The effects of flavonoids on bone

Current Osteoporosis Reports

Volumn 12, Issue 2, 2014, Pages 205-210

  Welch, Ailsa A ^a   Hardcastle, Antonia C ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Anthocyanins; Catechins; Flavones; Flavonoids; Fractures; Osteoporosis

Indexed keywords

FLAVONOID; INTERLEUKIN 1; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 7; TUMOR NECROSIS FACTOR ALPHA; ANTHOCYANIN; CATECHIN; FLAVONE DERIVATIVE;

BONE; BONE DENSITY; BONE MASS; BONE REMODELING; DIET SUPPLEMENTATION; FOOD COMPOSITION; HIP FRACTURE; HUMAN; INTRACELLULAR SIGNALING; MEDICAL RESEARCH; NONHUMAN; NUTRITIONAL ASSESSMENT; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PHYTOCHEMISTRY; REVIEW; SEX DIFFERENCE; DIET; FEMALE; MALE; METABOLISM; OSTEOPOROTIC FRACTURES; PHYSIOLOGY; STATISTICS AND NUMERICAL DATA;

ANTHOCYANINS; BONE AND BONES; BONE DENSITY; CATECHIN; DIET; FEMALE; FLAVONES; FLAVONOIDS; HUMANS; MALE; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES;

EID: 84904171725     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-014-0212-5     Document Type: Review

References (48)

