Heat shock proteins and cardiovascular pathophysiology

Physiological Reviews

Volumn 81, Issue 4, 2001, Pages 1461-1497

  Snoeckx, Luc H E H ^a   Cornelussen, Richard N ^a   Van Nieuwenhoven, Frans A ^a   Reneman, Robert S ^a   Van Der Vusse, Ger J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CELL SURVIVAL; CELLULAR IMMUNITY; ENDOTOXEMIA; EUKARYOTIC CELL; HEART MUSCLE ISCHEMIA; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FOLDING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW; STRESS;

EID: 0034784780     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.4.1461     Document Type: Review

References (456)

1. Identification of heme oxygenase and cytochrome P450 in the rabbit heart
2. The human heat shock protein HSP70 interacts with HSF, the transcription factor that regulates heat shock gene expression
3. An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation
4. A fatal, systemic mitochondrial disease with decreased mitochondrial enzyme activities, abnormal ultrastructure of the mitochondria and deficiency of heat shock protein 60
5. Evidence for reversible, non-microtubtfie and non-microfilament-dependent nuclear translocation of HSP90 after heat shock in human fibroblasts
6. HSP90 interacts with and regulates the activity of heat shock factor in Xenopus oocytes
7. Co-expression of ICAM-1, VCAM-1, ELAM-1 and HSP60 in human arterial and venous endothelial cells in response to cytokines and oxidized low-density lipoproteins
8. Induction of thermotolerance by prostaglandin A in human cells
9. Antiproliferative prostaglandins activate heat shock transcription factor
10. Kinetics of induction and protective effect of heat shock proteins after cardioplegic arrest
11. Relative induction of heat shock protein in coronary endothelial cells and cardiomyocytes: Implications for myocardial protection
12. Role of catalase and heat shock protein on recovery of cardiac endothelial and mechanical function after ischemia
13. Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes
14. Binding activity of glucocorticoid receptors after heat shock
15. Expression of heat shock proteins in the normal and stunned myocardium
16. Expression and function of the low-molecular-weight heat shock proteins
17. Dynamic changes in the structure and intracellular locale of the mammalian low-molecular-weight heat shock protein
18. Refolding intermediates of acid-unfolded mitochondrial aspartate aminotransferase bind to hsp70
19. Oxidative injury of coronary venular endothelial cells depletes intracellular glutathione and induces HSP70 mRNA
20. Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats
21. Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1
22. Heat shock gene regulation by nascent polypeptides and denatured proteins: Hsp70 as a potential autoregulatory factor
23. The 90-kDa heat shock protein protects mammalian cells from thermal stress but not from viral infection
24. Binding of cytosolic proteins to myofibrils in ischemic rat hearts
25. Coronary flow as a determinant of c-myc and c-fos proto-oncogene expression in an isolated adult heart
26. Delayed myocardial protection following ischaemic preconditioning
27. Depressed expression of the inducible form of HSP70 (HSP72) in brain and heart after in vivo heat shock
28. Heat shock proteins as molecular chaperones
29. Examining the function and regulation of HSP 70 in cells subjected to metabolic stress
30. Interaction of HSP70 with newly synthesized proteins: Implications for protein folding and assembly
31. Elevation of superoxide dismutase in Halobacterium halobium by heat shock
32. Induction of stress proteins in cultured myogenic cells
33. Activation of the heat shock transcription factor by hypoxia in mammalian cells
34. Stress (heat shock) proteins: Molecular chaperones in cardiovascular biology and disease
35. Temporospatial expression of the small HSP/αB-crystallin in cardiac and skeletal muscle during mouse differentiation
36. αB-crystallin in cardiac tissue. Association with actin and desmin filaments
37. Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity
38. Immunohistochemical localization of heat shock protein 70 in normal-appearing atherosclerotic specimens of human arteries
39. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effects of endotoxin
40. Cloning and subcellular localization of human mitochondrial hsp70
41. Concomitant decline in heat-induced hyperthermia and HSP70 mRNA expression in aged rats
42. Ubiquitin is a heat shock protein in chicken embryo fibroblasts
43. Hypertension, aging, and myocardial synthesis of heat shock protein 72
44. Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2)
45. Excess protein in nuclei isolated from heat-shocked cells results from a reduced extractability of nuclear proteins
46. Endotoxin and release of tumor necrosis factor and interleukin 1α in acute heat stroke
47. A new case of multiple mitochondrial enzyme deficiencies with decreased amount of heat shock protein 60
48. Molecular chaperones and the centrosome. A role for HSP73 in centrosomal repair following heat shock treatment
49. The constitutive and stress inducible forms of hsp70 exhibit functional similarities and interact with one another in an ATP-dependent fashion
50. Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases reperfusion injury of isolated rat hearts
51. Left ventricular subendocardial necrosis
