Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro

Life Sciences

Volumn 108, Issue 2, 2014, Pages 94-103

  Choi, Young Ji ^a   Kim, Da Hye ^a   Kim, Sang Jun ^a   Kim, Ju ^a   Jeong, Seung Il ^a   Chung, Chang Ho ^a   Yu, Kang Yeol ^a   Kim, Seon Young ^a  

^a Jeonju Bio Materials Institute   (South Korea)

Author keywords

Decursin; Liver fibrosis; NADPH oxidase; ROS; TGF beta

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; ANTIBIOTIC AGENT; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CASPASE 3; COLLAGEN TYPE 1; DECURSIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMAD PROTEIN; SUPEROXIDE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; FIBROGENESIS; HEPATIC FIBROGENESIS; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION;

MUS;

DECURSIN; LIVER FIBROSIS; NADPH OXIDASE; ROS; TGF-BETA;

ACTINS; ANIMALS; BENZOPYRANS; BUTYRATES; CARBON TETRACHLORIDE; CELL LINE; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84903901823     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.05.012     Document Type: Article

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