Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Dorca Arévalo, Jonatan ^a,b   Pauillac, Serge ^c   Díaz Hidalgo, Laura ^a,d   Martín Satué, Mireia ^a,b   Popoff, Michel R ^c   Blasi, Juan ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c INSTITUT PASTEUR   (France)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CYSTEINE; EPSILON TOXIN; GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; HYBRID PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIUM MUTANT; BLOOD BRAIN BARRIER; BRAIN TISSUE; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOTOXICITY; ENTEROTOXEMIA; GENERALIZED EDEMA; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; KIDNEY CELL; KIDNEY DISTAL TUBULE; KIDNEY EPITHELIUM; LETHALITY; MALE; MDCK CELL LINE; MOUSE; NONHUMAN; PARENCHYMA; WILD TYPE; ANIMAL; BRAIN; CLOSTRIDIUM INFECTION; DOG; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; MORTALITY; MUTATION; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; PRIMARY CELL CULTURE; STRUCTURE ACTIVITY RELATION; SURVIVAL; TOXICITY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BACTERIAL TOXINS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CLOSTRIDIUM INFECTIONS; CLOSTRIDIUM PERFRINGENS; DOGS; ENTEROTOXEMIA; EPITHELIAL CELLS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; KIDNEY TUBULES, DISTAL; MADIN DARBY CANINE KIDNEY CELLS; MALE; MICE; MUTATION; PRIMARY CELL CULTURE; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SURVIVAL ANALYSIS;

EID: 84904262393     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102417     Document Type: Article

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