Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines

Journal of Cancer Research and Clinical Oncology

Volumn 140, Issue 7, 2014, Pages 1103-1109

  Germoush, Mousa O ^a   Mahmoud, Ayman M ^b  

^a JOUF UNIVERSITY   (Saudi Arabia)

^b BENI SUEF UNIVERSITY   (Egypt)

Author keywords

Berberine; Cyclophosphamide; Cytokines; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BERBERINE; BILIRUBIN; CYCLOOXYGENASE 2; CYCLOPHOSPHAMIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID; MESSENGER RNA; SERUM ALBUMIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DRUG EFFICACY; ENZYME ACTIVITY; GENE EXPRESSION; LIPID PEROXIDATION; LIVER FUNCTION; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; TOXIC HEPATITIS;

ANIMALS; BERBERINE; CYCLOPHOSPHAMIDE; CYTOKINES; CYTOPROTECTION; DRUG-INDUCED LIVER INJURY; INFLAMMATION MEDIATORS; LIVER FUNCTION TESTS; MALE; OXIDATIVE STRESS; RATS;

EID: 84904129987     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-014-1665-8     Document Type: Article

References (44)

1. Baumann F, Preiss R (2001) Cyclophosphamide and related anticancer drugs. J Chromatogr B Biomed Sci Appl 764:173-192 (Pubitemid 33044665)
2. Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61(5):882-888
3. Beyaert R, Fiers W (1998) Tumor necrosis factor and lymphotoxin. In: Mire-Sluis AR, Thorpe R (eds) Cytokines. Academic Press, San Diego, pp 335-359
4. Bukowski R (1999) The need for cytoprotection. Eur J Cancer 32A:S2-S4
5. Canadian Council on Animal Care (1993) Guide to the care and use of experimental animals, vol 2. CCAC, Ottawa
6. Cho BJ, Im EK, Kwon JH et al (2005) Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells. Mol Cell 20:429-434
7. Choi BH, Ahn IS, Kim YH et al (2006) Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Exp Mol Med 38:599-605
8. Chomzynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Annu Rev Biochem 162:156-159
9. Cicero AF, Rovati LC, Setnikar I (2007) Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol lowering agents. A single-blind clinical investigation. Arzneimittelforschung 57:26-30 (Pubitemid 46212985)
10. Das UB, Mallick M, Debnath JM, Ghosh D (2002) Protective effect of ascorbic acid on cyclophosphamide-induced testicular gametogenic and androgenic disorder in male rats. Asian J Androl 4:201-207
11. Feng AW, Gao W, Zhou GR, Yu R, Li N, Huang XL, Li QR, Li JS (2012) Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia. Int Immunopharmacol 12:182-188
12. Ghosh D, Das UB, Ghosh S, Mallick M, Debnath J (2002) Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: a correlative study with testicular oxidative stress. Drug Chem Toxicol 25:281-292 (Pubitemid 34831279)
13. Gonzalez-Amaro R, Garcia-Monzon C, Garcia-Buey L, Moreno-Otero R, Alonso JL, Yague E, Pivel JP, Lopez-Cabrera M, Fernandez-Ruiz E, Sanchez-Madrid F (1994) Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis. J Exp Med 179:841-848 (Pubitemid 24065641)
14. Haque R, Bin-Hafeez B, Parvez S, Pandey S, Sayeed I, Ali M, Raisuddin S (2003) Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide-induced biochemical toxicity. Hum Exp Toxicol 22:473-480 (Pubitemid 37279290)
15. Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, Billiar TR, Tweardy DJ (1998) Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 187:917-928 (Pubitemid 28141665)
16. Hsiang CY, Wu SL, Cheng SE, Ho TY (2005) Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci 12:791-801
17. Hwang JM, Wang CJ, Chou FP et al (2002) Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver. Arch Toxicol 76:664-670
18. IFCC (1983) Methods for the measurement of catalytic concentration of enzymes. J Clin Chem Clin Biochem 18:521-534
19. Imanshahidi M, Hosseinzadeh H (2008) Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res 22:999-1012
