Peptide-based affinity adsorbents with high binding capacity for the purification of monoclonal antibodies

Industrial and Engineering Chemistry Research

Volumn 52, Issue 26, 2013, Pages 8800-8811

  Kish, William S ^a   Naik, Amith D ^b   Menegatti, Stefano ^a   Carbonell, Ruben G ^a,b  

^a North Carolina State University   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY PURIFICATION; BINDING CAPACITIES; CHROMATOGRAPHIC SUPPORTS; CLEANING IN PLACE; DYNAMIC BINDING CAPACITY; HEXAPEPTIDE LIGANDS; POLYMETHACRYLATES; REACTION CONDITIONS;

AMINO ACIDS; CELL CULTURE; COUPLING AGENTS; LIGANDS; MONOCLONAL ANTIBODIES; PURIFICATION; RESINS; REUSABILITY; SURFACE PLASMON RESONANCE;

PEPTIDES;

EID: 84879871408     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie302345w     Document Type: Article

References (37)

1. Brekke, O.; Sandlie, I. Therapeutic antibodies for human diseases at the dawn of the twenty-first century Nat. Rev. Drug Discovery 2003, 2, 52-62
2. Liossis, S.; Tsokos, G. Monoclonal antibodies and fusion proteins in medicine J. Allergy Clin. Immunol. 2005, 116, 721-729
3. Carter, P. Potent antibody therapeutics by design Nat. Rev. Immunol. 2006, 6, 343-357
4. Nelson, A. L.; Dhimolea, E.; Reichert, J. M. Development trends for human monoclonal antibody therapeutics Nat. Rev. Drug Discovery 2010, 9, 767-774
5. Waldmann, T. Immunotherapy: past, present and future Nat. Med. 2003, 9, 269-277
6. Chon, J. H.; Zarbis-Papastoitsis, G. Advances in the production and downstream processing of antibodies New Biotechnol. 2011, 28, 458-463
7. Samaranayake, H.; Wirth, T.; Schenkwein, D.; Raty, J. K.; Yla-Herttuala, S. Challenges in monoclonal antibody-based therapies Ann. Med. 2009, 41, 322-331
8. Wong, Y.; Meropol, N. J.; Speier, W.; Sargent, D.; Goldberg, R. M.; Beck, J. R. Cost implications of new treatments for advanced colorectal cancer Cancer 2009, 115, 2081-2091
9. Roque, A.; Lowe, C.; Taipa, M. Antibodies and genetically engineered related molecules: production and purification Biotechnol. Prog. 2004, 20, 639-654
10. Follman, D.; Farner, R. Factorial screening of antibody purification processes using three chromatography steps without protein A J. Chromatogr., A 2004, 1024, 79-85
11. Hale, G. Repeated cleaning of protein-a affinity column with sodium-hydroxide J. Immunol. Methods 1994, 171, 15-21
12. Ishihara, T.; Kadoya, T.; Endo, N.; Yamamoto, S. Optimization of elution salt concentration in stepwise elution of protein chromatography using linear gradient elution data-reducing residual protein A by cation-exchange chromatography in monoclonal antibody purification J. Chromatogr., A 2006, 1114, 97-101
13. Gagnon, P. Purification Tools for Monoclonal Antibodies; Validated Biosystems: 1996.
14. Bloom, J. Detection and reduction of protein-a contamination in immobilized protein-a purified monoclonal-antibody preparations J. Immunol. Methods 1989, 117, 83-89
15. Brorson, K.; Brown, J.; Hamilton, E.; Stein, K. Identification of protein A media performance attributes that can be monitored as surrogates for retrovirus clearance during extended re-use J. Chromatogr., A 2003, 989, 155-163
16. Naik, A. D.; Raina, M.; Lali, A. M. AbSep-An amino acid based pseudobioaffinity adsorbent for the purification of immunoglobulin G J. Chromatogr., A 2011, 1218, 1756-1766
17. Lowe, C. Combinatorial approaches to affinity chromatography Curr. Opin. Chem. Biol. 2001, 5, 248-256
18. Roque, A. C. A.; Silva, C. S. O.; Taipa, M. A. Affinity-based methodologies and ligands for antibody purification: Advances and perspectives J. Chromatogr., A 2007, 1160, 44-55
