-
1
-
-
61849157257
-
Alzheimer's disease
-
Burns A, Iliffe S. Alzheimer's disease. BMJ 338: 467-71 (2009).
-
(2009)
BMJ
, vol.338
, pp. 467-471
-
-
Burns, A.1
Iliffe, S.2
-
2
-
-
0037025256
-
Mitochondria, Ca2+ and neurodegenerative disease
-
Krieger C, Duchen MR. Mitochondria, Ca2+ and neurodegenerative disease. Eur J Pharmacol 447(2-3): 177-88 (2002).
-
(2002)
Eur J Pharmacol
, vol.447
, Issue.2-3
, pp. 177-188
-
-
Krieger, C.1
Duchen, M.R.2
-
3
-
-
80053467489
-
Oxidative Stress Induced Mitochondrial DNA Deletion as a Hallmark forthe Drug Development in the Context of the Cerebrovascular Diseases
-
Aliev G, Li Y, Palacios HH, Obrenovich ME. Oxidative Stress Induced Mitochondrial DNA Deletion as a Hallmark forthe Drug Development in the Context of the Cerebrovascular Diseases. Recent Pat Cardiovasc Drug Discov 6(3): 222-41 (2011).
-
(2011)
Recent Pat Cardiovasc Drug Discov
, vol.6
, Issue.3
, pp. 222-241
-
-
Aliev, G.1
Li, Y.2
Palacios, H.H.3
Obrenovich, M.E.4
-
4
-
-
67249089661
-
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease
-
Shenk JC, Liu J, Fischbach K, Xu K, Puchowicz M, Obrenovich ME, et al. The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. J Neurol Sci 283(1-2): 199-206 (2009).
-
(2009)
J Neurol Sci
, vol.283
, Issue.1-2
, pp. 199-206
-
-
Shenk, J.C.1
Liu, J.2
Fischbach, K.3
Xu, K.4
Puchowicz, M.5
Obrenovich, M.E.6
-
5
-
-
79551673088
-
Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease
-
Palacios HH, Yendluri BB, Parvathaneni K, Shadlinski VB, Obrenovich ME, Leszek J, et al. Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease. CNS Neurol Disord Drug Targets 10(2): 149-62 (2011).
-
(2011)
CNS Neurol Disord Drug Targets
, vol.10
, Issue.2
, pp. 149-162
-
-
Palacios, H.H.1
Yendluri, B.B.2
Parvathaneni, K.3
Shadlinski, V.B.4
Obrenovich, M.E.5
Leszek, J.6
-
6
-
-
0347039407
-
Medicinal and chemical approaches to focused search of agents for treatment and therapy of Alzheimer disease
-
Bachurin SO. Medicinal and chemical approaches to focused search of agents for treatment and therapy of Alzheimer disease. Vopr Med Khim 47(2): 155-97 (2001).
-
(2001)
Vopr Med Khim
, vol.47
, Issue.2
, pp. 155-197
-
-
Bachurin, S.O.1
-
7
-
-
0030424974
-
The effect of dithiocarbamates on neurotoxic action of 1-methyl-4-phenyl-1, 2, 3, 6 tetrahydropyridine (MPTP) and on mitochondrial respiration chain
-
Bachurin SO, Shevtzova EP, Lermontova NN, Serkova TP, Ramsay RR. The effect of dithiocarbamates on neurotoxic action of 1-methyl-4-phenyl-1, 2, 3, 6 tetrahydropyridine (MPTP) and on mitochondrial respiration chain. Neurotoxicology 17(3-4): 897-903 (1996).
-
(1996)
Neurotoxicology
, vol.17
, Issue.3-4
, pp. 897-903
-
-
Bachurin, S.O.1
Shevtzova, E.P.2
Lermontova, N.N.3
Serkova, T.P.4
Ramsay, R.R.5
-
8
-
-
79551662910
-
Antioxidants in health, disease and aging
-
Obrenovich ME, Li Y, Parvathaneni K, Yendluri BB, Palacios HH, Leszek J, et al. Antioxidants in health, disease and aging. CNS Neurol Disord Drug Targets 10(2): 192-207 (2011).
