Pharmaceuticals in the Surface Water of the USA: A Review

Current environmental health reports

Volumn 1, Issue 2, 2014, Pages 113-122

  Deo, Randhir P ^a  

^a GRAND CANYON UNIVERSITY   (United States)

Author keywords

Antibiotics; Antidepressants; Biosolids; Contraceptives; Disinfectants; Effluents; Fate; Management; Pharmaceuticals; Review; Risk assessment; Surface water; Sustainable

Indexed keywords

EID: 84904285646     PISSN: None     EISSN: 21965412     Source Type: Journal    
DOI: 10.1007/s40572-014-0015-y     Document Type: Review

References (95)

1. Ruhoy IS, Daughton CG. Beyond the medicine cabinet: an analysis of where and why medications accumulate. Environ Int. 2008;34:1157–69.
2. Karnjanapiboonwong A, Suski JG, Shah AA, Cai QS, Morse AN, Anderson TA. Occurrence of PPCPs at a wastewater treatment plant and in soil and groundwater at a land application site. Water Air Soil Pollut. 2011;216:257–73.
3. Snyder S. Occurrence of pharmaceuticals in U.S. drinking water. In: Halden R, editor. Contaminants of emerging concern in the environment: ecological and human health considerations. Washington, D.C.: American Chemical Society; 2010. p. 69–80.
4. Sengupta A, Lyons JM, Smith DJ, Drewes JE, Snyder SA, Heil A, et al. The occurrence and fate of chemicals of emerging concern in coastal urban rivers receiving discharge of treated municipal wastewater effluent. Environ Toxicol Chem. 2014;33:350–8.
5. Daughton C. Pharmaceutical ingredients in drinking water: overview of occurrence and significance of human health considerations. In: Rolf UH, editor. Contaminants of emerging concern in the environment: ecological and human health considerations. Washington, D.C.: American Chemical Society; 2010. p. 9–68.
6. Kaplan S. Review: pharmacological pollution in water. Crit Rev Environ Sci Technol. 2013;43:1074–116. This study highlights research developments on pharmacological pollution in water, including pollution characterization, analytical methods, removal via wastewater treatment plants, and potential environmental impacts.
7. Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, et al. Pharmaceuticals and personal care products in the environment: what are the big questions? Environ Health Perspect. 2012;120:1221–9.
8. Gelsleichter J, Szabo NJ. Uptake of human pharmaceuticals in bull sharks (Carcharhinus leucas) inhabiting a wastewater-impacted river. Sci Total Environ. 2013;456:196–201.
9. Brodin T, Fick J, Jonsson M, Klaminder J. Dilute concentrations of a psychiatric drug alter behavior of fish from natural populations. Science. 2013;339:814–5.
10. Fair PA, Lee HB, Adams J, Darling C, Pacepavicius G, Alaee M, et al. Occurrence of triclosan in plasma of wild Atlantic bottlenose dolphins (Tursiops truncatus) and in their environment. Environ Pollut. 2009;157:2248–54.
11. Owen SF, Huggett DB, Hutchinson TH, Hetheridge MJ, Kinter LB, Ericson JF, et al. Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry. Aquat Toxicol. 2009;93:217–24.
12. Christenson T. Fish on morphine: protecting Wisconsin's natural resources through a comprehensive plan for proper disposal of pharmaceuticals. Wis Law Rev. 2008;1:141–79.
13. Brozinski J-M, Lahti M, Meierjohann A, Oikari A, Kronberg L. The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant. Environ Sci Technol. 2013;47:342–8.
14. Cunningham VL, Constable DJC, Hannah RE. Environmental risk assessment of paroxetine. Environ Sci Technol. 2004;38:3351–9.
15. Cunningham VL, Binks SP, Olson MJ. Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment. Regul Toxicol Pharmacol. 2009;53:39–45.
16. Fent K, Weston AA, Caminada D. Ecotoxicology of human pharmaceuticals. Aquat Toxicol. 2006;76:122–59.
