Linking alzheimer’s disease, β -amyloid, and lipids: A technical approach

Amyloid Precursor Protein: A Practical Approach

Volumn , Issue , 2004, Pages 129-144

  Grimm, Marcus O W ^a   Paetzold, Andreas J ^a   Grimm, Heike S ^a   Zinser, Eva G ^a   Ruppert, Thomas ^a   Hartmann, Tobias ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

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EID: 84903997976     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (29)

1. De Strooper, B. and Annaert, W. Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell Sci. 113, 1857-1870, 2000.
2. Sinha, S. and Lieberburg, I. Cellular mechanisms of beta-amyloid production and secretion. Proc. Natl. Acad. Sci. USA 96, 11049-11053, 1999.
3. Mahley, R.W. and Rall, S.C., Jr. Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1, 507-337, 2000.
4. Corder, E.H. et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261, 921-923, 1993.
5. Bales, K.R. et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat. Genet. 17, 263-264, 1997.
6. Nathan, B.P. et al. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 264, 850-852, 1994.
7. Grziwa, B. et al. The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted. J. Biol. Chem. 278, 6803-6308, 2003.
8. Lichtenthaler, S.F. et al. The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain. Proc. Natl. Acad. Sci. USA 99, 1365-1370, 2002.
9. Sparks, D.L. et al. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp. Neurol. 126, 88-94, 1994.
10. Simons, M. et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. USA 95, 6460-6464, 1998.
11. Cucchiara, B. and Kasner, S.E. Use of statins in CNS disorders. J. Neurol. Sci. 187, 81-89, 2001.
12. Kilsdonk, E.P. et al. Cellular cholesterol efflux mediated by cyclodextrins. J. Biol. Chem. 270, 17250-17256, 1995.
13. Frears, E.R. et al. The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 10, 1699-1705, 1999.
14. Fassbender, K. et al. Simvastatin strongly reduces levels of Alzheimer’s disease betaamyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98, 5856-5961, 2001.
15. Refolo, L.M. et al. Hypercholesterolemia accelerates the Alzheimer’s amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7, 321-3331, 2000.
16. Refolo, L.M. et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer’s disease. Neurobiol. Dis. 8, 890-899, 2001.
17. Tienari, P.J. et al. Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA 94, 4125-4130, 1997.
18. Fassbender, K. et al. Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide. Neurology 59, 1257-1258, 2002.
19. Schroder, J. et al. Cerebral changes and cerebrospinal fluid beta-amyloid in Alzheimer’s disease: a study with quantitative magnetic resonance imaging. Mol. Psychiatr 2, 505-507, 1997.
20. Roy, D. and Mukhopadhyay, C. GD1a in phospholipid bilayer: a molecular dynamics simulation. J. Biomol. Struct. Dyn. 18, 639-646, 2001.
21. Kappel, T. et al. Gangliosides affect membrane-channel activities dependent on ambient temperature. Cell. Mol. Neurobiol. 20, 579-590, 2000.
22. Cutler, R.G. et al. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 101, 2070-2075, 2004.
23. Bligh, E.G and Dyer, W.J. A rapid method of total lipid extraction and purification. Can. J. Med. Sci. 37, 911-917, 1959.
24. Hundrieser, K.E., Clark, R.M., and Jensen, R.G. Total phospholipid analysis in human milk without acid digestion. Am. J. Clin. Nutr. 41, 988-993, 1985.
25. Brugger, B. et al. Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc. Natl. Acad. Sci. USA 94, 2339-2344, 1997.
26. Ekroos, K. et al. Charting molecular composition of phosphatidylcholines by fatty acid scanning and ion trap MS3 fragmentation. J. Lipid Res. 44, 2181-2192, 2003.
27. Han, X. and Gross, R.W. Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids. Proc. Natl. Acad. Sci. USA 91, 10635-10639, 1994.
28. Kerwin, J.L., Tuininga, A.R., and Ericsson, L.H. Identification of molecular species of glycerophospholipids and sphingomyelin using electrospray mass spectrometry. J. Lipid Res. 35, 1102-1114, 1994.
29. Ida, N. et al. Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J. Biol. Chem. 271, 22908-22914, 1996.