-
(2011)
CNS Neurol Disord Drug Targets
, vol.10
, Issue.2
, pp. 192-207
-
-
Obrenovich, M.E.1
Li, Y.2
Parvathaneni, K.3
Yendluri, B.B.4
Palacios, H.H.5
Leszek, J.6
-
9
-
-
12244281831
-
Mitochondrial permeability transition in CNS trauma: Cause or effect of neuronal cell death?
-
Sullivan PG, Rabchevsky AG, Waldmeier PC, Springer JE. Mitochondrial permeability transition in CNS trauma: cause or effect of neuronal cell death? J Neurosci Res 79(1-2): 231-9 (2005).
-
(2005)
J Neurosci Res
, vol.79
, Issue.1-2
, pp. 231-239
-
-
Sullivan, P.G.1
Rabchevsky, A.G.2
Waldmeier, P.C.3
Springer, J.E.4
-
10
-
-
67649772111
-
The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI
-
Mazzeo AT, Beat A, Singh A, Bullock MR. The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI. Exp Neurol 218(2): 363-70 (2009).
-
(2009)
Exp Neurol
, vol.218
, Issue.2
, pp. 363-370
-
-
Mazzeo, A.T.1
Beat, A.2
Singh, A.3
Bullock, M.R.4
-
11
-
-
0036258363
-
Effect of beta-amyloid peptide fragment 25-35 on nonselective permeability of mitochondria
-
Shevtzova EF, Kireeva EG, Bachurin SO. Effect of beta-amyloid peptide fragment 25-35 on nonselective permeability of mitochondria. Bull Exp Biol Med 132(6): 1173-6 (2001).
-
(2001)
Bull Exp Biol Med
, vol.132
, Issue.6
, pp. 1173-1176
-
-
Shevtzova, E.F.1
Kireeva, E.G.2
Bachurin, S.O.3
-
12
-
-
41649086378
-
Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria
-
Vande Velde C, Miller TM, Cashman NR, Cleveland DW. Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc Natl Acad Sci USA 105(10): 4022-7 (2008).
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.10
, pp. 4022-4027
-
-
Vande Velde, C.1
Miller, T.M.2
Cashman, N.R.3
Cleveland, D.W.4
-
13
-
-
79952315766
-
Influence of aging on membrane permeability transition in brain mitochondria
-
Toman J, Fiskum G. Influence of aging on membrane permeability transition in brain mitochondria. J Bioenerg Biomembr 43: 2-10 (2011).
-
(2011)
J Bioenerg Biomembr
, vol.43
, pp. 2-10
-
-
Toman, J.1
Fiskum, G.2
-
14
-
-
0037713338
-
Mitochondria as a Target for Neurotoxins and Neuroprotective Agents
-
Bachurin SO, Shevtsova EP, Kireeva EG, Oxenkrug GF, Sablin SO. Mitochondria as a Target for Neurotoxins and Neuroprotective Agents. Ann NY Acad Sci 993: 334-44 (2003).
-
(2003)
Ann NY Acad Sci
, vol.993
, pp. 334-344
-
-
Bachurin, S.O.1
Shevtsova, E.P.2
Kireeva, E.G.3
Oxenkrug, G.F.4
Sablin, S.O.5
-
15
-
-
82055162842
-
Effects of Coenzyme Q and Creatine Supplementation on Brain Energy Metabolism in Rats Exposed to Chronic Cerebral Hypoperfusion
-
Horecky J, Gvozdjakova A, Kucharska J, E. Obrenovich M, H. Palacios H, Li Y, et al. Effects of Coenzyme Q and Creatine Supplementation on Brain Energy Metabolism in Rats Exposed to Chronic Cerebral Hypoperfusion. Curr Alzheimer Res 8(8): 868-75 (2011).
