Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis

Journal of Bone and Mineral Metabolism

Volumn 27, Issue 4, 2009, Pages 412-423

  Sakao, Kei ^a   Takahashi, Kenji A ^a   Arai, Yuji ^a   Saito, Masazumi ^a   Honjo, Kuniaki ^a   Hiraoka, Nobuyuki ^a   Asada, Hidetsugu ^a   Shin Ya, Masaharu ^a   Imanishi, Jiro ^a   Mazda, Osam ^a   Kubo, Toshikazu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Interleukin 6; Interleukin 8; Matrix metalloproteinase 13; Osteoarthritis; Osteophytes

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGENASE 3; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA;

ADULT; ARTICLE; BONE PLATE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEMUR NECK FRACTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROSTATIC PRESSURE; KNEE OSTEOARTHRITIS; MALE; MECHANICAL STRESS; OSTEOBLAST; OSTEOPHYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REAL TIME POLYMERASE CHAIN REACTION; SIMULATION;

AGED; AGED, 80 AND OVER; ALKALINE PHOSPHATASE; CELL LINE; CELLS, CULTURED; FEMALE; GENE EXPRESSION; HUMANS; HYDROSTATIC PRESSURE; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MATRIX METALLOPROTEINASE 13; MIDDLE AGED; OSTEOARTHRITIS; OSTEOBLASTS; OSTEOCALCIN; OSTEOPHYTE; RECEPTORS, INTERLEUKIN-6; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 67749132440     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-009-0058-6     Document Type: Article

References (48)

