Unfolding of a model protein on ion exchange and mixed mode chromatography surfaces

Journal of Chromatography A

Volumn 1355, Issue , 2014, Pages 238-252

  Gospodarek, Adrian M ^a   Hiser, Diana E ^a   O'Connell, John P ^a   Fernandez, Erik J ^a  

^a University of Virginia   (United States)

Author keywords

Hydrogen exchange mass spectrometry; Ion exchange chromatography; Mixed mode chromatography; Protein unfolding; Surface induced denaturation

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; HYDROGEN; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; LIGANDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; SOLVENTS;

CONFORMATIONAL CHANGE; HYDROGEN EXCHANGE; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; LOW SALT CONCENTRATION; MIXED-MODE CHROMATOGRAPHY; PRODUCT DEGRADATION; PROTEIN UNFOLDING;

PROTEINS;

HYDROGEN; BOVINE SERUM ALBUMIN;

ADSORPTION KINETICS; ARTICLE; CONCENTRATION (PARAMETERS); HYDROPHOBICITY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; MULTI MODE CHROMATOGRAPHY; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN STABILITY; SEPARATION TECHNIQUE; STATIC ELECTRICITY; ANIMAL; BOVINAE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROCEDURES; PROTEIN TERTIARY STRUCTURE; PROTEIN UNFOLDING; SURFACE PROPERTY;

ANIMALS; CATTLE; CHROMATOGRAPHY, ION EXCHANGE; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTEIN UNFOLDING; SERUM ALBUMIN, BOVINE; SURFACE PROPERTIES;

EID: 84904277925     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.06.024     Document Type: Article

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