-
(2011)
Curr Alzheimer Res
, vol.8
, Issue.8
, pp. 868-875
-
-
Horecky, J.1
Gvozdjakova, A.2
Kucharska, J.3
Obrenovich, E.M.H.4
Palacios, H.5
Li, Y.6
-
16
-
-
47149108940
-
Effect of Dimebon on cognition, activities of daily living, behavior, and global function in patients with mild-to-moderate Alzheimer's disease: A randomized, double-blind, placebo-controlled study
-
Doody RS, Gavrilova SI, Sano M, Rg T. Effect of Dimebon on cognition, activities of daily living, behavior, and global function in patients with mild-to-moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled study. Lancet 372: 207-15 (2008).
-
(2008)
Lancet
, vol.372
, pp. 207-215
-
-
Doody, R.S.1
Gavrilova, S.I.2
Sano, M.3
Rg, T.4
-
18
-
-
84869068528
-
Dimebon activates autophagosome components in human neuroblastoma SH-SY5Y cells
-
Khritankova IV, Kukharskiy MS, Lytkina OA, Bachurin SO, Shorning BY. Dimebon activates autophagosome components in human neuroblastoma SH-SY5Y cells. Dokl Biochem Biophys 446: 251-3 (2012).
-
(2012)
Dokl Biochem Biophys
, vol.446
, pp. 251-253
-
-
Khritankova, I.V.1
Kukharskiy, M.S.2
Lytkina, O.A.3
Bachurin, S.O.4
Shorning, B.Y.5
-
19
-
-
84881158430
-
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain
-
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, et al. Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Mol Psychiatry 18(8): 882-8 (2013).
-
(2013)
Mol Psychiatry
, vol.18
, Issue.8
, pp. 882-888
-
-
Steele, J.W.1
Ju, S.2
Lachenmayer, M.L.3
Liken, J.4
Stock, A.5
Kim, S.H.6
-
20
-
-
84877333097
-
Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model
-
Steele JW, Gandy S. Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy 9(4): 617-8 (2013).
-
(2013)
Autophagy
, vol.9
, Issue.4
, pp. 617-618
-
-
Steele, J.W.1
Gandy, S.2
-
21
-
-
77956214193
-
Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death
-
Zhang S, Hedskog L, Petersen CAH, Winblad B, Ankarcrona M. Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death. J Alzheimer's Dis 21(2): 389-402 (2010).
-
(2010)
J Alzheimer's Dis
, vol.21
, Issue.2
, pp. 389-402
-
-
Zhang, S.1
Hedskog, L.2
Petersen, C.A.H.3
Winblad, B.4
Ankarcrona, M.5
-
22
-
-
84863944817
-
Dimebon ameliorates amyloid-β induced impairments of mitochondrial form and function
-
Eckert SH, Eckmann J, Renner K, Eckert GP, Leuner K, Muller WE. Dimebon ameliorates amyloid-β induced impairments of mitochondrial form and function. J Alzheimer's Dis 31(1): 21-32 (2012).
-
(2012)
J Alzheimer's Dis
, vol.31
, Issue.1
, pp. 21-32
-
-
Eckert, S.H.1
Eckmann, J.2
Renner, K.3
Eckert, G.P.4
Leuner, K.5
Muller, W.E.6
-
23
-
-
50249154155
-
Isolation of mitochondria from rat brain using Percoll density gradient centrifugation
-
Sims NR, Anderson MF. Isolation of mitochondria from rat brain using Percoll density gradient centrifugation. Nat Protoc 3(7): 1228-39 (2008).
-
(2008)
Nat Protoc
, vol.3
, Issue.7
, pp. 1228-1239
-
-
Sims, N.R.1
Anderson, M.F.2
-
24
-
-
0025471534
-
Rapid isolation of metabolically active mitochondria from rat brain and subregions using percoll density gradient centrifugation
-
Sims NR. Rapid isolation of metabolically active mitochondria from rat brain and subregions using percoll density gradient centrifugation. J Neurochem 55(2): 698-707 (1990).
-
(1990)
J Neurochem
, vol.55
, Issue.2
, pp. 698-707
-
-
Sims, N.R.1
-
25
-
-
0017184389
-
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
-
Bradford MM. A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding. Anal Biochem 72: 248-54 (1976).
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
26
-
-
55549091082
-
The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition
-
Leung AWC, Varanyuwatana P, Halestrap AP. The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition. J Biol Chem 283(39): 26312-23 (2008).