20. Jeong HW, Hsu KC, Lee JW, Ham M, Huh JY, Shin HJ, Kim WS, Kim JB (2009) Berberine suppresses proinflammatory responses through AMPK activation in macrophages. Am J Physiol Endocrinol Metab 296:E955-E964
21. Kaplan LA, Pesce AJ (1984) Clinical chemistry: theory, analysis, and correlation. Mosby, St. Louis, pp 1032-1036
22. Kar M, Mishra D (1976) Catalase, peroxidase and polyphenoloxidase activities during rice leaf senescence. Plant Physiol 57:315-319
23. Ko YJ, Lee JS, Park BC, Shin HM, Kim JA (2007) Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells. Vasc Pharmacol 47:189-196 (Pubitemid 47095457)
24. Kumar G, Banu SG, Kannan V, Pandian RM (2005) Antihepatotoxic effect of β-carotene on paracetamol induced hepatic damage in rats. Ind J Exp Biol 43:351-355 (Pubitemid 40554711)
25. Lahouel M, Fillastre JP (2004) Role of flavonoids in the prevention of haematoxicity due to chemotherapeutic agents. Haema 7:313-320 (Pubitemid 39071077)
26. Lindley CMG, Hamilton JS, McCune S, Faucette S, Shord RL, Hawke H et al (2002) The effect of cyclophosphamide with and without dexamethasone on cytochrome p450 3A4 and 2B6 in human hepatocytes. Drug Metab Dispos 30:814-822 (Pubitemid 34671094)
27. Luo A, Fan Y (2011) Antioxidant activities of berberine hydrochloride. J Med Plants Res 5:3702
28. Mahmoud AM, Hussein OE, Ramadan SA (2013) Amelioration of cyclophosphamide-induced hepatotoxicity by the brown seaweed Turbenaria ornata. Int J Clin Toxicol 1:9-17
29. Marklund SL, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3):469-474
30. McDiarmid MA, Iype PT, Koldner K, Jacobnson KD, Strickland PT (1991) Evidence for acrolein-modified DNA in peripheral blood leu-cocytes of cancer patients treated with cyclophosphamide. Mutat Res 248:93-99
31. Murray R (1984) Aspartate aminotransferase. In: Kaplan A et al (eds) Clinical Chemistry. The CV Mosby Co, St Louis, Toronto, Princeton, pp 1112-1116
32. Nussler AK, Billiar TR (1993) Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol 54:171-178 (Pubitemid 23276408)
33. Peng PL, Hsieh YS, Wang CJ, Hsu JL, Chou FP (2006) Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicol Appl Pharmacol 214:8-15
34. Preuss HG, Jarrell ST, Scheckenbach R, Lieberman S, Anderson RA (1998) Comparative effect of chromium vanadium and Gymnema sylvestre on sugar-induced blood pressure elevation in SHR. J Am Coll Nutr 17:116-123 (Pubitemid 28160512)
35. Selvakumar E, Prahalathan C, Mythili Y, Varalakshmi P (2005) Mitigation of oxidative stress in cyclophosphamide-challenged hepatic tissue by DL-alpha-lipoic-acid. Mol Cell Biochem 272:179-185 (Pubitemid 40867379)
36. Simeonova PP, Gallucci RM, Hulderman T, Wilson R, Kommineni C, Rao M, Luster MI (2001) The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride. Toxicol Appl Pharmacol 177:112-120 (Pubitemid 34033045)
37. Sindhu G, Susithra M, Vijayalakshmi N (2012) Evaluation of the hepatoprotective effect of berberine in paracetamol induced experimental hepatotoxicity in Wistar rats. Int J Recent Sci Res 3(7):569-573
38. Sudharsan PT, Mythili Y, Selvakumar E, Varalakshmi P (2006) Lupeol and its ester exhibit protective role against cyclophosphamide-induced cardiac mitochondrial toxicity. J Cardiovasc Pharmacol 47(2):205-210 (Pubitemid 44384058)
39. Tang LQ, Wei W, Chen LM, Liu S (2006) Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol 108:109-115 (Pubitemid 44498992)
40. Teitz N (1986) Fundam of Clin Chem. W. B. Saunders Co., Philadelphia
41. Uchida K (1999) Current status of acrolein as a lipid product. Trends Cardiovasc Med 9:109-113
42. Vane JR, Bakhle YS, Botting RM (1998) Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38:97-120 (Pubitemid 28231490)
43. Webster D (1974) A study of the interaction of bromcresol green with isolated serum globulin fractions. Clin Chim Acta 53:109-115
44. Yu H, Kim KJ, Cha JD et al (2005) Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillinresistant Staphylococcus aureus. J Med Food 8:454-461 (Pubitemid 43121896)