The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

Cell Stress and Chaperones

Volumn 19, Issue 4, 2014, Pages 559-568

  Nahas, Eliana A P ^a   Nahas Neto, Jorge ^a   Orsatti, Claudio L ^a   Tardivo, Ana Paula ^a   Uemura, Gilberto ^a   Peraçoli, Maria Terezinha S ^a   Witkin, Steven S ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cardiovascular risk; Heat shock proteins; Menopause; Metabolic syndrome

Indexed keywords

ANTIBODY; C REACTIVE PROTEIN; CHAPERONIN 60; CHOLESTEROL; GLUCOSE; HEAT SHOCK PROTEIN 60 ANTIBODY; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 ANTIBODY; HIGH DENSITY LIPOPROTEIN; INSULIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; HSPD1 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN;

ABDOMINAL FAT; ADULT; AGED; AMENORRHEA; ARTICLE; BRAZIL; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENDOCRINE FUNCTION TEST; FEMALE; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; METABOLIC PARAMETERS; METABOLIC SYNDROME X; POSTMENOPAUSE; PRIORITY JOURNAL; RISK ASSESSMENT; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; BLOOD; CARDIOVASCULAR DISEASES; COMPLICATION; CROSS-SECTIONAL STUDY; EPIDEMIOLOGY; MIDDLE AGED; RISK FACTOR;

AGED; BRAZIL; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHAPERONIN 60; CROSS-SECTIONAL STUDIES; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; METABOLIC SYNDROME X; MIDDLE AGED; MITOCHONDRIAL PROTEINS; POSTMENOPAUSE; RISK FACTORS; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84904103935     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-013-0483-2     Document Type: Article

References (63)

