Distribution of Clostridium perfringens epsilon toxin in the brains of acutely intoxicated mice and its effect upon glial cells

Toxicon

Volumn 50, Issue 4, 2007, Pages 530-540

  Soler Jover, Alex ^a   Dorca, Jonatan ^a   Popoff, Michel R ^b   Gibert, Maryse ^b   Saura, Josep ^c   Tusell, Josep Maria ^c   Serratosa, Joan ^c   Blasi, Juan ^a   Martín Satué, Mireia ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUT PASTEUR   (France)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

Astrocyte; Blood brain barrier; Clostridium perfringens; Epsilon toxin; Microglia

Indexed keywords

CLOSTRIDIUM TOXIN; GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; CYTOTOXICITY TEST; EDEMA; FLUORESCENCE MICROSCOPY; GLIA CELL; MALE; MICROGLIA; MOUSE; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TOXIN ANALYSIS;

ANIMALS; ASTROCYTES; BACTERIAL TOXINS; BLOOD-BRAIN BARRIER; BRAIN; CELL DEATH; ENDOTHELIUM, VASCULAR; GREEN FLUORESCENT PROTEINS; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED C57BL; NEUROGLIA;

CLOSTRIDIUM PERFRINGENS; MUS;

EID: 34548412159     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2007.04.025     Document Type: Article

References (28)