1. AJ Bailey JP Mansell 1997 Do subchondral bone changes exacerbate or precede articular cartilage destruction in osteoarthritis of the elderly? Gerontology 43 296 304 (Pubitemid 27390311)
2. CJ Menkes NE Lane 2004 Are osteophytes good or bad? Osteoarthritis Cartilage 12 suppl A S53 S54
3. RW Moskowitz VM Goldberg 1987 Studies of osteophyte pathogenesis in experimentally induced osteoarthritis J Rheumatol 14 311 320 (Pubitemid 17113945)
4. M Kobayashi GR Squires A Mousa M Tanzer DJ Zukor J Antoniou U Feige AR Poole 2005 Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage Arthritis Rheum 52 128 135 (Pubitemid 40129241)
5. N Franchimont S Rydziel AM Delany E Canalis 1997 Interleukin-6 and its soluble receptor cause a marked induction of collagenase 3 expression in rat osteoblast cultures J Biol Chem 272 12144 12150 (Pubitemid 27202796)
6. F Legendre J Dudhia JP Pujol P Bogdanowicz 2003 JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression J Biol Chem 278 2903 2912 (Pubitemid 36801195)
7. A Matsukawa T Yoshimura T Maeda S Ohkawara K Takagi M Yoshinaga 1995 Neutrophil accumulation and activation by homologous IL-8 in rabbits. IL-8 induces destruction of cartilage and production of IL-1 and IL-1 receptor antagonist in vivo J Immunol 154 5418 5425
8. RC Billinghurst L Dahlberg M Ionescu A Reiner R Bourne C Rorabeck P Mitchell J Hambor O Diekmann H Tschesche J Chen H Van Wart AR Poole 1997 Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage J Clin Invest 99 1534 1545 (Pubitemid 27163804)
9. MN Vankemmelbeke I Holen AG Wilson MZ Ilic CJ Handley GS Kelner M Clark C Liu RA Maki D Burnett DJ Buttle 2001 Expression and activity of ADAMTS-5 in synovium Eur J Biochem 268 1259 1268 (Pubitemid 32231878)
10. JH Lee JB Fitzgerald MA Dimicco AJ Grodzinsky 2005 Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression Arthritis Rheum 52 2386 2395 (Pubitemid 41117423)
11. P Diehl M Schmitt J Schauwecker K Eichelberg H Gollwitzer R Gradinger M Goebel KT Preissner W Mittelmeier U Magdolen 2005 Effect of high hydrostatic pressure on biological properties of extracellular bone matrix proteins Int J Mol Med 16 285 289
12. RU Kleemann D Krocker A Cedraro J Tuischer GN Duda 2005 Altered cartilage mechanics and histology in knee osteoarthritis: relation to clinical assessment (ICRS Grade) Osteoarthritis Cartilage 13 958 963 (Pubitemid 41536127)
13. JH Kellgren JS Lawrence 1957 Radiological assessment of osteo-arthrosis Ann Rheum Dis 16 494 502
14. JN Beresford JA Gallagher M Gowen M Couch J Poser DD Wood RG Russell 1984 The effects of monocyte-conditioned medium and interleukin 1 on the synthesis of collagenous and non-collagenous proteins by mouse bone and human bone cells in vitro Biochim Biophys Acta 801 58 65 (Pubitemid 14005463)
15. T Ebisawa K Tada I Kitajima K Tojo TK Sampath M Kawabata K Miyazono T Imamura 1999 Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation J Cell Sci 112 pt 20 3519 3527
16. C De Bari F Dell'Accio P Tylzanowski FP Luyten 2001 Multipotent mesenchymal stem cells from adult human synovial membrane Arthritis Rheum 44 1928 1942 (Pubitemid 32758241)
17. WS Khan AB Adesida TE Hardingham 2007 Hypoxic conditions increase hypoxia-inducible transcription factor 2-alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients Arthritis Res Ther 9 R55
18. A Inoue KA Takahashi Y Arai H Tonomura K Sakao M Saito M Fujioka H Fujiwara Y Tabata T Kubo 2006 The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee Arthritis Rheum 54 264 270 (Pubitemid 43122211)
19. K Takahashi T Kubo Y Arai I Kitajima M Takigawa J Imanishi Y Hirasawa 1998 Hydrostatic pressure induces expression of interleukin 6 and tumour necrosis factor alpha mRNAs in a chondrocyte-like cell line Ann Rheum Dis 57 231 236 (Pubitemid 28323265)
20. SE Ahn S Kim KH Park SH Moon HJ Lee GJ Kim YJ Lee KH Park KY Cha HM Chung 2006 Primary bone-derived cells induce osteogenic differentiation without exogenous factors in human embryonic stem cells Biochem Biophys Res Commun 340 403 408 (Pubitemid 43021762)
21. JR Robbins B Thomas L Tan B Choy JL Arbiser F Berenbaum MB Goldring 2000 Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1-beta Arthritis Rheum 43 2189 2201
22. SA Bustin 2002 Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems J Mol Endocrinol 29 23 39 (Pubitemid 34965744)
23. K Sakao KA Takahashi Y Arai A Inoue H Tonomura M Saito T Yamamoto N Kanamura J Imanishi O Mazda T Kubo 2008 Induction of chondrogenic phenotype in synovium-derived progenitor cells by intermittent hydrostatic pressure Osteoarthritis Cartilage 16 805 814 (Pubitemid 351827809)
