Healthcare facility effluents as point sources of select pharmaceuticals to municipal wastewater

Water Environment Research

Volumn 84, Issue 4, 2012, Pages 339-345

  Nagarnaik, Pranav M ^a   Batt, Angela L ^b   Boulanger, Bryan ^a  

^a Department of Electrical and Computer Engineering   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Concentrations; Healthcare facilities; Mass loading; Pharmaceuticals; Wastewater effluents

Indexed keywords

ASSISTED LIVING; DRUG PRODUCTS; HOSPITALS; LOADING; NURSING; RISK ASSESSMENT;

ACTIVE PHARMACEUTICALS INGREDIENTS; CONCENTRATION; HEALTHCARE FACILITY; INDEPENDENT LIVING; MASS LOADINGS; MUNICIPAL WASTEWATERS; NURSING CARE; POINT-SOURCES; WASTE WATER SYSTEMS; WASTEWATER EFFLUENTS;

EFFLUENTS;

CIMETIDINE; CORTICOSTEROID; FLUTICASONE; GLIBENCLAMIDE; GLIPIZIDE; HYDROCODONE; IBUPROFEN; METHYLPREDNISOLONE; PREDNISOLONE; PREDNISONE; RANITIDINE; SALBUTAMOL; SULFAMETHOXAZOLE; TRIMETHOPRIM; WARFARIN;

ANTIBIOTICS; CONCENTRATION (COMPOSITION); DISCHARGE; EFFLUENT; HOSPITAL SECTOR; POLLUTION MONITORING; RISK ASSESSMENT; WASTEWATER;

ARTICLE; DRUG INDUSTRY; EFFLUENT; HEALTH CARE FACILITY; MUNICIPAL SOLID WASTE; PRIORITY JOURNAL; RISK ASSESSMENT; WASTE WATER;

TEXAS; UNITED STATES;

CHROMATOGRAPHY, LIQUID; ENVIRONMENTAL MONITORING; HEALTH FACILITIES; PHARMACEUTICAL PREPARATIONS; SEWAGE; TANDEM MASS SPECTROMETRY; TEXAS; WATER POLLUTANTS, CHEMICAL; WATER PURIFICATION;

EID: 84863336788     PISSN: 10614303     EISSN: 15547531     Source Type: Journal    
DOI: 10.1002/j.1554-7531.2012.tb00282.x     Document Type: Article

References (27)