52. Effects of heat on cell calcium and inositol lipid metabolism
53. Decreased expression of heat shock protein 70 mRNA and protein in WI-38 human fibroblasts aging in vitro
54. Membrane lipid perturbation modifies the set point of the temperature of heat shock response in yeast
55. The expanding small heat-shock protein family, and structure predictions of the conserved "α-crystallin domain"
56. Rat fibroblasts transfected with the human 70-kDa heat shock gene exhibit altered translation and eukaryotic initiation factor 2-α phosphorylation following heat shock
57. Okadaic acid markedly potentiates the heat-induced hsp70 promotor activity
58. Uncoating ATPase is a member of the 70 kilodalton family of stress proteins
59. Interactions of p60, a mediator of progesterone assembly, with heat shock proteins hsp90 and hsp70
60. Stable expression of a human HSP70 gene in a rat myogenic cell line confers protection against endotoxin
61. A role for a 70 kilodalton heat shock protein in lysosomal degradation of intracellular proteins
62. Activation of heat shock protein (hsp)70 and proto-oncogene expression by al adrenergic agonist in rat aorta with age
63. Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase-stimulatory carbon monoxide
64. Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1
65. Heat stress induced hsc70/nuclear topoisomerase I complex formation in vivo: Evidence for hsc70-mediated ATP-independent reactivation in vitro
66. A retinal heat shock protein is associated with elements of the cytoskeleton and binds to calmodulin
67. The dynamic state of heat shock proteins in chicken embryo fibroblasts
68. Right heart failure chronically stimulates heat shock protein 72 in heart and liver but not in other tissues
69. Ischemic contracture of the heart: "stone heart"
70. Biphasic effect of heat stress pretreatment on ischemic tolerance of isolated rat hearts
71. Heat stress protects aged hypertrophied and nonhypertrophied rat hearts against ischemic damage
72. Heat shock improves the ischemic tolerance of the hypertrophied rat heart
73. Heat pretreatment differentially affects cardiac fatty acid accumulation during ischemia and postischemic reperfusion
74. Calcium homeostasis in cardiomyocytes from heat-shocked hearts
75. Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation
76. A review of the role of 70 kDa heat shock proteins in protein translocation across membranes
77. Evidence suggesting that the two isoforms of heme oxygenase are products of different genes
78. The ability of heat stress and metabolic preconditioning to protect primary rat cardiac myocytes
79. Differential protection of primary rat cardiocytes by transfection of specific heat stress proteins
80. Effects of ischemia and reperfusion temperature on the synthesis of stress-induced (heat shock) proteins in isolated and perfused rat hearts
81. Protein synthesis in perfused rat hearts after in vivo hyperthermia and in vitro cold ischemia
82. Improved post-ischemic ventricular recovery in the absence of changes in energy metabolism in working rat hearts following heat-shock
83. Heat-shock response is associated with enhanced post-ischemic recovery
84. Induction of the heat shock response in rats modulates heart rate, creatine kinase and protein synthesis after a subsequent hyperthermic treatment
85. Analysis of RNA for transcripts for catalase and SP71 in rat hearts after in vivo hyperthermia
86. Characterization of the synthesis and accumulation of a 71-kilodalton protein induced in rat tissues after hyperthermia
87. Immunofluorescence localization of the 90-kDa heat-shock protein to cytoskeleton
88. Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins
89. Molecular adaptation of cellular defenses following preconditioning of the heart by repetitive ischemia
90. Preconditioning of heart by repeated stunning. Adaptive modification of antioxidative defense system
91. Induction of heat shock protein in cardiac allograft rejection: A cyclosporine-suppressible response
92. Evolution of the α-crystallin/small heat shock protein family
93. Synthesis of stress proteins in rat cardiac myocytes 2-4 days after imposition of hemodynamic overload
94. Ischemia of the dog heart induces the appearance of a cardiac mRNA coding for a protein with migration characteristics similar to heat-shock/stress protein 71
95. Heat shock proteins in myocardial stress
96. Rapid assay of HSF1 and HSF2 gene expression by RT-PCR
97. Heat shock gene expression in HSP70 and HSF1 gene-transfected human epidermoid A-431 cells
98. Hsp70 expression and function during gametogenesis
99. Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family
100. Heat-shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion
101. 2+ agonists on molecular chaperones in human umbilical vein endothelial cells
102. Heat shock-induced denaturation of proteins
103. Structure and expression of a human gene coding for a 71 kd heat shock "cognate" protein
104. Ischemic preconditioning: A potential role for constitutive low molecular weight stress protein translation phosphorylation
105. Therapeutic applications of heat shock proteins
106. Inhibition of heat stress protein induction by deuterium oxide and glycerol: Additional support for the abnormal protein hypothesis of induction
107. Stress response of senescent T lymphocytes: Reduced hsp70 is independent of the proliferative block
