Re-engineered p53 chimera with enhanced homo-oligomerization that maintains tumor suppressor activity

Molecular Pharmaceutics

Volumn 11, Issue 7, 2014, Pages 2442-2452

  Okal, Abood ^a   Cornillie, Sean ^a   Matissek, Stephan J ^b   Matissek, Karina J ^a,c   Cheatham, Thomas E ^a   Lim, Carol S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b BIBERACH UNIVERSITY OF APPLIED SCIENCES   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Bcr; breast cancer; coiled coil; dominant negative effect; p53; tetramerization domain; tumor suppressor

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER GENE THERAPY; CANCER INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; ANIMAL; CHLOROCEBUS AETHIOPS; COS CELL LINE; GENETICS; MCF-7 CELL LINE; MUTATION; PHYSIOLOGY; POLYMERIZATION; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; GENES, TUMOR SUPPRESSOR; HUMANS; MCF-7 CELLS; MUTATION; POLYMERIZATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84903955062     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500202p     Document Type: Article

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