Linear, no threshold response at low doses of ionizing radiation: Ideology, prejudice and science

Current Science

Volumn 107, Issue 1, 2014, Pages 46-53

  Kesavan, P C ^a  

^a M S SWAMINATHAN RESEARCH FOUNDATION   (India)

Author keywords

Genomic instability; Hormesis; LNT hypothesis; Radioadaptive response; Stochastic effects

Indexed keywords

EID: 84904005754     PISSN: 00113891     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (69)

1. Muller, H. J., Artificial transmutation of the gene. Science, 1927, 66, 84-87.
2. Muller, H. J., Production of mutations (Nobel lecture 1946); http://www.nobelprize.org/nobel_prizes/medicine/laureates/1946/muller-lecture.html
3. Calabrese, E. J., Muller's Nobel Prize lecture on dose-response for ionizing radiation: ideology or science? Arch. Toxicol., 2011, 85, 1495-1498.
4. Calabrese, E. J., Muller's Nobel Prize lecture: when ideology prevailed over science. Toxicol. Sci., 2012, 126, 1-4.
5. Caspari, E. and Stern, C., The influence of chronic irradiation with gamma rays at low dosages on the mutation rate in Drosophila melanogaster. Genetics, 1948, 33, 75-95.
6. Spencer, W. P. and Stern, C., Experiments to test the validity of the linear R-dose/mutation at low dosage. Genetics, 1948, 33, 43-74.
7. Oliver, C. P., The effect of varying the duration of X-ray treatment upon the frequency of mutation. Science, 1930, 71, 44-46.
8. Hanson, F. B. and Heys, F., Radium and lethal mutations in Drosophila; further evidence of the proportionality rule from the effects of equivalent doses differently applied. Am. Nat., 1932, 66, 335-345.
9. Timofeeff-Ressovsky, N. W., Zimmer, K. G. and Delbruck, M., Nachrichten von der gesselschaft der Wissenschaften zu Gottingen. Uber die nature der genmuation und der genstruktur. Biologie, 1935, 1(13).
10. Hanson, F. B. and Heys, F., An analysis of the effect of the different rays of radium in producing lethal mutations in Drosophila. Am. Nat., 1929, 63, 201-213.
11. Weinstein, A., The production of mutations and rearrangements of genes by X-rays. Science, 1928, LXVII, 376-377.
12. Stadler, L. J., Some genetic effects of X-rays in plants. J. Hered., 1930, 21, 3-19.
13. Serebrowsky, A. S. and Dubinin, N. P., X-ray experiments with Drosophila. J. Hered., 1930, 21, 259-265.
14. Koana, T., Okada, M. O., Ogura, K., Tsujimura, H. and Sakai, K., Reduction of background mutations by low-dose X-irradiation of Drosophila spermatocytes at a low dose-rate. Radiat. Res., 2007, 167, 217-221.
15. Koana, T., Takashima, Y., Okada, M. O., Ikehata, M., Miyakoshi, J. and Sakai, K., A threshold exists in the dose-response relationship for somatic mutation frequency induced by X-irradiation of Drosophila. Radiat. Res., 2004, 161, 391-396.
16. Olipitz, W. et al., Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~400-fold natural background radiation. Environ. Health Perspect., 2012, 120, 1130-1136.
17. Jayashree, B., Devasagayam, T. P. A. and Kesavan, P. C., Low dose radiobiology: mechanistic considerations. Curr. Sci., 2001, 80, 515-523.
18. Luckey, T. D., Radiation Hormesis, CRC Press, Boca Raton, FL, USA, 1992.
19. Lorenz, F., Hollcroft, J. W., Miller, E., Cogdon, C. C. and Schweisthal, R., Long term effects of acute and chronic radiation in mice. 1. Survival and tumor incidence following acute irradiation of 0.11 r per day. J. Natl. Cancer Inst., 1955, 15, 1049-1055.
20. Caratero, A., Courtade, M., Bonnet, L., Planel, H. and Caratero, C., Effect of a continuous gamma irradiation at a very low dose on the life span of mice. Gerontology, 1998, 44, 272-276.
21. Courtade, M., Billotet, C., Gasset, G., Caratero, A., Charlet, J. P., Pipy, B. and Caratero, C., Life-span, cancer and non-cancer diseases in mouse exposed to a continuous very low dose of r-irradiation. Int. J. Radiat. Biol., 2002, 78, 845-855.
22. Lacoste-Collin, L., Jozan, S., Cances-Lauwers, V., Pipy, B., Gasset, G., Ceratero, C. and Courtade-Saidi, M., Effect of continuous irradiation with very low dose of gamma rays on life span and the immune system in SJL mice prone to B-cell lymphoma. Radiat. Res., 2007, 168, 725-732.
23. Zhang, L. et al., Low-dose radiation-induced hormetic effect on hematopoietic reconstitution. Int. J. Radiat. Biol., 2010, 86, 329- 333.