108. Chaperonins
109. Protein folding in the cell: Competing models of chaperonin function
110. Molecular chaperones
111. MAP-KAP kinase 2 is activated by heat shock and TNF-alpha: In vitro phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade
112. Involvement of protein kinase C in activation of Drosophila fos and hsp70
113. Induction of heme oxygenase-1 (HSP32) mRNA in skeletal muscle following contractions
114. Rapid induction of heme oxgenase-1 mRNA and protein by hyperthermia in rat brain: Heme oxygenase-2 is not a heat shock protein
115. Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: Possible role in stress-mediated elevation of cyclic 3′-5′-guanosine monophosphate
116. Decreased expression of heat shock protein 70 mRNA and protein after heat shock treatment in cells of aged rats
117. Effects of neurohormonal stress and aging on the activation of the mammalian heat shock factor 1
118. Potentiation of heat stress-induced hsp70 expression in vivo by aspirin
119. HSP70: A multi-gene, multi-structure, multi-function family with potential Clinical applications
120. Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1
121. HSP70 prevents activation of stress kinases
122. Heat shock protein 72 in cardiac and skeletal muscles during hypertension
123. A cytoplasmic chaperonin that catalyzes β-actin folding
124. Role of the major heat shock proteins as molecular chaperones
125. Protein folding. The difference with prokaryotes
126. Protein folding in the cell
127. Developmental regulation of a constitutively expressed mouse mRNA encoding a 72 kDa heat shock-like protein
128. Can Hsp70 proteins act as force-generating motors?
129. Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities
130. Heat-inducible DNA binding of purified heat shock transcription factor 1
131. Anti-oxidant-mediated inhibition of the heat shock response leads to apoptosis
132. Purification and initial characterization of the 71-kilodalton rat heat shock protein and its cognate as fatty acid binding proteins
133. BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum
134. Heat stress genes in hypertension
135. Increased transcription of a major stress gene in spontaneously hypertensive mice
136. Diverse forms of stress lead to new patterns of gene expression through a common and essential metabolic pathway
137. Crystal structure of the DNA binding domain of the heat shock transcription factor
138. Protein folding in the cell. The role of molecular chaperones HSP70 and HSP60
139. Regulation of hsp70 induction in thermotolerant HeLa cells
140. Cellular localization of high molecular mass heat shock proteins in murine cells
141. HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin-challenged rats
142. Stable high level expression of a transfected human HSP70 gene protects a heart-derived muscle cell line against thermal stress
143. Differential stress protein mRNA expression during early ischaemic preconditioning in the rabbit heart and its relationship to adenosine receptor function
144. Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells
145. Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34
146. Molecular chaperone functions of heat shock proteins
147. Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA
148. Morphohological, biochemical and electrophysiological characterization of a clonal cell (H9c2) line from rat heart
149. HSP70 and aging
150. Expression of heat shock protein 70 is altered by age and diet at the level of transcription
151. Molecular chaperones and the heat shock response at Cold Spring Harbor
152. Cellular responses to stress. Comparison of a family of 71-73 kilodalton proteins rapidly synthesized in rat tissue slices and canavanine-treated cells in culture
153. Preferential synthesis of rat heat-shock and glucose-regulated proteins in stressed cardiovascular cells
154. HSP25 in isolated perfused rat hearts: Localization and response to hyperthermia
155. Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle
156. A short element required for turning off heat shock transcription factor: Evidence that phosphorylation enhances deactivation
157. 2: A growth-dependent response mediated by activation of heat shock transcription factor
158. Changes of serum antibodies to heat shock protein 65 in coronary heart disease and acute myocardial infarction
159. The mitochondrial protein import motor: Dissociation of mitochondrial hsp70 from its membrane anchor requires ATP binding rather than ATP hydrolysis
160. Effects of preconditioning with ebselen on glutathione metabolism and stress protein expression
161. Sublethal ischemia alters myocardial antioxidant activity in canine heart
162. Structure of the gene encoding the mouse 47-kDa heat-shock protein
163. Altered cardiac tissue gene expression during acute hypoxic expression
164. Rapid activation of the heat shock transcription factor, HSF1, by hypo-osmotic stress in mammalian cells
165. Heat-shock protein induction in adriamycin and picornavirus-infected cardiocytes
166. Co-precipitation of heat shock proteins with a cell surface glycoprotein
167. Involvement of heat shock elements and basal transcription elements in the differential induction of the 70-kDa heat shock protein and its cognate by cadmium chloride in 9L rat brain tumor cells
168. Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines
169. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70