24. F Legendre P Bogdanowicz K Boumediene JP Pujol 2005 Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular J Rheumatol 32 1307 1316
25. EM Gilbertson 1975 Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog. A study using microradiographic, microangiographic, and fluorescent bone-labelling techniques Ann Rheum Dis 34 12 25
26. JC Buckland-Wright JA Lynch B Dave 2000 Early radiographic features in patients with anterior cruciate ligament rupture Ann Rheum Dis 59 641 646 (Pubitemid 30617091)
27. JA Williams EJ Thonar 1989 Early osteophyte formation after chemically induced articular cartilage injury Am J Sports Med 17 7 15 (Pubitemid 19059836)
28. F Ozdemir O Tukenmez S Kokino FN Turan 2006 How do marginal osteophytes, joint space narrowing and range of motion affect each other in patients with knee osteoarthritis Rheumatol Int 26 516 522
29. Y Nagaosa P Lanyon M Doherty 2002 Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study Ann Rheum Dis 61 319 324 (Pubitemid 34257742)
30. K Gelse S Soder W Eger T Diemtar T Aigner 2003 Osteophyte development-molecular characterization of differentiation stages Osteoarthritis Cartilage 11 141 148 (Pubitemid 36221650)
31. MB Sweet EJ Thonar AR Immelman L Solomon 1977 Biochemical changes in progressive osteoarthrosis Ann Rheum Dis 36 387 398 (Pubitemid 8201499)
32. S Kaneko T Satoh J Chiba C Ju K Inoue J Kagawa 2000 Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis Cytokines Cell Mol Ther 6 71 79 (Pubitemid 30954057)
33. PG Mitchell HA Magna LM Reeves LL Lopresti-Morrow SA Yocum PJ Rosner KF Geoghegan JE Hambor 1996 Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage J Clin Invest 97 761 768 (Pubitemid 26060542)
34. D Stickens DJ Behonick N Ortega B Heyer B Hartenstein Y Yu AJ Fosang M Schorpp-Kistner P Angel Z Werb 2004 Altered endochondral bone development in matrix metalloproteinase 13-deficient mice Development (Camb) 131 5883 5895 (Pubitemid 40123905)
35. EV Tchetina M Kobayashi T Yasuda T Meijers I Pidoux AR Poole 2007 Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: Implications for development and arthritis Matrix Biol 26 247 258 (Pubitemid 46660592)
36. DL Cecil DM Rose R Terkeltaub R Liu-Bryan 2005 Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes Arthritis Rheum 52 144 154 (Pubitemid 40129243)
37. V Poli R Balena E Fattori A Markatos M Yamamoto H Tanaka G Ciliberto GA Rodan F Costantini 1994 Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion EMBO J 13 1189 1196 (Pubitemid 24074725)
38. SL Ferrari P Garnero S Emond H Montgomery SE Humphries SL Greenspan 2001 A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women Arthritis Rheum 44 196 201 (Pubitemid 32113135)
39. L Torres DD Dunlop C Peterfy A Guermazi P Prasad KW Hayes J Song S Cahue A Chang M Marshall L Sharma 2006 The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis Osteoarthritis Cartilage 14 1033 1040 (Pubitemid 44321374)
40. T Boegard O Rudling IF Petersson K Jonsson 1998 Correlation between radiographically diagnosed osteophytes and magnetic resonance detected cartilage defects in the tibiofemoral joint Ann Rheum Dis 57 401 407 (Pubitemid 28378499)
41. DT Felson DR Gale M Elon Gale J Niu DJ Hunter J Goggins MP Lavalley 2005 Osteophytes and progression of knee osteoarthritis Rheumatology (Oxf) 44 100 104 (Pubitemid 40124340)
42. LA Pottenger FM Phillips LF Draganich 1990 The effect of marginal osteophytes on reduction of varus-valgus instability in osteoarthritic knees Arthritis Rheum 33 853 858 (Pubitemid 20205765)
43. WA Hodge RS Fijan KL Carlson RG Burgess WH Harris RW Mann 1986 Contact pressures in the human hip joint measured in vivo Proc Natl Acad Sci USA 83 2879 2883 (Pubitemid 16041766)
44. P de la Torre T Diaz-Sanjuan I Garcia-Ruiz E Esteban F Canga T Munoz-Yague JA Solis-Herruzo 2005 Interleukin-6 increases rat metalloproteinase-13 gene expression through Janus kinase-2-mediated inhibition of serine/threonine phosphatase-2A Cell Signal 17 427 435 (Pubitemid 39643061)
45. MC Honorati M Bovara L Cattini A Piacentini A Facchini 2002 Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis Osteoarthritis Cartilage 10 799 807 (Pubitemid 35153721)
46. SM Dai ZZ Shan K Nishioka K Yudoh 2005 Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal Ann Rheum Dis 64 735 742 (Pubitemid 40559301)
47. W Wu RC Billinghurst I Pidoux J Antoniou D Zukor M Tanzer AR Poole 2002 Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13 Arthritis Rheum 46 2087 2094 (Pubitemid 34894765)
48. H Hulejova V Baresova Z Klezl M Polanska M Adam L Senolt 2007 Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone Cytokine 38 151 156 (Pubitemid 47248299)