An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

Biochemical Journal

Volumn 461, Issue 3, 2014, Pages 531-537

  Zhang, Jiazhen ^a   Clark, Kristopher ^a   Lawrence, Toby ^b   Peggie, Mark W ^a   Cohen, Philip ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

Inhibitor of nuclear factor B kinase (IKK); Interleukin 1 (IL 1); Linear ubiquitin chain assembly complex (LUBAC); Nuclear factor B(NF B); Transforming growth factor activated kinase 1 (TAK1)

Indexed keywords

I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE GAMMA; INTERLEUKIN 1ALPHA; LINEAR UBIQUITIN CHAIN ASSEMBLY COMPLEX PROTEIN; SERINE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SUBSTITUTION; ANIMALS; CELLS, CULTURED; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; GENE KNOCK-IN TECHNIQUES; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE KINASE KINASES; MICE; MICE, TRANSGENIC; MUTANT PROTEINS; PHOSPHORYLATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; SERINE; UBIQUITINATION;

EID: 84904128358     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140444     Document Type: Article

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