FYWHCLDE-based affinity chromatography of IgG: Effect of ligand density and purifications of human IgG and monoclonal antibody

Journal of Chromatography A

Volumn 1355, Issue , 2014, Pages 107-114

  Zhao, Wei Wei ^a   Shi, Qing Hong ^a,b   Sun, Yan ^a,b  

^a TIANJIN UNIVERSITY   (China)

^b Collaborative Innovation Center of Chemical Science and Engineering ^*  (China)

Author keywords

Affinity chromatography; Human immunoglobulin G; Ligand density; Monoclonal antibody; Peptide ligand; Purification

Indexed keywords

AFFINITY CHROMATOGRAPHY; BINDING ENERGY; BIOMIMETICS; BODY FLUIDS; CELL CULTURE; DISSOCIATION; MOLECULAR BIOLOGY; MONOCLONAL ANTIBODIES; PEPTIDES; PURIFICATION;

BOVINE SERUM ALBUMINS; CULTURE SUPERNATANT; DISSOCIATION CONSTANT; DYNAMIC BINDING CAPACITY; HUMAN IMMUNOGLOBULIN G; LIGAND DENSITY; MONOCLONAL ANTIBODIES (MAB); PEPTIDE LIGAND;

LIGANDS;

BOVINE SERUM ALBUMIN; IMMUNOGLOBULIN G; LIGAND; MONOCLONAL ANTIBODY; OCTAPEPTIDE; PHENYLALANYLTYROSYLTRYPTOPHYLHISTIDINYLCYSTEINYLLEUCYLGLUTAMIC ACID LIGAND; SEPHAROSE; UNCLASSIFIED DRUG; PEPTIDE;

ADSORPTION KINETICS; AFFINITY CHROMATOGRAPHY; ARTICLE; BINDING AFFINITY; CELL CULTURE; CHEMICAL BINDING; CONTROLLED STUDY; DENSITY; HUMAN; PRIORITY JOURNAL; PURIFICATION; SERUM; SUPERNATANT; ADSORPTION; ANIMAL; BOVINAE; CHEMISTRY; DEVICES; IMMUNOLOGY; ISOLATION AND PURIFICATION; PROCEDURES;

BOVINAE;

ADSORPTION; ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; CHROMATOGRAPHY, AFFINITY; HUMANS; IMMUNOGLOBULIN G; LIGANDS; PEPTIDES;

EID: 84904285081     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.05.083     Document Type: Article

References (40)

