β-adrenergic receptor blockade does not inhibit cold-induced thermogenesis in humans: Possible involvement of brown adipose tissue

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 4, 2011, Pages

  Wijers, Sander L J ^a   Schrauwen, Patrick ^a   Van Baak, Marleen A ^a   Saris, Wim H M ^a   Lichtenbelt, Wouter D Van Marken ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR; FATTY ACID; PROPRANOLOL;

ADULT; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; CORE TEMPERATURE; ENERGY EXPENDITURE; FATTY ACID BLOOD LEVEL; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUSCLE TISSUE; PRIORITY JOURNAL; SKELETAL MUSCLE; SKIN TEMPERATURE; TEMPERATURE ACCLIMATIZATION; THERMOGENESIS; VASOCONSTRICTION;

ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-ANTAGONISTS; ADULT; COLD TEMPERATURE; DOWN-REGULATION; ELECTRON TRANSPORT; FATTY ACIDS, NONESTERIFIED; HUMANS; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; NOREPINEPHRINE; PROPRANOLOL; SKIN TEMPERATURE; THERMOGENESIS; YOUNG ADULT;

EID: 79953893390     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-1957     Document Type: Article

References (41)

1. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M 2009 High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity. Diabetes 58:1526-1531
2. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ 2009 Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500-1508
3. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P 2009 Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518-1525
4. DaunceyMJ1981 Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis. Br J Nutr 45: 257-267 (Pubitemid 11107914)
5. van Marken Lichtenbelt WD, Schrauwen P, van De Kerckhove S, Westerterp-Plantenga MS 2002 Individual variation in body temperature and energy expenditure in response to mild cold. Am J Physiol Endocrinol Metab 282:E1077-E1083 (Pubitemid 34654722)
6. Wijers SL, Saris WH, van Marken LichtenbeltWD2007 Individual thermogenic responses to mild cold and overfeeding are closely related. J Clin Endocrinol Metab 92:4299-4305 (Pubitemid 350074748)
7. Contaldo F, Scalfi L, Coltorti A, Lanzilli A 1986 Reduced coldinduced thermogenesis in familial human obesity. Klin Wochenschr 64:177-180 (Pubitemid 16170294)
8. Claessens-van Ooijen AM, Westerterp KR, Wouters L, Schoffelen PF, van Steenhoven AA, van Marken Lichtenbelt WD 2006 Heat production and body temperature during cooling and rewarming in overweight and lean men. Obesity (Silver Spring) 14:1914-1920 (Pubitemid 46121921)
9. Wijers SL, Saris WH, van Marken Lichtenbelt WD 2010 Cold-induced adaptive thermogenesis in lean and obese. Obesity 18:1092-1099
10. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR 2009 Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509-1517
11. Wijers SL, Schrauwen P, Saris WH, van Marken Lichtenbelt WD 2008 Human skeletal muscle mitochondrial uncoupling is associated with cold-induced adaptive thermogenesis. PLoSONE3:e1777
12. Tseng YH, Cypess AM, Kahn CR 2010 Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 9:465-482
13. Bouchard C, Tremblay A, Després JP, Nadeau A, Lupien PJ, Thériault G, Dussault J, Moorjani S, Pinault S, FournierG1990 The response to long-term overfeeding in identical twins. N Engl J Med 322:1477-1482 (Pubitemid 20179860)
14. Levine JA, Eberhardt NL, Jensen MD 1999 Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 283:212-214
15. Lowell BB, SpiegelmanBM2000 Towards a molecular understanding of adaptive thermogenesis. Nature 404:652-660 (Pubitemid 30205070)
16. Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB 2002 βAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297:843-845 (Pubitemid 34839635)
17. Matsumoto T, Miyawaki C, Ue H, Kanda T, Yoshitake Y, Moritani T 2001 Comparison of thermogenic sympathetic response to food intake between obese and non-obese young women. Obes Res 9:78-85 (Pubitemid 33603833)
