Rous sarcoma virus synaptic complex capable of concerted integration is kinetically trapped by human immunodeficiency virus integrase strand transfer inhibitors

Journal of Biological Chemistry

Volumn 289, Issue 28, 2014, Pages 19648-19658

  Pandey, Krishan K ^a   Bera, Sibes ^a   Korolev, Sergey ^b   Campbell, Mary ^a   Yin, Zhiqi ^c   Aihara, Hideki ^c   Grandgenett, Duane P ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; KINETICS; MASS SPECTROMETRY; OLIGOMERS; OLIGONUCLEOTIDES; SIZE EXCLUSION CHROMATOGRAPHY; TUMORS; VIRUSES;

HUMAN IMMUNODEFICIENCY VIRUS; MASS SPECTROSCOPY; SARCOMA VIRUS; SCATTERING ANALYSIS; STRUCTURAL STUDIES; SYNAPTIC COMPLEX; VIRAL DNA; WILD TYPES;

DISEASES;

ANTIRETROVIRUS AGENT; DOLUTEGRAVIR; ELVITEGRAVIR; INTEGRASE; INTEGRASE INHIBITOR; MK 0536; MK 2048; RALTEGRAVIR; STRAND TRANSFER INHIBITOR; UNCLASSIFIED DRUG; VIRUS DNA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DRUG EFFICACY; DRUG HALF LIFE; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; LIGHT SCATTERING; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; ROUS SARCOMA ONCOVIRUS; SOLUBILITY; VIRUS ASSEMBLY; VIRUS DNA CELL DNA INTERACTION;

AIDS; ALPHARETROVIRUS; ANTIVIRAL AGENT; DNA-PROTEIN INTERACTION; ENZYME INHIBITOR; HIV-1 PROTEASE; INTEGRASE;

DNA, VIRAL; HIV INTEGRASE; HIV-1; HUMANS; PROTEIN STRUCTURE, TERTIARY; ROUS SARCOMA VIRUS; VIRUS ASSEMBLY;

EID: 84904189097     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.573311     Document Type: Article

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