-
(2008)
J Biol Chem
, vol.283
, Issue.39
, pp. 26312-26323
-
-
Leung, A.W.C.1
Varanyuwatana, P.2
Halestrap, A.P.3
-
27
-
-
73649092745
-
Increased Potassium Conductance of Brain Mitochondria Induces Resistance to Permeability Transition by Enhancing Matrix Volume
-
Hansson MJ, Morota S, Teilum M, Mattiasson G, Uchino H, Elmer E. Increased Potassium Conductance of Brain Mitochondria Induces Resistance to Permeability Transition by Enhancing Matrix Volume. J Bioligical Chem 285(1): 741-50 (2010).
-
(2010)
J Bioligical Chem
, vol.285
, Issue.1
, pp. 741-750
-
-
Hansson, M.J.1
Morota, S.2
Teilum, M.3
Mattiasson, G.4
Uchino, H.5
Elmer, E.6
-
28
-
-
84856526180
-
The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore
-
Varanyuwatana P, Halestrap AP. The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore. Mitochondrion 12: 120-5 (2012).
-
(2012)
Mitochondrion
, vol.12
, pp. 120-125
-
-
Varanyuwatana, P.1
Halestrap, A.P.2
-
29
-
-
51149113536
-
Resistance to Ca2+-induced opening of the permeability transition pore differs in mitochondria from glycolytic and oxidative muscles
-
Picard M, Csukly K, Robillard M-E, Godin R, Ascah A, Bourcier-Lucas C, et al. Resistance to Ca2+-induced opening of the permeability transition pore differs in mitochondria from glycolytic and oxidative muscles. Am J Physiol-Regul Integr Comp Physiol [Internet] 295(2): R659-68 (2008).
-
(2008)
Am J Physiol-Regul Integr Comp Physiol [Internet]
, vol.295
, Issue.2
-
-
Picard, M.1
Csukly, K.2
Robillard, M.-E.3
Godin, R.4
Ascah, A.5
Bourcier-Lucas, C.6
-
30
-
-
77952387355
-
Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism
-
Giorgetti M, Gibbons J a, Bernales S, Alfaro IE, Drieu La Rochelle C, Cremers T, et al. Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. J Pharmacol Exp Ther [Internet] 333(3): 748-57 (2010).
-
(2010)
J Pharmacol Exp Ther [Internet]
, vol.333
, Issue.3
, pp. 748-757
-
-
Giorgetti, M.1
Gibbons, J.A.2
Bernales, S.3
Alfaro, I.E.4
Drieu La Rochelle, C.5
Cremers, T.6
-
31
-
-
4243806448
-
Prevention of β-amyloid-induced neurotoxicity by tacrine and Dimebon
-
Bachurin SO, Lermontova N, Shevtzova E, Serkova T, Kireeva E. Prevention of β-amyloid-induced neurotoxicity by tacrine and Dimebon. J Neurochem 71(1) 71: 68 (1998).
-
(1998)
J Neurochem 71(1)
, vol.71
, pp. 68
-
-
Bachurin, S.O.1
Lermontova, N.2
Shevtzova, E.3
Serkova, T.4
Kireeva, E.5
-
32
-
-
79952707903
-
Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release
-
Naga KK, Geddes JW. Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release. Neuromolecular Med 13(1): 31-6 (2010).
-
(2010)
Neuromolecular Med
, vol.13
, Issue.1
, pp. 31-36
-
-
Naga, K.K.1
Geddes, J.W.2
-
33
-
-
67650245365
-
Regulation and pharmacology of the mitochondrial permeability transition pore
-
Zorov DB, Juhaszova M, Yaniv Y, Nuss HB, Wang S, Sollott SJ. Regulation and pharmacology of the mitochondrial permeability transition pore. Cardiovasc Res 83: 213-25 (2009).
