Caffeine prevents human prion protein-mediated neurotoxicity through the induction of autophagy

International Journal of Molecular Medicine

Volumn 34, Issue 2, 2014, Pages 553-558

  Moon, Ji Hong ^a   Lee, Ju Hee ^a   Park, Jin Young ^a   Kim, Sung Wook ^a   Lee, You Jin ^a   Kang, Seog Jin ^b   Seol, Jae Won ^a   Ahn, Dong Choon ^a   Park, Sang Youel ^a  

^a Chonbuk National University   (South Korea)

^b National Institute of Animal Science   (South Korea)

Author keywords

Autophagy; Caffeine; Neuroprotection; PrP(106 126)

Indexed keywords

3 METHYLADENINE; CAFFEINE; LC3 PROTEIN; PRION PROTEIN; PROTEIN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WORTMANNIN; MAP1LC3A PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PEPTIDE FRAGMENT; PRION; PRION PROTEIN (106-126);

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CENTRAL NERVOUS SYSTEM; DRUG EFFECTS; GENETICS; METABOLISM; NERVE CELL; NERVE DEGENERATION; PATHOLOGY; PRION; SCRAPIE; TUMOR CELL LINE;

AUTOPHAGY; CAFFEINE; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NERVE DEGENERATION; NEURONS; PEPTIDE FRAGMENTS; PRIONS; SCRAPIE;

EID: 84904257089     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1814     Document Type: Article

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