1. Bhown A.S., and Habeerb A.F. Structural studies on epsilon prototoxin of Clostridium perfringens type D. Localisation of the site of tryptic scission necessary for activation to epsilon toxin. Biochem. Biophys. Res. Commun. 78 (1977) 889-896
2. Borrmann E., Günther H., and Köhler H. Effect of Clostridium perfringens epsilon toxin on MDCK cells. FEMS Immunol. Med. Microbiol. 31 (2001) 85-92
3. Buxton D. Pulpy kidney disease and its diagnosis by histological examination. Vet. Rec. 102 (1978) 241
4. Buxton D. In-vitro effects of Clostridium welchii type-D epsilon toxin on guinea-pig, mouse, rabbit and sheep cells. J. Med. Microbiol. 11 (1978) 299-302
5. Cole A.R., Gibert M., Popoff M., Moss D.S., Titball R.W., and Basak A.K. Clostridium perfringens ε-toxin shows structural similarity to the pore-forming toxin aerolysin. Nat. Struct. Mol. Biol. 11 8 (2004) 797-798
6. Donelli G., Fiiorentini C., Matarrese P., Falzano L., Cardines R., Mastrantonio P., Payne D.E., and Titball R.W. Evidence for cytoskeletal changes secondary to plasma membrane functional alterations in the in vitro cell response to Clostridium perfringens epsilon toxin. Comp. Immunol. Microbiol. Infect. Dis. 26 (2003) 145-156
7. Finnie J.W. Ultrastructural changes in the brain of mice given Clostridium perfringens type D epsilon toxin. J. Comp. Pathol. 94 (1984) 445-452
8. Finnie J.W. Pathogenesis of brain damage produced in sheep by Clostridium perfringens type D epsilon toxin: a review. Aust. Vet. J. 81 4 (2003) 219-221
9. Finnie J.W. Neurological disorders produced by Clostridium perfringens type D epsilon toxin. Anaerobe 10 (2004) 145-150
10. Finnie J.W., and Hajduk P. An immunohistochemical study of plasma albumin extravasation in the brain of mice after the administration of Clostridium perfringens type D epsilon toxin. Aust. Vet. J. 69 (1992) 261-262
11. Finnie J.W., Blumbergs P.C., and Manavis J. Neuronal damage produced in rat brains by Clostridium perfringens type D epsilon toxin. J. Comp. Pathol. 120 (1999) 415-420
12. Ghabriel M.N., Zhu C., Reilly P.L., Blumbergs P.C., Manavis J., and Finnie J.W. Toxin-induced vasogenic cerebral oedema in a rat model. Acta Neurochir. 76 (2000) 231-236
13. Minami J., Katayama S., Matsushita O., Matsushita C., and Okabe A. Lambda-toxin of Clostridium perfringens activates the precursor of epsilon toxin by releasing its N- and C-terminal peptides. Microbiol. Immunol. 41 7 (1997) 527-535
14. Miyamoto O., Minami J., Toyoshima T., Nakamura T., Masada T., Nagao S., Negi T., Itano T., and Okabe A. Neurotoxicity of Clostridium perfringens epsilon toxin for the rat hippocampus via glutamatergic system. Infect. Immun. 66 6 (1998) 2501-2508
15. Miyamoto O., Sumitani K., Nakamura T., Yamagami S., Miyata S., Itano T., Negi T., and Okabe A. Clostridium perfringens epsilon toxin causes excessive release of glutamate in the mouse hippocampus. FEMS Microbiol. Lett. 189 (2000) 109-113
16. Morgan K.T., Kelly B.G., and Buxton D. Vascular leakage produced in the brains of mice by Clostridium welchii type D toxin. J. Comp. Pathol. 85 (1975) 461-466
17. Nagahama M., and Sakurai J. Distribution of labeled Clostridium perfringens epsilon toxin in mice. Toxicon 29 2 (1991) 211-217
18. Payne D., and Oyston P. The Clostridium perfringens ε-toxin. In: Rood J.I. (Ed). The Clostridia: Molecular Biology and Pathogenesis (1997), Academic Press, San Diego 439-447
19. Payne D.W., Williamson E.D., Havard H., Modi N., and Brown J. Evaluation of a new cytotoxicity assay for Clostridium perfringens type D epsilon toxin. FEMS Microbiol. Lett. 116 (1994) 161-167
20. Petit L., Gibert M., Gillet D., Laurent-Winter C., Boquet P., and Popoff M.R. Clostridium perfringens epsilon toxin acts on MDCK cells by forming a large membrane complex. J. Bacteriol. 179 (1997) 6480-6487
21. Petit L., Maier E., Gibert M., Popoff M.R., and Benz R. Clostridium perfringens epsilon toxin induces a rapid change of cell membrane permeability to ions and forms channels in artificial lipid bilayers. J. Biol. Chem. 276 19 (2001) 15736-15740
22. Petit L., Maier E., Gibert M., Popoff M.R., and Benz R. Clostridium perfringens epsilon toxin rapidly decreases membrane barrier permeability of polarised MDCK cells. Cell Microbiol. 5 (2003) 155-164
23. Saura J., Tusell J.M., and Serratosa J. High-yield isolation of murine microglia by mild trypsinisation. Glia 44 (2003) 183-189
24. Shortt S.J., Titball R.W., and Lindsay C.D. An assessment of the in vitro toxicology of Clostridium perfringens type D ε-toxin in human and animal cells. Hum. Exp. Toxicol. 19 (2000) 108-116
25. Soler-Jover A., Blasi J., Gómez de Aranda I., Navarro P., Gibert M., Popoff M.R., and Martín-Satué M. Effect of epsilon toxin-GFP on MDCK cells and renal tubules in vivo. J. Histochem. Cytochem. 52 7 (2004) 931-942
26. Uzal F.A., Kelly W.R., Morris W.E., and Assis R.A. Effects of intravenous injection of Clostridium perfringens type D epsilon toxin in calves. J. Comp. Pathol. 126 (2002) 71-75
27. Uzal F.A., Kelly W.R., Morris W.E., Bermudez J., and Baisón M. The pathology of peracute experimental Clostridium perfringens type D enterotoxemia in sheep. J. Vet. Diagn. Invest. 16 (2004) 403-411
28. Worthington R.W., and Mulders M.S. Effect of Clostridium perfringens epsilon toxin on the blood brain barrier of mice. Onderstepoort J. Vet. Res. 42 (1975) 25-27