NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles: Conformational changes are a key to antimicrobial activity

Journal of Biological Chemistry

Volumn 278, Issue 15, 2003, Pages 13110-13117

  Hsu, Shang Te D ^a   Breukink, Eefjan ^b   Bierbaum, Gabriele ^c   Sahl, Hans Georg ^c   De Kruijff, Ben ^b   Kaptein, Rob ^a   Van Nuland, Nico A J ^a   Bonvin, Alexandre M J J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; CRYSTAL STRUCTURE; LIPIDS; MICELLES; NUCLEAR MAGNETIC RESONANCE; TITRATION; X RAY ANALYSIS;

CELL WALL SYNTHESIS;

BIOCHEMISTRY;

4 AMINOBUTYRIC ACID; ALANINE; DODECYLPHOSPHORYLCHOLINE; LANTIBIOTIC; LIPID; MERSACIDIN; METHANOL; WATER; ANTIINFECTIVE AGENT; BACTERIOCIN; CYCLOPEPTIDE; DRUG DERIVATIVE; MURAMYL NAC (PENTAPEPTIDE)PYROPHOSPHORYL UNDECAPRENOL; MURAMYL-NAC-(PENTAPEPTIDE)PYROPHOSPHORYL-UNDECAPRENOL; PEPTIDE; PHOSPHORYLCHOLINE; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG CONFORMATION; MICELLE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BACILLUS; CHEMICAL STRUCTURE; CHEMISTRY; ISOLATION AND PURIFICATION; METHODOLOGY; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; SOLUTION AND SOLUBILITY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACILLUS; BACTERIOCINS; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PEPTIDES, CYCLIC; PHOSPHORYLCHOLINE; PROTEIN CONFORMATION; SOLUTIONS; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID;

EID: 0037699956     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211144200     Document Type: Article

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