-
(2009)
Cardiovasc Res
, vol.83
, pp. 213-225
-
-
Zorov, D.B.1
Juhaszova, M.2
Yaniv, Y.3
Nuss, H.B.4
Wang, S.5
Sollott, S.J.6
-
34
-
-
67349285823
-
The Molecular Composition of the Mitochondrial Permeability Transition Pore
-
Baines CP. The Molecular Composition of the Mitochondrial Permeability Transition Pore. J Mol Cell Cardiol 46(6): 850-7 (2009).
-
(2009)
J Mol Cell Cardiol
, vol.46
, Issue.6
, pp. 850-857
-
-
Baines, C.P.1
-
35
-
-
0041810128
-
The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death
-
Halestrap AP, Brenner C. The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death. Curr Med Chem 10: 1507-25 (2003).
-
(2003)
Curr Med Chem
, vol.10
, pp. 1507-1525
-
-
Halestrap, A.P.1
Brenner, C.2
-
36
-
-
77956061441
-
Impact of adenosine nucleotide translocase (ANT) proline isomerization on Ca2+-induced cysteine relative mobility/mitochondrial permeability transition pore
-
Pestana CR, Silva CHTP, Uyemura SA, Santos AC, Curti C. Impact of adenosine nucleotide translocase (ANT) proline isomerization on Ca2+-induced cysteine relative mobility/mitochondrial permeability transition pore. J Bioenerg Biomembr 42(4): 329-35 (2010).
-
(2010)
J Bioenerg Biomembr
, vol.42
, Issue.4
, pp. 329-335
-
-
Pestana, C.R.1
Silva, C.H.T.P.2
Uyemura, S.A.3
Santos, A.C.4
Curti, C.5
-
37
-
-
0037444667
-
Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria
-
Das M, Parker JE, Halestrap AP. Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria. J Physiol 547(Pt 3): 893-902 (2003).
-
(2003)
J Physiol
, vol.547
, Issue.PART 3
, pp. 893-902
-
-
Das, M.1
Parker, J.E.2
Halestrap, A.P.3
-
38
-
-
0036478989
-
The permeability transition pore complex: Another view
-
Halestrap AP, McStay GP, Clarke SJ. The permeability transition pore complex: another view. Biochimie 84(2-3): 153-66 (2002).
-
(2002)
Biochimie
, vol.84
, Issue.2-3
, pp. 153-166
-
-
Halestrap, A.P.1
McStay, G.P.2
Clarke, S.J.3
-
39
-
-
77956220629
-
Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease
-
Supnet C, Bezprozvanny I. Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease. J Alzheimer's Dis 20: S487-S498 (2010).
-
(2010)
J Alzheimer's Dis
, vol.20
-
-
Supnet, C.1
Bezprozvanny, I.2
-
40
-
-
34249092704
-
Calcium and neurodegeneration
-
Mattson MP. Calcium and neurodegeneration. Aging Cell 6(3): 337-50 (2007).
-
(2007)
Aging Cell
, vol.6
, Issue.3
, pp. 337-350
-
-
Mattson, M.P.1
-
41
-
-
0038143180
-
The Relationship between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria
-
Chalmers S, Nicholls DG. The Relationship between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria. J Biol Chem 278(21): 19062-70 (2003).
-
(2003)
J Biol Chem
, vol.278
, Issue.21
, pp. 19062-19070
-
-
Chalmers, S.1
Nicholls, D.G.2
-
42
-
-
84869777952
-
Stabilizers of Neuronal and Mitochondrial Calcium Cycling as a Strategy for Developing a Medicine for Alzheimer's Disease
-
Fernández-Morales J-C, Arranz-Tagarro J-A, Calvo-Gallardo E, Maroto M, Padín J-F, García AG, et al. Stabilizers of Neuronal and Mitochondrial Calcium Cycling as a Strategy for Developing a Medicine for Alzheimer's Disease. ACS Chem Neurosci Am Chem Soc 3(11): 873-83 (2012).
-
(2012)
ACS Chem Neurosci Am Chem Soc
, vol.3
, Issue.11
, pp. 873-883
-
-
Fernández-Morales, J.-C.1
Arranz-Tagarro, J.-A.2
Calvo-Gallardo, E.3
Maroto, M.4
Padín, J.-F.5
García, A.G.6
|