Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120

Pain

Volumn 73, Issue 3, 1997, Pages 383-391

  Noble, Florence ^a   Smadja, Claire ^a   Valverde, Olga ^a   Maldonado, Rafaël ^a   Coric, Pascale ^a   Turcaud, Serge ^a   Fournié Zaluski, Marie Claude ^a   Roques, Bernard P ^a  

^a Laboratoire de Pharmacochimie   (France)

Author keywords

Antinociception; Endogenous enkephalins; Enkephalin catabolism inhibitor; RB 120

Indexed keywords

ENZYME INHIBITOR; N [3 [(2 AMINO 4 METHYLTHIO)BUTYLDITHIO] 2 BENZYL 1 OXOPROPYL]ALANINE BENZYL ESTER; N [3 [(2 AMINO 4 METHYLTHIO)BUTYLDITHIO] 2 BENZYLPROPIONYL]PHENYLALANINE BENZYL ESTER; RB 120; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ELECTROSTIMULATION; HOT PLATE TEST; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ALANINE; ANIMALS; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENKEPHALINS; ENZYME INHIBITORS; HEAT; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED STRAINS; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; STIMULATION, CHEMICAL;

EID: 0031465021     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(97)00125-5     Document Type: Article

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