1. Adult Treatment Panel III (2001) Executive Summary of The Third Report of the National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. JAMA 285(19):2486-2497
2. Agrinier N, Cournot M, Dallongeville J, Arveiler D, Ducimetière P, Ruidavets JB, Ferrières J (2010) Menopause and modifiable coronary heart disease risk factors: a population based study. Maturitas 65(3):237-243
3. American Diabetes Association (ADA) (2006) Standards of medical care in diabetes - 2006. Diabetes Care 29(suppl 1):S4-S42
4. Armutcu F, Ataymen M, Atmaca H, Gurel A (2008) Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome. Clin Chem LabMed 46(6):785-790 (Pubitemid 351821641)
5. Barinas-Mitchell E, Cushman M, Meilahn EN, Tracy RP, Kuller LH (2001) Serum levels of C-reactive protein are associated with obesity, weight gain and hormone replacement therapy in healthy postmenopausal women. Am J Epidemiol 153(11):1094-1101 (Pubitemid 32493259)
6. Belfki H, Ben Ali S, Bougatef S, Ben Ahmed D, Haddad N, Jmal A, Abdennebi M, Ben Romdhane H (2012) Relationship of C-reactive protein with components of the metabolic syndrome in a Tunisian population. Eur J Intern Med 23(1):e5-e9
7. Bielecka-Dabrowa A, Barylski M, Mikhailidis DP, Rysz J, Banch M (2009) HSP 70 and atherosclerosis-protector or activator? Expert Opin Ther Targets 13(3):307-317
8. Blümel JE, Legorreta D, Chedraui P, Ayala F, Bencosme A, Danckers L, Lange D, Espinoza MT, Gomez G, Grandia E, Izaguirre H, Manriquez V, Martino M, Navarro D, Ojeda E, Onatra W, Pozzo E, Prada M, Royer M, Saavedra JM, Sayegh F, Tserotas K, Vallejo MS, Zuñiga C, Collaborative Group for Research of the Climacteric in Latin America (REDLINC) (2012) Optimal waist circumference cutoff value for defining themetabolic syndrome in postmenopausal Latin American women. Menopause 19(4):433-437
9. Calderwood SK, Mambula SS, Gray PJ Jr (2007) Extracellular heat shock proteins in cell signaling and immunity. Ann N YAcad Sci 1113(1):28-39
10. Chung J, Nguyen AK, Henstridge DC, Holmes AG, Chan MH, Mesa JL, Lancaster GI, Southgate RJ, Bruce CR, Duffy SJ, Horvath I, Mestril R, Watt MJ, Hooper PL, Kingwell BA, Vigh L, Hevener A, Febbraio MA (2008) HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A 105:1739-1744 (Pubitemid 351346584)
11. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R (2005) Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111(11):1448-1454 (Pubitemid 40396812)
12. Ding OF, Hayashi T, Zhang XJ, Funami J, Ge L, Li J, Huang XL, Cao L, Zhang J, Akihisa I (2007) Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly postmenopausal women. J Diabetes Compl 21(5):315-319 (Pubitemid 47354230)
13. Dulin E, García-Barreno P, Guisasola MC (2010) Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in general population. Cell Stress Chaperones 15(6):929-937
14. Ellins E, Shamaei-Tousi A, Steptoe A, Donald A, O'Meagher S, Halcox J, Henderson B (2008) The relationship between carotid stiffness and circulating levels of heat shock protein 60 in middle-aged men and women. J Hypertens 26(12):2389-2392
15. Ford ES, Giles WH, Mokad AH (2004) Increasing prevalence of the metabolic syndrome among US adults. Diabetes Care 27(10):2444-2449 (Pubitemid 39281399)
16. Geloneze B, Repetto EM, Geloneze SR, Tambascia MA, Ermetice MN (2006) The threshold value for insulin resistance (HOMA-IR) in an admixture population IR in the Brazilian Metabolic Syndrome Study. Diabetes Res Clin Pract 72(2):219-220
17. Ghayour-Mobarhan M, Lamb DJ, Lovell DP, Livingstone C, Wang T, Ferns GAA (2005) Plasma antibody titres to heat shock proteins-60, -65 and-70: their relationship to coronary risk factors in dyslipidaemic patients and healthy individuals. Scand J Clin Lab Invest 65(7):601-613 (Pubitemid 43160456)
18. Ghayour-Mobarhan M, Taylor A, Lamb DJ, Ferns GA (2007) Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians. Int J Obes (Lond) 31(1):197-200 (Pubitemid 46006034)
19. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee (2013) Heart disease and stroke statistics - 2013 update: a report from the American Heart Association. Circulation 127(1):e6-e245
20. Gregor MF, Hotamisligil GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol 29(1):415-445
21. Gruden G, Barutta F, Pinach S, Lorenzati B, Cavallo-Perin P, Giunti S, Bruno G (2013) Circulating anti-Hsp70 levels in nascent metabolic syndrome: the Casale Monferrato Study. Cell Stress and Chaperones 18(3):353-357