17. Nietch CT, Quinlan EL, Lazorchak JM, Impellitteri CA, Raikow D, Walters D. Effects of a chronic lower range of triclosan exposure on a stream mesocosm community. Environ Toxicol Chem. 2013;32:2874–87.
18. Cleuvers M. Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid. Ecotoxicol Environ Saf. 2004;59:309–15.
19. Cleuvers M. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett. 2003;142:185–94.
20. Kostich MS, Batt AL, Lazorchak JM. Concentrations of prioritized pharmaceuticals in effluents from 50 large wastewater treatment plants in the USA and implications for risk estimation. Environ Pollut. 2014;184:354–9.
21. Komori K, Suzuki Y, Minamiyama M, Harada A. Occurrence of selected pharmaceuticals in river water in Japan and assessment of their environmental risk. Environ Monit Assess. 2013;185:4529–36.
22. Ortiz de Garcia S, Pinto Pinto G, Garcia-Encina PA, Irusta Mata R. Ranking of concern, based on environmental indexes, for pharmaceutical and personal care products: an application to the Spanish case. J Environ Manag. 2013;129:384–97.
23. Ferrari B, Mons R, Vollat B, Fraysse B, Paxeus N, Lo Giudice R, et al. Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment? Environ Toxicol Chem. 2004;23:1344–54.
24. Carlsson C, Johansson AK, Alvan G, Bergman K, Kuhler T. Are pharmaceuticals potent environmental pollutants? Part I: environmental risk assessments of selected active pharmaceutical ingredients. Sci Total Environ. 2006;364:67–87.
25. Oliveira R, McDonough S, Ladewig JCL, Soares AMVM, Nogueira AJA, Domingues I. Effects of oxytetracycline and amoxicillin on development and biomarkers activities of zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2013;36:903–12.
26. Orias F, Perrodin Y. Characterisation of the ecotoxicity of hospital effluents: a review. Sci Total Environ. 2013;454:250–76.
27. Carlsson C, Johansson AK, Alvan G, Bergman K, Kuhler T. Are pharmaceuticals potent environmental pollutants? Part II: environmental risk assessments of selected pharmaceutical excipients. Sci Total Environ. 2006;364:88–95.
28. Carlsson G, Orn S, Larsson DGJ. Effluent from bulk drug production is toxic to aquatic vertebrates. Environ Toxicol Chem. 2009;28:2656–62.
29. Verlicchi P, Al Aukidy M, Galletti A, Petrovic M, Barcelo D. Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. Sci Total Environ. 2012;430:109–18. This study compared the chemical and ecotoxicological characteristics of hospital wastewater, for 73 pharmaceuticals compounds from 12 different therapeutic classes, with those in other influent wastewater entering wastewater treatment plant. The study found that pharmaceutical compounds found in hospital wastewater were consistently higher than those found in other influent wastewater, suggesting that hospital wastewater requires more specific treatment options.
30. Hernando MD, Mezcua M, Fernandez-Alba AR, Barcelo D. Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta. 2006;69:334–42.
31. Kumar A, Xagoraraki I. Human health risk assessment of pharmaceuticals in water: An uncertainty analysis for meprobamate, carbamazepine, and phenytoin. Regul Toxicol Pharmacol. 2010;57:146–56.
32. Kumar A, Chang B, Xagoraraki I. Human health risk assessment of pharmaceuticals in water: issues and challenges ahead. Int J Environ Res Pub Health. 2010;7:3929–53.
33. Leung HW, Jin L, Wei S, Tsui MMP, Zhou B, Jiao L, et al. Pharmaceuticals in tap water: human health risk assessment and proposed monitoring framework in China. Environ Health Perspect. 2013;121:839–46.
34. Phillips PJ, Smith SG, Kolpin DW, Zaugg SD, Buxton HT, Furlong ET, et al. Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents. Environ Sci Technol. 2010;44:4910–6.