24. Planel, H. et al., Influence on cell proliferation of background radiation or exposure to very low, chronic gamma irradiation. Health Phys., 1987, 52, 571-578.
25. Kawanishi, M., Okuyama, K., Shiraishi, K., Matsuda, Y., Taniguchi, R., Shiomi, N. and Yonezawa, M., Growth retardation of paramecium and mouse cells by shielding them from background radiation. Int. J. Radiat. Res., 2012, 53, 404-410.
26. Wolff, S., The adaptive response in radiobiology: evolving insights and implications. Environ. Health Perspect., 1998, 106, 277-283.
27. Bonner, W. M., Low-dose radiation: thresholds, bystander effects, and adaptive responses. Proc. Natl. Acad. Sci. USA, 2003, 100, 4973-4975.
28. Farooqui, Z. and Kesavan, P. C., Low dose radiation-induced adaptive response in bone marrow cells of mice. Mutat. Res., 1993, 302, 83-89.
29. Rigaud, O. and Moustacchi, E., Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response. Mutat. Res., 1996, 358(2), 127-134.
30. Thierens, H., Vral, A., Barbe, M., Meijlaers, M., Baeyens, A. and Ridder, L. D., Chromosomal radiosensitivity study of temporary nuclear workers and the support of the adaptive response induced by occupational exposure. Int. J. Radiat. Biol., 2002, 78, 1117-1126.
31. Schollnberger, H., Mitchell, R. L. J., Azzam, E. I., Crawwford-Brown, D. J. and Hofmann, W., Explanation of protective effects of low doses of r-irradiation with a mechanistic radiobiological model. Int. J. Radiat. Biol., 2002, 78, 1159-1173.
32. Portess, D. I., Bauer, G., Hill, M. A. and O'Neil, P., Low-dose radiation on non-transformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis. Cancer Res., 2007, 67, 1246-1253.
33. Nagasawa, H. and Little, J. B., Induction of sister-chromatid exchanges by extremely low-dose alpha particles. Cancer Res., 1992, 52, 6394-6396.
34. Wojewodzka, M., Kruszewski, M. and Szumiel, I., Effect of signal transduction inhibition in adapted lymphocytes: micronuclei frequency and DNA repair. Int. J. Radiat. Biol., 1997, 71, 245- 252.
35. Azzam, E. I., de Toledo, S., Gooding, M. T. and Little, J. B., Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluencies of alpha particles. Radiat. Res., 1998, 150, 497-504.
36. Zhou, H., Randers-Pehrson, C. A., Geard, C. R., Brenner, D. J., Hall, E. J. and Hei, T. K., Interaction between radiation-induced adaptive response and bystander mutagenesis. Radiat. Res., 2003, 160, 512-516.
37. Azzam, E. I., de Toledo, S. M. and Little, J. B., Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha particle irradiated to non-irradiated cells. Proc. Natl. Acad. Sci. USA, 2001, 98, 473-478.
38. Little, J. B., Nagasawa, H., Pfenning, T. and Vetrovs, H., Radiation- induced genomic instability: delayed mutagenic and cytogenetic effects of X-rays and alpha particles. Radiat. Res., 1997, 148, 299-307.
39. Lorimore, S. A. and Wright, E. G., Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review. Int. J. Radiat. Biol., 2003, 79, 15-25.
40. Yang, C. R., Leskov, K., Hosley-Eberlein, K., Criswell, T., Pink, J. J., Kinsella, T. J. and Boothman, D. A., Nuclear clusterin/XIP8, an X-ray-induced Ku70-binding protein that signals cell death. Proc. Natl. Acad. Sci. USA, 2000, 97, 5907-5912.
41. Belyakov, O. V., Folkard, M., Mothersill, C., Prise, K. M. and Michael, B. D., Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiat. Prot. Dosimetry, 2002, 99, 249-251.
42. Belyakov, O. V., Folkard, M., Mothersill, C., Prise, K. M. and Michael, B. D., Bystander-induced differentiation: a major response to targeted irradiation of a urothelial explant model. Mutat. Res., 2006, 597, 43-49.
43. Bauer, G., Low dose radiation and intercellular induction of apoptosis: potential implications for the control of oncogenesis. Int. J. Radiat. Biol., 2007, 83, 873-888.
44. Liu, S. Z., Cancer control related to stimulation of immunity by low dose irradiation. Dose-Response, 2006, 5(1), 39-47.
45. Redpath, J. L., Radiation-induced neoplastic transformation in vitro: evidence for a protective effect at low doses of low LET. Cancer Metastasis Rev., 2004, 23(3-4), 333-339.
46. Mothersill, C., Seymour, R. J. and Seymour, C. B., Bystander effects in repair-deficient cell lines. Radiat. Res., 2004, 161, 256-263.
47. Tubiana, M., Feinendegen, L. E., Yang, C. and Kaminski, J. M., The linear no-threshold relationship is inconsistent with radiation biologic and experimental data. Radiology, 2009, 251(1), 13-22.
