Ranolazine attenuates hypoxia- and hydrogen peroxide-induced increases in sodium channel late openings in ventricular myocytes

Journal of Cardiovascular Pharmacology

Volumn 64, Issue 1, 2014, Pages 60-68

  Ma, Jihua ^a   Song, Yejia ^b   Shryock, John C ^c   Hu, Liangkun ^a   Wang, Weiping ^a   Yan, Xisheng ^a   Zhang, Peihua ^a   Belardinelli, Luiz ^c  

^a WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c GILEAD SCIENCES   (United States)

Author keywords

cardiac myocytes; hydrogen peroxide; hypoxia; late sodium current; ranolazine

Indexed keywords

HYDROGEN PEROXIDE; LIDOCAINE; RANOLAZINE; SODIUM CHANNEL; TETRODOTOXIN; ACETANILIDE DERIVATIVE; ANTIARRHYTHMIC AGENT; PIPERAZINE DERIVATIVE;

ACTION POTENTIAL; ADULT; ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGICAL PROCEDURES; EXPERIMENTAL GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; MEMBRANE CURRENT; MUSCLE ACTION POTENTIAL; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; SODIUM CHANNEL LATE OPENING; SODIUM CURRENT; WHOLE CELL; ANIMAL; CELL HYPOXIA; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GUINEA PIG; MALE; METABOLISM; TIME;

ACETANILIDES; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CELL HYPOXIA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HYDROGEN PEROXIDE; MALE; MYOCYTES, CARDIAC; PIPERAZINES; SODIUM CHANNELS; TIME FACTORS;

EID: 84904247278     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000090     Document Type: Article

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