Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis

Immunogenetics

Volumn 66, Issue 7-8, 2014, Pages 501-506

  Wang, Nancy ^a,b   Elso, Colleen M ^a   Mackin, Leanne ^a   Mannering, Stuart I ^a   Strugnell, Richard A ^b   Wijburg, Odilia L ^b   Brodnicki, Thomas C ^a  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Congenic NOD mice; Idd14; Idd31; Listeria monocytogenes; Listr2; Type 1 diabetes

Indexed keywords

ALLELE; ARTICLE; BACTERIAL LOAD; CHROMOSOME 13; CONGENIC STRAIN; EPISTASIS; GENE INTERACTION; GENE LOCUS; INBRED MOUSE STRAIN; INSULIN DEPENDENT DIABETES MELLITUS; LISTERIOSIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NONOBESE DIABETIC MOUSE; OVERLAPPING GENE; PRIORITY JOURNAL; PROGENY; SALMONELLA ENTERICA; STREPTOCOCCUS PNEUMONIAE;

LISTERIA MONOCYTOGENES; MUS;

ALLELES; ANIMALS; DIABETES MELLITUS, TYPE 1; EPISTASIS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; IMMUNOGENETIC PHENOMENA; LISTERIOSIS; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, INBRED NOD;

EID: 84904252737     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-014-0782-5     Document Type: Article

References (30)

1. Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, OukkaM, Sharpe AH, Sobel R, Kuchroo VK,Wicker LS (2009) Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. J Immunol 183:5146-5157
2. Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 41: 703-707
3. Boyartchuk VL, Broman KW, Mosher RE, D'Orazio SE, StarnbachMN, Dietrich WF (2001) Multigenic control of Listeria monocytogenes susceptibility in mice. Nat Genet 27:259-260 (Pubitemid 32201844)
4. Brodnicki TC, Quirk F, Morahan G (2003) A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice. Diabetes 52:218-222 (Pubitemid 36042131)
5. Bult CJ, Eppig JT, Blake JA, Kadin JA, Richardson JE, Mouse Genome Database G (2013) The mouse genome database: genotypes, phenotypes, and models of human disease. Nucleic Acids Res 41: D885-D891
6. Chapman SJ, Khor CC, Vannberg FO, Maskell NA, Davies CW, Hedley EL, Segal S, Moore CE, Knox K, Day NP, Gillespie SH, Crook DW, Davies RJ, Hill AV (2006) PTPN22 and invasive bacterial disease. Nat Genet 38:499-500
7. Cheers C, McKenzie IF (1978) Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun 19:755-762
8. Driver JP, Serreze DV, Chen YG (2011) Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol 33:67-87
9. Fraser HI, Dendrou CA, Healy B, Rainbow DB, Howlett S, Smink LJ, Gregory S, Steward CA, Todd JA, Peterson LB, Wicker LS (2010) Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. J Immunol 184:5075-5084
10. Garifulin O, Boyartchuk V (2005) Listeria monocytogenes as a probe of immune function. Brief Funct Genomic Proteomic 4:258-269 (Pubitemid 43055807)
11. Ghosh S, Palmer SM, Rodrigues NR, Cordell HJ, Hearne CM, Cornall RJ, Prins JB, McShane P, Lathrop GM, Peterson LB et al (1993) Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nat Genet 4:404-409 (Pubitemid 23231491)
12. Gomez LM, Anaya JM, Martin J (2005) Genetic influence of PTPN22 R620W polymorphism in tuberculosis. Hum Immunol 66:1242- 1247
13. Hamilton-Williams EE, Serreze DV, Charlton B, Johnson EA, Marron MP, Mullbacher A, Slattery RM (2001) Transgenic rescue implicates β2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proc Natl Acad Sci U S A 98:11533-11538 (Pubitemid 32928763)
14. Hamilton-Williams EE, Rainbow DB, Cheung J, Christensen M, Lyons PA, Peterson LB, Steward CA, Sherman LA,Wicker LS (2013) Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mamm Genome 24:358-375
15. Hollis-Moffatt JE, Hook SM, Merriman TR (2005) Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat). Diabetes 54:2820-2825 (Pubitemid 41233609)
16. Howson JM, Cooper JD, Smyth DJ, Walker NM, Stevens H, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS, Type 1 Diabetes Genetics Consortium, (2012) Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. Diabetes 61:3012-3017
17. Hunter K, Rainbow D, Plagnol V, Todd JA, Peterson LB, Wicker LS (2007) Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. J Immunol 179:8341-8349
18. Kissler S, Stern P, Takahashi K, Hunter K, Peterson LB,Wicker L (2006) In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat Genet 38:479-483
19. Lin X, Hamilton-Williams EE, Rainbow DB, Hunter KM, Dai YD, Cheung J, Peterson LB, Wicker LS, Sherman LA (2013) Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabeticmousemodel of type 1 diabetes. J Immunol 190:3109-3120
20. McAleer MA, Reifsnyder P, Palmer SM, Prochazka M, Love JM, Copeman JB, Powell EE, Rodrigues NR, Prins JB, Serreze DV et al (1995) Crosses of NOD mice with the related NON strain. A polygenic model for IDDM. Diabetes 44:1186-1195
21. McGuire HM, Vogelzang A, Hill N, Flodstrom-Tullberg M, Sprent J, King C (2009) Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proc Natl Acad Sci U S A 106:19438-19443
22. Morahan G, Mehta M, James I, Chen WM, Akolkar B, Erlich HA, Hilner JE, Julier C, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS, Type 1 Diabetes Genetics C, (2011) Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs. Diabetes 60:1030-1040
23. Morin J, Boitard C, Vallois D, Avner P, Rogner UC (2006) Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction. Mamm Genome 17:1105-1112 (Pubitemid 44764288)
24. Pociot F, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nierras CR, Todd JA, Rich SS, Nerup J (2010) Genetics of type 1 diabetes: what's next? Diabetes 59:1561-1571
25. Qi Z, Wang J, Han X, Yang J, Zhao G, Cao Y (2014) Listr1 locus regulates innate immunity against Listeria monocytogenes infection in the mouse liver possibly through Cxcl11 polymorphism. Immunogenetics 66:231-242
26. Razavi R, Chan Y, Afifiyan FN, LiuXJ,Wan X, Yantha J, Tsui H, Tang L, Tsai S, Santamaria P, Driver JP, Serreze D, Salter MW, Dosch MH (2006) TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune disease. Cell 127:1123-1135 (Pubitemid 44894522)
27. Tan IK, Mackin L, Wang N, Papenfuss AT, Elso CM, Ashton MP, Quirk F, Phipson B, Bahlo M, Speed TP, Smyth GK, Morahan G, Brodnicki TC (2010) A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility. Genome Res 20:1629-1638
28. Usami J, Hiromatsu K, Matsumoto Y, Maeda K, Inagaki H, Suzuki T, Yoshikai Y (1995) A protective role of gd T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. Immunology 86:199-205
29. Wang N, Strugnell R, Wijburg O, Brodnicki T (2011)Measuring bacterial load and immune responses in mice infected with Listeria monocytogenes. J Vis Exp. doi:10.3791/3076
30. Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P (2007) Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 39:329-337 (Pubitemid 46328484)