48. Yin, E., Nelson, D. O., Coleman, M. A., Peterson, L. E. and Wyrobek, A. J., Gene expression changes in mouse brain after exposure to low-dose ionizing radiation. Int. J. Radiat. Biol., 2003, 79(10), 759-775.
49. Mezentsev, A. and Amundson, S. A., Global gene expression responses to low- or high-dose radiation in a human threedimensional tissue model. Radiat. Res., 2011, 175, 677-688.
50. United Nations Scientific Committee on the Effects of Atomic Radiations, Biological mechanisms of radiation actions at low doses. UNSCEAR, New York, 2012; www.unscear.org
51. Ding, L. H. et al., Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat. Res., 2005, 164, 17-26.
52. Manning, G., Kabacik, S., Finnon, P., Paillier, F., Bouffler, S. and Badie, C., Assessing a new gene expression analysis technique for radiation biodosimetry applications. Radiat. Meas., 2011, 46, 1014-1018.
53. Taubes, G., Epidemiology faces its limits. Science, 1995, 269, 164-169.
54. BEIR VII-Phase 2, National Research Council, Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation, Health Risks from Low Levels of Ionizing Radiation, The National Academies Press, Washington, DC, 2006.
55. Tubiana, M. et al., Dose-effect relationships and estimation of the carcinogenic effects of low doses of ionizing radiation. Joint Report No. 2, French Academy of Sciences-French National Academy of Medicine, Edition Nucleon, Paris, 30 March 2005; http://www.academiemedicine/fr/actualities/rapports.asp
56. Luckey, T. D., Nuclear law stands on thin ice. Int. J. Nucl. Law, 2008, 2, 33-65.
57. BEIR Committee, Health Effects of Exposure to Low Levels of Ionizing Radiation, The National Academy Press, Washington DC, 1990.
58. Shimizu, Y., Kato, H. and Schull, W. J., Studies on the mortality of A-bomb survivors. 9. Mortality 1950-1985: Part 2. Cancer mortality based on recently revised doses (DS 86). Radiat. Res., 1992, 121, 120-141.
59. Shimizu, Y., Kato, H. and Schull, W. J., Risk of cancer among atomic bomb survivors. J. Radiat. Res. (Suppl. 2), 1991, 32, 54-63.
60. Miller, A. B. et al., Mortality from breast cancer after irradiation during fluoroscopic examination in patients being treated for tuberculosis. New Eng. J. Med., 1989, 321, 11285-11288.
61. Cardis, E. et al., Effects of low doses and low dose-rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat. Res., 1995, 142, 117-132.
62. United Nations Scientific Committee on the Effects of Atomic Radiations, Report to the General Assembly, Annex D: Occupational radiation exposures, United Nations, New York, 1993.
63. Kesavan, P. C., Indian research on high levels of natural radiation: pertinent observations for further studies. In High Levels of Natural Radiation 1996, Radiation Dose and Health Effects (eds Wei, L., Sugahara, T. and Tao, Z.), Elsevier Science B.V., 1997, pp. 111-117.
64. Kesavan, P. C., Low-dose radiation health hazards: radiobiological mechanisms versus theoretical predictions based on linear, nothreshold model. In India's Nuclear Energy Programme. Future Plans, Prospects and Concerns (ed. Rajaraman, R.), published by Academic Foundation in association with the Indian National Science Academy, New Delhi, 1997, pp. 89-126.
65. Jaikrishan, G., Andrews, V. J., Thampi, M. V., Koya, P. K., Rajan, V. K. and Chauhan, P. S., Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. I. Prevalence of congenital malformations in newborns. Radiat. Res. (Suppl. 6), 1999, 152, 149-153.
66. Nair, M. K. et al., Population study in the high natural background radiation area in Kerala, India. Radiat. Res., 1999, 152, 145-148.
67. Tao, Z. F. et al., Study on cancer mortality among the residents in high background radiation area of Yang Jiang, China. In High Levels of Natural Radiation: Radiation Dose and Health Effects. (eds Wei, L., Sugahara, T. and Tao, Z.), Elsevier Science B.V., 1997, pp. 249-254.
68. Taylor, L. S., Some nonscientific influences on radiation protection standards and practice, the 1980 Sievert Lecture. Health Phys., 1980, 39, 851-874.
69. United Nations Scientific Committee on the Effects of Atomic Radiations, Report to the General Assembly, Scientific Annex A: Levels and effects of radiation exposure due to the nuclear accident after the 2011 great east-Japan earthquake and tsunami, 2013.