1. Guiochon G., Beaver L.A. Separation science is the key to successful biopharmaceuticals. J. Chromatogr. A 2011, 1218:8836-8858.
2. Naik A.D., Raina M., Lali A.M. AbSep-An amino acid based pseudobioaffinity adsorbent for the purification of immunoglobulin G. J. Chromatogr. A 2011, 1218:1756-1766.
3. Ishihara T., Nakajima N., Kadoya T. Evaluation of new affinity chromatography resins for polyclonal, oligoclonal and monoclonal antibody pharmaceuticals. J. Chromatogr. B 2010, 878:2141-2144.
4. ® A2P. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2005, 814:209-215.
5. Strohl W.R., Knight D.M. Discovery and development of biopharmaceuticals: current issues Editorial overview. Curr. Opin. Biotechnol. 2009, 20:668-672.
6. Gaso-Sokac D., Josic D. The role of proteomics in plasma fractionation and quality control of plasma-derived therapeutic proteins. Blood Tranfus. 2010, 8:S86-S91.
7. Tong H.F., Lin D.Q., Gao D., Yuan X.M., Yao S.J. Caprylate as the albumin-selective modifier to improve IgG purification with hydrophobic charge-induction chromatography. J. Chromatogr. A 2013, 1285:88-96.
8. Shukla A.A., Thommes J. Recent advances in large-scale production of monoclonal antibodies and related proteins. Trends Biotechnol. 2010, 28:253-261.
9. Vermasvuori R., Hurme M. Economic comparison of diagnostic antibody production in perfusion stirred tank and in hollow fiber bioreactor processes. Biotechnol. Prog. 2011, 27:1588-1598.
10. Low D., O'Leary R., Pujar N.S. Future of antibody purification. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2007, 848:48-63.
11. Hober S., Nord K., Linhult M. Protein A chromatography for antibody purification. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2007, 848:40-47.
12. Roque A.C.A., Silva C.S.O., Taipa M.A. Affinity-based methodologies and ligands for antibody purification: advances and perspectives. J. Chromatogr. A 2007, 1160:44-55.
13. Menegatti S., Hussain M., Naik A.D., Carbonell R.G., Rao B.M. mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands. Biotechnol. Bioeng. 2013, 110:857-870.
14. Haigh J.M., Hussain A., Mimmack M.L., Lowe C.R. Affinity ligands for immunoglobulins based on the multicomponent Ugi reaction. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009, 877:1440-1452.
15. Clonis Y.D. Affinity chromatography matures as bioinformatic and combinatorial tools develop. J. Chromatogr. A 2006, 1101:1-24.
16. Ghose S., Hubbard B., Cramer S.M. Evaluation and comparison of alternatives to Protein A chromatography - Mimetic and hydrophobic charge induction chromatographic stationary phases. J. Chromatogr. A 2006, 1122:144-152.
17. Yang H., Gurgel P.V., Carbonell R.G. Hexamer peptide affinity resins that bind the Fc region of human immunoglobulin G. J. Pept. Res. 2005, 66:120-137.
18. Yang H., Gurgel P.V., Carbonell R.G. Purification of human immunoglobulin G via Fc-specific small peptide ligand affinity chromatography. J. Chromatogr. A 2009, 1216:910-918.
19. Lund L.N., Gustavsson P.E., Michael R., Lindgren J., Norskov-Lauritsen L., Lund M., Houen G., Staby A., St Hilaire P.M. Novel peptide ligand with high binding capacity for antibody purification. J. Chromatogr. A 2012, 1225:158-167.
20. Zhao W.W., Liu F.F., Shi Q.H., Dong X.Y., Sun Y. Biomimetic design of affinity peptide ligands for human IgG based on protein A-IgG complex. Biochem. Eng. J. 2014, 88:1-11.
21. Wang R.Z., Lin D.Q., Tong H.F., Lu H.L., Yao S.J. Evaluation of mixed-mode chromatographic resins for separating IgG from serum albumin containing feedstock. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2013, 936:33-41.
22. Yu L.L., Tao S.P., Dong X.Y., Sun Y. Protein adsorption to poly(ethylenimine)-modified Sepharose FF: I. A critical ionic capacity for drastically enhanced capacity and uptake kinetics. J. Chromatogr. A 2013, 1305:76-84.
23. Carta G., Ubiera A.R., Pabst T.M. Protein mass transfer kinetics in ion exchange media: Measurements and interpretations. Chem. Eng. Technol. 2005, 28:1252-1264.
24. Boyer P.M., Hsu J.T. Experimental studies of restricted protein diffusion in an agarose matrix. AlChE J. 1992, 38:259-272.
25. Weaver L.E., Carta G. Protein adsorption on cation exchangers: comparison of macroporous and gel-composite media. Biotechnol. Prog. 1996, 12:342-355.
26. Özdural A.R., Alkan A., Kerkhof P.J. Modeling chromatographic columns: Non-equilibrium packed-bed adsorption with non-linear adsorption isotherms. J. Chromatogr. A 2004, 1041:77-85.
27. Engvall E., Perlmann P. Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G. Immunochemistry 1971, 8:871-874.
28. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
29. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., Klenk D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 1985, 150:76-85.
30. Thomas H., de Neuville B.C., Storti G., Morbidelli M., Joehnck M., Schulte M. Role of tentacles and protein loading on pore accessibility and mass transfer in cation exchange materials for proteins. J. Chromatogr. A 2013, 1285:48-56.
31. Chen W.D., Dong X.Y., Bai S., Sun Y. Dependence of pore diffusivity of protein on adsorption density in anion-exchange adsorbent. Biochem. Eng. J. 2003, 14:45-50.
32. Yang K., Sun Y. Structured parallel diffusion model for intraparticle mass transport of proteins to porous adsorbent. Biochem. Eng. J. 2007, 37:298-310.
33. Yu L.L., Sun Y. Protein adsorption to poly(ethylenimine)-modified Sepharose FF: II. Effect of ionic strength. J. Chromatogr. A 2013, 1305:85-93.
34. Wesselingh J., Bosma J. Protein ion-exchange adsorption kinetics. AlChE J. 2001, 47:1571-1580.
35. Ghose S., Hubbard B., Cramer S.M. Binding capacity differences for antibodies and Fc-fusion proteins on protein A chromatographic materials. Biotechnol. Bioeng. 2007, 96:768-779.
36. Hahn R., Shimahara K., Steindl F., Jungbauer A. Comparison of protein A affinity sorbents III. Life time study. J. Chromatogr. A 2006, 1102:224-231.
37. Naik A.D., Menegatti S., Gurgel P.V., Carbonell R.G. Performance of hexamer peptide ligands for affinity purification of immunoglobulin G from commercial cell culture media. J. Chromatogr. A 2011, 1218:1691-1700.
38. Kish W.S., Naik A.D., Menegatti S., Carbonell R.G. Peptide-based affinity adsorbents with high binding capacity for the purification of monoclonal antibodies. Ind. Eng. Chem. Res. 2013, 52:8800-8811.
39. Bakhshpour M., Bereli N., Şenel S. Preparation and characterization of thiophilic cryogels with 2-mercapto ethanol as the ligand for IgG purification. Colloids Surf. B: Biointerfaces 2014, 113:261-268.
40. Yang H.O., Gurgel P.V., Williams D.K., Bobay B.G., Cavanagh J., Muddiman D.C., Carbonell R.G. Binding site on human immunoglobulin G for the affinity ligand HWRGWV. J. Mol. Recognit. 2010, 23:271-282.