22. Gupta S, Knowlton AA (2002) Cytosolic heat shock protein 60, hypoxia, and apoptosis. Circulation 106(21):2727-2733 (Pubitemid 35364929)
23. Herz I, Rosso R, Roth A, Keren G, George J (2006) Serum levels of anti heat shock protein 70 antibodies in patients with stable and unstable angina pectoris. Acute Card Care 8(1):46-50
24. Hooper PL, Hooper PL (2009) Inflammation, heat shock proteins, and type II diabetes. Cell Stress Chaperones 14(2):113-115
25. Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K (2008) Menopause and the metabolic syndrome: the study of women's health across the nation. Arch Intern Med 168(14):1568-1575
26. Kannel WB, D'Agostino RB, Sullivan L, Wilson PWF (2004) Concept and usefulness of cardiovascular risk profiles. Am Heart J 148(1):16-26 (Pubitemid 38900476)
27. Kocsis J, Veres A, Vatay A, Duba J, Karádi I, Füst G, Prohászka Z (2002) Antibodies against the human heat shock protein hsp70 in patients with severe coronary artery disease. Immunol Invest 31(3-4):219-231 (Pubitemid 35397078)
28. Lakoski SG, Greenland P, Wong ND, Schreiner PJ, Herrington DM, Kronmal RA, Liu K, Blumenthal RS (2007) Coronary artery calcium scores and risk for cardiovascular events in women classified as "low risk" based on Framingham Risk Score: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med 167(22):2437-2442 (Pubitemid 350254902)
29. Lambrinoudaki I, Armeni E, Georgiopoulos G, Kazani M, Kouskouni E, Creatsa M, Alexandrou A, Fotiou S, Papamichael C, Stamatelopoulos K (2013) Subclinical atherosclerosis in menopausal women with low to medium calculated cardiovascular risk. Int J Cardiol 164(1):70-76
30. Lann D, LeRoith D (2007) Insulin resistance as the underlying cause for the metabolic syndrome. Med Clin North Am 91(6):1063-1077 (Pubitemid 47625441)
31. Lin JW, Caffrey JL, Chang MH, Lin YS (2010) Sex, menopause, metabolic syndrome, and all-cause and cause-specific mortality-cohort analysis from the third national health and nutrition examination survey. J Clin Endocrin Metab 95(9):4258-4267
32. Lu X, Kakkar V (2010) The role of heat shock protein (HSP) in atherosclerosis: patho-physiology and clinical opportunists. Curr Med Chemistry 17(10):957-973
33. Mente A, Yusuf S, Islam S, McQueen MJ, Tanomsup S, Onen CL, Rangarajan S, Gerstein HC, Anand SS, INTERHEART Investigators (2010) Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries. J Am Coll Cardiol 55(21):2390-2398
34. Mosca L, Banka CL, Benjamin EJ, Berra K, Bushnell C, Dolor RJ, Ganiats TG, Gomes AS, Gornik HL, Gracia C, Gulati M, Haan CK, Judelson DR, Keenan N, Kelepouris E, Michos ED, Newby LK, Oparil S, Ouyang P, Oz MC, Petitti D, Pinn VW, Redberg RF, Scott R, Sherif K, Smith SC Jr, Sopko G, Steinhorn RH, Stone NJ, Taubert KA, Todd BA, Urbina E, Wenger NK, Expert Panel/Writing Group (2007) Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. Circulation 115(11):1481-1501 (Pubitemid 46648385)
35. Musaad S, Haynes EN (2007) Biomarkers of obesity and subsequent cardiovascular events. Epidemiol Rev 29(10):98-114 (Pubitemid 47229641)
36. Nahas EAP, Padoani NP, Nahas-Neto J, Orsatti FL, Tardivo AP, Dias R (2009) Metabolic syndrome and its associated risk factors in Brazilian postmenopausal women. Climacteric 12(5):431-438
37. Nahas EA, Andrade AM, Jorge MC, Orsatti CL, Dias FB, Nahas-Neto J (2013) Different tools for estimating cardiovascular risk in Brazilian postmenopausal women. Gynecol Endocrinol 29(10):921-925
38. Pappa T, Alevizaki M (2012) Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period. Eur J Endocrinol 167(2):145-156
39. Pelletier P, Lapointe A, Laflamme N, Piche ME, Weisnagel SJ, Nadeau A, Lemieux S, Bergeron J (2009) Discordances among different tools used to estimate cardiovascular risk in postmenopausal women. Can J Cardiol 25(12):e413-e416
40. Piché ME, Lemieux S, Weisnagel SJ, Corneau L, Nadeau A, Bergeron J (2005) Relation of high sensitivity C-protein, interleukin-6, tumor necrosis factor-alpha, and fibrinogen abdominal adipose tissue, blood pressure, and cholesterol and triglyceride levels in healthy postmenopausal women. Am J Cardiol 96(1):92-97 (Pubitemid 40853948)
41. Piegas LS, Avezum A, Pereira JC, Neto JM, Hoepfner C, Farran JA, Ramos RF, Timerman A, Esteves JP, AFIRMAR Study Investigators (2003) Risk factors for myocardial infarction in Brazil. Am Heart J 146(2):331-338 (Pubitemid 36951780)