170. Chromosomal localization of five murine HSP70 gene family members: hsp70-1, hsp70-2, hsp70-3, hsc70t, and grp78
171. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/HSP27 pathway in vascular endothelial cells
172. HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress
173. Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo
174. Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection
175. Induction of the synthesis of hsp27 and αB-crystallin in tissues of heat-stressed rats and its suppression by ethanol or an α-adrenergic antagonist
176. Age-related changes before and after imposition of hemodynamic stress in the mammalian heart
177. Heat shock protein expression in hearts hypertrophied by genetic and nongenetic hypertension
178. Induction of HSP70 in cultured rat neonatal cardiomyocytes by hypoxia and metabolic stress
179. 2
180. Small heat shock proteins are molecular chaperones
181. Transient interaction of HSP90 with early unfolding intermediates of citrate synthase
182. Expression of proto-oncogenes, genes for muscle specific isoforms and heat shock protein (HSP)-70 gene in hypertrophied cardiac muscles from patients with atrial septal defects or tetralogy of Fallot
183. Effect of heat shock proteins on survival of isolated aortic cells from normal and atherosclerotic Cynomolgus macaques
184. Atherosclerosis alters the localization of HSP70 in human and macaque aortas
185. Exogenous HSP70 becomes cell associated, but not internalized, by stressed arterial smooth muscle cells
186. Differential expression of hsp70 stress proteins in human endothelium cells exposed to heat-shock and hydrogen peroxide
187. 2 triggers the first phase of the thermal stress response and exhibits cell-type specificity
188. Effect of sodium salicylate on the human heat shock response
189. Arachidonate is a potent modulator of human heat shock gene transcription
190. Requirement for HSP70 in the mitochondrial matrix for translocation of precursor proteins
191. Acquisition and decay of heat-shock-enhanced post-ischemic ventricular recovery
192. Separate regulation of heme oxygenase and heat shock protein 70 mRNA expression in the rat hearts by hemodynamic stress
193. Tissue distribution and development profiles of immunoreactive αB-crystallin in the rat determined with a sensitive immunoassay
194. ATP induces dissociation of the 90 kDa heat shock protein from F-actin: Interference with the binding of heavy meromyosin
195. Heat shock protein 70 kDa: Molecular biology, biochemistry, and physiology
196. Regional distribution of HSP70 proteins after myocardial infarction
197. Nuclear localization and phosphorylation of three 25-kilodalton rat stress proteins
198. Properties of a clonal muscle cell line from rat heart
199. Expression of the murine small heat shock proteins hsp25 and αB-crystallin in the absence of stress
200. Repression of human heat shock factor 1 activity at control temperature by phosphorylation
201. The role of heat shock proteins in the heart
202. Mutation of amino acids 246-251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability
203. Antisense, heat shock proteins, and the heart
204. Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia
205. A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat-shock protein 70 in the isolated, erythrocyte perfused rabbit heart
206. Phosphorylation at tyrosine-524 influences nuclear accumulation of HSP72 with heat stress
207. Differential expression of heat shock proteins in normal and failing human hearts
208. Stress-induced proteins in aortic smooth muscle cells and aorta of hypertensive rats
209. Two mammalian heat shock proteins, HSP90 and HSP100 are actin-binding proteins
210. Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity
211. HSP70 accumulation in tissues of heat-stressed rats is blunted with advancing age
212. Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element
213. Oxidant stress increases heat shock protein 70 mRNA in isolated perfused heart
214. Expression of hsp70 gene in lymphocytes from normotensive and hypertensive humans
215. Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia
216. Quantitation and intracellular localization of the 85 kDa heat shock protein by using monoclonal and polyclonal antibodies
217. Cardiovascular regulatory mechanisms in advanced age
218. Evidence for the existence of a novel mechanism for the nuclear import of Hsc70
219. Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells
220. Cloning and sequencing of a cDNA encoding the canine HSP27 protein
221. Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock
222. Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27
223. Alpha-B crystallin in the normal human myocardium and cardiac conduction system
224. Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden-death pigs with hypertrophic cardiomyopathy
225. A 16-kDa protein functions as a new regulatory protein for Hsc70 molecular chaperone and is identified as a member of the Nm23/nucleoside diphosphate kinase family
226. The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B′) and isolation of its cDNA and genomic DNA
227. Prognostic implications of echocardiographic determined left ventricular mass in the Framingham Heart Study
228. Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein
229. T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol
230. Heat shock protein HSP70 protects cells from thermal stress even after deletion of its ATP-binding domain
231. Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene
232. Effects of expressing human Hsp70 and its deletion derivatives on heat killing and on RNA and protein synthesis
233. Fluid shear stress induces the phosphorylation of small heat shock proteins in vascular endothelial cells
234. Transcriptional regulation of heat shock genes
235. Cloning, nucleotide sequence and expression of rat heart inducible hsp70 gene
236. Molecular events involved in transcriptional activation of heat shock genes become progressively refractory to heat stimulation during aging of human diploid fibroblasts
237. Expression of human hsp70 in rat fibroblasts enhances cell survival and facilitates recovery from translational and transcriptional inhibition following heat shock
238. Heat shock. A new approach for myocardial preservation in cardiac surgery
239. Diminished heat shock response in the aged myocardium
240. Enhanced postischemic myocardial recovery following exercise induction of HSP72
241. Protein phosphatase inhibitors and heat preconditioning prevent Hsp27 dephosphorylation, F-actin disruption and deterioration of morphology in ATP-depleted endothelial cells
242. Cardiac α-crystallin. I. Isolation and identification
243. Cardiac α-crystallin. II. Intracellular localization
244. Effects of calcium channel blockers on stress protein synthesis in cardiac myocytes
245. Molecular adaptation of vascular cells to oxidative stress
246. Reduction in heat shock gene expression correlates with increased thermosensitivity in senescent human fibroblasts
247. Abundance and location of the small heat hock proteins HSP25 and alphaB-crystallin in rat and human heart
248. Heat-shock proteins and molecular chaperones: Implications for pathogenesis, diagnostics, and therapeutics
249. Sensitization of rat hepatocytes to hyperthermia by calcium
250. Thermosensitivity, a possible new locus involved in genetic hypertension
251. Nitric oxide is involved in heat-induced HSP70 accumulation
252. Sequential action of mitochondrial chaperones in protein import into the matrix
253. Tissue-specific differences in heat shock protein hsc70 and hsp70 in the control and hyperthermic rabbit
254. Myocardial stunning and hibernation: The physiology behind the colloquialisms
255. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction
256. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury
257. Attenuation by heat stress of a submaximal calcium paradox in the rabbit heart
258. Cardiac 72-and 60-kDa stress protein induction by repetitive ischemia and heat stress
259. Myocardial protection after whole body heat stress in the rabbit is dependent on metaboLic substrate and is related to the amount of the inducible 70-kD heat stress protein
260. Repetitive ischaemia and heat stress results in delayed myocardial protection
261. Small heat shock proteins and protection against ischemic injury in cardiac myocytes
262. Drug-induced heat shock preconditioning improves postischemic recovery after cardiopulmonary bypass
263. Induction of the haem oxygenase gene expression during the reperfusion of ischemic rat myocardium
264. Myocardial adaptation to ischemia by oxidative stress induced by endotoxin
265. Improved postischemic ventricular functional recovery by amphetamine is linked with its abiLity to induce heat shock
266. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme-oxygenase-3
267. A brief period of retrograde hyperthermic perfusion enhances myocardial protection from global ischemia: Association with the accumulation of Hsp70 mRNA and protein
268. The rapid expression of myocardial HSP70 mRNA and the heat shock 70 kDa protein can be achieved after only a brief period of retrograde hyperthermic perfusion
269. Myocardial self-preservation: Absence of heat shock factor activation and heat shock proteins 70 mRNA accumulation in the human heart during cardiac surgery
270. Heat shock protein (HSP72) expression in patients undergoing cardiac operations
271. Differences in adaptive stabilization of structures in response to stress and hypoxia relate with the accumulation of hsp70 isoforms
272. 3-DAG mechanism in the adaptive stabilization of structures and heart protection
273. Constitutive expression of human hsp27, Drosophila hsp27, or human αB-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxity in stable transfected murine L929 fibroblasts
274. Small stress proteins as novel regulators of apoptosis: Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death
275. Heat shock protein 70 expression in native and heterotopically transplanted hearts
276. Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through α1 adrenoceptors
277. Endotoxin induces cardiac HSP70 and resistance to endotoxemic myocardial depression in rats
278. Structural and functional similarities of bovine α-crystallin and mouse small heat shock protein. A family of chaperones
279. Isolation of a novel inducible rat heat-shock protein (HSP70) gene and its expression during ischaemia/hypoxia and heat shock
280. Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury
281. Heat shock proteins and protection against myocardial ischemia
282. Adenovirus-mediated gene transfer of a heat shock protein 70 (hsp70i) protects against simulated ischemia
