiyama H. 2010. Id1, Id2 and Id3 are induced in rat melanotrophs of the pituitary gland by dopamine suppression under continuous stress. Neuroscience 169:1527-1534.
17. Maeda M, Tsuda M, Tozaki-Saitoh H, Inoue K, Kiyama H. 2010. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia 58:1838-1846.
18. Molander C, Grant G. 1985. Cutaneous projections from the rat hindlimb foot to the substantia gelatinosa of the spinal cord studied by transganglionic transport of WGA-HRP conjugate. J Comp Neurol 237:476-484.
19. Molander C, Grant G. 1986. Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat. Neuroscience 19:297-312.
20. National Research Council, Guide for the Care and Use of Laboratory Animals, Washington DC: The National Academic Press, 1996.
21. Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, Kiyama H. 2010. Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular junctions. J Neurosci 30:6954-6962.
22. Nasu T, Taguchi T, Mizumura K. 2010. Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats. Eur J Pain 14:236-244.
23. Ogawa T, Kiryu-Seo S, Tanaka M, Konishi H, Iwata N, Saido T, Watanabe Y, Kiyama H. 2005. Altered expression of neprilysin family members in the pituitary gland of sleep-disturbed rats, an animal model of severe fatigue. J Neurochem 95:1156-1166.
24. Ogawa T, Sei H, Konishi H, Shishioh-Ikejima N, Kiyama H. 2012. The absence of somatotroph proliferation during continuous stress is a result of the lack of extracellular signal-regulated kinase 1/2 activation. J Neuroendocrinol 24:1335-1345.
25. Ogawa T, Shishioh-Ikejima N, Konishi H, Makino T, Sei H, Kiryu-Seo S, Tanaka M, Watanabe Y, Kiyama H. 2009. Chronic stress elicits prolonged activation of alpha-MSH secretion and subsequent degeneration of melanotroph. J Neurochem 109:1389-1399.
26. Shishioh-Ikejima N, Ogawa T, Yamaguti K, Watanabe Y, Kuratsune H, Kiyama H. 2010. The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients. BMC Neurol 10:73.
27. Takahashi K, Taguchi T, Itoh K, Okada K, Kawakita K, Mizumura K. 2005. Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes. Somatosens Mot Res 22:299-305.
28. Tanaka M, Nakamura F, Mizokawa S, Matsumura A, Nozaki S, Watanabe Y. 2003. Establishment and assessment of a rat model of fatigue. Neurosci Lett 352:159-162.
29. Tokizane K, Konishi H, Yasui M, Ogawa T, Sasaki K, Minamino N, Kiyama H. 2013. Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine. Mol Cell Endocrinol 372:49-56.
30. Tsuda M, Beggs S, Salter MW, Inoue K. 2013. Microglia and intractable chronic pain. Glia 61:55-61.
31. Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K. 2003. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424:778-783.
32. Tynan RJ, Naicker S, Hinwood M, Nalivaiko E, Buller KM, Pow DV, Day TA, Walker FR. 2010. Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions. Brain Behav Immun 24:1058-1068.
33. Yasui M, Shiraishi Y, Ozaki N, Hayashi K, Hori K, Ichiyanagi M, Sugiura Y. 2012. Nerve growth factor and associated nerve sprouting contribute to local mechanical hyperalgesia in a rat model of bone injury. Eur J Pain 16:953-965.
34. Zimmermann M. 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109-110.