35. Daughton CG, Ternes TA. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect. 1999;107:907–38.
36. Daughton CG, Ruhoy IS. Environmental footprint of pharmaceuticals: the significance of factors beyond direct excretion to sewers. Environ Toxicol Chem. 2009;28:2495–521.
37. Nagarnaik PM, Batt AL, Boulanger B. Healthcare facility effluents as point sources of select pharmaceuticals to municipal wastewater. Water Environ Res. 2012;84:339–45.
38. Ternes TA, Joss A, Siegrist H. Scrutinizing pharmaceuticals and personal care products in wastewater treatment. Environ Sci Technol. 2004;38:392A–9A.
39. Ruhoy IS, Daughton CG. Types and quantities of leftover drugs entering the environment via disposal to sewage - revealed by coroner records. Sci Total Environ. 2007;388:137–48.
40. Glassmeyer ST, Hinchey EK, Boehme SE, Daughton CG, Ruhoy IS, Conerly O, et al. Disposal practices for unwanted residential medications in the USA. Environ Int. 2009;35:566–72.
41. Heidler J, Halden RU. Meta-analysis of mass balances examining chemical fate during wastewater treatment. Environ Sci Technol. 2008;42:6324–32.
42. Venkatesan AK, Halden RU. Wastewater treatment plants as chemical observatories to forecast ecological and human health risks of manmade chemicals. Sci Rep. 2014, 4.
43. McClellan K, Halden RU. Pharmaceuticals personal care products in archived US biosolids from the 2001 EPA national sewage sludge survey. Water Res. 2010;44:658–68.
44. Chen W, Xu J, Lu S, Jiao W, Wu L, Chang AC. Fates and transport of PPCPs in soil receiving reclaimed water irrigation. Chemosphere. 2013;93:2621–30.
45. Katz BG, Griffin DW, Davis JH. Groundwater quality impacts from the land application of treated municipal wastewater in a large karstic spring basin: Chemical and microbiological indicators. Sci Total Environ. 2009;407:2872–86.
46. Deo RP, Halden RU. Pharmaceuticals in the built and natural water environment of the USA. Water. 2013;5:1346–65.
47. Phillips P, Chalmers A. Wastewater effluent, combined sewer overflows, and other sources of organic compounds to Lake Champlain. J Am Water Resour Assoc. 2009;45:45–57.
48. Shala L, Foster GD. Surface water concentrations and loading budgets of pharmaceuticals and other domestic-use chemicals in an urban watershed (Washington, DC, USA). Arch Environ Contam Toxicol. 2010;58:551–61.
49. Halden RU, Paull DH. Co-occurrence of triclocarban and triclosan in US water resources. Environ Sci Technol. 2005;39:1420–6.
50. Fram MS, Belitz K. Occurrence and concentrations of pharmaceutical compounds in groundwater used for public drinking-water supply in California. Sci Total Environ. 2011;409:3409–17.
51. Levine H, Berman T, Goldsmith R, Goeen T, Spungen J, Novack L, et al. Exposure to tobacco smoke based on urinary cotinine levels among Israeli smoking and nonsmoking adults: a cross-sectional analysis of the first Israeli human biomonitoring study. BMC Public Health. 2013;13:1241.
52. USEPA PBT Profiler software. Available at http://www.pbtprofiler.net 2013.
53. Hernando MD, Gomez MJ, Aguera A, Fernandez-Alba AR. LC-MS analysis of basic pharmaceuticals (beta-blockers and anti-ulcer agents) in wastewater and surface water. Trac-Trends Anal Chem. 2007;26:581–94.
54. Yu Y, Wu L, Chang AC. Seasonal variation of endocrine disrupting compounds, pharmaceuticals and personal care products in wastewater treatment plants. Sci Total Environ. 2013;442:310–6.
55. Blair BD, Crago JP, Hedman CJ, Klaper RD. Pharmaceuticals and personal care products found in the Great Lakes above concentrations of environmental concern. Chemosphere. 2013;93:2116–23.
