Identification of natural compound inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using In Silico high-throughput virtual screening and In Vitro validation

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Aparna, Vasudevan ^a   Dineshkumar, Kesavan ^a   Mohanalakshmi, Narasumani ^a,c   Velmurugan, Devadasan ^b   Hopper, Waheeta ^a  

^a SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

^b UNIVERSITY OF MADRAS   (India)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; CARBENICILLIN; DAIDZEIN; ETHIDIUM BROMIDE; GENTISIC ACID; LANATOSIDE C; LEVOFLOXACIN; MULTIDRUG EFFLUX PUMP DERIVATIVE; MULTIDRUG EFFLUX PUMP INHIBITOR; NATURAL PRODUCT; PHENYLALANYLARGININE 2 NAPHTHYLAMIDE; PLANT MEDICINAL PRODUCT; PROTEIN ACRB; PROTEIN MEXB; PROTOCATECHUIC ACID; SCOPOLAMINE; UMBELLIFERONE; UNCLASSIFIED DRUG; ACRB PROTEIN, E COLI; ANTIINFECTIVE AGENT; BIOLOGICAL PRODUCT; CARRIER PROTEIN; ESCHERICHIA COLI PROTEIN; ETHIDIUM; LIGAND; MEXB PROTEIN, PSEUDOMONAS AERUGINOSA; MULTIDRUG RESISTANCE PROTEIN; OUTER MEMBRANE PROTEIN; PROTEIN BINDING;

ARTICLE; ASSAY; BACTERIAL CELL; BIOACCUMULATION; CHEMICAL MODEL; COMPUTER MODEL; CONTROLLED STUDY; DATA BASE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; ESCHERICHIA COLI; FLUORESCENCE ANALYSIS; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PSEUDOMONAS AERUGINOSA; VALIDATION STUDY; VIRTUAL REALITY; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; DRUG DEVELOPMENT; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; MULTIDRUG RESISTANCE; REPRODUCIBILITY; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BIOLOGICAL PRODUCTS; COMPUTER SIMULATION; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ETHIDIUM; HIGH-THROUGHPUT SCREENING ASSAYS; IN VITRO TECHNIQUES; LIGANDS; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHYTOCHEMICALS; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; REPRODUCIBILITY OF RESULTS; SEQUENCE ALIGNMENT;

EID: 84904269915     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101840     Document Type: Article

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