Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 15, 2014, Pages 3422-3425

  Rosatelli, Emiliano ^a   Carotti, Andrea ^a   Ceruso, Mariangela ^b   Supuran, Claudiu T ^b   Gioiello, Antimo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrases; Docking; Flow synthesis; Sulfonamides

Indexed keywords

4 METHYL N PHENYL BENZENESULFONAMIDE; ACETAZOLAMIDE; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; ISOENZYME; LYASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG; 4 METHYL N PHENYLBENZENESULFONAMIDE; CARBONATE DEHYDRATASE INHIBITOR; HYDROLYASE INHIBITOR; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; TUMOR ANTIGEN;

ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW; IC 50; FLOW KINETICS; HYDROPHILICITY; HYDROPHOBICITY; IC50; MEDICINAL CHEMISTRY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; SYNTHESIS;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84904054080     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.086     Document Type: Article

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