Inhibition of osteosarcoma-induced thermal hyperalgesia in mice by the orally active dual enkephalinase inhibitor PL37. Potentiation by gabapentin

European Journal of Pharmacology

Volumn 596, Issue 1-3, 2008, Pages 50-55

  Menéndez, Luis ^a   Hidalgo, Agustín ^a   Meana, Álvaro ^b   Poras, Hervé ^c   Fournié Zaluski, Marie Claude ^c   Roques, Bernard P ^c   Baamonde, Ana ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b Centro Comunitario de Sangre y Tejidos del Principado de Asturias   (Spain)

^c Pharmaleads   (France)

Author keywords

Bone cancer induced pain; Enkephalin degrading inhibitor; Gabapentin; Osteosarcoma; PL37; Thermal hyperalgesia

Indexed keywords

1 2 [(1 ETHOXY CARBONYLOXY ETHOXYCARBONYLMETHYL) CARBAMOYL] 3 PHENYL PROPYLDISULFANYLMETHYL 3 METHYLSULFANYL PROPYLAMMONIUM; 17 METHYLNALOXONE; CYPRODIME; DELTA OPIATE RECEPTOR; ENKEPHALINASE INHIBITOR; GABAPENTIN; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NALTRINDOLE; NORBINALTORPHIMINE; PL 37; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; HYPERALGESIA; LOW DRUG DOSE; MOUSE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; AMINES; ANALGESICS; ANIMALS; BONE NEOPLASMS; CYCLOHEXANECARBOXYLIC ACIDS; DISULFIDES; DRUG SYNERGISM; GAMMA-AMINOBUTYRIC ACID; HOT TEMPERATURE; HYPERALGESIA; MICE; NALOXONE; NEPRILYSIN; OSTEOSARCOMA; PROPYLAMINES; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

EID: 53049105222     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.07.043     Document Type: Article

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