Tests for genetic interactions in type 1 diabetes linkage and stratification analyses of 4,422 affected sib-pairs

Diabetes

Volumn 60, Issue 3, 2011, Pages 1030-1040

  Morahan, Grant ^a,b   Mehta, Munish ^a,b   James, Ian ^c   Chen, Wei Min ^d   Akolkar, Beena ^e   Erlich, Henry A ^f   Hilner, Joan E ^g   Julier, Cécile ^h,i   Nerup, Jørn ^j   Nierras, Concepcion ^k   Pociot, Flemming ^l   Todd, John A ^m   Rich, Stephen S ^d  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c MURDOCH UNIVERSITY   (Australia)

^d UNIVERSITY OF VIRGINIA   (United States)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^f ROCHE MOLECULAR SYSTEMS   (United States)

^g UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^h INSERM   (France)

ⁱ UNIVERSITÉ PARIS DESCARTES   (France)

^j STENO DIABETES CENTER   (Denmark)

^k Juvenile Diabetes Research Foundation International   (United States)

^l GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^m UNIVERSITY OF CAMBRIDGE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 19Q; DIABETES MELLITUS; GENE LOCUS; GENETIC LINKAGE; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM;

ANALYSIS OF VARIANCE; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC LINKAGE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; RISK FACTORS; SIBLINGS;

EID: 79952367420     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1195     Document Type: Article

References (32)

1. Rich SS. Mapping genes in diabetes. Genetic epidemiological perspective. Diabetes 1990;39:1315-1319
2. Rich SS, Akolkar B, Concannon P, et al. Current status and the future for the genetics of type I diabetes. Genes Immun 2009;10(Suppl. 1):S128-S131
3. Rich SS, Concannon P, Erlich H, et al. The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci 2006;1079:1-8 (Pubitemid 44968694)
4. Concannon P, Erlich HA, Julier C, et al. Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes 2005;54:2995-3001 (Pubitemid 41401098)
5. Concannon P, Chen WM, Julier C, et al. Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes 2009;58:1018-1022
6. Barrett JC, Clayton DG, Concannon P, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009;41:703-707
7. Rich SS, Akolkar B, Concannon P, et al. Results of the MHC fine mapping workshop. Diabetes Obes Metab 2009;11(Suppl. 1):108-109
8. Julier C, Akolkar B, Concannon P, Morahan G, Nierras C, Pugliese A. The Type I Diabetes Genetics Consortium 'rapid response' family-based candidate gene study: strategy, genes selection, and main outcome. Genes Immun 2009;10(Suppl. 1):S121-S127
9. Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature 2009;461:747-753
10. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998;63:259-266 (Pubitemid 30428342)
11. Sun L, Wilder K, McPeek MS. Enhanced pedigree error detection. Hum Hered 2002;54:99-110 (Pubitemid 36091883)
12. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin: rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002;30:97-101
13. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575 (Pubitemid 47330214)
14. Kong A, Cox NJ. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997;61:1179-1188 (Pubitemid 27492328)
15. Delépine M, Pociot F, Habita C, et al. Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6. Am J Hum Genet 1997;60:174-187 (Pubitemid 26427792)
16. Davies JL, Kawaguchi Y, Bennett ST, et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994;371:130-136 (Pubitemid 24284009)
17. Field LL, Tobias R, Thomson G, Plon S. Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. Genomics 1996;33:1-8 (Pubitemid 26119389)
18. Luo DF, Bui MM, Muir A, Maclaren NK, Thomson G, She JX. Affected-sibpair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27. Am J Hum Genet 1995;57:911-919
19. Morahan G, Huang D, Tait BD, Colman PG, Harrison LC. Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus. Science 1996;272:1811-1813
20. Morahan G, Huang D, Ymer SI, et al. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. Nat Genet 2001;27:218-221 (Pubitemid 32157453)
21. Bennett ST, Todd JA. Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annu Rev Genet 1996;30:343-370 (Pubitemid 27014472)
22. Pugliese A, Miceli D. The insulin gene in diabetes. Diabetes Metab Res Rev 2002;18:13-25 (Pubitemid 34257362)
23. Lucassen AM, Julier C, Beressi JP, et al. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat Genet 1993;4:305-310 (Pubitemid 23205182)
24. Fourlanos S, Varney MD, Tait BD, et al. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care 2008;31:1546-1549
25. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS. Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet 1999;65:876-884 (Pubitemid 30468731)
26. Morahan G, Mehta M, McKinnon E, James I. Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex. Diabetes Obes Metab 2009;11(Suppl. 1):67-73
27. Clayton DG. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet 2009;5:e1000540
28. Leiter EH. Nonobese diabetic mice and the genetics of diabetes susceptibility. Curr Diab Rep 2005;5:141-148 (Pubitemid 40823498)
29. Ridgway WM, Peterson LB, Todd JA, et al. Gene-gene interactions in the NOD mouse model of type 1 diabetes. Adv Immunol 2008;100:151-175
30. Craddock N, Hurles ME, Cardin N, et al. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010;464:713-720
31. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009;324:387-389
32. Risch N. A note on multiple testing procedures in linkage analysis. Am J Hum Genet 1991;48:1058-1064 (Pubitemid 21903067)