1. Barnes, K. K.; Kolpin, D. W.; Furlong, E. T.; Zaugg, S. D.; Meyer, M. T.; Barber, L. B. (2008) A National Reconnaissance of Pharmaceuticals and Other Organic Wastewater Contaminants in the United States - I) Groundwater. Sci. Total Environ., 402 (2-3), 192-200.
2. Brown, K. D.; Kulis, J.; Thomson, B.; Chapman, T. H.; Mawhinney, D. B. (2006) Occurrence of Antibiotics in Hospital, Residential, and Dairy Effluent, Municipal Wastewater, and the Rio Grande in New Mexico. Sci. Total Environ., 366 (2-3), 772-783.
3. Chang, X.; Meyer, M. T.; Liu, X.; Zhao, Q.; Chen, H.; Chen, J.; Qiu, Z.; Yang, L.; Cao, J.; Shu, W. (2010) Determination of Antibiotics in Sewage from Hospitals, Nursery and Slaughter House, Wastewate Treatment Plant and Source Water in Chongqing Region of Three Gorge Reservoir in China. Environ. Pollut. (Oxford, U.K.), 158 (5), 1444-1450.
4. Focazio, M. J.; Kolpin, D. W.; Barnes, K. K.; Furlong, E. T.; Meyer, M. T.; Zaugg, S. D.; Barber, L. B.; Thurman, M. E. (2008) A National Reconnaissance for Pharmaceuticals and Other Organic Wastewater Contaminants in the United States - II) Untreated Drinking Water Sources. Sci. Total Environ., 402 (2-3), 201-216.
5. Gomez, M. J.; Aguera, A.; Mezcua, M.; Hurtado, J.; Mocholi, F.; Fernandez-Alba, A. R. (2007) Simultaneous Analysis of Neutral and Acidic Pharmaceuticals as Well as Related Compounds by Gas Chromatography-Tandem Mass Spectrometry in Wastewater. Talanta, 73 (2), 314-320.
6. Gomez, M. J.; Malato, O.; Ferrer, I.; Aguera, A.; Fernandez-Alba, A. R. (2007) Solid-Phase Extraction Followed by Liquid Chromatography-Time-of-Flight- Mass Spectrometry to Evaluate Pharmaceuticals in Effluents. A Pilot Monitoring Study. J. Environ. Monit., 9, 718-729.
7. Gomez, M. J.; Petrovic, M.; Fernandez-Alba, A. R.; Barcelo, D. (2006) Determination of Pharmaceuticals of Various Therapeutic Classes by Solid-Phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry Analysis in Hospital Effluent Wastewaters. J. Chromatogr., A, 1114 (2), 224-233.
8. Hai, A.; Kümmerer, K. (2006) Biodegradability of the X-Ray Contrast Compound Diatrizoic Acid, Identification of Aerobic Degradation Products and Effects against Sewage Sludge Micro-Organisms. Chemosphere, 62 (2), 294-302.
9. Heberer, T.; Feldmann, D. (2005) Contribution of Effluents from Hospitals and Private Households to the Total Loads of Diclofenac and Carbamazepine in Municipal Sewage Effluents - Modeling Versus Measurements. J. Hazard. Mater., 122 (3), 211-218.
10. IMS Health Incorporated. (2007) Channel Distribution by US Sales. http://www.imshealth.com/deployedfiles/ims/Global/Content/Corporate/ Press%20Room/Top-line%20Market%20Data/2009%20Top-line%20Market%20Data/ Channel%20Distribution%20by%20U.S.Sales.pdf (accessed April 2012).
11. Kolpin, D. W.; Furlong, E. T.; Meyer, M. T.; Thurman, E. M.; Zaugg, S. D.; Barber, L. B.; Buxton, H. T. (2002) Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999-2000: A National Reconnaissance. Environ. Sci. Technol., 36 (6), 1202-1211.
12. Kümmerer, K. (2003) Significance of Antibiotics in the Environment. J. Antimicrob. Chemother., 52 (1), 5-7.
13. Kümmerer, K.; Al-Ahmad, A. (1997) Biodegradability of the Antitumor Agents 5-Fluorouracil, Cytarabine, and Gemcitabine. Impact of the Chemical Structure and Synergistic Toxicity with Hospital Effluent. Acta Hydrochim. Hydrobiol., 25 (4), 166-172.
14. Kümmerer, K.; Erbe, T.; Gartiser, S.; Brinker, L. (1998) Aox - Emissions from Hospitals into Municipal Wastewater. Chemosphere, 36 (11), 2437-2445. (Pubitemid 28143841)
15. Kümmerer, K.; Henninger, A. (2003) Promoting Resistance by the Emission of Antibiotics from Hospitals and Households into Effluent. Clin. Microbiol. Infect., 9 (12), 1203-1214. (Pubitemid 38028870)
16. Langford, K. H.; Thomas, K. V. (2009) Determination of Pharmaceutical Compounds in Hospital Effluents and Their Contribution to Wastewater Treatment Works. Environ. Int., 35 (5), 766-770.
17. Lin, A. Y. C.; Yu, T. H.; Lin, C. F. (2008) Pharmaceutical Contamination in Residential, Industrial, and Agricultural Waste Streams: Risk to Aqueous Environments in Taiwan. Chemosphere, 74 (1), 131-141.
18. Lindberg, R.; Jarnheimer, P. A.; Olsen, B.; Johansson, M.; Tysklind, M. (2004) Determination of Antibiotic Substances in Hospital Sewage Water Using Solid Phase Extraction and Liquid Chromatography/Mass Spectrometry and Group Analogue Internal Standards. Chemosphere, 57 (10), 1479-1488.
19. North American Industry Classification System Association. (2007) 2007 NAICS Manual. North American Industry Classification System Association: Rockaway, New Jersey.
20. Pérez, S.; Barceló, D. (2007) Fate and Occurrence of X-Ray Contrast Media in the Environment. Anal. Bioanal. Chem., 387 (4), 1235-1246.
21. Ramirez, A. J.; Brain, R. A.; Usenko, S.; Mottaleb, M. A.; O'Donnell, J. G.; Stahl, L. L.; Wathen, J. B.; Snyder, B. D.; Pitt, J. L.; Perez-Hurtado, P.; Dobbins, L. L.; Brooks, B. W.; Chambliss, C. K. (2009) Occurrence of Pharmaceuticals and Personal Care Products in Fish: Results of a National Pilot Study in the United States. Environ. Toxicol. Chem., 28 (12), 2587-2597.
22. Samaras, V. G.; Thomaidis, N. S.; Stasinakis, A. S.; Gatidou, G.; Lekkas, T. D. (2010) Determination of Selected Non-Steroidal Anti-Inflammatory Drugs in Wastewater by Gas Chromatography-Mass Spectrometry. Int. J. Environ. Anal. Chem., 90 (3-6), 219-229.
23. Schriks, M.; van Leerdam, J. A.; van der Linden, S. C.; van der Burg, B.; van Wezel, A. P.; de Voogt, P. (2010) High-Resolution Mass Spectrometric Identification and Quantification of Glucocorticoid Compounds in Various Wastewaters in the Netherlands. Environ. Sci. Technol., 44 (12), 4766-4774.
24. Sim, W. J.; Lee, J. W.; Oh, J. E. (2010) Occurrence and Fate of Pharmaceuticals in Wastewater Treatment Plants and Rivers in Korea. Environ. Pollut., 158 (5), 1938-1947.
25. Thomas, K. V.; Dye, C.; Schlabach, M.; Langford, K. H. (2007) Source to Sink Tracking of Selected Human Pharmaceuticals from Two Oslo City Hospitals and a Wastewater Treatment Works. J. Environ. Monit., 9 (12), 1410-1418.
26. Watkinson, A. J.; Murby, E. J.; Kolpin, D. W.; Costanzo, S. D. (2009) The Occurrence of Antibiotics in an Urban Watershed: from Wastewater to Drinking Water. Sci. Total Environ., 407 (8), 2711-2723.
27. Zorita, S.; Martensson, L.; Mathiasson, L. (2009) Occurrence and Removal of Pharmaceuticals in a Municipal Sewage Treatment System in the South of Sweden. Sci. Total Environ., 407 (8), 2760-2770.