283. Cytoplasmic chaperones in precursor targeting to mitochondria: The role of MSF and hsp70
284. Mutational analysis of the human HSP70 protein: Distinct domains for nucleolar localization and adenosine triphosphate binding
285. Structure and expression of the three MHC-Linked Hsp70 genes
286. Preconditioning of the isolated rat heart is mediated by protein kinase C
287. Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses
288. Phenylephrine, vasopressin and angiotensin II as determinants of proto-oncogene and heat-shock protein gene expression in adult rat heart and aorta
289. Heat stress attenuates free radical release in the isolated perfused rat heart
290. Cells in stress: Transcriptional activation of heat shock genes
291. Transcriptional regulation of heat shock genes
292. Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes
293. Heat shock proteins: A broader perspective
294. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
295. The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70
296. Preconditioning with ischemia: A delay of lethal injury in ischemia myocardium
297. Loss of asymmetric distribution of sarcolemmal phosphatidylethanolamine during simulated ischemia in the isolated neonatal rat cardiomyocyte
298. Heat shock protein 70 mRNA is induced by anaerobic metabolism in the heart
299. HSP90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl propyl isomerases
300. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway
301. Involvement of the stress protein HSP47 in procollagen processing in the endoplasmic reticulum
302. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator
303. Tumor necrosis factor-α confers resistance to hypoxic injury in the adult mammalian cardiac myocyte
304. Tumor necrosis factor-α-induced expression of heat shock protein 72 in adult feLine cardiac myocytes
305. Blocking the endogenous increase in HSP72 increases the susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes
306. Monophosphoryl lipid A protects adult rat cardiomyocytes with induction of the 72-kD heat shock protein: A cellular model of pharmacologic preconditioning
307. Delayed preconditioning of cultured adult rat cardiac myocytes: Role of 70- and 90-kDa heat stress proteins
308. Analysis by confocal microscopy of the behavior of heat shock protein 70 within the nucleus and of a nuclear matrix polypeptide during prolonged heat shock response in HeLa cells
309. Reperfusion causes significant activation of heat shock transcription factor 1 in ischemic rat heart
310. Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart
311. Diminished heat shock protein 70 mRNA induction in aged rats after ischemia
312. Interleukin-1 receptor antagonist reduces mortality from endotoxemic shock
313. The relationship between HSP70 localization and heat resistance
314. Identification of a nuclear protein that constitutively recognizes the sequence containing a heat-shock element. Its binding properties and possible function modulating heat-shock induction of the rat heme oxygenase gene
315. Cultured neonatal rat heart cells can be preconditioned by ischemia, but not by heat shock. The role of stress proteins
316. The expression of heat shock protein 70 decreases with age in lymphocytes from rats and rhesus monkeys
317. + but not ATP hydrolysis
318. HSP70-protein complexes
319. Interaction of HSP70 with unfolded proteins. Effects of temperature and nucleotides on the kinetics of binding
320. Protection of the heart by ischaemic preconditioning: Mechanisms and possibilities for pharmacological exploitation
321. Structure and expression of an inducible hsp70-encoding gene from Mus musculus
322. Differential accumulation of mRNA for immediate early genes and heat shock genes after ischaemic injury
323. Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery
324. Mitochondria are selective targets for the protective effects of heat shock against oxidative injury
325. Antibodies against stress proteins in sera of patients with dilated cardiomyopathy
326. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein
327. The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor
328. Induction of 72-kDa heat shock protein does not produce a second window of ischemic preconditioning in rat heart
329. Dissociation of heat shock proteins expression with ischemic tolerance by whole body hyperthermia in rat heart
330. Molecular cloning and expression of a human heat shock factor, HSF1
331. Regulation of heat shock factor trimer formation: Role of a conserved leucine zipper
332. Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding actMty in vivo
333. Cardioprotective effects of 70-kDa heat shock protein in transgenic mice
334. Partner proteins determine multiple functions of HSP70
335. Preconditioning. Definitions, proposed mechanisms, and implications for myocardial protection in ischemia and reperfusion
336. Heat shock is lethal to fibroblasts microinjected with antibodies against hsp70
337. Aging and the cellular response to stress: Reduction in the heat shock response
338. A new puffing pattern induced by a temperature shock and DNP in Drosophila
339. Accelerated recovery of postischemic stunned myocardium after induced expression of heat shock protein (HSP70)
340. Stress proteins and atherosclerosis
341. Eukaryotic cytosolic chaperonin contains t-complex polypeptide-1 and seven related subunits
342. 1: An effect associated with heat shock transcription factor activation
343. Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells
344. A heat-shock gene at 14q22: Mapping and expression
345. Acute heat stress protects rats against endotoxin shock
346. Unfolded proteins stimulate nucleolar chaperone Hsc70 ATPase by accelerating ADP/ATP exchange
347. HSP70 and other possible heat shock proteins or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise
348. Binding of heat-shock protein 70 (hsp70) to tubulin
349. Human heat-shock protein 70 (hsp70) protects murine cells from injury during metabolic stress
350. Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells
351. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress
352. Expression of heat shock factor 2 in mouse testes: Potential role as a regulator of heat shock protein gene expression during spermatogenesis
353. Human major histocompatibility complex contains genes for the major heat shock protein Hsp70
354. Negative regulation of the heat shock transcriptional response by HSBP1
355. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70
356. Isolation of a cDNA for HSF2: Evidence for two heat shock factor genes in humans
357. Coexpression of heat shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T-cells to aortic endothelium of rats in response to endotoxin
358. Expression and immunohistochemical localization of heat shock protein-70 in preconditioned porcine myocardium
359. Role of small heat shock proteins in the cardiovascular system
360. Molecular biology of the coronary vascular and myocardial responses to ischemia
361. Alterations in the chaperone activity of HSP70 in aging organisms
362. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription
363. Preconditioning of smooth muscle cells via induction of the heat shock response limits proliferation following mechanical injury
364. Expression and cellular distribution of heat-shock and nuclear oncogene proteins in rat hearts
365. The effects of global ischemia and reperfusion on compensated hypertrophied hearts of aorta banded rats
366. Myocardial function in normal and spontaneously hypertensive rats during reperfusion after a period of global ischemia
367. Differences in ischemia tolerance between hypertrophied hearts of adult and aged spontaneously hypertensive rats
368. Heat pretreatment protects translation during subsequent severe heat stress in H9c2 cells
369. Three hsp70 genes are located in the C4-H-2D region: Possible candidates for the Orch-1 locus
370. Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells
371. Factors controlling beating of collagen gels by neonatal heart cells
372. The protective effect of heat stress against reperfusion arrhythmias in the rat
373. Increased endogenous catalase activity caused by heat stress does not protect the isolated rat heart against exogenous hydrogen peroxide
374. The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signaling pathways co-operate to mediate the activation of the hsp90β gene by interleukin-6 but have opposite effects on its inducibility by heat shock
375. Signal transduction and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the HSP-70 and HSP-90β gene promoters
376. Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain
377. Developmental and afterload stress regulation of heat shock proteins in the ovine myocardium
378. Hsp70 in mitochondrial biogenesis: From chaperoning nascent polypeptide chains to facilitation of protein degradation
379. Constitutive and inducible hsp70s are involved in oxidative resistance evoked by heat shock or ethanol
380. HSPs and thermotolerance: Comparison of induction kinetics
381. Association between the mammalian 110,000 dalton heat shock protein and nucleoli
382. Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs
383. Reduction in myocardial apoptosis associated with overexpression of heat shock protein 70
384. In vivo gene transfer with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat
385. Induction of myocardial heat shock protein 70 during cardiac surgery
386. The C-terminal region of αA-crystallin: Involvement in protection against heat-induced denaturation
387. Different thresholds in the responses of two heat shock transcription factors, HSF1 and HSF3
388. Ischemic preconditioning elevates cardiac stress protein but does not limit infarct size 24 or 48 h later in rabbits
389. Expression of heat shock protein after ischemic preconditioning in rabbit hearts
390. Time-course of late preconditioning against myocardial stunning in conscious pigs
391. Tissue-specific expression of heat shock proteins of the mouse in the absence of stress
392. Changes in ischemic tolerance and effects of ischemic preconditioning in middle-aged rat hearts
393. Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11
394. A hitchhiker's guide to the human Hsp70 family
395. The requirement of heat shock cognate 70 protein for mitochondrial import varies among precursor proteins and depends on precursor length
396. Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73 kDa heat shock cognate protein
397. Role of catalase in metabolism of hydrogen peroxide
398. Human gene encoding the 78.000-dalton glucose-regulated protein and its pseudogene: Structure, conservation, and regulation
399. Protein synthesis in salivary glands of Drosophila melanogaster. Relation to chromosomal puffs
400. Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70
