Lupeol and its ester exhibit protective role against cyclophosphamide- induced cardiac mitochondrial toxicity

Journal of Cardiovascular Pharmacology

Volumn 47, Issue 2, 2006, Pages 205-210

  Sudharsan, Periyasamy Thandavan ^a   Mythili, Yenjerla ^a   Selvakumar, Elangovan ^a   Varalakshmi, Palaninathan ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Cyclophosphamide; Electron microscopy; Lupeol; Lupeol inoleate; Mitochondrial dysfunction

Indexed keywords

CYCLOPHOSPHAMIDE; ESTER DERIVATIVE; ISOCITRATE DEHYDROGENASE; LUPEOL; LUPEOL LINOLEATE; MALATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; ALKYLATING AGENT; CARDIOTONIC AGENT; ESTER; MULTIENZYME COMPLEX; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; CRATAEVA NURVALA; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ELECTRON MICROSCOPY; ELECTRON TRANSPORT; ENZYME ACTIVITY; HEART MITOCHONDRION; HEART PROTECTION; MALE; MEDICINAL PLANT; NONHUMAN; PLANT STEM; PRIORITY JOURNAL; RAT; ANIMAL; CELL NUCLEUS; COMPARATIVE STUDY; ENZYMOLOGY; HEART MUSCLE; METABOLISM; MICROFILAMENT; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CARDIOTONIC AGENTS; CELL NUCLEUS; CYCLOPHOSPHAMIDE; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ESTERS; MALE; MICROFILAMENTS; MITOCHONDRIA, HEART; MYOCARDIUM; RATS; RATS, WISTAR; TRITERPENES;

EID: 33746411167     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000200658.89629.ba     Document Type: Article

References (36)