1. van Staa TP, Dennison EM, Leufkens HG, Cooper C. Epidemiology of fractures in England and Wales. Bone. 2001;29(6):517-22. (Pubitemid 33124293)
2. Sambrook P, Cooper C. Osteoporosis. Lancet. 2006;367(9527):2010-8. (Pubitemid 43867702)
3. Hardcastle AC, Aucott L, Fraser WD, Reid DM, Macdonald HM. Dietary patterns, bone resorption and bone mineral density in early post-menopausal Scottish women. Eur J Clin Nutr. 2011;65(3):378-85.
4. McNaughton SA, Wattanapenpaiboon N, Wark JD, Nowson CA. An energy-dense, nutrient-poor dietary pattern is inversely associated with bone health in women. J Nutr. 2011;141(8):1516-23.
5. • Weaver CM, Alekel DL, Ward WE, Ronis MJ. Flavonoid intake and bone health. J Nutr Gerontol Geriat. 2012;31(3):239-53. A comprehensive review of flavonoid intake and bone health.
6. Wei P, Liu M, Chen Y, Chen DC. Systematic review of soy isoflavone supplements on osteoporosis in women. Asia Pac J Trop Med. 2012;5(3):243-8.
7. Svedbom A, Hernlund E, Ivergard M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: a compendium of country-specific reports. Arch Osteoporos. 2013;8(1-2):137.
8. Becker DJ, Kilgore ML, Morrisey MA. The societal burden of osteoporosis. Curr Rheumatol Rep. 2010;12(3):186-91.
9. The Surgeon General. Bone Health and Osteoporosis: a report of the Surgeon General. Rockville, MD: US Department ofHealth and Human Services, Office of the Surgeon General. 2004.
10. United Nations. World Population Prospects: the 2012 Revision, Highlights and Advance Tables. 2013.
11. Tucker KL, Chen H, Hannan MT, Cupples LA, Wilson PW, Felson D, et al. Bone mineral density and dietary patterns in older adults: the Framingham osteoporosis study. Am J Clin Nutr. 2002;76(1):245-52. (Pubitemid 34686574)
12. Chen YM, Ho SC, Woo JL. Greater fruit and vegetable intake is associated with increased bone mass among postmenopausal Chinese women. Br J Nutr. 2006;96(4):745-51. (Pubitemid 46470199)
13. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 1999;69(4):727-36. (Pubitemid 29193397)
14. Zalloua PA, Hsu YH, Terwedow H, Zang T, Wu D, Tang G, et al. Impact of seafood and fruit consumption on bone mineral density. Maturitas. 2006
15. Prynne CJ, Mishra GD, O'Connell MA, Muniz G, Laskey MA, Yan L, et al. Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts. Am J Clin Nutr. 2006;83(6):1420-8. (Pubitemid 44713075)
16. Hardcastle A. The influence of fruit and vegetables on postmenopausal women's bone health: Aberdeen University; 2008.
17. Macdonald HM, Black AJ, Aucott L, Duthie G, Duthie S, Sandison R, et al. Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial. Am J Clin Nutr. 2008;88(2):465-74.
18. Macdonald HM, Hardcastle AC, Duthie GG, Duthie SJ, Aucott L, Sandison R, et al. Changes in vitamin biomarkers during a 2-year intervention trial involving increased fruit and vegetable consumption by free-living volunteers. Br J Nutr. 2009;102(10):1477-86 [Epub Jun 23, 2009].
19. Lin P-H, Ginty F, Appel LJ, Aickin M, Bohannon A, Garnero P, et al. The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults. J Nutr. 2003;133(10):3130-6. (Pubitemid 37222227)
20. Muhlbauer RC, Lozano A, Reinli A. Onion and a mixture of vegetables, salads, and herbs affect bone resorption in the rat by a mechanism independent of their base excess. J Bone Miner Res. 2002;17(7):1230-6. (Pubitemid 34680499)
21. USDA database for the flavonoid content of selected foods [Internet]. 2013. Available at: http://www.ars.usda.gov/nutrientdata/flav.
22. Amanatidis S, Mackerras D, Simpson JM. Comparison of two frequency questionnaires for quantifying fruit and vegetable intake. Pub Health Nutr. 2001;4(2):233-9. (Pubitemid 32318676)
23. Haraldsdottir J. Minimizing error in the field: quality control in dietary surveys. Eur J Clin Nutr. 1993;47 Suppl 2:S19-24. (Pubitemid 23308124)
24. Bingham S, Luben R, Welch A, Low YL, Khaw KT, Wareham N, et al. Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study. Int J Epidemiol. 2008;37(5):978-87.
25. •• Hardcastle AC, Aucott L, Reid DM, Macdonald HM. Associations between dietary flavonoid intakes and bone health in a Scottish population. J Bone Miner Res. 2011;26(5):941-7. The first study looking at associations between flavonoids and bone health in humans.
26. Kyle JA. Flavonoids in Health and Disease: University of Aberdeen; 2006.
27. Chun OK, Lee SG, Wang Y, Vance T, Song WO. Estimated flavonoid intake of the elderly in the United States and around the world. J Nutr Gerontol Geriatr. 2012;31(3):190-205.
28. •• Welch A, MacGregor A, Jennings A, Fairweather-Tait S, Spector T, Cassidy A. Habitual flavonoid intakes are positively associated with bone mineral density in women. J Bone Miner Res. 2012;27(9):1872-8. The second published study on associations between human bone health and flavonoid intakes.
29. Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med. 1995;155(4):381-6.
30. Kimira M, Arai Y, Shimoi K, Watanabe S. Japanese intake of flavonoids and isoflavonoids from foods. J Epidemiol. 1998;8(3):168-75. (Pubitemid 128788426)
31. Johnell O, Gullberg B, Kanis JA, Allander E, Elffors L, Dequeker J, et al. Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study. J Bone Miner Res. 1995;10(11):1802-15.
32. Kanis J, Johnell O, Gullberg B, Allander E, Elffors L, Ranstam J, et al. Risk factors for hip fracture in men from southern Europe: the MEDOS study. Mediterranean Osteoporosis Study. Osteoporos Int. 1999;9(1):45-54. (Pubitemid 29086164)
33. Hernandez-Avila M, Stampfer MJ, Ravnikar VA, Willett WC, Schiff I, Francis M, et al. Caffeine and other predictors of bone density among pre- and peri-menopausal women. Epidemiology. 1993;4(2):128-34. (Pubitemid 23102081)
34. Wu CH, Yang YC, Yao WJ, Lu FH, Wu JS, Chang CJ. Epidemiological evidence of increased bone mineral density in habitual tea drinkers. Arch Intern Med. 2002;162(9):1001-6. (Pubitemid 34492528)
35. Hegarty VM, May HM, Khaw KT. Tea drinking and bone mineral density in older women. Am J Clin Nutr. 2000;71(4):1003-7. (Pubitemid 30176586)
36. Chen Z, Pettinger MB, Ritenbaugh C, LaCroix AZ, Robbins J, Caan BJ, et al. Habitual tea consumption and risk of osteoporosis: a prospective study in the women's health initiative observational cohort. Am J Epidemiol. 2003;158(8):772-81. (Pubitemid 37237241)
37. Welch A, Camus J, Dalzell N, Oakes S, Reeve J, Khaw KT. Broadband ultrasound attenuation (BUA) of the heel bone and its correlates in men and women in the EPIC-Norfolk cohort: a cross-sectional population-based study. Osteoporos Int. 2004;15(3):217-25 [Epub Jan 28, 2004]. (Pubitemid 38391537)
38. Khaw KT, Reeve J, Luben R, Bingham S, Welch A, Wareham N, et al. Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet. 2004;363(9404):197-202. (Pubitemid 38114717)
39. Das S, Crockett JC. Osteoporosis - a current view of pharmacological prevention and treatment. Drug Design Dev Ther. 2013;7:435- 48.
40. Nishimura R, Hata K, Matsubara T, Wakabayashi M, Yoneda T. Regulation of bone and cartilage development by network between BMP signalling and transcription factors. J Biochem. 2012;151(3):247-54.
41. Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 2008;473(2):139-46.
42. Shen CL, Yeh JK, Cao JJ, Chyu MC, Wang JS. Green tea and bone health: evidence from laboratory studies. Pharmacol Res. 2011;64(2):155-61.
43. Khosla S, Melton III LJ, Riggs BL. The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed? J Bone Miner Res. 2011;26(3):441-51.
44. • Nieves JW. Skeletal effects of nutrients and nutraceuticals, beyond calcium and vitamin D. Osteoporos Int. 2013;24(3):771-86. A comprehensive review of nutrients and bioactive compounds.
45. Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010;31(3):266-300.
46. Shen CL, von Bergen V, Chyu MC, Jenkins MR, Mo H, Chen CH, et al. Fruits and dietary phytochemicals in bone protection. Nutr Res. 2012;32(12):897-910.
47. Peluso I, Raguzzini A, Serafini M. Effect of flavonoids on circulating levels of TNF-alpha and IL-6 in humans: a systematic review and meta-analysis. Molec Nutr Food Res. 2013;57(5):784-801.
48. • Horcajada MN, Offord E. Naturally plant-derived compounds: role in bone anabolism. Curr Molec Pharmacol. 2012;5(2):205-18. A comprehensive review of the role of plant-derived compounds on mechanisms relating to bone health.