CD4+CD25 high FOXP3+ Regulatory T Cells Correlate with FEV1 in North Indian Children with Cystic Fibrosis

Immunological Investigations

Volumn 43, Issue 6, 2014, Pages 535-543

  Anil, Nidhi ^a,b   Singh, Meenu ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Cystic fibrosis; FEV1; Regulatory T cells

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; CD4 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADOLESCENT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE ASSOCIATION; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; HUMAN; INDIAN; LUNG FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPIROMETRY; CELL SEPARATION; DISEASE COURSE; FEMALE; IMMUNOLOGY; INDIA; LUNG FUNCTION TEST; MALE; METABOLISM;

ADOLESCENT; ANTIGENS, CD4; CELL SEPARATION; CHILD; CYSTIC FIBROSIS; DISEASE PROGRESSION; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INDIA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; RESPIRATORY FUNCTION TESTS; T-LYMPHOCYTES, REGULATORY;

EID: 84903984927     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.3109/08820139.2014.888447     Document Type: Article

References (25)

1. Akbari O, Stock P, Dekruff RH, Umeotsu DT. (2003 Role of regulatory T cells in allergy and asthma. Curr Opin Immunol, 15, 627-33. (Pubitemid 37434069)
2. Baecher-Allan C, Viglietta V, Hafler DA. (2004 Human CD4+CD25+ regulatory T cells. Semin Immunol, 16, 89-97. (Pubitemid 38234760)
3. Bellinghausen I, Klostermann B, Knop J, Saloga J. (2003 Human CD4(+) CD25(+) T cells derived from the majority of atopic donors are able to suppress T(H)1 T(H)2 cytokine production. J Allergy Clin Immunol, 111, 862-8. (Pubitemid 36470261)
4. Bluestone JA, Abbas AK. (2003 Natural versus adaptive regulatory T cells. Nat Rev Immunol, 3, 253-7. (Pubitemid 37323210)
5. Boucher RC. (2004 New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir, 23, 146-58. (Pubitemid 38088512)
6. Chmiel JF, Davis PB. (2003 State of the art: Why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection. Respir Res, 4, 1-9.
7. Davis PB, Drumm M, Konstan MW. (1996 Cystic fibrosis. Am J Respir Crit Care Med, 154, 1229-56. (Pubitemid 26391164)
8. Decraene A, Willems-Widyastutti A, Kasran A, et al. (2010 Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable cystic fibrosis patients. Respir Res, 11, 177-85.
9. Elizur A, Cannon CL, Ferkol TW. (2008 Airway inflammation in cystic fibrosis. Chest, 133, 489-95. (Pubitemid 351272410)
10. Hartl D, Koller B, Mehlhorn AT, et al. (2007 Quantitative and functional impairment of pulmonary CD4+ CD25high regulatory T cells in pediatric asthma. J Allergy Clin Immunol, 119, 1258-66. (Pubitemid 46654192)
11. Hori S, Nomura T, Sakaguchi S. (2003 Control of regulatory T cell development by transcription factor Foxp3. Science, 299, 1057-61. (Pubitemid 36222930)
12. Ivanov I, Zhou L, Littman DR. (2007 Transcriptional regulation of Th17 cell differentiation. Semin Immunol, 19, 409-17. (Pubitemid 351274050)
13. Jacquot J, Tabary O. (2008 Hyperinflammation in airways of cystic fibrosis patients: Whats new? Expert Rev Mol Diagn, 8, 359-63. (Pubitemid 351962082)
14. Kehm AP, Carpentier PA, Anger HA Muller SD. (2002 Cutting edge: CD4+CD25+ regulatory T cells suppress antigen specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune enchalomyelitis. J Immunol, 169, 4712-16. (Pubitemid 35217131)
15. Lee JH, Yu HH, Wang LC, et al. (2007 The levels of CD4+ CD25+ regulatory T cells in pediatric patients with allergic rhinitis and bronchial asthma. Clin Exp Immunol, 148, 53-63.
16. Lohr J, Knoechel B, Caretto D, Abbas AK. (2009 Balance of Th1 and Th17 effector and peripheral regulatory T Cells. Microbes Infect, 11, 589-93.
17. McHugh RS, Shevach EM. (2002 The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol, 110, 693-702. (Pubitemid 35423170)
18. Miller MR, Hankinson J, Brusasco V, et al. (2005 Standardization of spirometry. Eur Respir J, 26, 319-38.
19. Muhlebach MS, Stewart PW, Leigh MW, Noah TL. (1999 Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Am J Respir Crit Care Med, 160, 186-91. (Pubitemid 29326086)
20. Ochs HD, Ziegler SF, Torgerson TR. (2005 FOXP3 acts as a rheostat of the immune response. Immunol Rev, 203, 156-64. (Pubitemid 40179700)
21. Ozdemir C, Akdis M, Akdis CA. (2009 T regulatory cells and their counterparts: masters of immune regulation. Clin Exp Allergy, 39, 626-39.
22. Provoost S, Maes T, van Durme YM, et al. (2009 Decreased FOXP3 protein expression in patients with asthma. Allergy, 64, 1539-46.
23. Sakaguchi S, Sakaguchi N, Asano M, et al. (1995 Immunologic self tolerance maintained by activated T cells expressing IL-2 receptor alpha chains (CD25) breakdown of a single mechanism of self tolerance causes various autoimmune diseases. J Immunol, 166, 1151-64.
24. Strickland DH, Stumbles PA, Zosky GR, et al. (2005 Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells. J Exp Med, 202, 1539-47.
25. Takahashi T, Tagami T, Yamazaki S, et al. (2000 Immunologic self tolerance maintained by CD25+CD4+regulatory T cells constitutively expressing cytotoxic T lymphocyte associated antigen 4. J Exp Med, 192, 387-96.