1. Lee LK, Harman GS, Hohl RJ, et al. Fatal cyclophosphamide cardiomyopathy: its clinical course and treatment. Bone Marrow Transpl. 1996;18:573-577.
2. Moore MJ. Clinical pharmacokinetics of cyclophosphamide. Clin Pharmacokinet. 1991;20:194-208.
3. 2+ dependent damage of rat heart and liver mitochondria by cyclosporin A. Comp Biochem Phys A. 1998;121:209-214.
4. Ai-Harbi MM, Qureshi S, Ahmed MM, et al. Effect of camel urine on the cytological and biochemical changes induced by cyclophosphamide in mice. J Ethnopharmacol. 1996;52:129-137.
5. Sudharsan PT, Mythili Y, Selvakumar E, et al. Lupeol and its ester ameliorate the cyclophosphamide provoked cardiac lysosomal damage studied in rat. Mol Cell Biochem. 2006;282:23-29.
6. Patocka J. Biologically active pentacyclic triterpenes and their current medicine signification. J Appl Biomed. 2003;1:7-12.
7. Sunitha M, Nagaraj M, Varalakshmi P. Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defense system in cadmium-induced hepatotoxicity in rats. Fitoterapia. 2001;72:516-523.
8. Vidya L, Malini MM, Varalakshmi P. Effect of Pentacyclic triterpenes on oxalate induced changes in rat erythrocytes. Pharmacol Res. 2000;42:314-316.
9. Geetha T, Varalakshmi P. Anti inflammatory activity of lupeol and lupeol linoleate in adjuvant induced arthritis. Fitoterapia. 1998;69:13-19.
10. Saleem R, Ahmad SI, Ahmed M, et al. Hypotensive activity and toxicology of constituents from Bombax ceiba stem bark. Biol Pharm Bull. 2003;26:41-46.
11. Nicolosi RJ, Rogers EJ, Kritchevsky D, et al. Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery. 1997;22:266-277.
12. Kikugawa K. Effect of ω 6 and ω 3 fatty acid supplementation on rat tissue lipid peroxidation. World Rev Nutr Diet. 2001;88:28-34.
13. Nikiema JB, Vanhaelen-Fastre R, Vanhaelen M, et al. Effects of anti-inflammatory triterpenes isolated from Leptadenia hastata latex on keratinocyte proliferation. Phytother Res. 2001;15:131-134.
14. Sudharsan PT, Mythili Y, Selvakumar E, et al. Cardioprotective effect of pentacyclic triterpene, lupeol and its ester on cyclophosphamide induced oxidative stress. Hum Exp Toxicol. 2005;24:313-318.
15. Sudharsan PT, Mythili Y, Sudhahar V, et al. Role of lupeol and its ester on cyclophosphamide induced hyperlipidemic cardiomyopathy in rats. J Pharm Pharmacol. 2005;57:1437-1444.
16. Baskar R, Malini MM, Varalakshmi P, et al. Effect of lupeol isolated from Crataeva nurvala stem bark against free radical induced toxicity in experimental urolithiasis. Fitoterapia. 1996;67:121-125.
17. Takasawa M, Hayakawa M, Sugiyama S, et al. Age associated damage in mitochondrial function in rat hearts. Exp Gerontol. 1993;28:269-280.
18. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
19. Bernt E, Bergmeyer HU. Methods of Enzymatic Analysis. New York: Academic Press; 1974:624-627.
20. Slater EC, Borner WD. The effect of fluoride on the succinic oxidase system. Biochem J. 1952;52:185-196.
21. Mehler AH, Kornberg A, Grisolia S, et al. The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate. J Biol Chem. 1948;174:961-977.
22. Minakami S, Ringer RL, Singer TP. Studies on the respiratory chain-linked dihydrodiphosphopyridine nucleotide dehydrogenase. I. Assay of the enzyme in particulate and in soluble preparations. J Biol Chem. 1962;237:569-576.
23. Ziegler DM, Doeg KA. Studies on the electron transport system. The isolation of a succinic-coenzyme Q reductase from beef heart mitochondria. Arch Biochem Biophys. 1962;97:41-50.
24. Green DE, Burkhard RK. Studies on the electron transport system. 33. Succinic-cytochrome c reductase. Arch Biochem Biophys. 1961;92:312-320.
25. Wharton DC, Tzagoloff A. Cytochrome oxidase from beef heart mitochondria. Methods Enzymol. 1967;10:240-250.
26. Wutzen J. Cyclophosphamide effect on ultrastructural myocardial changes in rats on low-magnesium diet. Mater Med Pol. 1992;24:35-40.
27. Robert WG, Jeanne MLS, Roderick AC. The cristal membrane of mitochondria is the principal site of oxidative phosphorylation. FEBS Lett. 2003;546:355-358.
28. Lee SM, Huh TL, Park JW. Inactivation of NADP+-dependent isocitrate dehydrogenase by reactive oxygen species. Biochimie. 2001;83:1057-1065.
29. Anderson D, Bishop JB, Garner RC, et al. Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. Mutat Res. 1995;330:115-181.
30. Pushpa S, Paul DM. Ascorbate reduces superoxide production and improves mitochondrial respiratory chain function in human fibroblasts with electron transport chain deficiencies. Mitochondrion. 2001;1:191-198.
31. Clayton DA. Replication of animal mitochondrial DNA. Cell. 1982;28:693-705.
32. Pitakanen S, Robinson BH. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J Clin Invest. 1996;98:345-351.
33. Raha S, McEachern EG, Myint TA, et al. Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase. Free Radic Biol Med. 2000;29:170-180.
34. Drouet M, Lauthier F, Charmes JP, et al. Age associated changes in mitochondrial parameters on peripheral human lymphocytes. Exp Gerontol. 1999;34:69-78.
35. Singh RJ. Glutathione: a marker and antioxidant for aging. J Lab Clin Med. 2002;140:380-381.
36. Paradies G, Ruggiero FM, Petrosillo G, et al. Age-dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipin. FEBS Lett. 2001;406:136-138.