Association of interleukin-6 promoter polymorphism with knee osteoarthritis: A meta-analysis

Chinese Medical Journal

Volumn 127, Issue 13, 2014, Pages 2492-2496

  Ai, Zhi Peng ^a   Ning, Xian Ming ^b   Shou, Tao ^b   Tang, Wen Ru ^a   Luo, Ying ^a   Zhang, Ji Hong ^a  

^a KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b First Hospital of Yunnan Province   (China)

Author keywords

Interleukin 6; Knee osteoarthritis; Meta analysis; Polymorphisms

Indexed keywords

INTERLEUKIN 6;

GENETIC POLYMORPHISM; GENETICS; HUMAN; META ANALYSIS; OSTEOARTHRITIS, KNEE; PROMOTER REGION;

HUMANS; INTERLEUKIN-6; OSTEOARTHRITIS, KNEE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC;

EID: 84904264242     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20132846     Document Type: Article

References (33)

1. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001; 60: 91-97.
2. Buckwalter JA, Saltzman C, Brown T. The impact of osteoarthritis: implications for research. Clin Orthop Relat Res 2004; 427 (Suppl): S6-S15.
3. Michou L. Genetics of digital osteoarthritis. Joint Bone Spine 2011; 78: 347-351.
4. Vargiolu M, Silvestri T, Bonora E, Dolzani P, Pulsatelli L, Addimanda O, et al. Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis. Osteoarthritis Cartilage 2010; 18: 810-816.
5. Swellam M, Mahmoud MS, Samy N, Gamal AA. Potential influence of interleukin-1 receptor antagonist gene polymorphism on knee osteoarthritis risk. Dis Markers 2010; 28: 299-305.
6. Smith AJ, Keen LJ, Billingham MJ, Perry MJ, Elson CJ, Kirwan JR, et al. Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis. Genes Immun 2004; 5: 451-460.
7. Southam L, Heath O, Chapman K, Loughlin J. Association analysis of the interleukin 17 genes IL17A and IL17F as potential osteoarthritis susceptibility loci. Ann Rheum Dis 2006; 65: 556-557.
8. Hulin-Curtis SL, Bidwell JL, Perry MJ. Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet 2012; 39: 106-109.
9. Guerne PA, Carson DA, Lotz M. IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. J Immunol 1990; 144: 499-505.
10. Sakao K, Takahashi KA, Arai Y, Saito M, Honjo K, Hiraoka N, et al. Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis. J Bone Miner Metab 2009; 27: 412-423.
11. Fonseca JE, Santos MJ, Canhão H, Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev 2009; 8: 538-542.
12. Kaneko S, Satoh T, Chiba J, Ju C, Inoue K, Kagawa J. Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. Cytokines Cell Mol Ther 2000; 6: 71-79.
13. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, et al. The effect of novel polymorphism in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic onset juvenile chronic arthritis. J Clin Invest 1998; 102: 1369-1376.
14. Moos V, Rudwaleit M, Herzog V, Höhlig K, Sieper J, Muller B. Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis. Arthritis Rheum 2000; 43: 2417-2422.
15. Walston J, Arking DE, Fallin D, Li T, Beamer B, Xue Q, et al. IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women. Exp Gerontol 2005; 40: 344-352.
16. Honsawek S, Deepaisarnsakul B, Tanavalee A, Yuktanandana P, Bumrungpanichthaworn P, Malila S, et al. Association of the IL-6-174G/C gene polymorphism with knee osteoarthritis in a Thai population. Genet Mol Res 2011; 10: 1674-1680.
17. Lv C, Xu X, Wang J, Zhang Z, Zhang D, Guo C, et al. Combined effect of cytokine gene polymorphisms on end-stage knee osteoarthritis from Chinese Han population. Rheumatol Int 2012; 32: 3625-3629.
18. Kämäräinen OP, Solovieva S, Vehmas T, Luoma K, Riihimäki H, Ala-Kokko L, et al. Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis. Arthritis Res Ther 2008; 10: R21.
19. Pola E, Papaleo P, Pola R, Gaetani E, Tamburelli FC, Aulisa L, et al. Interleukin-6 gene polymorphism and risk of osteoarthritis of the hip: a case-control study. Osteoarthritis Cartilage 2005; 13: 1025-1028.
20. Tamm A, Lintrop M, Veske K, Hansen U, Tamm A. Prevalence of patello-and tibiofemoral osteoarthritis in Elva, Southern Estonia. J Rheumatol 2008; 35: 543-544.
21. Syddall HE, Aihie Sayer A, Dennison EM, Martin HJ, Barker DJ, Cooper C. Cohort profile: the Hertfordshire cohort study. Int J Epidemiol 2005; 34: 1234-1242.
22. Valdes AM, Spector TD, Doherty S, Wheeler M, Hart DJ, Doherty M. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann Rheum Dis 2009; 68: 1916-1920.
23. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719-748.
24. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177-188.
25. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-634.
26. Shlopov BV, Lie WR, Mainardi CL, Cole AA, Chubinskaya S, Hasty KA. Osteoarthritic lesions: involvement of three different collagenases. Arthritis Rheum 1997; 40: 2065-2074.
27. Helmy N, Maly FE, Bestmann L. Detection of the single-base substitution-174 G-->C in the interleukin-6 gene by real-time polymerase chain reaction: comment on the article by Moos et al. Arthritis Rheum 2001; 44: 2213-2214.
28. Nakamura H, Yoshino S, Kato T, Tsuruha J, Nishioka K. T-cell mediated inflammatory pathway in osteoarthritis. Osteoarthritis Cartilage 1999; 7: 401-402.
29. Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002; 39: 237-246.
30. de Hooge AS, van de Loo FA, Bennink MB, Arntz OJ, de Hooge P, van den Berg WB. Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. Osteoarthritis Cartilage 2005; 13: 66-73.
31. Krenn V, Hensel F, Kim HJ, Souto Carneiro MM, Starostik P, Ristow G, et al. Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: a degenerative disease is associated with a specific, not locally generated immune response. Lab Invest 1999; 79: 1377-1384.
32. Bennermo M, Held C, Stemme S, Ericsson CG, Silveira A, Green F, et al. Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases? Clin Chem 2004; 50: 2136-2140.
33. Valdes AM, Hart DJ, Jones KA, Surdulescu G, Swarbrick P, Doyle DV, et al. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Arthritis Rheum 2004; 50: 2497-2507.