19. Palombo, G.; De Falco, S.; Tortora, M.; Cassani, G.; Fassina, G. A synthetic ligand for IgA affinity purification J. Mol. Recognit. 1998, 11, 243-246
20. Dinon, F.; Salvalaglio, M.; Gallotta, A.; Beneduce, L.; Pengo, P.; Cavallotti, C.; Fassina, G. Structural refinement of protein A mimetic peptide J. Mol. Recognit. 2011, 24, 1087-1094
21. Lund, L. N.; Gustavsson, P.; Michael, R.; Lindgren, J.; Norskov-Lauritsen, L.; Lund, M.; Houen, G.; Staby, A.; St. Hilaire, P. M. Novel peptide ligand with high binding capacity for antibody purification J. Chromatogr., A 2012, 1225, 158-167
22. Yang, H.; Gurgel, P.; Carbonell, R. Hexamer peptide affinity resins that bind the Fc region of human immunoglobulin G J. Pept. Res. 2005, 66, 120-137
23. Liu, Z.; Gurgel, P. V.; Carbonell, R. G. Effects of peptide density and elution pH on affinity chromatographic purification of human immunoglobulins A and M J. Chromatogr., A 2011, 1218, 8344-8352
24. Menegatti, S.; Naik, A. D.; Gurgel, P. V.; Carbonell, R. G. Purification of polyclonal antibodies from Cohn fraction II + III, skim milk, and whey by affinity chromatography using a hexamer peptide ligand J. Sep. Sci. 2012, DOI: 10.1002/jssc.201200199
25. Naik, A. D.; Menegatti, S.; Reese, H. R.; Gurgel, P. V.; Carbonell, R. G. Process for purification of monoclonal antibody expressed in transgenic lemna plant extract using dextran-coated charcoal and hexamer peptide affinity resin J. Chromatogr., A 2012, 1260, 61-66
26. Menegatti, S.; Naik, A. D.; Gurgel, P. V.; Carbonell, R. G. Alkaline-stable peptide ligand affinity adsorbents for the purification of biomolecules J. Chromatogr., A 2012, 1245, 55-64
27. Naik, A. D.; Menegatti, S.; Gurgel, P. V.; Carbonell, R. G. Performance of hexamer peptide ligands for affinity purification of immunoglobulin G from commercial cell culture media J. Chromatogr., A 2011, 1218, 1691-1700
28. Yang, H.; Gurgel, P. V.; Carbonell, R. G. Purification of human immunoglobulin G via Fc-specific small peptide ligand affinity chromatography J. Chromatogr., A 2009, 1216
29. Boi, C.; Sarti, G. C. Development and characterization of affinity membranes for immunoglobulin purification Sep. Sci. Technol. 2007, 42, 2987-3001
30. Boi, C.; Algeri, C.; Sarti, G. C. Preparation and characterization of polysulfone affinity membranes bearing a synthetic peptide ligand for the separation of murine immunoglobulins Biotechnol. Prog. 2008, 24, 1304-1313
31. Boi, C.; Dimartino, S.; Sarti, G. C. Performance of a new protein a affinity membrane for the primary recovery of antibodies Biotechnol. Prog. 2008, 24, 640-647
32. Dimartino, S.; Boi, C.; Sarti, G. C. Influence of protein adsorption kinetics on breakthrough broadening in membrane affinity chromatography J. Chromatogr., A 2011, 1218, 3966-3972
33. Boi, C.; Dimartino, S.; Sarti, G. C. Modelling and simulation of affinity membrane adsorption J. Chromatogr., A 2007, 1162, 24-33
34. Boi, C.; Busini, V.; Salvalaglio, M.; Cavallotti, C.; Sarti, G. C. Understanding ligand-protein interactions in affinity membrane chromatography for antibody purification J. Chromatogr., A 2009, 1216, 8687-8696
35. Dimartino, S.; Boi, C.; Sarti, G. C. A validated model for the simulation of protein purification through affinity membrane chromatography J. Chromatogr., A 2011, 1218, 1677-1690
36. Wrzosek, K.; Gramblicka, M.; Polakovic, M. Influence of ligand density on antibody binding capacity of cation-exchange adsorbents J. Chromatogr., A 2009, 1216, 5039-5044
37. Mallia, A. K.; Smith, P. K.; Hermanson, G. T. Immobilized Affinity Ligand Techniques; Academic Press: San Diego, Calfornia, 1992.