Discovery of novel P-glycoprotein-mediated multidrug resistance inhibitors bearing triazole core via click chemistry

Chemical Biology and Drug Design

Volumn 84, Issue 2, 2014, Pages 182-191

  Liu, Baomin ^a   Qiu, Qianqian ^a   Zhao, Tianxiao ^a   Jiao, Lei ^a   Hou, Jianyu ^a   Li, Yunman ^a   Qian, Hai ^a   Huang, Wenlong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

click chemistry; multidrug resistance inhibitors; P glycoprotein; reversal activity

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; TETRAHYDROISOQUINOLINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL; WK X 34; WX K 34; ANTINEOPLASTIC ANTIBIOTIC; BENZAMIDE DERIVATIVE; WK-X-34;

ARTICLE; CHEMOSENSITIZATION; CLICK CHEMISTRY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; K562 CELL LINE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; METABOLISM; MULTIDRUG RESISTANCE; NEOPLASMS;

ANTIBIOTICS, ANTINEOPLASTIC; BENZAMIDES; CLICK CHEMISTRY; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; HUMANS; K562 CELLS; NEOPLASMS; P-GLYCOPROTEIN; TRIAZOLES;

EID: 84904131625     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12301     Document Type: Article

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