56. Wieczorkiewicz SM, Kassamali Z, Danziger LH. Behind closed doors: medication storage and disposal in the home. Ann Pharmacother. 2013;47:482–9. This study investigated the disposal of prescription and nonprescription medications, and found that 59% of consumers disposed medications in the household garbage, 31% flushed them down the toilet or sink, suggesting that most consumers are unaware of proper disposal of leftover medications.
57. Daughton CG, Ruhoy IS. The afterlife of drugs and the role of PharmEcovigilance. Drug Saf. 2008;31:1069–82.
58. Daughton CG. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy. Environ Health Perspect. 2003;111:757–74.
59. Escher BI, Baumgartner R, Koller M, Treyer K, Lienert J, McArdell CS. Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater. Water Res. 2011;45:75–92.
60. Aurelien BH, Sylvie B, Alain D, Jerome G, Yves P. Ecotoxicological risk assessment linked to the discharge by hospitals of bio-accumulative pharmaceuticals into aquatic media: the case of mitotane. Chemosphere. 2013;93:2365–72.
61. Kummerer J, Hempel M. Green and sustainable pharmacy. 1st ed. Berlin: Springer-Verlag; 2010.
62. Le-Minh N, Khan SJ, Drewes JE, Stuetz RM. Fate of antibiotics during municipal water recycling treatment processes. Water Res. 2010;44:4295–323.
63. Petrovic M, De Alda MJL, Diaz-Cruz S, Postigo C, Radjenovic J, Gros M, et al. Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration. Philos Trans R Soc A Math Phys Eng Sci. 2009;367:3979–4003.
64. Jones OAH, Voulvoulis N, Lester JN. Human pharmaceuticals in wastewater treatment processes. Crit Rev Environ Sci Technol. 2005;35:401–27.
65. Onesios KM, Yu JT, Bouwer EJ. Biodegradation and removal of pharmaceuticals and personal care products in treatment systems: a review. Biodegradation. 2009;20:441–66.
66. Chang PH, Li ZH, Yu TL, Munkhbayer S, Kuo TH, Hung YC, et al. Sorptive removal of tetracycline from water by palygorskite. J Hazard Mater. 2009;165:148–55.
67. Wilcox JD, Bahr JM, Hedman CJ, Hemming JDC, Barman MAE, Bradbury KR. Removal of organic wastewater contaminants in septic systems using advanced treatment technologies. J Environ Qual. 2009;38:149–56.
68. Werner JJ, McNeill K, Arnold WA. Photolysis of chlortetracycline on a clay surface. J Agric Food Chem. 2009;57:6932–7.
69. Santoke H, Song WH, Cooper WJ, Greaves J, Miller GE. Free-radical-induced oxidative and reductive degradation of fluoroquinolone pharmaceuticals: kinetic studies and degradation mechanism. J Phys Chem A. 2009;113:7846–51.
70. Hu L, Martin HM, Arcs-Bulted O, Sugihara MN, Keatlng KA, Strathmann TJ. Oxidation of carbamazepine by Mn(VII) and Fe(VI): reaction kinetics and mechanism. Environmental Science &. Technology. 2009;43:509–15.
71. Leech DM, Snyder MT, Wetzel RG. Natural organic matter and sunlight accelerate the degradation of 17 beta-estradiol in water. Sci Total Environ. 2009;407:2087–92.
72. Benotti MJ, Brownawell BJ. Microbial degradation of pharmaceuticals in estuarine and coastal seawater. Environ Pollut. 2009;157:994–1002.
73. Yu TH, Lin AYC, Lateef SK, Lin CF, Yang PY. Removal of antibiotics and non-steroidal anti-inflammatory drugs by extended sludge age biological process. Chemosphere. 2009;77:175–81.
74. Wu CX, Spongberg AL, Witter JD. Sorption and biodegradation of selected antibiotics in biosolids. J Environ Sci Health Part A Toxic/Hazard Subst Environ Eng. 2009;44:454–61.
75. Wu CX, Spongberg AL, Witter JD. Adsorption and degradation of triclosan and triclocarban in solis and biosolids-amended soils. J Agric Food Chem. 2009;57:4900–5.
76. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance. Environ Sci Technol. 2002;36:1202–11.