42. Pockley AG, Wu R, Lemne C, Kiessling R, de Faire U, Frostegard J (2000) Circulating HSP 60 is associated with early cardiovascular disease. Hypertension 36(2):303-373
43. Pockley AG, de Faire U, Kiessling R, Lemne C, Thulin T, Frostegård J (2002) Circulating heat shock protein and heat shock protein antibody levels in established hypertension. J Hypertens 20(9):1815-1820
44. Prohászka Z, Duba J, Horváth L, Császár A, Karádi I, Szebeni A, Singh M, Fekete B, Romics L, Füst G (2001) Comparative study on antibodies to human and bacterial 60 kDa heat shock proteins in a large cohort of patients with coronary heart disease and healthy subjects. Eur J Clin Invest 31(4):285-292
45. Ridker PM, Hennekenes CH, Buring JE, Rifai N (2000) C-reactive protein and other marker of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342(12):836-843 (Pubitemid 30165206)
46. Royer M, Castelo-Branco C, Blümel JE, Chedraui PA, Danckers L, Bencosme A, Collaborative Group for Research of the Climacteric in Latin America (2007) The US national cholesterol education programme adult treatment panel III (NCEP ATP III): prevalence of the metabolic syndrome in postmenopausal Latin American women. Climacteric 10:164-170 (Pubitemid 46482170)
47. Schneider JG, Tompkins C, Blumenthal RS, Mora S (2006) The metabolic syndrome in women. Cardiol Res 14(6):286-291 (Pubitemid 44624587)
48. Shamaei-Tousi A, Halcox JP, Henderson B (2007) Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease. Cardiovasc Res 74(10):19-28 (Pubitemid 46366943)
49. Snoeckx LH, Cornelussen RN, Van Nieuwenhoven FA, Reneman RS, Van Der Vusse GJ (2001) Heat shock proteins and cardiovascular pathophysiology. Physiol Rev 81(4):1461-1497 (Pubitemid 32947777)
50. Sowers MF, Zheng H, Tomey K, Karvonen-Gutierrez C, Jannausch M, Li X, Yosef M, Symons J (2007) Changes in body composition in women over six years at midlife: ovarian and chronological aging. J Clin Endocrinol Metab 92(3):895-901 (Pubitemid 46465660)
51. Srivastava P (2002) Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2(3):185-194
52. WHO (2002) Diet, Nutrition and the prevention of chronic diseases. In: World Heath Organization. Geneva: WHO/FAO (Reports of WHO/FAO. Expert Consultation on diet, nutrition and prevention of chronic diseases)
53. Wildman RP, Kaplan R, Manson JE, Rajkovic A, Connelly SA, Mackey RH, Tinker LF, Curb JD, Eaton CB, Wassertheil-Smoller S (2011) Body size phenotypes and inflammation in the Women's Health Initiative Observational Study. Obesity (Silver Spring) 19(7):1482-1491
54. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97(18):1837-1847 (Pubitemid 28213628)
55. Xiao Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Kiechl S, Xu Q (2005) Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study. Stroke 36(12):2571-2576
56. Xu Q, Schett G, Perschinka H, Mayr M, Egger G, Oberhollenzer F, Willeit J, Kiechl S, Wick G (2000) Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation 102(1):14-20 (Pubitemid 30430547)
57. Young D, Camhi S, Wu T, Hagberg J, Stefanick M (2013) Relationships among changes in C-reactive protein and cardiovascular disease risk factors with lifestyle interventions. Nutr Metab Cardiovasc Dis 23(9):857-863
58. Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR (2006) Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR signaling. J Clin Invest 116(7):2022-2032 (Pubitemid 44033326)
59. Zhang C, Rexrode KM, vanDam RM, Li TY, Hu FB (2008a) Abdominal obesity and the risk of all-cause, cardio-vascular, and cancer mortality, 16 years of follow-up in US women. Circulation 117(13):1658-1667 (Pubitemid 351482590)
60. Zhang X, He M, Cheng L, Chen Y, Zhou L, Zeng H, Pockley AG, Hu FB, Wu T (2008b) Elevated heat shock protein 60 levels are associated with higher risk coronary disease in Chinese. Circulation 118(25):2687-2693
61. Zhang X, Xu Z, Zhou L, Chen Y, He M, Cheng L, Hu FB, Tanguay RM, Wu T (2010) Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk to acute coronary syndrome. Cell Stress Chaperones 15(5):675-686
62. Zhu J, Quyyumi AA, Rott D, Csako G, Wu H, Halcox J, Epstein SE (2001) Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis. Circulation 103(8):1071-1075 (Pubitemid 32200179)
63. Zhu J, Quyyumi AA, Wu H, Csako G, Rott D, Zalles-Ganley A, Ogunmakinwa J, Halcox J, Epstein SE (2003) Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease. Arterioscler Thromb Vasc Biol 23(6):1055-1059 (Pubitemid 36713560)