18. Astrup A, Bülow J, Madsen J, Christensen NJ 1985 Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man. Am J Physiol 248:E507-E515 (Pubitemid 15018367)
19. Simonsen L, Bülow J, Madsen J, Christensen NJ 1992 Thermogenic response to epinephrine in the forearm and abdominal subcutaneous adipose tissue. Am J Physiol 263:E850-E855
20. Acheson K, Jéquier E, Wahren J 1983 Influence of β-adrenergic blockade on glucose-induced thermogenesis in man. J Clin Invest 72:981-986 (Pubitemid 14212615)
21. DeFronzo RA, Thorin D, Felber JP, Simonson DC, Thiebaud D, Jequier E, Golay A 1984 Effect of β and α adrenergic blockade on glucose-induced thermogenesis in man. J Clin Invest 73:633-639 (Pubitemid 14156842)
22. Zed C, James WP 1986 Dietary thermogenesis in obesity. Response to carbohydrate and protein meals: The effect of β-adrenergic blockade and semistarvation. Int J Obes 10:391-405 (Pubitemid 17182281)
23. Thörne A, Wahren J 1989 Beta-adrenergic blockade does not influence the thermogenic response to a mixed meal in man. Clin Physiol 9:321-332 (Pubitemid 19194643)
24. Vernet O, Nacht CA, Christin L, Schutz Y, Danforth Jr E, Jequier E 1987 β-Adrenergic blockade and intravenous nutrient-induced thermogenesis in lean and obese women.AmJ Physiol 253:E65-E71
25. Seaton T, Welle S, Alex S, Lilavivat U, Campbell R 1984 The effect of adrenergic blockade on glucose-induced thermogenesis. Metabolism 33:415-419 (Pubitemid 14143872)
26. van Ooijen AM, van Marken Lichtenbelt WD, van Steenhoven AA, Westerterp KR 2004 Seasonal changes in metabolic and temperature responses to cold air in humans. Physiol Behav 82:545-553 (Pubitemid 38981644)
27. Schoffelen PF, Westerterp KR, Saris WH, Ten Hoor F 1997 A dualrespiration chamber system with automated calibration. J Appl Physiol 83:2064-2072 (Pubitemid 28006510)
28. Rubinstein EH, Sessler DI 1990 Skin-surface temperature gradients correlate with fingertip blood flow in humans. Anesthesiology 73: 541-545 (Pubitemid 20298163)
29. KaamanM,SparksLM,van Harmelen V, Smith SR, Sjölin E,Dahlman I, Arner P 2007 Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia 50:2526-2533 (Pubitemid 350060639)
30. Barrow RE, Wolfe RR, Dasu MR, Barrow LN, Herndon DN 2006 The use of β-adrenergic blockade in preventing trauma-induced hepatomegaly. Ann Surg 243:115-120 (Pubitemid 43054063)
31. Nonogaki K 2000 New insights into sympathetic regulation of glucose and fat metabolism. Diabetologia 43:533-549 (Pubitemid 30322070)
32. Stocks JM, Taylor NA, Tipton MJ, Greenleaf JE 2004Humanphysiological responses to cold exposure. Aviat Space Environ Med 75: 444-457
33. Roatta S, FarinaD2010 Sympathetic actions on the skeletal muscle. Exerc Sport Sci Rev 38:31-35
34. Shanks RG 1991 Clinical pharmacology of vasodilatory β-blocking drugs. Am Heart J 121:1006-1011
35. Cannon B, Nedergaard J 2004 Brown adipose tissue: Function and physiological significance. Physiol Rev 84:277-359 (Pubitemid 38054374)
36. VrydagW,MichelMC2007 Tools to study β 3-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 374:385-398
37. Lynch GS, Ryall JG 2008 Role of β-adrenoceptor signaling in skeletal muscle: Implications for muscle wasting and disease. Physiol Rev 88:729-767 (Pubitemid 351520091)
38. Baba S, Tatsumi M, Ishimori T, Lilien DL, Engles JM, Wahl RL 2007 Effect of nicotine and ephedrine on the accumulation of 18FFDG in brown adipose tissue. J Nucl Med 48:981-986 (Pubitemid 46909927)
39. Söderlund V, Larsson SA, Jacobsson H 2007 Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol. Eur J Nucl Med Mol Imaging 34:1018-1022 (Pubitemid 46919548)
40. Agrawal A, Nair N, BaghelNS2009Anovel approach for reduction of brown fat uptake on FDG PET. Br J Radiol 82:626-631
41. Nedergaard J, Cannon B 2010 The changed metabolic world with human brown adipose tissue: Therapeutic visions. Cell Metab 11: 268-272