77. Vanderford BJ, Snyder SA. Analysis of pharmaceuticals in water by isotope dilution liquid chromatography/tandem mass spectrometry. Environ Sci Technol. 2006;40:7312–20.
78. Haggard BE, Bartsch LD. Net changes in antibiotic concentrations downstream from an effluent discharge. J Environ Qual. 2009;38:343–52.
79. Schultz MM, Furlong ET, Kolpin DW, Werner SL, Schoenfuss HL, Barber LB, et al. Antidepressant pharmaceuticals in two US effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue. Environ Sci Technol. 2010;44:1918–25.
80. Wu CX, Witter JD, Spongberg AL, Czajkowski KP. Occurrence of selected pharmaceuticals in an agricultural landscape, western Lake Erie basin. Water Res. 2009;43:3407–16.
81. Ferrer I, Thurman EM. Analysis of 100 pharmaceuticals and their degradates in water samples by liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr A. 2012;1259:148–57.
82. Young TA, Heidler J, Matos-Perez CR, Sapkota A, Toler T, Gibson KE, et al. Ab initio and in situ comparison of caffeine, triclosan, and triclocarban as indicators of sewage-derived microbes in surface waters. Environ Sci Technol. 2008;42:3335–40.
83. Boyd GR, Grimm DA. In: McLachlan JA, Guillette LJ, Iguchi T, Toscano WA, editors. Occurrence of pharmaceutical contaminants and screening of treatment alternatives for southeastern Louisiana. 2001. p. 80–9.
84. Monteiro SC, Boxall ABA. Occurrence and fate of human pharmaceuticals in the environment. In: Whitacre DM, editor. Reviews of environmental contamination and toxicology, vol. 202. Summerfield: Springer; 2010. p. 53–154.
85. Batt AL, Kostich MS, Lazorchak JM. Analysis of ecologically relevant pharmaceuticals in wastewater and surface water using selective solid-phase extraction and UPLC-MS/MS. Anal Chem. 2008;80:5021–30.
86. Bartelt-Hunt SL, Snow DD, Damon T, Shockley J, Hoagland K. The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska. Environ Pollut. 2009;157:786–91.
87. Schultz MM, Furlong ET. Trace analysis of antidepressant pharmaceuticals and their select degradates in aquatic matrixes by LC/ESI/MS/MS. Anal Chem. 2008;80:1756–62.
88. Gibs J, Heckathorn HA, Meyer MT, Klapinski FR, Alebus M, Lippincott RL. Occurrence and partitioning of antibiotic compounds found in the water column and bottom sediments from a stream receiving two wastewater treatment plant effluents in Northern New Jersey, 2008. Sci Total Environ. 2013;458:107–16.
89. Boyd GR, Reemtsma H, Grimm DA, Mitra S. Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada. Sci Total Environ. 2003;311:135–49.
90. Lindsey ME, Meyer M, Thurman EM. Analysis of trace levels of sulfonamide and tetracycline antimicrobials, in groundwater and surface water using solid-phase extraction and liquid chromatography/mass spectrometry. Anal Chem. 2001;73:4640–6.
91. Standley LJ, Rudel RA, Swartz CH, Attfield KR, Christian J, Erickson M, et al. Wastewater-contaminated groundwater as a source of endogenous hormones and pharmaceuticals to surface water ecosystems. Environ Toxicol Chem. 2008;27:2457–68.
92. Guo YC, Krasner SW. Occurrence of primidone, carbamazepine, caffeine, and precursors for n-nitrosodimethylamine in drinking water sources impacted by wastewater. J Am Water Resour Assoc. 2009;45:58–67.
93. Spongberg AL, Witter JD. Pharmaceutical compounds in the wastewater process stream in Northwest Ohio. Sci Total Environ. 2008;397:148–57.
94. Ferguson PJ, Bernot MJ, Doll JC, Lauer TE. Detection of pharmaceuticals and personal care products (PPCPs) in near-shore habitats of southern Lake Michigan. Sci Total Environ. 2013;458:187–96.
95. Halden RU, Paull DH. Analysis of triclocarban in aquatic samples by liquid chromatography electrospray ionization mass spectrometry. Environ Sci Technol. 2004;38:4849–55.