401. New model for 70 kDa heat-shock proteins' potential mechanisms of function
402. The isolated neonatal rat-cardiomyocyte used as an in vitro model for "ischemia." Induction of the 68 kDa heat shock protein
403. Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response
404. Aortic cross-transplantation between young and old rats: Effect upon the heat shock protein 70 stress response
405. Adrenergic regulation of adrenal and aortic heat shock protein
406. The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria
407. Isolation and characterization of a rat hsp27 gene
408. Performance of the isolated, ejecting heart: Effects of aortic impedance and exogenous substrates
409. αB-crystallin and hsp25 in neonatal cardiac cells: Differences in cellular localization under stress conditions
410. Heat stress pretreatment mitigates postischemic arachidonic acid accumulation in rat heart
411. Heat-induced modifications in the association of specific proteins with the nuclear matrix
412. HSP70 improves the recovery of protein translation after severe beat stress in H9c2 cells
413. Prevention by dexamethasone of the marked antiarrhythmic effects of preconditioning induced 20 h after rapid cardiac pacing
414. HSP70: Nuclear concentration during environmental stress and cytoplasmic storage during recovery
415. Heat shock causes protein aggregation and reduces protein solubility at the centrosome and other cytoplasmic locations
416. 2+ in killing by heat and induction of thermotolerance
417. Pathways of heat shock protein 28 phosphorylation by TNF in human fibroblasts
418. Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects
419. Rabbit cardiac and skeletal muscle myocytes differ in constitutive and inducible expression of the glucose-regulated protein GRP94
420. Isolation and functional analysis of a human 70,000-dalton heat shock protein segment
421. Heat stress limits infarct size in the isolated perfused rat heart
422. Role of catalase in myocardial protection against ischemia in heat shocked rats
423. Involvement of 70-kD heat-shock proteins in peroxisomal import
424. Response of the neonatal rat cardiomyocyte in culture to energy depletion: Effects of cytokines, nitric oxide, and heat shock proteins
425. Function of heat shock protein 72 prevents neutrophil-mediated human endothehal cell necrosis
426. Nuclear protein redistribution in heat-shocked cells
427. Phorbol ester calcium ionophore, or serum added to quiescent rat embryo fibroblast cells all result in the elevated phosphorylation of two 28,000-dalton mammalian stress proteins
428. Mammalian stress response: Cell physiology, structure/ function of stress proteins, and implications for medicine and disease
429. Influence of molecular and chemical chaperones on protein folding
430. Purification of the major mammalian heat shock proteins
431. Nuclear and nucleolar localization of the 72,000 dalton heat-shock protein in heat-shocked mammalian cells
432. Morphological study of the mammalian stress response: Characterization of changes in cytoplasmic organelle, cytoskeleton, and nucleoli, and the appearance of intranuclear actin filaments in rat fibroblasts after heat shock treatment
433. Cellular and biochemical events in mammalian cells during and after recovery of stress
434. The mammalian stress response and the cytoskeleton: Alterations in intermediate filaments
435. Characterization of the thermotolerant cell. Effects of the intracellular distribution of heat-shock protein 70, intermediate filamants, and small nuclear ribonucleoprotein complexes
436. The heat-shock response attenuates lipopolysaccharide-mediated apoptosis in cultured sheep pulmonary artery endothelial cells
437. The effect of age on the synthesis of two heat shock proteins in the HSP70 family
438. Heat shock transcription factors: Structure and regulation
439. Hyperphosphorylation of heat shock transcription factor 1 is correlated with transcriptional competence and slow dissociation of active trimers
440. Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit
441. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock proteins 65
442. Acute hypertension induces heat shock protein 70 gene expression in rat aorta
443. Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells
444. The role of heat shock proteins in protection and pathophysiology of the arterial wall
445. Time-course of tolerance to ischemia-reperfusion injury and induction of heat shock protein 72 by heat stress in the rat heart
446. Whole-body hyperthermia provides biphasic cardioprotection against ischemia/reperfusion injury in the rat
447. Infarct limitation in the second window of protection in a conscious rabbit model
448. Whole body heat stress fails to limit infarct size in the reperfused rabbit heart
449. The protective role of heat stress in the ischemic and reperfused rabbit myocardium
450. In cultured chick embryo fibroblasts the hexose transport components are not the 75,000 and 95000 dalton polypeptide synthesized following glucose deprivation
451. The beneficial effects of heat shock for prolonged hypothermic storage
452. Oxidized-LDL induce the expression of heat shock protein 70 in human endothelial cells
453. Oxidized LDL induce hsp70 expression in human smooth muscle cells
454. Repression of heat shock transcription factor HSF1 by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1